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D005334: Fever

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

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Correlated Drug Terms (5)


Name (Synonyms) Correlation
drug3189 Stamaril (live attenuated yellow fever vaccine) Wiki 0.58
drug3560 Tympanic Temperature Wiki 0.58
drug3460 Thermography Wiki 0.58
Name (Synonyms) Correlation
drug1382 Galidesivir Wiki 0.58
drug2505 Placebo Wiki 0.03

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D015004 Yellow Fever NIH 0.82

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0001945 Fever HPO 1.00

Clinical Trials

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There are 3 clinical trials


1 Using Systems Vaccinology to Elucidate the Effects of Anti-inflammatory Therapy on Immune Response After Vaccination With a Live Attenuated Vaccine

Since the 1st pandemic of the 21st century caused by SARS coronavirus, the world has experienced outbreaks of swine origin H1N1 influenza, Ebola and Zika viruses, which have all resulted in global health crises. Rapid mass vaccination with an effective vaccine such as a live attenuated vaccine, of vulnerable immune-naïve populations to establish herd immunity is an approach to control outbreaks. Such live attenuated vaccine had been used with great success in sporadic yellow fever outbreaks and recently successfully employed in Ebola field trial, both of these diseases have the potential for pandemic spread. Indeed, live attenuated vaccines have proven especially effective in controlling childhood diseases and have even succeeded in eradicating polio and measles from most parts of the world. However, deployment of such vaccines for pandemic control cannot be limited to children but must include adults in order to rapidly elevate herd immunity rates to halt transmission. Vaccinating adults may produce efficacy rates significantly different to those observed in children due to the prevalence of chronic diseases and their associated metabolic complications. Presently, there are 1 billion people who are overweight, many suffer from concurrent metabolic disorders. As activation of the adaptive immunity is reliant on a robust innate immune response to vaccines, metabolic disorders and long-term anti-inflammatory therapy with interventions such as statins may reduce vaccine immunogenicity resulting in suboptimal efficacy in this subpopulation. This study would therefore test the hypothesis that statins reduce live attenuated vaccine immunogenicity. We will combine a clinical trial with systems vaccinology approaches to define the impact statins has on the innate immune, B and T-cell responses to live attenuated vaccination. Our study will thus extend upon another recently completed trial by us and will provide new insights into the determinants of vaccine efficacy in a rapidly growing and aging population globally

NCT03116802
Conditions
  1. Yellow Fever Vaccine
  2. Yellow Fever
Interventions
  1. Drug: Stamaril (live attenuated yellow fever vaccine)
MeSH:Yellow Fever Fever
HPO:Fever

Primary Outcomes

Description: the difference in neutralizing antibody titer to YF17D at Day 28, as measured by plaque reduction neutralization test (PRNT)

Measure: the adaptive immune response to YF vaccination in (A): Adult human volunteers who are on long term statins therapy and (B): Adult human volunteers (controls)

Time: 28 days

Secondary Outcomes

Description: viremia levels response in adult human volunteers on long term statins therapy compared to controls post-YF vaccination

Measure: the difference in innate immune response to YF vaccination in adult human volunteers on long term statins therapy compared to controls post-YF vaccination

Time: 28 days

Description: To examine the Cd4+ and Cd8+ T cell response in adult human volunteers on long term statins therapy compared to controls post-YF vaccination

Measure: the cellular immune response of adult human volunteers on long term statins therapy with controls following YF vaccination.

Time: 28 days
2 A Phase 1b Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Safety, Pharmacokinetics, and Anti-viral Effects of Galidesivir Administered Via Intravenous Infusion to Subjects With Yellow Fever or COVID-19

This is a placebo-controlled, randomized, double-blind study to evaluate the pharmacokinetics, safety and antiviral activity of galidesivir in subjects with yellow fever (YF) or COVID-19.

NCT03891420
Conditions
  1. COVID-19
  2. Yellow Fever
Interventions
  1. Drug: Galidesivir
  2. Drug: Placebo
MeSH:Yellow Fever Fever
HPO:Fever

Primary Outcomes

Measure: number of subjects with treatment emergent adverse events and serious adverse events

Time: absolute number through the end of the study, approximately 56 days

Measure: number of subjects with change in laboratory parameters

Time: absolute number and change from baseline through the end of the study, approximately 56 days

Measure: exposure of galidesivir as measured by plasma concentrations

Time: 24 hours post dose on Day 1 through 12 hours post dose on Day 7

Secondary Outcomes

Measure: yellow fever virus (YFV) titer (Group A)

Time: change in YFV titer from baseline through Day 21

Measure: antiviral effect on SARS-CoV-2 in the respiratory tract - COVID-19 (Group B)

Time: change in SARS-CoV-2 from baseline through Day 21

Measure: changes in clinical status using 8-point ordinal scale in COVID-19 (Group B)

Time: through Day 21

Measure: changes from baseline and time to improvement using NEWS in COVID-19 (Group B)

Time: through Day21

Measure: mortality

Time: mortality at Day 56
3 COVID-19 Response - Thermography Based Fever Detection for Triaging of Patients - A Feasibility Study

