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    HP:0012532: Chronic pain

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (37)


    Name (Synonyms) Correlation
    drug1276 Deferoxamine Wiki 0.31
    drug3897 Self-Compassion for Chronic Pain Virtual Group Treatment Program Wiki 0.27
    drug1477 Electrotherapy group Wiki 0.27
    Name (Synonyms) Correlation
    drug2183 Intervention program Wiki 0.27
    drug4887 chronic pain team Wiki 0.27
    drug528 BMS-986337 Placebo Wiki 0.27
    drug1694 Flywheel exercise Wiki 0.27
    drug1562 Exercise Testing and Training Wiki 0.27
    drug3214 Placebo 250 cc 24 hours continuous infusion for 15 days Wiki 0.27
    drug1280 Degarelix Wiki 0.27
    drug1289 Desidustat Wiki 0.27
    drug1290 Detection of anti-COVID-19 antibody level Wiki 0.27
    drug985 Choices and judgements Wiki 0.27
    drug1560 Exercise Group Wiki 0.27
    drug1292 Device used to record voice for screening Wiki 0.27
    drug1278 Defibrotide 25 mg/kg 24 hours continuous infusion for 15 days Wiki 0.27
    drug723 Buspirone 10 Mg Oral Tablet Wiki 0.27
    drug527 BMS-986337 Wiki 0.27
    drug4606 VCPM Wiki 0.27
    drug4301 Tele-Yoga Therapy Wiki 0.27
    drug4508 Triazolam 0.25 MG Oral Tablet Wiki 0.27
    drug4881 chiropractic team Wiki 0.27
    drug4775 Yoga Therapy Wiki 0.27
    drug909 Cannabis, Medical Wiki 0.27
    drug5171 questionnaire assesment Wiki 0.24
    drug1293 Dexamethasone Wiki 0.23
    drug4436 Tocilizumab Injection Wiki 0.19
    drug1917 Home exercise Wiki 0.19
    drug2551 Meditation (1 x 20-minute guided audio training) Wiki 0.19
    drug3083 Paracetamol Wiki 0.19
    drug1277 Defibrotide Wiki 0.19
    drug1640 Famotidine Wiki 0.12
    drug3844 Saline Wiki 0.08
    drug2606 Methylprednisolone Wiki 0.07
    drug3273 Placebo oral tablet Wiki 0.05
    drug4102 Standard of Care Wiki 0.04
    drug3195 Placebo Wiki 0.01

    Correlated MeSH Terms (37)


    Name (Synonyms) Correlation
    D059350 Chronic Pain NIH 1.00
    D000070627 Chronic Traumatic Encephalopathy NIH 0.27
    D010148 Pain, Intractable NIH 0.27
    Name (Synonyms) Correlation
    D005879 Tourette Syndrome NIH 0.27
    D013122 Spinal Diseases NIH 0.19
    D001714 Bipolar Disorder NIH 0.19
    D000070642 Brain Injuries, Traumatic NIH 0.18
    D012640 Seizures NIH 0.15
    D006526 Hepatitis C NIH 0.15
    D001930 Brain Injuries, NIH 0.15
    D000690 Amyotrophic Lateral Sclerosis NIH 0.13
    D000755 Anemia, Sickle Cell NIH 0.13
    D016472 Motor Neuron Disease NIH 0.13
    D005356 Fibromyalgia NIH 0.12
    D051346 Mobility Limitation NIH 0.12
    D020370 Osteoarthritis, Knee NIH 0.12
    D001927 Brain Diseases NIH 0.11
    D010003 Osteoarthritis, NIH 0.11
    D059352 Musculoskeletal Pain NIH 0.09
    D003095 Collagen Diseases NIH 0.09
    D015212 Inflammatory Bowel Diseases NIH 0.09
    D013313 Stress Disorders, Post-Traumatic NIH 0.09
    D010300 Parkinsonian NIH 0.08
    D012216 Rheumatic Diseases NIH 0.08
    D003424 Crohn Disease NIH 0.07
    D001172 Arthritis, Rheumatoid NIH 0.07
    D009103 Multiple Sclerosis NIH 0.06
    D012598 Scoliosi NIH 0.06
    D001168 Arthritis NIH 0.06
    D013577 Syndrome NIH 0.05
    D040921 Stress Disorders, Traumatic NIH 0.05
    D014947 Wounds and Injuries NIH 0.04
    D004194 Disease NIH 0.04
    D003141 Communicable Diseases NIH 0.02
    D007239 Infection NIH 0.01
    D045169 Severe Acute Respiratory Syndrome NIH 0.01
    D018352 Coronavirus Infections NIH 0.01

    Correlated HPO Terms (12)


    Name (Synonyms) Correlation
    HP:0100754 Mania HPO 0.19
    HP:0006802 Abnormal anterior horn cell morphology HPO 0.13
    HP:0007354 Amyotrophic lateral sclerosis HPO 0.13
    Name (Synonyms) Correlation
    HP:0002355 Difficulty walking HPO 0.12
    HP:0005086 Knee osteoarthritis HPO 0.12
    HP:0001250 Seizure HPO 0.12
    HP:0001298 Encephalopathy HPO 0.11
    HP:0002758 Osteoarthritis HPO 0.11
    HP:0002037 Inflammation of the large intestine HPO 0.09
    HP:0001370 Rheumatoid arthritis HPO 0.07
    HP:0100280 Crohn's disease HPO 0.07
    HP:0001369 Arthritis HPO 0.06

    Clinical Trials

    Navigate: Correlations   HPO

    There are 14 clinical trials


    1 Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD

    The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical injuries and exposure to psychological trauma. Health behavior change has become increasingly important in treating these conditions and proactively preventing long-term negative health sequelae, in order to benefit these Veterans directly and reduce the growing challenges to our healthcare system. The proposed CDA-2 program of research will use an innovative translational research approach to study whether a chronic progressive -based exercise program will reduce chronic pain in patients with PTSD and to elucidate and modify potential PTSD-related deficiencies in neurobiological and psychological responses to exercise to optimize the physical and psychological benefits of exercise for these individuals.

