Ritonavir (RTV) is a protease inhibitor (PI) commonly used to increase drug levels of other PIs in HIV drug treatment. The purpose of this study is to compare a combination of drugs which includes RTV and 2 protease inhibitors (PIs) with 2 combinations that include RTV and another PI. This study also will compare the effectiveness, safety, tolerability, and drug levels in the blood of these anti-HIV drug combinations.

NCT00028366

Conditions

1. HIV Infections

Interventions

1. Drug: Fosamprenavir
2. Drug: Lopinavir/Ritonavir
3. Drug: Ritonavir
4. Drug: Tenofovir disoproxil fumarate

MeSH:HIV Infections

Note: Accrual into A5143 and A5147S has been discontinued. --- A5147S ---

- Midazolam within 7 days of study entry - Allergic or sensitive to study drugs - Excessive drug or alcohol use - Serious illness requiring treatment and/or hospitalization and have not completed therapy, or are not stable on therapy for at least 14 days prior to study entry - Pregnant or breastfeeding Note: Accrual into A5143 and A5147S has been discontinued. --- A5147S ---

In substudy A5147S, intensive 12-hour pharmacokinetic sampling for APV, LPV, and RTV will be conducted. --- A5147S ---