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  • HP:0003251: Male infertility
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    HP:0003251: Male infertility

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (1)


    Name (Synonyms) Correlation
    drug1589 Exposure: Covid-19 infection Wiki 0.71

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D007248 Infertility, Male NIH 1.00
    D007246 Infertility NIH 0.50

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0000789 Infertility HPO 0.50

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Determining the Reproductive Health of Men Post-COVID-19 Infection

    Study rationale 1. An increasing proportion of the worldwide population is being infected with COVID-19. 2. There are ongoing and currently unanswered safety concerns about the effects of COVID-19 on reproductive health. 3. It will be immensely reassuring to rapidly report that COVID-19 has no detectable effects on male endocrine or sperm function. Conversely, if COVID-19 does impair male reproductive health, appropriate screening can be performed in couples trying to conceive, and further research can be undertaken. 4. The proposed study will be simple, rapid, and authoritative for the UK and worldwide.

    NCT04414904
    Conditions
    1. Infertility, Male
    2. Testosterone Deficiency
    Interventions
    1. Other: Exposure: Covid-19 infection
    MeSH:Infertility Infertility, Male
    HPO:Infertility Male infertility

    Primary Outcomes

    Description: Sperm concentration (x10^6/ml) between case and control group.

    Measure: Semen parameters

    Time: 3 visits (up to 75 days apart)

    Description: Sperm Motility (%) between case and control group.

    Measure: Sperm Parameters

    Time: 3 visits (up to 75 days apart)

    Description: Sperm normal morphology (%) between case and control group.

    Measure: Sperm Parameters

    Time: 3 visits (up to 75 days apart)

    Description: Testosterone (nmol/L) between case and control group.

    Measure: Hormones measurement

    Time: 3 visits (up to 75 days apart)

    Description: Follicle Stimulating Hormone(IU/L) between case and control group.

    Measure: Hormones measurement

    Time: 3 visits (up to 75 days apart)

    Description: Luteinising hormone(IU/L) between case and control group.

    Measure: Hormones measurement

    Time: 3 visits (up to 75 days apart)

    Secondary Outcomes

    Description: Compare seminal reactive oxidative species (RLU/second/10^6sperm) between case and control group.

    Measure: Seminal Reactive oxygen species

    Time: 3 visits (up to 75 days apart)

    Description: Compare Sperm DNA fragmentation rate (%) between case and control group.

    Measure: Sperm DNA fragmentation rate

    Time: 3 visits (up to 75 days apart)
    2 Corona Virus Disease 19 (COVID-19) Vaccine and Impact on Fertility Study

    The purpose of this study is to investigate the effects of COVID-19 Vaccination on semen parameters and to determine how long these possible changes may last following vaccination.

    NCT04665258
    Conditions
    1. Infertility, Male
    MeSH:Infertility Infertility, Male
    HPO:Infertility Male infertility

    Primary Outcomes

    Description: As measured from semen samples.

    Measure: Sperm concentration

    Time: up to 6 months

    Description: As measured from semen samples.

    Measure: Sperm motility

    Time: up to 6 months

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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