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  • HP:0000509: Conjunctivitis
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    HP:0000509: Conjunctivitis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (3)


    Name (Synonyms) Correlation
    drug2052 IVERMECTIN (IVER P®) arm will receive IVM 600 µg / kg once daily plus standard care. CONTROL arm will receive standard care. Wiki 0.71
    drug3887 Schirmer Test I Wiki 0.71
    drug2059 Icosapent ethyl Wiki 0.50

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D003231 Conjunctivitis NIH 1.00
    D015817 Eye Infections NIH 0.71
    D007249 Inflammation NIH 0.12
    Name (Synonyms) Correlation
    D014777 Virus Diseases NIH 0.07

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Tear Fluid miRNA Analysis in Sars-Cov2 Conjunctivitis

    The aim of this study is to assess the virus RNA, and miRNA levels related to viral infection, and inflammatory response in tears of hospitalized patients with a diagnosis of COVID-19 with and without conjunctivitis and to correlate them with clinical condition. Tears will be collected by using Schirmer Test I, a non invasive painless test which can be performed at the patient's bed. Tears will be collected on the graduated paper strips pulling the lower lid gently downward for 5 minutes. Following, the strip will be placed in a 2.0 mL Eppendorf tube and stored at -80◦C (or - 20°C)

    NCT04346160
    Conditions
    1. COVID
    2. Conjunctivitis
    Interventions
    1. Diagnostic Test: Schirmer Test I
    MeSH:Conjunctivitis
    HPO:Conjunctivitis

    Primary Outcomes

    Description: - to asses virus RNA and miRNA levels in tears

    Measure: virus molecular analysis

    Time: 2 weeks

    Description: - to asses inflammatory response molecules

    Measure: host molecular analysis

    Time: 2 weeks

    Secondary Outcomes

    Description: To analyze the prevalence of conjunctivitis in patients with a diagnosis of COVID-19 and the assessment of the predictive value of conjunctivitis in the development of the COVID-19 disease (or in developing respiratory distress forms-ARDS).

    Measure: Epidemiologic data

    Time: 2 weeks
    2 Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients Presenting With Conjunctivitis to the Ophthalmology Clinics During the COVID-19 Pandemic

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified, highly contagious RNA virus causing respiratory infectious disease, Coronavirus Disease 2019 (COVID-19). Conjunctivitis has been reported as a rare finding of the disease, and preliminary studies showed that the virus RNA could be detected in ocular secretions using polymerase chain reaction (PCR) assays when conjunctivitis present. This study aims to estimate the proportion of SARS-CoV-2 associated conjunctivitis among patients with suspected viral conjunctivitis presented to the ophthalmology clinics of Wilmer Eye Institute during the COVID-19 pandemic. The investigators also aim to identify whether SARS-CoV-2 associated conjunctivitis is an isolated finding or an early sign of COVID-19.

    NCT04374656
    Conditions
    1. Conjunctivitis
    2. SARS-CoV-2
    3. COVID-19
    4. Ocular Infection, Viral
    5. Ocular Inflammation
    MeSH:Eye Infections Virus Diseases Eye Infections, Viral Conjunctivitis Inflammation
    HPO:Conjunctivitis

    Primary Outcomes

    Description: Number of conjunctival samples with positive PCR divided by the total number of conjunctival samples

    Measure: Proportion of conjunctival samples tested positive for SARS-CoV-2

    Time: 1 year

    Secondary Outcomes

    Description: Number of nasal samples with positive PCR divided by the number of conjunctival samples with positive PCR

    Measure: Proportion of nasal samples tested positive for SARS-CoV-2 among patients with positive conjunctival samples

    Time: 1 year

    Description: Number of nasopharyngeal samples with positive PCR divided by the number of conjunctival samples with positive PCR

    Measure: Proportion of nasopharyngeal samples tested positive for SARS-CoV-2 among patients with positive conjunctival samples

    Time: 1 year

    Description: Number of patients developed COVID-19 divided by the number of the study population

    Measure: Rate of development of COVID-19 in the study patient population

    Time: 1 year

    Description: Number of conjunctival samples with positive PCR divided by the number of patients developed COVID-19

    Measure: Positive conjunctival sample rate in patient developed COVID-19

    Time: 1 year

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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