Effects of different doses of remifentanil on hemodynamic response to anesthesia induction in elderly patients ABSTRACT OBJECTİVE: The investigators compared the effects of three different doses of remifentanil infusion, which have been performed for the induction of anesthesia in elder patients, on cardiovascular response. PATIENTS AND METHODS: The present study was designed as a randomized, prospective and double-blind study. A total of 90 ASA I-II patients over the age of 65 years were enrolled and each group consisted of 30 subjects. The patients were randomly (by lot) assigned to receive one of the three doses of remifentanil infusion (0.1, 0.2 or 0.3 µg/kg/min) for two minutes. Subsequently, 0.5 mg/kg propofol was administered via IV route and, 0.5 mg/kg rocuronium was administered via IV route at the time eyelash reflex disappeared. Intubation was performed after two minutes. After recording baseline values of heart rate (HR), systolic arterial pressure (SBP), diastolic arterial pressure (DBP) and mean arterial pressure (MAP), these values were recorded at the 1st, 2nd, 3rd, 4th and 5th minutes of induction.

NCT02763098

Conditions

1. Anesthesia

Interventions

1. Drug: Remi 0.1
2. Drug: Remi 0.2
3. Drug: Remi 0.3

Physiological parameters; measurement of heart rate was calculated on the ECG trace (Hewlett-Packard HP M1002A).. Inclusion Criteria: - Normotensive patients - ASA I-II - Patients over the age of 65 years - Undergoing elective non-cardiac surgery Exclusion Criteria: - Patients who had allergy against opioids - Chronic benzodiazepine, opioid, alcohol or substance users - Obese (body mass index > 30) - Expected to have difficult airway - Patients had hypertension - Patients have been receiving any drug influencing the cardiovascular system (beta -adrenergic blocker, calcium channel blocker, etc.) Inclusion Criteria: - Normotensive patients - ASA I-II - Patients over the age of 65 years - Undergoing elective non-cardiac surgery Exclusion Criteria: - Patients who had allergy against opioids - Chronic benzodiazepine, opioid, alcohol or substance users - Obese (body mass index > 30) - Expected to have difficult airway - Patients had hypertension - Patients have been receiving any drug influencing the cardiovascular system (beta -adrenergic blocker, calcium channel blocker, etc.) Anesthesia The present study was carried out after the approval of "Dokuz Eylül University School of Medicine, Clinical Researches Ethics Committee and informed consents of the patients were obtained. --- M1002A ---

Measurement of systemic arterial pressure was done by automatic oscillometry (Hewlett-Packard HP M1008B) and heart rate (HR) was calculated on the ECG trace (Hewlett-Packard HP M1002A). --- M1002A ---