    NCT03283163
    Conditions
    1. Chronic Musculoskeletal Pain
    2. Posttraumatic Stress Disorder (PTSD)
    3. Mild or Moderate Traumatic Brain Injury
    Interventions
    1. Behavioral: Exercise Testing and Training
    MeSH:Musculoskeletal Pain Brain Injuries Brain Injuries, Traumatic Chronic Pain Stress Disorders, Post-Traumatic
    HPO:Chronic pain

    Primary Outcomes

    Description: To be administered at: Screening Evaluation & Endpoint 13 week exercise test sessions This 30-item structured interview is designed to assess both the 17 symptoms of PTSD and the 8 hypothesized associated features. The scale yields a dichotomous diagnosis of PTSD, and also provides a continuous score of frequency and severity for each symptom. In addition, a behaviorally anchored probe question is provided for each symptom to increase the reliability of administration. The CAPS-5 is currently in the process of being validated however its previous version demonstrated excellent sensitivity (.81) and specificity (.95).57

    Measure: Change from Baseline: Clinician Administered PTSD Scale -5

    Time: Baseline and endpoint (at 13 weeks)

    Description: The WHY-MPI has been demonstrated to be applicable across a variety of clinical pain conditions. Its brevity, validity/ reliability, self-report nature and ease of scoring make it ideal for both clinical and research purposes. The WHY-MPI is sensitive to change following rehabilitation. Please note only the interference subscale of the WHY-MPI will be administered in this study.

    Measure: Change from Baseline: West Haven=Yale Multidimensional Pain Inventory- Interference Subscale (WHY-MPI)

    Time: Baseline, Midpoint (at 6 weeks) and Endpoint (at 13 weeks)
    2 Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19

    This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

    NCT03944447
    Conditions
    1. Chronic Pain
    2. Chronic Pain Syndrome
    3. Chronic Pain Due to Injury
    4. Chronic Pain Due to Trauma
    5. Fibromyalgia
    6. Seizures
    7. Hepatitis C
    8. Cancer
    9. Crohn Disease
    10. HIV/AIDS
    11. Multiple Sclerosis
    12. Traumatic Brain Injury
    13. Sickle Cell Disease
    14. Post Traumatic Stress Disorder
    15. Tourette Syndrome
    16. Ulcerative Colitis
    17. Glaucoma
    18. Epilepsy
    19. Inflammatory Bowel Diseases
    20. Parkinson Disease
    21. Amyotrophic Lateral Sclerosis
    22. Chronic Traumatic Encephalopathy
    23. Anxiety
    24. Depression
    25. Insomnia
    26. Autism
    27. Opioid-use Disorder
    28. Bipolar Disorder
    29. Covid19
    30. SARS-CoV Infection
    31. COVID-19
    32. Corona Virus Infection
    33. Coronavirus
    Interventions
    1. Drug: Cannabis, Medical
    MeSH:Infection Communicable Diseases Hepatitis C Coronavirus Infections Severe Acute Respiratory Syndrome Fibromyalgia Crohn Disease Inflammatory Bowel Diseases Parkin Parkinson Disease Multiple Sclerosis Brain Injuries Brain Injuries, Traumatic Seizures Motor Neuron Disease Amyotrophic Lateral Sclerosis Brain Diseases Tourette Syndrome Chronic Traumatic Encephalopathy Anemia, Sickle Cell Disease Syndrome Sclerosis Chronic Pain Wounds and Injuries Stress Disorders, Traumatic Bipolar Disorder Stress Disorders, Post-Traumatic
    HPO:Abnormal anterior horn cell morphology Amyotrophic lateral sclerosis Bilateral tonic-clonic seizure Bipolar affective disorder Chronic pain Crohn's disease Encephalopathy Focal-onset seizure Generalized-onset seizure Inflammation of the large intestine Mania Seizure

    Primary Outcomes

    Description: Covid-19 infection rates in cannabis users will be compared to rates in the general population. Our online questionnaire responses will compare infection rates of cannabis users in this study against the Johns Hopkins University Coronavirus Research Center data (https://coronavirus.jhu.edu).

    Measure: Prevention of COVID-19

    Time: Five years

    Description: Severity of persistent symptoms in cannabis users testing positive for active infection and/or antibodies will also be compared to the general population. Patients will answer the widely used FLU-PRO questionnaire, which asks about flu symptoms and severity, to capture diagnoses, symptoms, and medical interventions related to COVID-19. The data from cannabis user patients will be compared with national and international data surveys, such as the Covid Symptom Study (https://covid.joinzoe.com/us-2).

