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    HP:0000938: Osteopenia

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (6)


    Name (Synonyms) Correlation
    drug1886 High Intensity Resistance (HIT-RT) and Endurance exercise (HIIT) Wiki 1.00
    drug4744 Wellness Wiki 1.00
    drug1981 Hydroxychloroquine Sulfate Regular dose Wiki 0.71
    Name (Synonyms) Correlation
    drug1980 Hydroxychloroquine Sulfate Loading Dose Wiki 0.71
    drug973 Chloroquine Wiki 0.38
    drug3195 Placebo Wiki 0.04

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D001851 Bone Diseases, Metabolic NIH 1.00

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Effects of an Optimized 13-month Physical Exercise on (Early)-Postmenopausal Risk Factors in Women With Osteopenia and Osteoporosis (Actlife)

    Menopause usually have a serious impact on a woman's life, associated with negative consequences for health and quality of life. Early preventive assessments are very difficult to implement due to the complex hormone-deficiency-induced effects on a large variety of organs and systems with estrogen receptors. In fact, only a few types of interventions have the potential to comprehensively improve the various risk factors and complaints of the menopausal transition. In detail, however, not every form of exercise training or every training protocol is effective for exerting positive effects on selected risk factors. In particular, the training concept for addressing musculoskeletal or cardio-metabolic risk factors differ fundamentally. In several studies, we confirmed the effect of different complex training programs on risk factors of different postmenopausal female cohorts with special consideration of osteoporotic aspects. The training programs applied in this context were characterized by the consistent implementation of recognized training principles and an in general exercise intensity-oriented approach. Recent studies confirmed the effectiveness of this proceeding for women with relevant postmenopausal risk factors including low bone strength. However, the crucial issue of the most effective, feasible and easily customizable training protocol for addressing postmenopausal risk factors remains to be answered, taking into account that the majority of exercise programs were realized in an ambulatory group setting. The aim of the study will be to evaluate the effects of an optimized physical training on risk factors and complaints of (early) postmenopausal women with special consideration of the osseous fracture risk. Note (05.06.2020): Of importance, the intervention has to be cancelled due to COVID-19 lockdown in March 2020 after 13 months of intervention.

    NCT03959995
    Conditions
    1. Osteopenia, Osteoporosis
    Interventions
    1. Other: High Intensity Resistance (HIT-RT) and Endurance exercise (HIIT)
    2. Other: Wellness
    MeSH:Osteoporosis Bone Diseases, Metabolic
    HPO:Osteopenia

    Primary Outcomes

    Description: Bone Mineral Density (BMD) at the lumbar spine region of interest as determined by Dual Energy x-Ray Absorptiometry (DXA)

    Measure: BMD Lumbar Spine

    Time: from baseline to 13 month follow-up

    Secondary Outcomes

    Description: Bone Mineral Density at the total hip region of interest as determined by DXA

    Measure: BMD total Hip

    Time: from baseline to 13 month follow-up

    Description: Muscle density at the para-vertebral region as determined by Magnetic Resonance Imaging (MRI)

    Measure: Para-vertebral muscle density

    Time: from baseline to 13 month follow-up

    Description: Muscle density at the mid-thigh region as determined by MRI

    Measure: Mid-thigh muscle density

    Time: from baseline to 13 month follow-up

    Description: Metabolic Syndrome Z-Score according to the Internationale Diabetes Federation (IDF)

    Measure: Metabolic Syndrome

    Time: from baseline to 13 month follow-up

    Description: Visceral body fat as determined by Magnetic Resonance Imaging (MRI)

    Measure: Visceral body fat

    Time: from baseline to 13 month follow-up

    Description: Total body fat as determined by whole body DXA

    Measure: Total body fat

    Time: from baseline to 13 month follow-up

    Description: Total Lean Body Mass as determined by whole body DXA

    Measure: Total Lean Body Mass

    Time: from baseline to 13 month follow-up

    Description: Menopausal complaints as determined by the Menopause Rating Scale (German version. Questionnaire with 11 items; scale from 0 (no complaints/problems) to 4 (very severe complaints/problem)

    Measure: Menopausal complaints

    Time: from baseline to 13 month follow-up

    Description: Maximum isokinetic leg extensor strength as determined by an isokinetic leg press

