The purpose of the study is to better understand how the body handles sugars glucose and fats, such as cholesterol and triglycerides in sickle cell disease, and what puts certain persons at risk to develop diabetes. This understanding may help us to find new treatments to control blood sugar and prevent diabetes in people with and without sickle cell disease (SCD). In this research, DNA and RNA will be isolated from blood cells. DNA will be used to find genes that cause or protect from diabetes, high cholesterol and high triglyceride, and RNA will be used for studies designed to find out how genes are doing their job of eventually producing proteins.

NCT02922296

Conditions

1. Sickle Cell Disease
2. Diabetes Mellitus

MeSH:Anemia, Sickle Cell

The investigators will analyze the expression of transcripts to determine if alterations can explain the clinical observations.. Inclusion Criteria: - Major sickling genotype (hemoglobin SS, Sbeta0-thalassemia, SOarab, SDpunjab) - Age >35 years - BMI <25 kg/m2 or >26 kg/m2 - Steady state, defined as >two weeks from a hospitalization for vaso-occlusive crisis, infection or surgery and not requiring immediate parenteral medication for pain control - Fasting state (>8 hours since ingesting food or medication for diabetes) Exclusion Criteria: - Patients receiving insulin therapy - Acute inflammatory or infectious illness or injury Inclusion Criteria: - Major sickling genotype (hemoglobin SS, Sbeta0-thalassemia, SOarab, SDpunjab) - Age >35 years - BMI <25 kg/m2 or >26 kg/m2 - Steady state, defined as >two weeks from a hospitalization for vaso-occlusive crisis, infection or surgery and not requiring immediate parenteral medication for pain control - Fasting state (>8 hours since ingesting food or medication for diabetes) Exclusion Criteria: - Patients receiving insulin therapy - Acute inflammatory or infectious illness or injury Sickle Cell Disease Diabetes Mellitus Anemia, Sickle Cell Sickle cell disease (SCD) is due to homozygosity for a Glu6Val mutation in HBB (sickle cell anemia; hemoglobin SS) or to compound heterozygous forms like hemoglobin SC disease and hemoglobin S-β thalassemia. --- Glu6Val ---