    Measure: Treatment of COVID-19

    Time: Five years

    Description: The primary objective is to assess the efficacy and safety of medical cannabis as medicine for treatment of chronic pain and other chronic debilitating diseases. Pain will be measured by Brief Pain Inventory (BPI) numeric scale. Change from baseline in BPI will be assessed at 3-month intervals. For prospective associations between cannabis use and outcomes, use of a lagged mixed-effects models will examine temporal associations between cannabis use and pain severity, opioid sparing, and patient satisfaction. Data will be analyzed from baseline and the annual follow-up waves.

    Measure: Treatment of Symptoms

    Time: Five years

    Secondary Outcomes

    Description: Secondary objectives include evaluating increases or decreases in quality of life, and increases or decreases in concomitant opioid use. Satisfaction with treatment will be measured by a Visual Analog Score (VAS). Change From baseline in Satisfaction with treatment measured by (VAS) be assessed at 3-month intervals.

    Measure: Cannabis Impact on Quality of Life

    Time: Five years

    Description: Tertiary objectives will examine preferences for routes of administration, and preferences for THC / CBD ratios. Categorical factors will be summarized using frequencies and percentages, while continuous measure distributions will be described using means, standard deviations, and quartiles of interest.

    Measure: Cannabis Route and Dosing

    Time: Five years

    Description: Incidence of Treatment-Related Adverse Events will be measured by Physician Global Assessment (PGA) numeric scale. Number of participants with Treatment-Related Adverse Events will be assessed by CTCAE v4.0.

    Measure: Monitoring Adverse Events

    Time: Five years
    3 Psychological Impact of Quarantine in Rheumatoid Arthritis Patient During COVID-19 Outbreak

    Clinical data about psychological impact of quarantine are well studied in transient event or more prolonged situation like jail incarceration. In recent metaanalysis, psychological impact of quarantine was well documented in a specific population during first SARS epidemy. Even after the end of quarantine several patients were still with symptom of avoiding mainly agoraphobia, frequent hand washing and a carefull return to normal life COVID-19 infection is already associated with psychological symptom like anxiety, depression, sleep disorders and symptoms of acute stress However psychological impact of quarantine is on none in chronic painful inflammatory rheumatism in France. The prevalence of rheumatoid arthritis is 0.5% of the population with frequent comorbidity such as anxiety and depression. During the quarantine secondary to COVID-19 pandemic it's possible to evaluated the psychological impact of adult RA patients. The present study is an "emergency" being realize before the end of the quarantine.

    NCT04351399
    Conditions
    1. Sars-CoV2
    2. Rheumatic Diseases
    3. Rheumatoid Arthritis
    4. Chronic Pain
    Interventions
    1. Other: questionnaire assesment
    MeSH:Arthritis Arthritis, Rheumatoid Rheumatic Diseases Collagen Diseases Chronic Pain
    HPO:Arthritis Chronic pain Polyarticular arthritis Rheumatoid arthritis

    Primary Outcomes

    Measure: Frequency of RA patients with emotional impact (feeling of isolation)

    Time: maximum 1 week from baseline on

    Secondary Outcomes

    Description: Self reported questionnaire with questions to assess the characteristic,intensity of pain on quality of life, and consumption of analgesic.

    Measure: self-reported questionnaire for painful

    Time: maximum 1 week from baseline on
    4 Psychological Impact of Quarantine in Chronic Pain Patient During COVID-19 Outbreak

    In the context of quarantine with COVID-19, we will study the experience and psychological impact of pain in adult patients living with chronic pain. We will evaluate the link between the question of physical and psychological confinement in the experience of pain in this particular situation

    NCT04353011
    Conditions
    1. Sars-CoV2
    2. Chronic Pain
    Interventions
    1. Other: questionnaire assesment
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Measure: Hospital Anxiety and Depression Scale questionnaire

    Time: 1 week from baseline on

    Secondary Outcomes

    Measure: Quality of life (SF36)

    Time: 1 week from baseline on

    Measure: self-reported questionnaire for painful

    Time: 1 week from baseline on

    Measure: qualitive questionnaire

    Time: 1 week from baseline on
    5 The Impact of Quarantine and the Effectiveness of Telerehabilitation in Patients With Chronic Pain During COVID-19 Pandemic.

    The quarantine during COVID-19 pandemic has changed daily routine. Staying at home for prolonged periods of time can pose a significant challenge for patients with chronic pain. The purpose of the current study is to investigate how the quarantine effects of psychosocial factors, quality of life, sleep, nutrition and physical activity in patients with chronic musculoskeletal pain. Another purpose is to examine whether a telerehabilitation exercise program is effective during the lockdown period.

    NCT04381000
    Conditions
    1. Chronic Pain
    Interventions
    1. Other: Exercise Group
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: To measure the levels of anxiety and depression Hospital Anxiety and Depression Scale (HADS), will be used. Patients have to score 14 opinions. Seven of the items relate to anxiety and seven relate to depression. A cut-off point of 8/21 for anxiety or depression has been recommended.

    Measure: Anxiety and Depression

    Time: Change From Baseline in HADS at 40 days

    Description: To measure quality of life, EQ-5D-3L will be used. The EQ-5D-3L essentially consists of 2 pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The EQ-5D-3L descriptive system comprises the following five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 3 levels: no problems, some problems, and extreme problems. The patient is asked to indicate his/her health state by ticking the box next to the most appropriate statement in each of the five dimensions. This decision results into a 1-digit number that expresses the level selected for that dimension. The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.

