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  • HP:0002293: Alopecia of scalp
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    HP:0002293: Alopecia of scalp

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (9)


    Name (Synonyms) Correlation
    drug3430 Proxalutamide Wiki 0.71
    drug1392 Dutasteride Wiki 0.71
    drug730 CAG length <22 Wiki 0.71
    Name (Synonyms) Correlation
    drug731 CAG length >=22 Wiki 0.71
    drug497 BI 1569912 Wiki 0.71
    drug499 BI 474121 Wiki 0.50
    drug2804 Nitazoxanide Wiki 0.18
    drug453 Azithromycin Wiki 0.11
    drug3195 Placebo Wiki 0.06

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D000505 Alopecia NIH 1.00
    D011470 Prostatic Hyperplasia NIH 0.71
    D006965 Hyperplasia NIH 0.50
    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.03
    D018352 Coronavirus Infections NIH 0.02

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0008711 Benign prostatic hyperplasia HPO 0.71

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity

    The COVID-19 Androgen Sensitivity Test is a non-invasive In-Vitro Diagnostic device that utilizes Next Generation Sequencing Technology (NGS). The results of the test are used by a physician to assess the risk of developing severe symptoms following COVID-19 infection, The COVID-19 Androgen Sensitivity Test requires a health care professional to collect a DNA sample using an FDA cleared DNA sample collection kit.

    NCT04368897
    Conditions
    1. SARS-CoV 2
    2. COVID
    3. COVID-19
    4. Androgenetic Alopecia
    5. Androgen Receptor Abnormal
    6. Androgen Deficiency
    Interventions
    1. Diagnostic Test: CAG length <22
    2. Diagnostic Test: CAG length >=22
    MeSH:Alopecia
    HPO:Alopecia Alopecia of scalp Frontal balding

    Primary Outcomes

    Description: Defined as 28 days minus the number of days from randomization to discharge home. If a patient has not been discharged home prior to day 28 or dies prior to day 28, hospital free days will be zero.

    Measure: Hospital-free days to Day 28 [ Time Frame: 28 days]

    Time: 28 days

    Description: Defined as discharged, hospitalization, admission to intensive care unit [ICU] and death

    Measure: 1. Severity of Disease

    Time: Day 28
    2 Anti-Androgen Treatment for COVID-19

    This study is intended to explore the possible protective role of anti-androgens in SARS-CoV-2 infection

    NCT04446429
    Conditions
    1. COVID-19
    2. SARS-CoV2
    3. Androgenetic Alopecia
    4. Prostate Cancer
    5. Benign Prostatic Hyperplasia
    6. SARS (Severe Acute Respiratory Syndrome)
    Interventions
    1. Drug: Dutasteride
    2. Drug: Nitazoxanide
    3. Drug: Azithromycin
    4. Drug: Proxalutamide
    MeSH:Severe Acute Respiratory Syndrome Coronavirus Infections Prostatic Hyperplasia Alopecia Hyperplasia
    HPO:Alopecia Alopecia of scalp Benign prostatic hyperplasia Frontal balding

    Primary Outcomes

    Description: Percentage of subjects hospitalized due to COVID-19

    Measure: COVID-19 hospitalization

    Time: 30 days

    Description: COVID Ordinal Scale defined as: Death Hospitalized on invasive mechanical ventilation or ECMO ( extracorporeal membrane oxygenation) Hospitalized on non-invasive ventilation or high flow nasal cannula Hospitalized on supplemental oxygen Hospitalized not on supplemental oxygen Not hospitalized with limitation in activity (continued symptoms) Not hospitalized without limitation in activity (no symptoms)

    Measure: COVID-19 Ordinal Outcomes Scale

    Time: 30 days

    Secondary Outcomes

    Description: Symptoms severity of COVID-19 using Brescia-COVID Respiratory Severity Scale (BCRSS)/Algorithm

    Measure: Symptoms severity of COVID-19

    Time: 30 days

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

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