Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases. Several polymorphisms related to NADPH oxidase expression or NADPH oxidase activity has been identified. The investigators are going to compare the distribution of the allelic frequencies of A-930G and C242T polymorphisms and their possible relationship with the levels of 8-isoprostanes as a marker of oxidative stress in patients with OSA and in a control group without OSA.

NCT01141829

Conditions

1. Sleep Apnea Syndrome
2. Oxidative Stress
3. Single Nucleotide Polymorphism

MeSH:Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Syndrome

HPO:Apnea Obstructive sleep apnea Sleep apnea

The investigators are going to compare the distribution of the allelic frequencies of A-930G and C242T polymorphisms and their possible relationship with the levels of 8-isoprostanes as a marker of oxidative stress in patients with OSA and in a control group without OSA. --- C242T ---

Sleep Apnea Syndrome Oxidative Stress Single Nucleotide Polymorphism Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Syndrome DESIGN: CASE-CONTROL STUDY METHODS: We are going to determine the A-930G and C242T p22phox genotypes in patients with OSA and healthy subjects recruited from sleep unit of Son Dureta University Hospital, (Palma de Mallorca, Spain). --- C242T ---