    Measure: Quality of Life and overall health

    Time: Change From Baseline in EQ-5D-3L at 40 days

    Description: The Numeric Pain Rating Scale (NPRS) is a unidimensional measure of pain intensity in adults and it will be used in the current study. The most commonly used is the 11-item NPRS. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable").The NPRS is a valid and reliable scale to measure pain intensity. In this study, will rate current pain intensity and mean pain intensity during the past 7 days.

    Measure: Pain Intensity

    Time: Change From Baseline in NPRS Scores at 40 days

    Secondary Outcomes

    Description: The Pittsburgh Sleep Quality Index (PSQI) is an effective instrument used to measure the quality and patterns of sleep in the older adult. PSQI will be used to assess quality and patterns of sleep in the current study. PSQI differentiates "poor" from "good" sleep by measuring seven domains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction over the last month. The client self-rates each of these seven areas of sleep. Scoring of the answers is based on a 0 to 3 scale, whereby 3 reflects the negative extreme on the Likert Scale. A global sum of "5" or greater indicates a "poor" sleeper. Although there are several questions that request the evaluation of the client's bed mate or roommate, these are not scored, nor reflected in the attached instrument. An update to the scoring: if 5 is not complete or the value is missing, it now counts as a "0".

    Measure: Quality and patterns of sleep

    Time: Change From Baseline in PSQI Scores at 40 days

    Description: Patients' illness perceptions will be measured based on the Brief Illness Perception Questionnaire (BIPQ). The patient has to rate 8 statements on a 10-point scale (1-10). The higher the score, the greater is the extent to which the patient's illness perceptions are threatening him or her.

    Measure: Patients' illness perceptions

    Time: Change From Baseline in BIPQ Scores at 40 days

    Description: Disability will be assessed using Oswestry Disability Index (ODI) that present ten sections cover Pain, Personal Care, Lifting, Walking, Sitting, Standing, Sleeping, Sex Life, Social Life, and Traveling. Each section has six statements reflecting an increasing level of disability. Respondents choose the statement that most applies to them in each section. The first statement is scored 0; the second is scored 1 and so on to 5 for the last statement. The sum of the section scores is divided by 50 if all sections are completed and multiplied by 100 for the final percentage score.

    Measure: Disability

    Time: Change From Baseline in ODI Scores at 40 days
    6 Early Care, Therapeutic Education, and Psychological Intervention for the Management of Post-intensive Care Syndrome and Chronic Pain After Coronavirus Disease 2019 Infection. Simple-blind, Controlled, Randomized Trial.

    COVID-19 (coronavirus 2019) disease has led to a large number of hospital admissions, many of which require admission to intensive care (ICU). Post-intensive care syndrome (PICS) is defined as deterioration or worsening of previous deterioration in the mental, physical or cognitive status that appears as a consequence of a critical illness and which persists after acute hospital care. Also, there is evidence that patients who survive a critical illness have a high prevalence of moderate to extreme chronic pain. Patients with COVID-19 disease are an especially susceptible population to develop PICS due to acute respiratory distress syndrome (ARDS) survivors have significant long-term deterioration in mental, cognitive, and functional health. This study hypothesis is that a specific care program based on early therapeutic education and psychological intervention improves the quality of life of patients at risk of developing PICS and chronic pain after COVID-19 disease.

    NCT04394169
    Conditions
    1. Post ICU Syndrome
    2. Chronic Pain
    3. Covid-19
    Interventions
    1. Behavioral: Intervention program
    MeSH:Syndrome Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: Health-related quality of life reported by the patient assessed through the visual analogue scale of the EQoL 5D/5L questionnaire at six months after discharge. [European quality of life 5 dimensions/5 levels ; from 0 (the worst imaginable health) to 100 (the best imaginable health) ]

    Measure: Impact of intervention program on health-related quality of life (VAS)

    Time: Six months after discharge

    Secondary Outcomes

    Description: Health-related quality of life reported by the patient assessed through the visual analogue scale of the EQoL 5D / 5L questionnaire at three months after discharge. [European quality of life 5 dimensions/5 levels ; from 0 (the worst imaginable health) to 100 (the best imaginable health)]

    Measure: Impact of intervention program on health-related quality of life (VAS)

    Time: Three months after discharge.

    Description: Health-related quality of life reported by the patient assessed through health index of the EQoL 5D/5L questionnaire at three months after discharge. [European quality of life 5 dimensions/5 levels ; the questionnaire assesses quality of life in study participants according to 5 domains (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) each scored according to a scale of 1 (no problems) to 5 (indicating extreme problems) and generating a 5-digit code corresponding to quality of life]

    Measure: Impact of intervention program on health-related quality of life (Index)

    Time: Three months after discharge

    Description: Health-related quality of life reported by the patient assessed through health index of the EQoL 5D/5L questionnaire at six months after discharge. [European quality of life 5 dimensions/5 levels ; the questionnaire assesses quality of life in study participants according to 5 domains (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) each scored according to a scale of 1 (no problems) to 5 (indicating extreme problems) and generating a 5-digit code corresponding to quality of life]

    Measure: Impact of intervention program on health-related quality of life (Index)

    Time: Six months after discharge

    Description: Chronic pain intensity defined by BPI questionnaire (short version), at three and six months after discharge. [Brief pain inventory; A multidimensional questionnaire that evaluates pain intensity in the last 24 hours (worst, lowest, average) and current (right now). The questions are rated on a scale of 0 to 10, with 10 being the worst possible value. Subsequently, the average intensity score (BPI intensity score) is calculated.]

