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  • HP:0002072: Chorea
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    HP:0002072: Chorea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug4624 Valbenazine Wiki 1.00
    drug1224 DAS181 Wiki 0.41

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D002819 Chorea NIH 1.00
    D006816 Huntington Disease NIH 0.58

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease

    This is a Phase 3, open-label study to evaluate the long-term safety and tolerability of valbenazine, and to provide subjects continued access to valbenazine for the treatment of chorea associated with Huntington disease.

    NCT04400331
    Conditions
    1. Chorea, Huntington
    Interventions
    1. Drug: Valbenazine
    MeSH:Huntington Disease Chorea
    HPO:Chorea Paroxysmal dyskinesia

    Primary Outcomes

    Measure: Number of Participants with Treatment-Emergent Adverse Events (TEAEs)

    Time: Up to 104 weeks

    Secondary Outcomes

    Description: The TMC is part of the motor assessment of the UHDRS and measures chorea in 7 different body parts including the face, oral-buccal-lingual region, trunk and each limb independently. The TMC score is the sum of the individual scores and ranges from 0 to 28. A decrease in score indicates improvement in chorea.

    Measure: Change from Baseline in the Unified Huntington's Disease Rating Scale (UHDRS) Total Maximal Chorea (TMC) Score

    Time: Up to 104 weeks

    HPO Nodes


    HP:0002072: Chorea
    Genes 309
    EZR TECR TRNK KCNA1 CLTC B3GALNT2 COX20 GRIA2 SLC2A1 TRAPPC11 NSUN2 DHX30 SLC20A2 PIK3R5 PIGN PUM1 ND2 ZNF142 ARX NGLY1 ST3GAL3 SIGMAR1 ACAT2 GPR88 ASH1L HPRT1 ND1 MRPS34 PRNP PDE10A UGDH DCAF17 SLC2A1 MYORG SYT1 AARS1 SPOP NDUFB8 TUBB4A MBD5 MMUT RSRC1 ARSA FBXO31 PTS PNPT1 AIMP1 SLC2A1 VPS13A TNIK PDGFRB CSNK2B EPB41L1 SLC30A9 NKX2-1 PANK2 PSAP KCNQ5 ATP1A2 KCNA1 MICU1 GRIN1 STXBP1 SYNGAP1 CLIP1 TBP SARS1 TRAPPC9 OPA3 NDUFAF5 GCDH CC2D1A BRSK2 XPR1 PNKD CRBN FOXG1 NADK2 TYROBP PRRT2 GNAO1 PDE10A NUP62 GCH1 ATM CDKL5 MBOAT7 ATN1 SLC2A1 RHOBTB2 PRRT2 GRIN2B ND4 PDGFB PTS NEUROD2 TAF1 CUX1 ADAR NDUFA9 PRSS12 PIGP FXN NUP62 FTL PITX3 ADCY5 TSEN34 SPG11 EDC3 SLC2A1 ERCC2 PLA2G6 CLCN4 FRRS1L KDM5B PRRT2 PRRT2 SLC6A8 SCN8A IRF2BPL VAMP2 OPA3 UBTF POLG CHAMP1 DDC TRNV SLC2A1 GABRA2 GRIK2 ADA2 NDST1 ZMYND11 MAN1B1 ATP1A3 NDUFAF3 PRRT2 GRIN2B PNPT1 EEF1A2 CDH15 KDM5B CACNA2D2 TRNW VPS13A CACNG2 SLC6A3 ERCC6 DYSF NGLY1 ATXN1 APTX UBTF SUOX NADK2 IREB2 DOCK8 GRIA4 MYT1L SCO2 ATXN2 PDHA1 ARSA FTL DCAF17 NKX2-1 ND5 HTT KIF1A TBP NDUFA13 TRIM8 PNKD PDGFB PRNP SURF1 GTPBP2 TAOK1 NDUFA1 GCDH ATP7A POU3F3 PPP3CA ALS2 MECP2 SCN2A PNKP DYNC1H1 CAMK2A LMAN2L PANK2 SPR QDPR MRE11 CLPB PIGC ATP5MK GNAS MECP2 