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D000013: Congenital Abnormalities

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug2381 PET-CT of 18F-FDG Wiki 0.71
drug2803 Randomized to Delayed Cord Clamping at birth Wiki 0.71
drug2804 Randomized to Umbilical Cord Milking at birth Wiki 0.71
Name (Synonyms) Correlation
drug1540 Hydroxychloroquine Sulfate + Azithromycin Wiki 0.71
drug1538 Hydroxychloroquine Sulfate Wiki 0.41
drug2505 Placebo Wiki 0.03

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D047928 Premature Birth NIH 0.41
D007239 Infection NIH 0.04

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0001622 Premature birth HPO 0.71

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 Two Year Developmental Follow-up for Premature Infants Receiving Milking or Delayed Cord Clamping: PREMOD2

An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC. This prospective multi-national randomized controlled trial (RCT) is a two-arm parallel non-inferiority design of two alternative approaches of treatment.

NCT03476980
Conditions
  1. Neurodevelopmental Abnormality
Interventions
  1. Procedure: Randomized to Umbilical Cord Milking at birth
  2. Procedure: Randomized to Delayed Cord Clamping at birth
MeSH:Premature Birth Congenital Abnormalities
HPO:Premature birth

Primary Outcomes

Description: Bayley Scales of Infant Development (BSID), 3rd or 4th Ed. Composite Score (cognitive 55-145, language 45-155, motor 45-155; higher scores are better)

Measure: Developmental Outcome

Time: 22-26 months corrected gestational age (CGA). All assessments may be extended to 42 months CGA due to Covid-19 pandemic.

Secondary Outcomes

Description: Defined having at least one of the following: a cognitive score <70, GMFCS greater or equal 2, blindness (vision <20/200), or hearing impairment interfering with the ability to communicate with amplification.

Measure: Moderate/Severe Neurodevelopmental Impairment

Time: 22-26 months corrected gestational age

Description: Defined having at least one of the following: a cognitive score 70-84, GMFCS =1, unilateral blindness (vision <20/200 in only one eye), or hearing impairment which does not interfere with the ability to communicate.

Measure: Mild Neurodevelopmental Impairment

Time: 22-26 months corrected gestational age

Description: The GMFCS is a validated system used to describe the severity of motor dysfunction. Scale measured from Level 0-5 with Level 0 being normal and Level 5 being the worst score. Measures ability to walk, sit, head control, voluntary movements and postures.

Measure: Gross Motor Function Classification System Scale (GMFCS)

Time: 22-26 months corrected gestational age

Description: Classified as None, Mild, Moderate or Severe based on GMFCS score; No CP = GMFCS Level 0, Mild CP = GMFCS Level 1, Moderate CP = GMFCS Levels 2-3, Severe CP = GMFCS Levels 4-5

Measure: Cerebral Palsy (CP)

Time: 22-26 months corrected gestational age

Description: Each domain is scored from 0 to 60, the higher score is better.

Measure: Developmental Outcomes assessed by Ages & Stages Questionnaire, 3rd ed. (ASQ-3) five domains: Communication, Gross motor, Fine motor, Problem solving and Personal-social in infants born between 23-32+6 weeks GA who received UCM or DCC.

Time: 22-26 months corrected gestational age

Description: BSID Cognitive, Language & Motor composite scores (cognitive 55-145, language 45-155, motor 45-155; higher scores are better) in infants 23-27 weeks GA and 28-32+6 weeks GA.

Measure: Developmental Outcomes in infants born at 23 -27 and 28-32 weeks GA who received UCM or DCC

Time: 22-26 months corrected gestational age

Description: ASQ-3 scores (0 to 60, the higher score is better) in infants 23-27 weeks GA and 28-32+6 weeks GA.

Measure: Developmental Outcomes in infants born at 23 -27 and 28-32 weeks GA who received UCM or DCC

Time: 22-26 months corrected gestational age

Description: Mild, moderate or severe impairment

Measure: Compare levels of developmental impairment as assessed by BSID-3 or 4 versus the ASQ-3 screening tool.

Time: 22-26 months corrected gestational age

Description: Any IVH grade from 1 to grade 4, higher grade is worse

Measure: Any grade intraventricular hemorrhage (IVH) in premature newborns 23 - 32+6 weeks GA who received UCM or DCC by mode of delivery (C-Section vs vaginal delivery)

Time: From birth through hospital discharge, up to 6 months corrected gestational age (CGA)

Description: Death

Measure: Death in premature newborns 23 - 32+6 weeks GA who received UCM or DCC by mode of delivery (C-Section vs vaginal delivery)

Time: From birth through hospital discharge, up to 6 months corrected gestational age (CGA)

Description: BSID Cognitive, Language & Motor composite scores (cognitive 55-145, language 45-155, motor 45-155; higher scores are better)

Measure: Compare neurodevelopmental outcomes from BSID assessments in newborns 23-32 weeks GA delivered by C-Section with those born by vaginal delivery receiving UCM or DCC.

Time: 22-26 months corrected gestational age

Description: ASQ-3 scores (0 to 60, the higher score is better).

Measure: Compare neurodevelopmental outcomes from ASQ assessments in newborns 23-32 weeks GA delivered by C-Section with those born by vaginal delivery receiving UCM or DCC.

Time: 22-26 months corrected gestational age

Other Outcomes

Description: Any grade IVH, from 1 to 4 (higher is worse)

Measure: Exploratory, hypothesis-generating

Time: From birth through hospital discharge, up to 6 months corrected gestational age (CGA)

Description: Hemoglobin or Hematocrit at 4 hours of age

Measure: Exploratory, hypothesis-generating

Time: 4 hours of life +/- 2 hours

Description: Delivery room interventions received: positive pressure ventilation, continuous positive airway pressure, intubation, chest compressions and medications

Measure: Exploratory, hypothesis-generating

Time: In the first 10 minutes of life

Description: Blood pressures in the first 24 hours of life: on admission, 6, 12, 18 and 24 hours of life

Measure: Exploratory, hypothesis-generating

Time: In the first 24 hours of life
2 CT Abnormalities Evocative of Lung Infection Are Associated With Lower 18F-FDG Uptake in Confirmed COVID-19 Patients

CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas 18F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 18F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on 18F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing.

NCT04512118
Conditions
  1. Presence of COVID-19 Compatible CT Abnormalities
Interventions
  1. Diagnostic Test: PET-CT of 18F-FDG
MeSH:Infection Congenital Abnormalities

Primary Outcomes

Description: Visual analysis of the pulmonary lobes by calculating a extent score for each patient

Measure: Visual analysis of pulmonary lobes

Time: 1 day

Secondary Outcomes

Description: Measurement of metabolic activity with SUV max of lung areas with CT abnormalities

Measure: Measurement of metabolic activity

Time: 1 day

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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4,180 reports on interventions/drugs

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691 reports on MeSH terms

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