    Measure: Impact of intervention program on chronic pain (intensity)

    Time: Three and six months after discharge.

    Description: Limitation of daily activities due to chronic pain, defined by BPI (short version), at three and six months after discharge. [Brief pain inventory; Multidimensional questionnaire that assesses the impact of pain on daily activities (general activity, encouragement, work, relationships with other people, sleep, enjoying life and the ability to walk). The questions are rated on a scale of 0 to 10, with 10 being the worst possible value. Subsequently, the mean score of the responses related to pain interference in activities (BPI interference score) is calculated.]

    Measure: Impact of intervention program on chronic pain (limitation of daily activities)

    Time: Three and six months after discharge.

    Description: Pain catastrophization assessed by Pain Catastrophizing Scale at three and six months after hospital discharge. [Pain Catastrophizing Scale; Consisting of 13 questions that explore the frequency of thoughts and feelings that the interviewees have in the presence of current or anticipated pain, which are grouped into three scoring subscales (magnification, rumination and defenselessness). Each question is rated on a 5-point scale (0: not at all; 4: all the time). Being the maximum total score of 52 points.]

    Measure: Impact of intervention program on chronic pain (Pain catastrophization)

    Time: Three and six months after discharge.

    Description: Clinically significant anxiety or depression symptoms prevalence at three and six months, assessed by the HAD test. [hospital anxiety and depression test; 14 questions, with two subscales, one for anxiety and the other for depression, with seven items each, the maximum score is 21 for each subscale. The cut-off points from zero to seven imply the absence of clinically relevant anxiety and depression, from eight to ten symptoms that require consideration and from 11 to 21 reports the presence of relevant symptoms, with a very probable diagnosis of anxiety or depression.]

    Measure: Impact of intervention program on anxiety or depression incidence

    Time: Three and six months after discharge.

    Description: Probable post-traumatic stress syndrome prevalence at three and six months after discharge assessed by the DSM ( Diagnostic and Statistical Manual of Mental Disorders) V PTSD Checklist questionnaire (PCL-5) [PTSD Checklist questionnaire; It contains 20 questions that correspond to the DSM V PTSD (Post Traumatic Stress Disorder) criteria. Participants rated their symptoms on a scale of 0 (not at all), 1 (slightly), 2 (moderately), 3 (quite) to 4 (extremely), with a score ranging from 0 to 80. A total of the severity of the symptoms can be made, adding the score of each question (interval 0-80). The severity of each symptom can be evaluated, adding the score of the questions. The cut-off point to use for a provisional diagnosis of PTSD is 31 points.]

    Measure: Impact of intervention on probable post-traumatic stress syndrome incidence

    Time: Three and six months after discharge.
    7 A Self-compassion Group-based Treatment for Chronic Pain Via Video Conferencing During the COVID-19 Pandemic: Feasibility Study for a Potential New Mode of Treatment Delivery

    As a result of COVID-19 and measures taken by the Canadian Government to reduce the transmission of the virus, in-person psychology services have been suspended. Psychology services are now being conducted via video conferencing. The purpose of the current project is to pilot-test a 6-week Self Compassion Treatment for Chronic Pain delivered virtually, in order to understand its utility in the current environment. The treatment is to be delivered through a secure professional ZOOM licence. Objective 1 of the project is to assess the feasibility and acceptability of attending the treatment group through virtual participation. Objective 2 is to assess the effectiveness of the group treatment in improving self-compassion, mental health, relationship with pain, and quality of life.

    NCT04413006
    Conditions
    1. Chronic Pain
    Interventions
    1. Behavioral: Self-Compassion for Chronic Pain Virtual Group Treatment Program
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: Change over time in scores on the Self-Compassion Scale (SCS) (score range is 12-60 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Scores on the Self-Compassion Scale (SCS)

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in scores on the Pain Disability Index (score range is 0-70 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Scores on the Pain Disability Index

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Secondary Outcomes

    Description: Change over time in scores on the on the Chronic Pain Acceptance Questionnaire - 8 (CPAQ-8) (score range is 0-48 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Scores on the Chronic Pain Acceptance Questionnaire - 8

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in scores on the on the Pain Catastrophizing Scale-6 (PCS-6) (score range is 0-24 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Scores on the Pain Catastrophizing Scale -6

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in Scores on the Pain Self-Efficacy Questionnaire-4 (PSEQ-4) (score range is 0-24 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Scores on the Pain Self-Efficacy Questionnaire-4

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in scores on the Numeric Rating Scale (NRS) for pain (score range is 0-10 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Pain Intensity

    Time: at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in scores on the Patient Health Questionnaire-9 (PHQ-9) (score range is 0-27 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Depression Symptoms as measured by the Patient Health Questionnaire-9 (PHQ-9)

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in scores on the Generalized Anxiety Scale (GAD-7) (score range is 0-21 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Changes over time in Anxiety Symptoms as measured by the Generalized Anxiety Scale-7