This study will refine and pilot the feasibility of introducing a thermal imaging test to detect fever in 100 patients being triaged within the Emergency Department. The only additional research requirement for the patient is to have a thermal image of their face taken. Other triage tests will be routine. The aims of the feasibility study are to: - Understand the acceptability of introducing the intervention within the Emergency Department setting - Establish indicative patient recruitment numbers per week - Determine the likely proportion of patients recruited from this group who have a high temperature - Provide preliminary evidence that the technology can identify a high temperature in this diverse group of patients - Provide preliminary data for machine learning training to support classification of patients as being with or without fever The feasibility study will then inform the design and size of larger study to further develop and validate the the thermal imaging screening test to provide a 'with/ without' fever result.

NCT04397380
Conditions
  1. Pyrexia
  2. COVID
Interventions
  1. Device: Thermography
  2. Device: Tympanic Temperature
MeSH:Fever
HPO:Fever

Primary Outcomes

Description: Measurement of temperature

Measure: Temperature

Time: During Emergency Department Stay (first 4 hours of hospitalisation)

HPO Nodes


HP:0001945: Fever
Genes 340
LIFR CYBA NKX2-1 PRSS1 KLHL7 KCNJ1 EIF2B3 LBR BIRC3 SPTB ELP1 EIF2B4 BLNK NAB2 RANBP2 LPIN1 EPB42 CD79A IL36RN STAT5B SPINK1 NOTCH3 TP53 MEFV TP53 TRNF ERCC5 IL12A-AS1 TREX1 SLC11A1 CTLA4 MLX PRKAR1A RUNX1 IGHM AVPR2 GPR35 PRSS2 RAG2 PML SLC29A3 ADA2 STAT3 EPB41 CYP11B2 EDA IGH NGF GLA CALR CCR1 MALT1 ND1 ND4 GPC3 XPC IL6 CCND1 KLRC4 ND1 CFH PSTPIP1 SAMHD1 HLA-B TCF4 TRNQ LPIN2 BCOR BRCA2 P4HTM NOD2 NLRP3 BCL10 IRF2BP2 SH2B3 NLRP3 SH3KBP1 CYBC1 BCL6 IRF8 CACNA1S LIG4 MYD88 BCL2 RYR1 ZBTB16 IL7R GCH1 LACC1 KIF1B HMGCL CASK NLRP3 SCNN1A COX3 ATP6 HAVCR2 TREX1 HLA-B POMP STX11 POU6F2 TNFRSF1A C4A CYP11B2 IKZF1 ATM LIPA UBAC2 NOD2 TMEM165 NUMA1 AQP2 RAG2 ABCC2 RARA RB1 MST1 NCF4 LIFR SPTA1 LYST PMP22 ADA RAG1 PTPN22 ORAI1 F5 DST TRNS2 SLCO1B3 KRT8 EIF2B5 TRIM28 GALC TLR3 AK2 AQP2 TRAF3 FIP1L1 WT1 TNFAIP3 SPP1 WT1 RNASEH2B EIF2B2 ELANE BCAP31 SLC29A3 HLA-DPB1 HTR1A UNC13D HLA-DPA1 CPT2 LRRC8A GYPC QDPR TSC2 DCLRE1C CFTR TRIM28 TRNS1 TLR4 NPM1 ANK1 SCNN1B ACAT1 AVPR2 ND5 NLRP3 TRNH FAS ATP1A3 CYP21A2 PEX6 GFI1 CHEK2 IL12A IGH LPIN2 TICAM1 NLRC4 CD3D ELANE PSMB9 WIPF1 IL2RG REST NLRC4 SRP54 TSC1 CD247 XPA PRKAR1A IRF8 MVK NCF2 ERCC3 HLA-DRB1 CACNA1A CD3E ZFHX2 ATP13A2 XIAP STIM1 NABP1 GALC NLRP1 IL10 IFNGR1 IL12B STAT4 MIF HLA-DRB1 WAS STAT4 RNF168 RMRP IL23R SLCO1B1 MEFV STXBP2 DIS3L2 RAB27A ERAP1 IBA57 MPL FOXP1 STAT3 STAT6 SCYL1 CALR MPL NLRP3 SPTB TRIP13 ADAR MEFV CACNA1S IFIH1 BTNL2 COX1 TBL1XR1 PTPN22 CFHR1 TRNW PRNP ATP1A2 ND5 CRLF1 PTPN3 CD79B CHD7 BCR GATA2 HBB SLC19A3 IGLL1 IRAK1 RYR1 PRTN3 CTRC COG6 UNC93B1 CYBB ND6 TCIRG1 TBK1 IL7R TH SLC12A3 G6PD GAA HLA-B IGH CYTB FBP1 PTS IL2RG JAK2 HMGCL JAK2 STING1 DDB2 ND4 MEFV AVP NLRP3 TRNL1 SLC4A1 RYR1 ADAMTS13 SPTA1 ND3 EIF2B1 NTRK1 RNASEH2C KRT18 POLR3A ALPL TRNK SLC12A1 TRNW SCNN1G ERCC2 ND6 TCF3 ND2 TNFRSF1A PSMB4 JAK2 PIK3R1 COX2 COL1A1 H19 CFTR NCF1 RNASEH2A HLA-DRB1 TRNV PSAP NGLY1 CD27 BTK HLA-DRB1 ABL1 LACC1 NLRP3 ERCC4 COL1A1 PMM2 TRNL1 RAG1 HAVCR2 CFHR3 TET2 ASAH1 TET2 NLRP12 MYD88

