Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, it is reported that over 35% of patients treated with ondansetron experience PONV. Though the cause of failure in ondansetron treatment is not clear, the investigators assumed that polymorphism in the 5-HT3 receptor gene would contribute to such inter-individual variation. In this study, the investigators examine whether the polymorphisms of 5-HT3 receptor gene affect the efficacy of ondansetron to prevent PONV in patients undergoing general anesthesia for laparoscopic surgery.

NCT01657786

Conditions

1. Post Operative Nausea and Vomiting

Interventions

1. Dietary Supplement: administration of ondanstron and screening of genomic DNA

MeSH:Nausea Vomiting Postoperative Nausea and Vomiting

HPO:Nausea Vomiting

The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG). --- S253N --- --- Y129S ---

The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).. Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Post Operative Nausea and Vomiting Nausea Vomiting Postoperative Nausea and Vomiting null --- S253N --- --- Y129S ---