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Change over time in scores on the Physical Health and Mental Health Quality of Life scores from the PROMIS GLOBAL-10 (score range is 7-35 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Change over time in Quality of Life as measured by the PROMIS GLOBAL- 10

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Description: Changes over time in score on the Mindfulness Attention and Awareness Scale (MAAS) (score range is 15-90 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

    Measure: Changes over time in Mindfulness

    Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

    Other Outcomes

    Description: Scores on the Client Satisfaction Questionnaire

    Measure: Client Satisfaction

    Time: post treatment (6 weeks after beginning the treatment)
    8 Tele- Yoga Therapy for Patients With Chronic Pain During Covid-19 Lockdown: A Prospective Non-randomized Single Arm Clinical Trial

    Chronic pain is highly prevalent and associated with a large symptom burden, that is had been more concerning during Covid-19 outbreak and lockdown. Benefits of yoga in chronic pain management are very well known. With this background we developed Tele-Yoga therapy program and evaluated the success of this single arm study.

    NCT04457388
    Conditions
    1. Chronic Pain
    Interventions
    1. Other: Tele-Yoga Therapy
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: visual-analogic scale (VAS), using pain level from "no pain" (0) to "worst imaginable pain" (10)

    Measure: Pain Intensity

    Time: From baseline to 6-week post intervention

    Secondary Outcomes

    Description: Pain Disability Index (PDI) using seven rating scales, structured in Likert form, from "no disability" (0) to "worst disability" (10)

    Measure: Pain Disability

    Time: From baseline to 6-week post intervention

    Description: Hospital Anxiety Depression Scale, consisting of 7 scales for measuring anxiety levels

    Measure: Anxiety

    Time: From Baseline to 6-week post intervention

    Description: Hospital Anxiety Depression Scale, consisting of 7 scales for measuring depression levels

    Measure: Depression

    Time: From baseline to 6-week post intervention
    9 An Observational Study of Integrated Chronic Pain Management in a Community Health Center

    This was a prospective observational study with the primary objective of quantifying a change in pain scores after 6-12 months of two separate interventions within the study site (pain team and chiropractic team). Target enrollment was 30 participants for each intervention. The primary outcome was a change from baseline of the Pain Disability Questionnaire (PDQ), the study tool. Secondary outcomes were reduction of opioid dose by morphine equivalent daily dose, and its effect on PDQ scores.

    NCT04490291
    Conditions
    1. Chronic Pain
    2. Spine Disease
    Interventions
    1. Other: chronic pain team
    2. Other: chiropractic team
    MeSH:Spinal Diseases Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: 6-12 month follow up pain score - (minus) baseline. scores range from 0 (no pain or disability) to 150 (severe pain and disability)

    Measure: change in Pain Disability Questionnaire (PDQ) score

    Time: 6-12 month

    Secondary Outcomes

    Description: ability to successfully wean off opioid prescription

    Measure: prescription opioid weaning

    Time: 6-12 months
    10 Paracetamol Discontinuation in the Elderly After Long-term Consumption

    To investigate if long-term treatment of paracetamol can be discontinued without no worsening on pain, health-related quality-of-life and level of function compared to continuing paracetamol treatment in patients aged 65 years or more.

    NCT04523740
    Conditions
    1. Pain, Chronic
    2. Pain, Medication
    3. Pain, Discontinuation
    Interventions
    1. Drug: Placebo
    2. Drug: Paracetamol
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: Comparison of changes in visual analog scale (VAS) pain intensity during the last 24 hours, from baseline value at week 2 between the control and intervention group. VAS is a 0-100 mm scale where 0 is "no pain" and 100 is "worst pain"

    Measure: Visual analog scale (VAS) pain during til last 24 hours

    Time: Change from baseline value at week 2

    Secondary Outcomes

    Description: Comparison of changes in EQ5D-5L index from baseline values at week 2 between the control and intervention group. EQ-5D is an abbreviation for "European Quality of life - 5 Dimensions" and measures Quality of Life. The scale has five subcomponents with scores from 1 (best) to 5 (worst). The five subcomponents constitute a health state that is translated into an index value using the Danish Crosswalk Index Value Calculator from Euroqol's website. The index value is anchored at 0 = death and 1 = full health and the range in the Danish population is from -0.624 (worse than death) to 1.0 (full health). Higher values / increases in index value is better than lower values / decreases in index value.

    Measure: EQ5D-5L index

    Time: Change from baseline value at week 2

    Description: Number of participants that initiate other regular analgesics or withdraw from the trial

    Measure: Treatment failure.

    Time: Week 2

    Description: Functional level is measured by grib strength with a Hand Dynamometer

    Measure: Grip strength

    Time: Change from baseline value at week 2

    Description: Functional level is measured by a sitting-rising test

    Measure: Sitting-rising test

    Time: Change from baseline value at week 2

    Description: Collected from a trial diary. Visual analog scale (VAS) is a 0-100 mm scale where 0 is "no pain" and 100 is "worst pain"

    Measure: Sum of daily visual analog scale (VAS) pain

    Time: Sum from baseline to week 2

    Description: Did the intervention change the participants' paracetamol consumption after ending the treatment period.

    Measure: Followup: Number of regular users (3 grams of paracetamol or more per day) since ending treatment period.

