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    HP:0001269: Hemiparesis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (9)


    Name (Synonyms) Correlation
    drug4753 Without haptic stimulation Wiki 0.71
    drug3623 Rehabilitation by Eccentric exercises Wiki 0.71
    drug2912 Observation of Virtual Actions (step 4) Wiki 0.71
    Name (Synonyms) Correlation
    drug2911 Observation of Virtual Actions Wiki 0.71
    drug204 Acceptability questionnaire Wiki 0.71
    drug3622 Rehabilitation by Concentric exercises Wiki 0.71
    drug3136 Performing Virtual Actions Wiki 0.71
    drug1851 Haptic stimulation Wiki 0.71
    drug3630 Relaxation Wiki 0.71

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D010291 Paresis NIH 1.00
    D055948 Sarcopenia NIH 0.50

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 VERARE : Effectiveness of Virtual Motor Actions for Improving Walking in Patients With Post-resuscitation Muscle Weakness

    After a hospitalization in Intensive Care Unit (ICU), approximately 50% of patients usually have a ICU-Weakness, i.e. nerves and muscles injury secondary to immobilization and to treatments which had to be used. This disease is expected to be similar or even higher in patients suffering from COVID-19 and hospitalized in ICU due to the average length of hospitalization of several weeks in this population. This condition will delay the return-to-walk of these patients, their discharge from hospitalization and may deteriorate their autonomy in daily life activities. Virtual Reality (VR) environments are already used and have proven their worth for the assessment and rehabilitation of patients with neurological diseases. It therefore seems appropriate to offer the use of virtual environments for this type of population. VR represents a unique opportunity for the rehabilitation care of these patients, and in particular those who have been reached by COVID-19, due to the possible mismatch between the amount of motor rehabilitation to be provided and the fatigability and breathlessness at the slightest effort which seem particularly intense in this population. The main objective of our project is to improve and to accelerate gait recovery in patients hospitalized in Physical and Rehabilitation Medicine after discharge from Resuscitation or Continuous Care Unit and in patients hospitalized in ICU and presenting ICU-weakness secondary to resuscitation, notably due to COVID-19 infection, thanks to the use of Virtual Reality tools. The VR tool will consist of virtual environments presented using a Virtual Reality headset where an avatar (double) of the patient hospitalized in Physical and Rehabilitation Medicine or in ICU will be represented, who will perform different motor tasks involving their lower limbs (ex: walking, or kicking a ball) in several different virtual environments (settings). The patient will be asked to observe actions, then to imagine carrying out their actions which will be performed by the avatar in the virtual environment, then they will be able to control the actions of the avatar using their legs thanks to sensors, then feel walking sensations through the use of haptic devices.

    NCT04441164
    Conditions
    1. Weakness of the Lower Limbs
    Interventions
    1. Other: Observation of Virtual Actions
    2. Other: Relaxation
    3. Other: Acceptability questionnaire
    4. Other: Observation of Virtual Actions (step 4)
    5. Other: Performing Virtual Actions
    6. Other: Haptic stimulation
    7. Other: Without haptic stimulation
    MeSH:Muscle Weakness Paresis
    HPO:Hemiparesis

    Primary Outcomes

    Description: Number of meters taken during the 6-minute test the day after the last session.

    Measure: 6-minute test

    Time: Day 10

    Secondary Outcomes

    Description: Gait assessment before the start of the first session, the day after the last session and 1 month from inclusion: 10-meter test (time in seconds)

    Measure: Time for 10-meter test

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Gait assessment before the start of the first session, the day after the last session and 1 month from inclusion: 6-minute walk test (need for breaks, scale de Borg, existence of desaturation)

    Measure: 6-minute walk test

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Gait assessment before the start of the first session, the day after the last session and 1 month from inclusion: recovery time for walking over 10 meters without human or technical assistance

    Measure: Recovery time

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Assessment of balance before the start of the first session, the day after the last session and 1 month from inclusion: normal or deficient posture balance in sitting and standing

    Measure: Normal or deficient posture balance in sitting and standing

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Assessment of balance before the start of the first session, the day after the last session and 1 month from inclusion: Berg Balance Scale. Berg's balance scale includes 14 tests that assess static balance and dynamic balance. Each test is rated from 0 (needs help) to 4 (can do on him/her own). Total score is on 56 points.

