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  • HP:0100601: Eclampsia
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    HP:0100601: Eclampsia

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (1)


    Name (Synonyms) Correlation
    drug686 Breastfeeding self-efficacy (BSE) Wiki 1.00

    Correlated MeSH Terms (6)


    Name (Synonyms) Correlation
    D004461 Eclampsia NIH 1.00
    D011225 Pre-Eclampsia NIH 0.71
    D046110 Hypertension, Pregnancy-Induced NIH 0.71
    Name (Synonyms) Correlation
    D014115 Toxemia NIH 0.38
    D011248 Pregnancy Complications NIH 0.32
    D006973 Hypertension NIH 0.20

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0100603 Toxemia of pregnancy HPO 0.71
    HP:0000822 Hypertension HPO 0.20

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Improving Cardiovascular Health in New Mothers: Multi-Centre Open-Label Randomized Trial of a Breastfeeding Intervention to Improve Breastfeeding Practices and Lower Blood Pressure in Women With Hypertensive Disorders of Pregnancy

    Hypertensive disorders of pregnancy (HDP) are increasingly recognized sex-specific risk factors for premature cardiovascular disease (CVD) in women. HDP, including preeclampsia and gestational hypertension, confer a 2- to 3-fold increase in the risk of chronic hypertension and ischemic heart disease 10-15 years after delivery. Observational data suggest that breastfeeding can lower maternal blood pressure (BP), risk of metabolic syndrome, and other markers of cardiovascular risk in the short term and long term, possibly by helping to re-set the metabolic changes of pregnancy. We recently demonstrated an 11% reduction in the risk of metabolic syndrome among postpartum women with a variety of complications in pregnancy, including HDP, who breastfed for > 6 months, compared to those who did not breastfeed and those who breastfed for shorter durations. An analysis of 622 postpartum women at Kingston General Hospital showed that breastfeeding women had nearly a 6-mmHg lower systolic BP than women who did not breastfeed with an apparent dose-response effect of breastfeeding duration. Women with pregnancy complications including HDP are vulnerable to early weaning. Interactive, multi-modal approaches targeting a mother's breastfeeding self-efficacy (i.e., confidence about breastfeeding) have been effective in healthy postpartum women. However, breastfeeding support interventions have not yet been tested specifically in HDP women, who stand to derive substantial benefit from breastfeeding. This is an important area to study since nurse-led breastfeeding supportive interventions can be widely applied to the postpartum care of women with HDP and can be integrated into comprehensive CVD risk reduction programs for these women. Our primary outcome is postpartum BP, since hypertension is a key mediating factor in women's heart health. We conducted a feasibility study of a breastfeeding self-efficacy intervention to enhance breastfeeding outcomes among women with HDP showing feasibility (achieving pre-defined targets of a recruitment rate of >50% , attrition rates of < 30%), and > 70% participant satisfaction with the intervention, measured at the 6-month time point. Additionally, data showed trends in both systolic and diastolic BP favoring the intervention group. We are now conducting a multi-site open-label randomized trial to assess for a difference in blood pressure and breastfeeding between groups, and to serve as a cohort of HDP women for longitudinal follow-up.

    NCT04580927
    Conditions
    1. Hypertensive Disorder of Pregnancy
    2. Pregnancy Complications
    3. Pre-Eclampsia
    4. Hypertension, Pregnancy-Induced
    5. Breastfeeding
    Interventions
    1. Behavioral: Breastfeeding self-efficacy (BSE)
    MeSH:Toxemia Eclampsia Pre-Eclampsia Pregnancy Complications Hypertension, Pregnancy-Induced Hypertension
    HPO:Eclampsia Hypertension Preeclampsia Toxemia of pregnancy

    Primary Outcomes

    Description: Evaluate whether a nurse-led BSE intervention will result in a lower systolic and/or diastolic BP 12 months postpartum

    Measure: Systolic and/or diastolic BP, in mmHg.

    Time: 12 months

    Description: Evaluate whether a nurse-led BSE intervention will result in a lower need for antihypertensive therapy

    Measure: Use of antihypertensive therapy

    Time: 12 months

    Secondary Outcomes

    Description: Evaluate whether a nurse-led BSE intervention will result in longer duration of exclusive breastfeeding

    Measure: Duration of exclusive breastfeeding (weeks)

    Time: 12 months

    Description: Evaluate whether a nurse-led BSE intervention will result in higher rates of any continued breastfeeding at 6 months

    Measure: The proportion who breastfeed (exclusive or non-exclusive)

    Time: 12 months

    Description: Evaluate whether a nurse-led BSE intervention will result in lower metabolic syndrome

    Measure: Metabolic syndrome

    Time: 12 months

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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