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  • HP:0002740: Recurrent E. coli infections
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    HP:0002740: Recurrent E. coli infections

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (7)


    Name (Synonyms) Correlation
    drug2235 Ivermectin 3mg Tab Wiki 1.00
    drug5245 strain CVD 1208S-122 Wiki 1.00
    drug1982 Hydroxychloroquine Sulfate Tablets Wiki 0.71
    Name (Synonyms) Correlation
    drug3335 Povidone-Iodine Wiki 0.50
    drug4781 Zinc Wiki 0.35
    drug4690 Vitamin C Wiki 0.27
    drug3195 Placebo Wiki 0.04

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D004405 Dysentery, Bacillary NIH 1.00
    D004927 Escherichia coli Infections NIH 1.00
    D003141 Communicable Diseases NIH 0.07
    Name (Synonyms) Correlation
    D007239 Infection NIH 0.05

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Phase 1 Study of the Safety, Tolerability, and Immunogenicity of Oral Doses of CVD 1208S-122, a Prototype Attenuated Shigella Flexneri 2a Live Vector Expressing Enterotoxigenic Escherichia Coli Antigens

    The purpose of this study is to determine whether a live, oral, combined Shigella-ETEC vaccine candidate, known as strain CVD 1208S-122, is safe and immunogenic.

    NCT04634513
    Conditions
    1. Shigella Infection
    2. Enterotoxigenic Escherichia Coli Infection
    Interventions
    1. Biological: strain CVD 1208S-122
    2. Other: Placebo
    MeSH:Infection Communicable Diseases Dysentery, Bacillary Escherichia coli Infections
    HPO:Recurrent E. coli infections

    Primary Outcomes

    Description: The number, proportion, and severity of fever, diarrhea, or dysentery (hemoccult testing will only be performed during the inpatient days) within 7 days of vaccination, for all those receiving vaccine and for each of the vaccine dosages evaluated

    Measure: Number, Proportion, and Severity of Fever, Diarrhea, or Dysentery

    Time: 7 days following vaccination

    Description: The number, proportion, and severity of solicited local and systemic adverse reactions (diarrhea, dysentery, fever, nausea, vomiting, abdominal discomfort, tenesmus, myalgia, arthralgia, and anorexia) within 7 days of vaccination for all those receiving vaccine and for each of the vaccine dosages evaluated

    Measure: Number, Proportion, and Severity of Solicited Local and Systemic Adverse Reactions

    Time: 7 days following vaccination

    Description: The number, proportion, severity, and relatedness of non-serious unsolicited adverse reactions within 28 days of vaccination for all those receiving vaccine and for each of the vaccine dosages evaluated

    Measure: Number, Proportion, Severity, and Relatedness of Non-Serious Unsolicited Adverse Reactions

    Time: 28 days following vaccination

    Description: The number, proportion, and severity of clinical safety laboratory adverse events from the time of each study vaccination through approximately 7 days after each study vaccination.

    Measure: Number, Proportion, and Severity of Clinical Safety Laboratory Adverse Events

    Time: 7 days following vaccination

    Description: The occurrence of SUSARs in the study

    Measure: Occurrence of SUSARs

    Time: The entire study period (6-7 months)

    Description: The occurrence of all SAEs, regardless of the assessment of relatedness, from the time of the first vaccination through approximately 6 months after the last study vaccination

    Measure: Occurrence of all SAEs

    Time: The entire study period (6-7 months)

    Description: The geometric mean number (and interquartile range) of vaccine organisms, per day and at the peak of shedding, expressed as cfu/mL for each dosage group

    Measure: Geometric Mean Number of Vaccine Organisms

    Time: for each day of the 7 days following vaccination

    Description: The number and proportion of sequential days of fecal shedding of Shigella organisms which are documented to contain the genes expressing ETEC antigens for each dosage group. Genetically stable organisms will be defined as being PCR positive for Shigella (ipaH or virG), CFA/I (cfaB), and LTB (eltB)

    Measure: Number and Proportion of Sequential Days of Fecal Shedding of Shigella Organisms

    Time: for each day of the 7 days following vaccination

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

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