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    HP:0002354: Memory impairment

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug4297 Technology based social interactions Wiki 1.00
    drug2840 No research related technology based social interactions Wiki 1.00
    drug510 BIIB133 (Dapirolizumab pegol) Wiki 1.00
    Name (Synonyms) Correlation
    drug3195 Placebo Wiki 0.04

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D008569 Memory Disorders NIH 1.00
    D000544 Alzheimer Disease NIH 0.32
    D060825 Cognitive Dysfunction NIH 0.22

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0002511 Alzheimer disease HPO 0.32
    HP:0001268 Mental deterioration HPO 0.22

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Impact of Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults With and Without Cognitive Impairment

    The current study will examine the impact of frequent social interaction through communication technologies during COVID-19 pandemic in the cognitive status of socially-isolated older adults with and without cognitive impairment. Patients will take place in an experimental crossover study, participants will complete one month of an intervention and one month of as passive control. The goal of this study is to determine: A.) if frequent social interaction through ICT during COVID-19 pandemic will have a significant positive impact in cognitive performance on testing, and B.) how social isolation and cognitive status influence misconceptions around the current pandemic.

    NCT04480112
    Conditions
    1. Memory Disorders
    2. Alzheimer Disease
    3. Mild Cognitive Impairment
    Interventions
    1. Behavioral: Technology based social interactions
    2. Other: No research related technology based social interactions
    MeSH:Alzheimer Disease Memory Disorders Cognitive Dysfunction
    HPO:Alzheimer disease Cognitive impairment Memory impairment Mental deterioration

    Primary Outcomes

    Description: The Oral Trail Making Test B (TMT-B) will be used to assess memory performance. It is a neuropsychological measure that provides an assessment of sequential set-shifting. Participants are asked to count from 1 to 25 switching between number and letter, eg 1-A-2-B-3-C, until stopped.

    Measure: Change in memory performance

    Time: Baseline,1 month

    Description: Repeatable Battery for the Assessment of Neuropsychological Status (R-BANS) will be administered to assess cognitive decline or improvement. The 12 items on the RBANS assess five cognitive domains: immediate memory, visuospatial/constructional abilities, language, attention, and delayed memory. Scores can range from 0-160 and are interpreted as: 130 and above- very superior; 120-129 - superior; 110-119- high average; 90-109- average; 80-89- low average; 70-79- borderline; 60 and below extremely low.

    Measure: Change in cognition

    Time: Baseline, 1 month

    Description: Phonemic fluency will be assessed by asking participants to produce orally as many words as possible beginning with a specific letter or for a specific category (eg animals, fruits, etc). The test consists of three trials, of 1 min each. The higher the number of words provided, the greater the verbal fluency.

    Measure: Change in phonemic fluency

    Time: Baseline, 1 month

    Secondary Outcomes

    Description: The 6-item version of the Lubben Social Network scale (LSNS-6) will be used to assess social isolation. For each of the 6 questions the participant rates from 0 to 5 their perceived social engagement where 0=less social engagement and 5= more social engagement. The summed total score ranges between 0 and 30. Lower total scores indicate more social isolation.

    Measure: Social isolation

    Time: 1 month

    Description: Loneliness will be assessed using the UCLA loneliness scale. Participants rate each item as either O ("I often feel this way"= 3),S ("I sometimes feel this way"=2), R ("I rarely feel this way"=1), N ("I never feel this way"=0). A total score is computed by adding up the response to each question and can range from 0 to 60. The average loneliness score on the measure is 20. A score of 25 or higher reflects a high level of loneliness. A score of 30 or higher reflects a very high level of loneliness.

    Measure: Loneliness

    Time: 1 month

    Description: The Geriatric Depression Scale (GDS) will be used to assess depression. It consists of 15 questions- 10 indicate the presence of depression when answered positively, while the rest (question numbers 1, 5, 7, 11, 13) indicate depression when answered negatively. Scores of 0-4 are considered normal, depending on age, education, and complaints; 5-8 indicate mild depression; 9-11 indicate moderate depression; and 12-15 indicate severe depression.

    Measure: Depressive symptoms

    Time: 1 month

    Description: An investigator developed questionnaire based on survey results published by Geldsetzer P in Annals of Internal Medicine, 3-2020 will be used to assess Covid-19 misinformation.

    Measure: Misinformation about Covid-19

    Time: 1 month

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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