ZC3H14 DCPS SEPSECS DLAT HTT HNMT SLC2A3 TSEN2 GRIN2B PLP1 NDUFS2 DMXL2 TRAPPC11 SCN1B GJC2 STXBP1 TRAPPC11 KCNA1 KIRREL3 TNFAIP3 ND3 TREM2 GM2A ADCY5 METTL23 TRPM3 KCNMA1 FBXL4 MED23 HSD17B10 PDE10A CAMK2B IQSEC1 PRNP C9ORF72 RAB11A AP2M1 PGAP1 HSPD1 MICOS13 HIVEP2 ATXN1 KIF5A GUF1 ATN1 SLC25A22 PRRT2 MED25 CP SYT1 CP TCF4 XPA HTT MECR GNAO1 LINS1 ATXN7 HSD17B10 WASHC4 SETX CASK ACP5 FRRS1L ND6 ST3GAL5 CIC C12ORF4 FMN2 MRE11 TUSC3 DEAF1 CARS2 HCFC1 CHMP1A MED12L NKX2-1 GM2A SIK1 GNAO1 NAXD PDE10A KIF1C FOXG1 ATP6 SLC45A1 ARX GAMT CTDP1 CACNA1B CRADD FUS SLC25A42 SLC6A3 GRIN1 ATP6 MICU1 JPH3 JPH3 MRM2 MMUT TAF1 EIF2AK2 SETX AP1S2 SET PIGQ ELP2 TRNL1
    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0002072: Chorea
    Genes 309
    EZR TECR TRNK KCNA1 CLTC B3GALNT2 COX20 GRIA2 SLC2A1 TRAPPC11 NSUN2 DHX30 SLC20A2 PIK3R5 PIGN PUM1 ND2 ZNF142 ARX NGLY1 ST3GAL3 SIGMAR1 ACAT2 GPR88 ASH1L HPRT1 ND1 MRPS34 PRNP PDE10A UGDH DCAF17 SLC2A1 MYORG SYT1 AARS1 SPOP NDUFB8 TUBB4A MBD5 MMUT RSRC1 ARSA FBXO31 PTS PNPT1 AIMP1 SLC2A1 VPS13A TNIK PDGFRB CSNK2B EPB41L1 SLC30A9 NKX2-1 PANK2 PSAP KCNQ5 ATP1A2 KCNA1 MICU1 GRIN1 STXBP1 SYNGAP1 CLIP1 TBP SARS1 TRAPPC9 OPA3 NDUFAF5 GCDH CC2D1A BRSK2 XPR1 PNKD CRBN FOXG1 NADK2 TYROBP PRRT2 GNAO1 PDE10A NUP62 GCH1 ATM CDKL5 MBOAT7 ATN1 SLC2A1 RHOBTB2 PRRT2 GRIN2B ND4 PDGFB PTS NEUROD2 TAF1 CUX1 ADAR NDUFA9 PRSS12 PIGP FXN NUP62 FTL PITX3 ADCY5 TSEN34 SPG11 EDC3 SLC2A1 ERCC2 PLA2G6 CLCN4 FRRS1L KDM5B PRRT2 PRRT2 SLC6A8 SCN8A IRF2BPL VAMP2 OPA3 UBTF POLG CHAMP1 DDC TRNV SLC2A1 GABRA2 GRIK2 ADA2 NDST1 ZMYND11 MAN1B1 ATP1A3 NDUFAF3 PRRT2 GRIN2B PNPT1 EEF1A2 CDH15 KDM5B CACNA2D2 TRNW VPS13A CACNG2 SLC6A3 ERCC6 DYSF NGLY1 ATXN1 APTX UBTF SUOX NADK2 IREB2 DOCK8 GRIA4 MYT1L SCO2 ATXN2 PDHA1 ARSA FTL DCAF17 NKX2-1 ND5 HTT KIF1A TBP NDUFA13 TRIM8 PNKD PDGFB PRNP SURF1 GTPBP2 TAOK1 NDUFA1 GCDH ATP7A POU3F3 PPP3CA ALS2 MECP2 SCN2A PNKP DYNC1H1 CAMK2A LMAN2L PANK2 SPR QDPR MRE11 CLPB PIGC ATP5MK GNAS MECP2 ZC3H14 DCPS SEPSECS DLAT HTT HNMT SLC2A3 TSEN2 GRIN2B PLP1 NDUFS2 DMXL2 TRAPPC11 SCN1B GJC2 STXBP1 TRAPPC11 KCNA1 KIRREL3 TNFAIP3 ND3 TREM2 GM2A ADCY5 METTL23 TRPM3 KCNMA1 FBXL4 MED23 HSD17B10 PDE10A CAMK2B IQSEC1 PRNP C9ORF72 RAB11A AP2M1 PGAP1 HSPD1 MICOS13 HIVEP2 ATXN1 KIF5A GUF1 ATN1 SLC25A22 PRRT2 MED25 CP SYT1 CP TCF4 XPA HTT MECR GNAO1 LINS1 ATXN7 HSD17B10 WASHC4 SETX CASK ACP5 FRRS1L ND6 ST3GAL5 CIC C12ORF4 FMN2 MRE11 TUSC3 DEAF1 CARS2 HCFC1 CHMP1A MED12L NKX2-1 GM2A SIK1 GNAO1 NAXD PDE10A KIF1C FOXG1 ATP6 SLC45A1 ARX GAMT CTDP1 CACNA1B CRADD FUS SLC25A42 SLC6A3 GRIN1 ATP6 MICU1 JPH3 JPH3 MRM2 MMUT TAF1 EIF2AK2 SETX AP1S2 SET PIGQ ELP2 TRNL1
    Protein Mutations 0
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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