    Measure: Maximum leg strength

    Time: from baseline to 13 month follow-up

    Description: Total fat rate as determined by Bio Impedance technique (BIA)

    Measure: Total fat rate

    Time: from baseline to 13 month follow-up

    Description: Fat free mass as determined by BIA

    Measure: Fat free mass

    Time: from baseline to 13 month follow-up

    HPO Nodes


    HP:0000938: Osteopenia
    Genes 291
    HECW2 PIGU BNC1 SLC34A1 DPM2 OCA2 MAGEL2 PROK2 FGFR2 PLS3 COL7A1 LIFR FAT4 SRP54 TRPV6 MAGEL2 COL1A1 ATP6V0A2 SPRY4 OTX2 GTF2IRD1 CAVIN1 DDOST IARS2 CHD7 PIGY MMP14 TACR3 FKBP14 GATA1 PMM2 PHGDH POLE SLC39A8 GBA FBN1 NDN NOTCH2 SOX3 OCA2 PIK3CD GLI2 CDH23 TCF4 AEBP1 PSAP XYLT2 CYP3A4 IL17RD GEMIN4 LMNA PSAT1 TBL2 NDN PIGT STN1 PLOD1 CRTAP COX4I2 TAC3 SIM1 GNPTAB PLEKHM1 CLIP2 FOXA2 MPLKIP SLC34A1 RFC2 GPAA1 ELN SNORD116-1 TARS1 NF1 GNPAT TMEM38B SPIDR PROP1 PYGL LIMK1 KISS1 HESX1 ADAMTS2 KRAS PMM2 LMNA BRAF ZMPSTE24 HSD17B4 SMPD1 SMARCD2 MGAT2 ELN UROS SEC23A GNAS GNRH1 RPL11 SATB2 STAT3 CCND1 POLR3H HS6ST1 GLIS3 USP9X PDE11A MST1 FGFR1 SLC39A13 FKBP10 HRAS PSMC3IP MEN1 B4GALT7 RNF113A HNRNPK FGFR1 SLC39A8 PROP1 COL1A1 PYCR1 NPAP1 PIGT COL5A1 GCM2 FAT4 CDH23 ERCC2 KNSTRN CHST3 KCNJ1 TMEM67 GORAB NUP107 SMARCAL1 MEN1 FLRT3 SNRPN MTTP SNORD115-1 DNAJC21 MBTPS2 NAGA STAT3 DUSP6 MKRN3-AS1 CTC1 CRIPT GNRHR B4GALT7 UNC80 AIP IFITM5 ALDH18A1 TAPT1 RNU4ATAC MDM4 P3H1 RSPRY1 GCM2 SLC35A2 POU1F1 GZF1 LHX4 ATP6V0A2 TRPS1 SNRPN PDGFRB B3GALT6 DCAF17 SGMS2 SEC24D SLC7A7 COL1A1 TAF1 PRLR ANTXR2 PWRN1 FGF17 IPW SLC9A3R1 CREB3L1 TCIRG1 GTF2I MAGEL2 FBN2 DCHS1 ESR1 STAT1 SRP54 KISS1R NPR2 DCHS1 IL1RN MTAP EED GTF2H5 EIF2AK3 B3GAT3 NSMF RECQL4 SNRPN FUT8 DUSP6 HNRNPK HPGD SERPINH1 NDN SKI STAT1 ANTXR2 KL ADCY10 FKBP14 TERT CDC73 COG1 NRAS SCARB2 FARSB MMP2 PRKACA OCA2 SNRPN LRP5 NOTCH2 SKI RSPRY1 LRP5 MMP2 GPAA1 HERC2 SBDS HBB AVP SATB2 EFL1 MAFB ESR1 CYP19A1 MMP1 UROS ATP7A MAGEL2 MLXIPL ANO5 POLR3A BMP15 TREM2 MAGEL2 PTH1R ADAMTS2 MRPS22 PLOD2 RNF125 P4HB SLC12A1 TONSL COG1 ELANE ANOS1 GTF2E2 PRKAR1A NR5A1 MAN2B1 GPR35 BAZ1B SH3PXD2B MAN2B1 FSHR PROKR2 ANAPC1 PWAR1 CTCF SLC17A5 COL5A2 FGF8 ERCC3 GFI1 SLC39A13 FGF17 IER3IP1 KISS1R PLOD3 ANO5 NDN IRX5 ADAMTSL2 TRPS1 WDR11 IGF1 MKRN3
    Protein Mutations 2
    H295R M184V
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0000938: Osteopenia
    Genes 291
    HECW2 PIGU BNC1 SLC34A1 DPM2 OCA2 MAGEL2 PROK2 FGFR2 PLS3 COL7A1 LIFR FAT4 SRP54 TRPV6 MAGEL2 COL1A1 ATP6V0A2 SPRY4 OTX2 GTF2IRD1 CAVIN1 DDOST IARS2 CHD7 PIGY MMP14 TACR3 FKBP14 GATA1 PMM2 PHGDH POLE SLC39A8 GBA FBN1 NDN NOTCH2 SOX3 OCA2 PIK3CD GLI2 CDH23 TCF4 AEBP1 PSAP XYLT2 CYP3A4 IL17RD GEMIN4 LMNA PSAT1 TBL2 NDN PIGT STN1 PLOD1 CRTAP COX4I2 TAC3 SIM1 GNPTAB PLEKHM1 CLIP2 FOXA2 MPLKIP SLC34A1 RFC2 GPAA1 ELN SNORD116-1 TARS1 NF1 GNPAT TMEM38B SPIDR PROP1 PYGL LIMK1 KISS1 HESX1 ADAMTS2 KRAS PMM2 LMNA BRAF ZMPSTE24 HSD17B4 SMPD1 SMARCD2 MGAT2 ELN UROS SEC23A GNAS GNRH1 RPL11 SATB2 STAT3 CCND1 POLR3H HS6ST1 GLIS3 USP9X PDE11A MST1 FGFR1 SLC39A13 FKBP10 HRAS PSMC3IP MEN1 B4GALT7 RNF113A HNRNPK FGFR1 SLC39A8 PROP1 COL1A1 PYCR1 NPAP1 PIGT COL5A1 GCM2 FAT4 CDH23 ERCC2 KNSTRN CHST3 KCNJ1 TMEM67 GORAB NUP107 SMARCAL1 MEN1 FLRT3 SNRPN MTTP SNORD115-1 DNAJC21 MBTPS2 NAGA STAT3 DUSP6 MKRN3-AS1 CTC1 CRIPT GNRHR B4GALT7 UNC80 AIP IFITM5 ALDH18A1 TAPT1 RNU4ATAC MDM4 P3H1 RSPRY1 GCM2 SLC35A2 POU1F1 GZF1 LHX4 ATP6V0A2 TRPS1 SNRPN PDGFRB B3GALT6 DCAF17 SGMS2 SEC24D SLC7A7 COL1A1 TAF1 PRLR ANTXR2 PWRN1 FGF17 IPW SLC9A3R1 CREB3L1 TCIRG1 GTF2I MAGEL2 FBN2 DCHS1 ESR1 STAT1 SRP54 KISS1R NPR2 DCHS1 IL1RN MTAP EED GTF2H5 EIF2AK3 B3GAT3 NSMF RECQL4 SNRPN FUT8 DUSP6 HNRNPK HPGD SERPINH1 NDN SKI STAT1 ANTXR2 KL ADCY10 FKBP14 TERT CDC73 COG1 NRAS SCARB2 FARSB MMP2 PRKACA OCA2 SNRPN LRP5 NOTCH2 SKI RSPRY1 LRP5 MMP2 GPAA1 HERC2 SBDS HBB AVP SATB2 EFL1 MAFB ESR1 CYP19A1 MMP1 UROS ATP7A MAGEL2 MLXIPL ANO5 POLR3A BMP15 TREM2 MAGEL2 PTH1R ADAMTS2 MRPS22 PLOD2 RNF125 P4HB SLC12A1 TONSL COG1 ELANE ANOS1 GTF2E2 PRKAR1A NR5A1 MAN2B1 GPR35 BAZ1B SH3PXD2B MAN2B1 FSHR PROKR2 ANAPC1 PWAR1 CTCF SLC17A5 COL5A2 FGF8 ERCC3 GFI1 SLC39A13 FGF17 IER3IP1 KISS1R PLOD3 ANO5 NDN IRX5 ADAMTSL2 TRPS1 WDR11 IGF1 MKRN3
    Protein Mutations 2
    H295R M184V
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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