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  • HP:0003193: Allergic rhinitis
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    HP:0003193: Allergic rhinitis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug4493 Treatment A (Dymista): Fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray at Visit 5 Wiki 1.00
    drug4492 Treatment A (Dymista): Fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray at Visit 3 Wiki 1.00
    drug4496 Treatment B (Placebo): Nasal spray with no active dose (Dymista vehicle) at Visit 3 Wiki 1.00
    Name (Synonyms) Correlation
    drug4497 Treatment B (Placebo): Nasal spray with no active dose (Dymista vehicle) at Visit 5 Wiki 1.00

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D065631 Rhinitis, Allergic NIH 1.00
    D006255 Rhinitis, Allergic, Seasonal NIH 1.00
    D012220 Rhinitis, NIH 1.00

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0012395 Seasonal allergy HPO 1.00
    HP:0012384 Rhinitis HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Clinical Trial to Assess Onset of Action of Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray Delivered in a Single Spray (Dymista) in the Treatment of Allergen-Induced Allergic Rhinitis Symptoms in Comparison to Placebo in an Environmental Exposure Unit (EEU)

    This study is to assess the onset of action of fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray (Dymista) in treating the nasal symptoms of seasonal allergic rhinitis (SAR) induced by an allergen challenge in an Environmental Exposure Unit (EEU).

    NCT04652245
    Conditions
    1. Seasonal Allergic Rhinitis
    Interventions
    1. Drug: Treatment A (Dymista): Fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray at Visit 3
    2. Drug: Treatment B (Placebo): Nasal spray with no active dose (Dymista vehicle) at Visit 5
    3. Drug: Treatment A (Dymista): Fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray at Visit 5
    4. Drug: Treatment B (Placebo): Nasal spray with no active dose (Dymista vehicle) at Visit 3
    MeSH:Rhinitis Rhinitis, Allergic Rhinitis, Allergic, Seasonal
    HPO:Allergic rhinitis Rhinitis Seasonal allergy

    Primary Outcomes

    Description: The sum of the TNSS will contribute to a score ranging from 0 - 12

    Measure: Time to onset of action, measured by a difference from placebo in the change from baseline in patient -assessed instantaneous Total nasal symptom score (TNSS) following treatment

    Time: 0 to 4 hours post application

    Secondary Outcomes

    Description: The sum of the TOSS will contribute to a score ranging from 0 - 9.

    Measure: Time to onset of action, measured by a difference from placebo in the change from baseline in patient-assessed instantaneous total ocular symptom score (TOSS) following treatment

    Time: 0 to 4 hours post application

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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