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    HP:0002789: Tachypnea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (3)


    Name (Synonyms) Correlation
    drug4434 Tocilizumab 20 MG/ML Intravenous Solution [ACTEMRA]_#1 Wiki 1.00
    drug4435 Tocilizumab 20 MG/ML Intravenous Solution [ACTEMRA]_#1 (2 doses) Wiki 1.00
    drug257 AirFLO2 Wiki 1.00

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D059246 Tachypnea NIH 1.00
    D000860 Hypoxia NIH 0.18
    D045169 Severe Acute Respiratory Syndrome NIH 0.04
    Name (Synonyms) Correlation
    D018352 Coronavirus Infections NIH 0.03

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0012418 Hypoxemia HPO 0.18

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 AirFLO2 Treatment for Hypoxia and/or Tachypnea in Patients With COVID-19

    The study is an unblinded, randomized, controlled trial for use of the AirFlO2 device for patients admitted to Duke Hospital with COVID-19 and tachypnea (RR >20 breaths/min) and/or hypoxia (Oxygen saturation <94% on room air or requiring supplemental oxygen at baseline).

    NCT04649775
    Conditions
    1. Corona Virus Infection
    2. Respiratory Rate
    3. Hypoxia
    4. Covid19
    Interventions
    1. Device: AirFLO2
    MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Tachypnea Hypoxia
    HPO:Hypoxemia Tachypnea

    Primary Outcomes

    Description: Improve hypoxia as measured by change between baseline P:F ratio and repeat P:F ratio inspired oxygen- P:F ratio (PaO2:FiO2), a higher value indicates better oxygenation. Range 20 to 500.

    Measure: Improve hypoxia as measured by change between baseline P:F ratio and repeat P:F ratio

    Time: change from baseline compared to one to six hours after initial device intervention

    Secondary Outcomes

    Description: Improved symptoms related to dyspnea as measured by the change in the Modified Medical Research Council (MMRC).. Range 0 to 4 with lower values being better.

    Measure: Subject dyspnea symptoms

    Time: baseline to end of hospitalization, (discharge from hospital or death, 1 - 30 days range)

    Description: Improved symptoms related to cough as measured by the change in Leicester Cough Questionnaire (LCQ) questionnaire, score range 3-21, a higher score indicates better quality of life.

    Measure: Subject cough symptoms

    Time: baseline to up to six hours for device intervention participants; baseline to hospital discharge (up to 30 days) for all patients

    Description: Improve subjective symptoms related to cough as measured by the change in St George Respiratory Questionnaire (SGRC) questionnaire, score range 0-100, a higher score indicates worse quality of life.

    Measure: Subject respiratory symptoms

    Time: baseline to up to six hours for device intervention participants; baseline to hospital discharge (up to 30 days) for all patients

    Description: Reduce risk of respiratory deterioration as measured by change from baseline to end of hospitalization (discharge or patient death) to high flow nasal cannula (HFNC), non-invasive ventilation (NIV), or invasive ventilation

    Measure: Reduced risk progression of respiratory deterioration

    Time: baseline to end of hospitalization, (discharge from hospital or death, 1 - 30 days range)

    Description: Reduced intensive care unit (ICU) transfer risk, as measured by a change from baseline to end of hospitalization of ICU admission.

    Measure: Reduced risk of ICU transfer

    Time: baseline to end of hospitalization, (discharge from hospital or death, 1 - 30 days range)

    Description: Reduce risk for intubation requirement as measured by incidence of intubation occurring between baseline and end of hospitalization (discharge or death)

    Measure: Reduced risk for intubation

    Time: baseline to end of hospitalization, (discharge from hospital, or death, 1 - 30 days range)

    Description: Reduced hospitalization length of stay as measured by length of hospitalization after the baseline timepoint.

    Measure: Reduced hospitalization length of stay

    Time: baseline to end of hospitalization, (discharge from hospital or death, 1 - 30 days range)

    Description: Increased patient survival to hospital discharge as measured by the participant status at the end of the hospitalization (discharge or death)

    Measure: Increased patient survival to discharge

    Time: baseline to end of hospitalization, (discharge from hospital- 1 - 30 days expected range)

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    706 reports on MeSH terms

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    306 reports on HPO terms

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