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    HP:0100749: Chest pain

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

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    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug3581 Rapid diagnostics using Anyplex TMII RV16 Detection Wiki 1.00
    drug1281 Delayed diagnostics Anyplex TMII RV16 Detection Wiki 1.00
    drug4109 Standard of Care Treatment Wiki 0.71
    Name (Synonyms) Correlation
    drug1213 Cyclosporine Wiki 0.45

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D005335 Fever of Unknown Origin NIH 1.00
    D002637 Chest Pain NIH 1.00
    D004417 Dyspnea NIH 0.30

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0002098 Respiratory distress HPO 0.30

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 The Impact of Respiratory Pathogen PCR Assay on Treatment of Adult Patients: A Randomized Controlled Trial

    Viral respiratory infections are common and often require use of health care resources. Patients receive inappropriate bacterial antibiotics, which has many problems including side-effects, development of resistance and costs. A small portion of the infections leads to severe clinical manifestations including hospitalisations and deaths. The significance of influenza virus is well known and it is actively detected in all age groups. However, the benefits of detecting other respiratory viruses have mainly been studied among children but not among adults. The development of multiplex PCR technique has provided a new and sensitive method for diagnosing a large panel of viruses. To convince the economical benefits of the rapid viral diagnostic in adult infectious patient, more evidence is needed. In our randomized study, nasal and pharyngeal samples from the patients evaluated at the emergency clinic of internal medicine in the University Hospital of Oulu because of any respiratory symptom, chest pain or fever, will be collected. The samples will be tested for 16 different respiratory viruses by using Anyplex TMII RV16 Detection. The adult participants will be randomized in two groups. In one group the results of the testing will be reported for the attending physician as soon as possible, and in the other group 7 days after sampling. The effect of this delay to patient care is monitored. Also the results of children and adults are compared as well as results of men and women. The hypothesis is that rapid viral diagnostics shortens the length of admission and diminishes the use of bacterial antibiotics. New information on the viral epidemiology among children and adults is provided and clinical manifestations of specific viral infections in adults are described. The estimated 1500 samples are also tested for 5 different respiratory bacteria by Anyplex TM II RB5 Detection. These results will be examined after completion of the study period. The benefits of rapid bacterial detection are evaluated in respect to the clinical course of the disease and considering the infection control aspects as well.

    NCT02538770
    Conditions
    1. Respiratory Virus Infection
    2. Fever of Unknown Origin
    3. Dyspnea
    4. Chest Pain
    Interventions
    1. Other: Rapid diagnostics using Anyplex TMII RV16 Detection
    2. Other: Delayed diagnostics Anyplex TMII RV16 Detection
    MeSH:Dyspnea Chest Pain Fever of Unknown Origin
    HPO:Chest pain Dyspnea Respiratory distress

    Primary Outcomes

    Description: The number of days in hospital within one month after randomization

    Measure: Duration of hospitalization

    Time: One month

    Description: Number of days on antimicrobials within one month after randomization

    Measure: Antimicrobial consumption

    Time: One month

    Description: Defined daily doses of antimicrobial agents within one month after randomization

    Measure: Antimicrobial consumption

    Time: One month

    Secondary Outcomes

    Measure: Number of radiological examinations

    Time: One month

    Measure: Cost of other examinations in hospital

    Time: One month

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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