    Time: week 26

    Description: Comparison of changes from baseline and week 2 values at week 26 (post treatment period). Visual analog scale (VAS) is a 0-100 mm scale where 0 is "no pain" and 100 is "worst pain"

    Measure: Followup: Visual analog scale (VAS) pain during til last 24 hours

    Time: Week 26

    Description: Comparison of changes in EQ5D-5L index from baseline and week 2 values at week 26 (post treatment period) between the control and intervention group. EQ-5D is an abbreviation for "European Quality of life - 5 Dimensions" and measures Quality of Life. The scale has five subcomponents with scores from 1 (best) to 5 (worst). The five subcomponents constitute a health state that is translated into an index value using the Danish Crosswalk Index Value Calculator from Euroqol's website. The index value is anchored at 0 = death and 1 = full health and the range in the Danish population is from -0.624 (worse than death) to 1.0 (full health). Higher values / increases in index value is better than lower values / decreases in index value.

    Measure: Followup: EQ5D-5L index

    Time: Week 26

    Description: Number of participants who initiated regular use of other analgesics and comparison of changes between the control and intervention group (post treatment period)

    Measure: Trial failure

    Time: Week 26
    11 Virtual Pain Care for High Risk Veterans on Opioids During COVID19 (and Beyond)

    The COVID-19 pandemic is exacerbating the challenges faced by Veterans at risk of opioid overdose including Veterans prescribed moderate-to-high dose long-term opioid therapy (LTOT) whose usual treatment resources and coping strategies may be inaccessible. This project combines established VA care components to deploy and evaluate virtual models of care for Veterans on high-risk LTOT to meet the dual challenges of maintaining social distancing and delivery high quality care.

    NCT04539821
    Conditions
    1. Chronic Pain
    Interventions
    1. Other: VCPM
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: Although the project will use shared decision-making with Veterans, the percent of patients who agree to transfer will provide a realistic indicator of overall feasibility/acceptability.

    Measure: the percent of patients who agree to Buprenorphine transfer

    Time: 30 days

    Secondary Outcomes

    Description: overall measure of engagement

    Measure: percent of complete tapering or BUP transition

    Time: 60 days
    12 Investigation of the Effectiveness of a Structured Squat-based Program in Knee Osteoarthritis Rehabilitation

    The main purpose of the study is to examine the effect of squat-based exercise approach in individuals with knee osteoarthritis. The aim of this study is to compare effect to three groups (flywheel exercise group, electrotherapy modality group and home exercise group) and also decrease the pain, increase muscle strength, activation values and increase the functional level of individuals. Osteoarthritis is the most common rheumatological disease in the world that primarily results in progressive cartilage destruction. Changes occurring as a result of osteoarthritis are the main cause of disability and are most common in the knee joint. Osteoarthritis; problems such as pain, tenderness, joint stiffness, joint swelling, movement restriction, joint deformities, loss of muscle strength, decreased functional capacity and impaired quality of life are observed. The daily life activities of individuals with knee osteoarthritis are restricted by the problems of walking up and down stairs, getting out of the chair, standing, squatting, walking. Improving the symptoms of the disease is an important goal of the rehabilitation process of patients with knee osteoarthritis. In individuals with knee osteoarthritis, joint structure and deformation in cartilage also show loss of strength with muscles. Strengthening exercises have been used in patients with knee osteoarthritis for a long time. Squat exercise is a type of exercise that is widely used as a strengthening exercise.

    NCT04588558
    Conditions
    1. Osteoarthritis Knees Both
    2. Pain, Chronic
    3. Walking, Difficulty
    Interventions
    1. Device: Flywheel exercise
    2. Other: Home exercise
    3. Device: Electrotherapy group
    MeSH:Osteoarthritis Osteoarthritis, Knee Chronic Pain Mobility Limitation
    HPO:Chronic pain Difficulty walking Knee osteoarthritis Osteoarthritis

    Primary Outcomes

    Description: The primary outcome measures included the level of function determined by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) . WOMAC is a specific, valid, reliable criterion for knee osteoarthritis and includes 24 questions under three subheadings: pain, stiffness and physical function. Each question was scored according to the Likert scale as 0 = none, 1 = mild, 2 = moderate, 3 = severe, 4 = very severe.

    Measure: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

    Time: 10 minutes

    Secondary Outcomes

    Description: EMG-BF (Intelect Advanced Color Combo + EMG, Chattanooga Group, TN, USA) was used to evaluate muscle activation level. The screen scale was used as a visual feedback, as an increased or decreasing signal tone with varying muscle activity as sensory feedback. The undermentioned muscles will be evaluated in study, Rectus femoris Vastus lateralis Vastus medialis Biceps femoris Gastrocnemius

    Measure: EMG-BF

    Time: 10 minutes

    Description: A dynamometer was used to evaluate muscle strength. Muscle strength was evaluated in the following muscles, each measurement was made three times and the average was taken. M. Iliopsoas M. Gluteus Maximus M. Gluteus Medius M. Quadriceps Femoris Hamstring muscle group M. Gastrosoleus M. Tibialis Anterior

    Measure: Muscle strength

    Time: 10 minutes

    Description: The instrument that measures sensitivity to pain and gives a numerical value is called an algometer. In total, application was made at 4 different points. Medial point of heel - Right Medial point of heel - Left Medial point of knee-Right Medial point of knee-Left Measurements were made three times and averaged.