    Measure: Berg Balance Scale

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Assessment of balance before the start of the first session, the day after the last session and 1 month from inclusion: Timed Up and Go test (time in seconds)

    Measure: Timed Up and Go test

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Assessment of balance before the start of the first session, the day after the last session and 1 month from inclusion: test of the 10 chair lifts (duration in seconds, existence of a desaturation, Borg scale)

    Measure: Duration for the test of the 10 chair lifts

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Strength assessment before the start of the first session, the day after the last session and within 1 month of inclusion: MRC testing of the lower limbs. The Medical Research Council's scale (MRC scale) is an assessment of muscle power, rated form 0 (no contraction) to 5 (normal power).

    Measure: MRC scale

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Assessment of autonomy before the start of the first session, the day after the last session and within 1 month of inclusion: Functional Independence Measure. The Functional Independence Measure (FIM) is an 18-item instrument measuring a person's level of disability in terms of burden of care. Each item is rated from 1 (requiring total assistance) to 7 (completely independent). Three independent FIM scores can be generated by summing item scores: a total score (FIM total: 18 items), a motor score (FIM motor: eating, grooming, bathing, dressing - upper body, dressing - lower body, toileting, bladder management, bowel management, and transfers bed/chair/wheelchair, toilet, tub/shower, walk, stairs), and a cognitive score (FIM cognitive: auditory comprehension, verbal expression, social interaction, problem solving, and memory). Multiple studies support the reliability and validity of FIM scales in the older population.

    Measure: Functional Independence Measure

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion

    Description: Acceptability (a priori, patients and caregivers for stage 2) questionnaires

    Measure: Acceptability

    Time: Day 1 (step 2)

    Description: Acceptance (patients for stages 1, 3, 4 and 5) questionnaires

    Measure: Acceptance

    Time: Day 1 (step 2)

    Description: Fatigue assessment (visual analog scale) (steps 1, 3, 4, 5)

    Measure: Fatigue

    Time: End of each session, at days 1 to 9

    Description: Collections of possible undesirable effects by open question at the end of each session with the Virtual Reality tool (steps 1, 3, 4, 5)

    Measure: Undesirable effects

    Time: End of each session, at days 1 to 9

    Description: Assessment of confidence in the future using a questionnaire (steps 1, 3, 4, 5) before the start of the first session, the day after the last session and 1 month from inclusion

    Measure: Confidence in the future

    Time: Before the start of the first session (day 1), the day after the last session (day 9) and 1 month after inclusion
    2 Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection: Research Protocol for Randomized Controlled Trial (CovExc)

    With the COVID-19 pandemic, the number of patients to be treated in rehabilitation increased . Hospitalization for severe infection can induce muscular atrophy and muscular dysfunction that persists for several months and rehabilitation capacities may be exceeded. Exercises in eccentric mode could be performed, inducing greater muscular hypertrophy, muscle strength, power and speed than concentric exercises. The goal of this study was to compare functional recovery at 2 months after a training program in eccentric and concentric mode after severe COVID-19. An effective rehabilitation could help reduce costs and duration of care.

    NCT04649086
    Conditions
    1. Covid19
    2. Sarcopenia
    3. Muscle Weakness
    Interventions
    1. Other: Rehabilitation by Eccentric exercises
    2. Other: Rehabilitation by Concentric exercises
    MeSH:Muscle Weakness Sarcopenia Paresis
    HPO:Hemiparesis

    Primary Outcomes

    Description: Average change from baseline walking capacity measured by the 6-minutes walk test (6MWT), expressed in meters. All patients will be asked to cover the longest distance over a 30-meters distance in 6 min with or without stopping and with standardized verbal encouragements according to standard recommendations; to take into account a learning effect, the test will be performed twice, with the longer distance retained, expressed in meters. To prevent adverse effect, pulsed oxygen saturation (% of pSO²) and heart rate (heartbeat per minute) will be monitored continuously throughout the test by using a digital oximeter.

