There are 2 clinical trials
The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
A Validation Study of The Relationship Between ALDH2 and Aortic Dissection The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection. --- Glu504Lys ---
Description: DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.
Measure: Number of patients with different ALDH2 genotype Time: 1-30 days after samples collectedThe purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
The Relationship Between ALDH2 and Aortic Dissection The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection. --- Glu504Lys ---
Description: DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.
Measure: Number of patients with different ALDH2 genotype Time: 1-30 days after samples collectedDescription: Concentration of 4-HNE、MMP-2、MMP-9 detected by elisa kit、IHC or western blot in relevant specimen.
Measure: Concentration of inflammatory factors in blood and aortic specimen Time: 1-30 days after samples collectedDescription: Activity of ALDH2 was detected in blood and aortic specimen depend on its reducibility of NAD+
Measure: ALDH2 activity Time: 1-30 days after samples collected