This study will investigate pharmacological interventions between fluconazole and ibuprofen when they are given to premature newborn babys. This in order to find out if the drugs are influencing each other when they are given at the same time. The study is meant to find out if there are reasons to adjust the dose when fluconazole and ibuprofen are given together.

NCT02079298

Conditions

1. Ductus Arteriosis, Patent
2. Bacterial Infections and Mycoses

Interventions

1. Drug: Treatment with fluconazole.
2. Drug: 2. Treatment with both fluconazole and Ibuprofen.
3. Drug: 3. Treatment with ibuprofen.
4. Other: 4. No treatment with either fluconazole nor ibuprofen.

MeSH:Mycoses Bacterial Infections

Urinary concentrations of prostacycline (PGI2) and thromboxane A2 (TxA2) measured in picogram/milliliter.. To evaluate the effect of fluconazole and/or ibuprofen on the urinary excretion of two vasoactive arachidonic acid products, thromboxane A2 (TXA2) and prostacycline (PGI2), in newborn infants treated with one or both of these drugs for fungal infection prophylaxis and/or patent ductus arteriosis (PDA), respectively.. Concentration of thromboxane A2 (TXA2) and prostacycline (PGI2) in relation to genetic variation of the enzymes of the Cytochrome (P4502C) family.. --- P4502C ---

To evaluate if genetic variability in the enzyme Cytochrome (P4502C) influence the urinary excretion of two vasoactive arachidonic acid products: thromboxane A2 (TXA2) and prostacycline (PGI2) in newborn infants treated with fluconazole and/or ibuprofen.. Number of and type of Adverse Drug Reactions. --- P4502C ---