    Measure: Algometer

    Time: 5 minutes

    Description: Purpose and application of the test: The Visual Analog Scale (VAS) is used to convert some values that cannot be measured numerically into numericals. Two end definitions of the parameter to be evaluated are written on both ends of a 100 mm line and the patient is asked to indicate where his condition is appropriate by drawing a line or by placing a point or pointing on this line. Rest, activity and night were evaluated in three different time periods

    Measure: Visual Analog Scale (VAS) Evaluation

    Time: 5 minutes

    Description: To determine fall risk and measure the progress of balance, sit to stand and walking.The patient stands up upon therapist's command: walks 3 meters, turns around, walks back to the chair and sits down.

    Measure: Time up and go test

    Time: 20 seconds

    Description: The 30 Second Sit to Stand Test is also known as 30 second chair stand test ( 30CST), is for testing leg strength and endurance in older adults.The participant is encouraged to complete as many full stands as possible within 30 seconds. The participant is instructed to fully sit between each stand.

    Measure: 30 Seconds Sit To Stand Test

    Time: 30 Seconds

    Description: The individual is asked to climb and descend 7 times. The total time is recorded.

    Measure: Step test

    Time: 1 minute

    Description: Lower extremity joints and range of motion were evaluated. Hip Flexion Hip Extension Hip Internal Rotation Hip External Rotation Knee Flexion Knee Extension Ankle Plantar Flexion Ankle Dorsi Flexion

    Measure: goniometer

    Time: 10 minutes
    13 An Online Randomized Controlled Trial Comparing the Effects of Mindfulness, Sham Mindfulness and Book Listening Control on Pain Experience in Adults With Recurrent and Chronic Pain

    Both mindfulness meditation and expectancy effects are known to reduce pain intensity, pain unpleasantness and pain catastrophizing, but it is unknown whether and how expectancy effects contribute to the overall effect of mindfulness meditation on these outcomes, especially during significant global events such as the coronavirus pandemic. This study includes four interrelated aims that will probe these effects and interactions.

    NCT04602286
    Conditions
    1. Pain, Intractable
    2. Pain, Chronic
    Interventions
    1. Other: Meditation (1 x 20-minute guided audio training)
    MeSH:Chronic Pain Pain, Intractable
    HPO:Chronic pain

    Primary Outcomes

    Description: Assessed via a numerical rating scale (0=no pain, 10=most intense pain imaginable)

    Measure: Pain intensity

    Time: 40 minutes

    Description: assessed via a numerical rating scale (0=no pain, 10=most unpleasant pain imaginable)

    Measure: Pain Unpleasantness

    Time: 40 minutes

    Secondary Outcomes

    Description: assessed via the Pain Catastrophizing Scale (PCS; 0=no catastrophizing, 52=highest catastrophizing, 30+=clinically significant catastrophizing)

    Measure: Pain Catastrophizing

    Time: 40 minutes

    Other Outcomes

    Description: assessed via self-report questions (0=lowest expectancy, 10=highest expectancy)

    Measure: Expectancy

    Time: 40 minutes

    Description: assessed via the Pain-related Cognitive Processes Questionnaire (PCPQ-R; 0=lowest reappraisal, 4=highest reappraisal)

    Measure: Pain Reappraisal

    Time: 40 minutes

    Description: assessed via the Five Facet Mindfulness Questionnaire Observing Subscale (FFMQ-O; 1=lowest observing, 5=highest observing)

    Measure: Mindful observing

    Time: 40 minutes

    Description: assessed via the Five Facet Mindfulness Questionnaire Non-reacting Subscale (FFMQ-NR; 1=lowest non-reactivity, 5=highest non-reactivity)

    Measure: Mindful non-reactivity

    Time: 40 minutes

    Description: assessed via the State Mindfulness Survey (SMS; 1=lowest mindfulness, 21=highest mindfulness)

    Measure: State Mindfulness

    Time: 40 minutes

    Description: assessed via the Metacognitive Processes of Decentering - State (MpoD-s; 0=lowest decentering, 3=highest decentering)

    Measure: State Decentering

    Time: 40 minutes
    14 Efficacy of Yoga Based Self-Management Program for Chronic Pain: Community Based Clinical Efficacy Study

    Chronic pain is a major health issue with substantial economic burden.To support chronic pain patients during the COVID-19 pandemic, yoga based self-managed intervention was delivered through tele-health platform. Project was designed as community-based program, creating new social networks for patients, health care providers and academics. Platform to deliver intervention and data collection was AiM COVID mobile app. Our objective was to determine the efficacy of Yoga based self-management intervention for people living with chronic pain pain intensity, disability and health related quality of life.

    NCT04628130
    Conditions
    1. Chronic Pain
    Interventions
    1. Other: Yoga Therapy
    MeSH:Chronic Pain
    HPO:Chronic pain

    Primary Outcomes

    Description: Pain intensity and related disability was measured through Brief Pain Inventory

    Measure: Pain intensity and disability

    Time: From baseline to 6 week post intervention

    Description: Quality of life was measured through 36-Item Short-Form Survey

    Measure: Health Related Quality of Life

    Time: From baseline to 6 week post intervention

    Description: Self efficacy was measure through Pain Self-Efficacy Questionnaire

    Measure: Self-efficacy of pain

    Time: From baseline to 6 week post intervention

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