    Measure: Functional walking capacity

    Time: Day 0, Month 1, Month 2 and Month 6

    Secondary Outcomes

    Description: this test consists of assessing balance in a standing position, lifting from a chair (5 stand to-sit repetitions) and measuring 4-m walking speed (20). The patient walks 4 m at a normal and comfortable speed. The "test zone" (4 m) is preceded by an "acceleration zone" (1 m) and is followed by a "deceleration zone" (1 m). The assessor starts and stops the timing when the subject's foot meets the ground when entering and leaving the "test area", respectively.

    Measure: Evaluating of lower extremity functioning by Short Physical Performance Battery (SPPB) score

    Time: Day 0, Month 2 and Month 6

    Description: maximum muscle strength of the quadriceps, on the dominant limb, will be measured on a bench: - Strength during isometric contraction (at 90° knee flexion) - Standardized position with the arms crossed on the chest, the absence of back support during the measurement and the maintenance of the hips and the contralateral leg to avoid any compensating movement Three reproducible measurements (±10%) will be taken at 1-min intervals, with the highest value retained.

    Measure: Evaluating the maximum muscle strength of the quadriceps by Quadriceps Isometric Maximum Strength (QIMS) test

    Time: Day 0, Month 2

    Description: this test consists of performing 10 knee extensions at 10% QIMS, then gradually increasing the load (10% by 10%) until exhaustion (cannot perform the movement 2 consecutive times). The value retained is the last level (% QIMS) performed.

    Measure: Evaluating the fatigability of the quadriceps by Quadriceps Intermittent Fatigue (QIF) test

    Time: Day 0, Month 2

    Description: this scale explores cognitive (10 items), physical (9 items) and psychosocial (2 items) fatigue. The MFIS included 21 items with a total score ranging from 0 to 84 with higher scores indicating a greater impact of quality of life.

    Measure: Evaluating the global fatigability by Modified Fatigue Impact Scale (MFIS)

    Time: Day 0, Month 2 and Month 6

    Description: This questionnaire explores 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The EQ-5D-5L included 5 items independently scored from 1 to 5 (higher scores indicating a greater impact)and a 0-100 visual analogic scale exploring general health (0 means the worst heath patient can imagine, 100 means the best health patient can imagine).

    Measure: Evaluating functional capacities with EuroQol - 5 Dimensions (EQ-5D) questionnaire

    Time: Day 0, Month 2 and Month 6

    Description: measurement is in 90° elbow flexion, wrist in neutral position. Three reproducible measurements (± 10%) will be taken at 1-min intervals, with the highest value retained.

    Measure: Evaluating the handgrip strength by standard handgrip strength test

    Time: Day 0, Month 2

    Description: Plasma metabolome profile assessed by variation of number of blood metabolites. Changes from baseline to post-training intervention in plasma metabolome profile will be compared between excentric and concentric exercise groups.

    Measure: Metabolomic Profile

    Time: Day 0, Month 2 (post-training)

    Description: Biopsy from the Vastus lateralis will be performed and the variation of cross sectional area measurement of muscle fibers (µm2) will be analysed and compared between excentric and concentric exercise groups from baseline to post-training intervention.

    Measure: Cross sectional area measurement

    Time: Day 0, Month 2 (post-training)

    Description: Biopsy from the Vastus lateralis will be performed and the capillarization (variation of capillary to fiber ratio) will be analysed. Muscle adapations from baseline to post-training intervention will be compared between excentric and concentric exercise groups.

    Measure: Capillary to fibre ratio.

    Time: Day 0, Month 2 (post-training)

    Description: Biopsy from the Vastus lateralis will be performed and the evolution of number of satellite cell per muscle fiber will be analysed and compared between excentric and concentric exercise groups from baseline to post-training intervention.

    Measure: Satellite cell number

    Time: Day 0, Month 2 (post-training)

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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