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0001945: Fever
Genes 340
LIFR CYBA NKX2-1 PRSS1 KLHL7 KCNJ1 EIF2B3 LBR BIRC3 SPTB ELP1 EIF2B4 BLNK NAB2 RANBP2 LPIN1 EPB42 CD79A IL36RN STAT5B SPINK1 NOTCH3 TP53 MEFV TP53 TRNF ERCC5 IL12A-AS1 TREX1 SLC11A1 CTLA4 MLX PRKAR1A RUNX1 IGHM AVPR2 GPR35 PRSS2 RAG2 PML SLC29A3 ADA2 STAT3 EPB41 CYP11B2 EDA IGH NGF GLA CALR CCR1 MALT1 ND1 ND4 GPC3 XPC IL6 CCND1 KLRC4 ND1 CFH PSTPIP1 SAMHD1 HLA-B TCF4 TRNQ LPIN2 BCOR BRCA2 P4HTM NOD2 NLRP3 BCL10 IRF2BP2 SH2B3 NLRP3 SH3KBP1 CYBC1 BCL6 IRF8 CACNA1S LIG4 MYD88 BCL2 RYR1 ZBTB16 IL7R GCH1 LACC1 KIF1B HMGCL CASK NLRP3 SCNN1A COX3 ATP6 HAVCR2 TREX1 HLA-B POMP STX11 POU6F2 TNFRSF1A C4A CYP11B2 IKZF1 ATM LIPA UBAC2 NOD2 TMEM165 NUMA1 AQP2 RAG2 ABCC2 RARA RB1 MST1 NCF4 LIFR SPTA1 LYST PMP22 ADA RAG1 PTPN22 ORAI1 F5 DST TRNS2 SLCO1B3 KRT8 EIF2B5 TRIM28 GALC TLR3 AK2 AQP2 TRAF3 FIP1L1 WT1 TNFAIP3 SPP1 WT1 RNASEH2B EIF2B2 ELANE BCAP31 SLC29A3 HLA-DPB1 HTR1A UNC13D HLA-DPA1 CPT2 LRRC8A GYPC QDPR TSC2 DCLRE1C CFTR TRIM28 TRNS1 TLR4 NPM1 ANK1 SCNN1B ACAT1 AVPR2 ND5 NLRP3 TRNH FAS ATP1A3 CYP21A2 PEX6 GFI1 CHEK2 IL12A IGH LPIN2 TICAM1 NLRC4 CD3D ELANE PSMB9 WIPF1 IL2RG REST NLRC4 SRP54 TSC1 CD247 XPA PRKAR1A IRF8 MVK NCF2 ERCC3 HLA-DRB1 CACNA1A CD3E ZFHX2 ATP13A2 XIAP STIM1 NABP1 GALC NLRP1 IL10 IFNGR1 IL12B STAT4 MIF HLA-DRB1 WAS STAT4 RNF168 RMRP IL23R SLCO1B1 MEFV STXBP2 DIS3L2 RAB27A ERAP1 IBA57 MPL FOXP1 STAT3 STAT6 SCYL1 CALR MPL NLRP3 SPTB TRIP13 ADAR MEFV CACNA1S IFIH1 BTNL2 COX1 TBL1XR1 PTPN22 CFHR1 TRNW PRNP ATP1A2 ND5 CRLF1 PTPN3 CD79B CHD7 BCR GATA2 HBB SLC19A3 IGLL1 IRAK1 RYR1 PRTN3 CTRC COG6 UNC93B1 CYBB ND6 TCIRG1 TBK1 IL7R TH SLC12A3 G6PD GAA HLA-B IGH CYTB FBP1 PTS IL2RG JAK2 HMGCL JAK2 STING1 DDB2 ND4 MEFV AVP NLRP3 TRNL1 SLC4A1 RYR1 ADAMTS13 SPTA1 ND3 EIF2B1 NTRK1 RNASEH2C KRT18 POLR3A ALPL TRNK SLC12A1 TRNW SCNN1G ERCC2 ND6 TCF3 ND2 TNFRSF1A PSMB4 JAK2 PIK3R1 COX2 COL1A1 H19 CFTR NCF1 RNASEH2A HLA-DRB1 TRNV PSAP NGLY1 CD27 BTK HLA-DRB1 ABL1 LACC1 NLRP3 ERCC4 COL1A1 PMM2 TRNL1 RAG1 HAVCR2 CFHR3 TET2 ASAH1 TET2 NLRP12 MYD88

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook