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  • HP:0012191: B-cell lymphoma
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    HP:0012191: B-cell lymphoma

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug3987 Sintilimab Wiki 0.71
    drug297 Anakinra Wiki 0.21

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D016393 Lymphoma, B-Cell NIH 1.00
    D016403 Lymphoma, Large B-Cell, Diffuse NIH 0.71
    D008223 Lymphoma, NIH 0.45

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0002665 Lymphoma HPO 0.45

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 A Phase II Study of IL-1 Receptor Antagonist Anakinra to Prevent Severe Neurotoxicity and Cytokine Release Syndrome in Patients Receiving CD19-Specific Chimeric Antigen Receptor (CAR) T Cells And to Treat Systemic Inflammation Associated With COVID-19

    This study is being done to see if the investigational drug, anakinra, prevent or reverse the severe side effects caused by CAR-T cell therapy.

    NCT04148430
    Conditions
    1. B Cell ALL
    2. B-Cell Lymphoma
    3. B-cell Non Hodgkin Lymphoma
    Interventions
    1. Drug: Anakinra
    MeSH:Lymphoma Lymphoma, B-Cell
    HPO:B-cell lymphoma Lymphoma

    Primary Outcomes

    Description: Determine the rate of severe neurotoxicities, >/= Grade 3 or any grade seizure, within the first 4 weeks of treatment with prophylactic use of anakinra in participants receiving CD19-specific CAR T cells

    Measure: Arm 1 (CAR T Cell Group) Rate of Severe Neurotoxicities

    Time: 4 weeks

    Description: proportion of patients able to avoid death or mechanical ventilation within 28 days from the start of the treatment.

    Measure: Arm 2 (COVID-19 Group) proportion of patients able to avoid death or mechanical ventilation

    Time: 28 days from the start of treatment
    2 A Phase II Study of Anti-PD-1 Antibody (Sintilimab) Plus Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) as Second-line Salvage Therapy in Patients With Relapsed/ Refractory Diffuse Large B Cell Lymphoma (DLBCL)

    This study evaluates the addition of Sintilimab to current 2nd line salvage therapy of Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) for patients with relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL). All patients will receive four cycles of sintilimab plus R-GemOx. Afterwards, 1) patients who achieve CR assessed by PET-CT and are eligible for autologous stem cell transplantation (ASCT) will undergo ASCT. After transplantation, patients will receive sintilimab monotherapy up to 8 cycles or until disease recurrence and progression, death, intolerance and toxicity, withdrawal of informed consent, or other reasons specified in the protocol. 2) Patients who achieve CR assessed by PET-CT and are not eligible for ASCT will directly receive sintilimab monotherapy as maintenance treatment for a maximum of 8 cycles as described above. 3) Patients achieved PR, SD or PD assessed by PET/CT will withdraw from this study and receive proper treatment based on investigator's decision.

    NCT04659434
    Conditions
    1. Diffuse Large B Cell Lymphoma
    2. Relapsed Diffuse Large B-Cell Lymphoma
    3. Refractory Diffuse Large B-Cell Lymphoma
    Interventions
    1. Drug: Sintilimab
    MeSH:Lymphoma Lymphoma, B-Cell Lymphoma, Large B-Cell, Diffuse
    HPO:B-cell lymphoma Lymphoma

    Primary Outcomes

    Description: Complete response rate after treated by Sintilimab and R-GemOx

    Measure: Complete response rate

    Time: 6 weeks after the last dose of the combination therapy (each cycle is 21 days)

    Secondary Outcomes

    Description: Overall response rate after treated by Sintilimab and R-GemOx

    Measure: Over response rate (ORR)

    Time: 6 weeks after the last dose of the combination therapy (each cycle is 21 days)

    Description: from date of inclusion to date of progression, relapse, or death from any cause

    Measure: Overall Survival (OS)

    Time: 2 years

    Description: All the adverse events of the patients related will be assessed and graded by NCI CTCAE v 5.0

    Measure: Rate of grade 3 or 4 treatment related adverse effect

    Time: Time Frame: Up to 30 days after the last cycle of per-protocol treatment and 90 days after last dose of anti-PD-1 antibody (each cycle is 28 days)

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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