Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1996 | Medication Review Wiki | 0.41 |
| drug3661 | Virtual Group Exercise Wiki | 0.41 |
| drug2272 | Nutrition Consult and Protein Supplementation Wiki | 0.41 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug2641 | PreserVision AREDS formulation gel tabs Wiki | 0.41 |
| drug748 | Centrum Adult (under 50) multivitamin Wiki | 0.41 |
| drug3129 | Simplified Geriatric Evaluation Wiki | 0.41 |
| drug3158 | Socialization Wiki | 0.41 |
| drug1137 | ESOGER Wiki | 0.41 |
| drug1835 | Lifestyle App Wiki | 0.41 |
| drug2850 | Relation between frailty and clinical outcomes in elderly patients with COVID-19. Wiki | 0.41 |
| drug3041 | Sampling Wiki | 0.29 |
Navigate: Correlations HPO
There are 6 clinical trials
The ANRS EP66 SEPTAVIH Study aims to screen feasibility of evaluating frailty in people living with HIV aged 70 or older, to estimate its prevalence, to analyse associated risk factors and to evaluate the impact of frailty on pejorative events. SEPTAVIH is a French, multicentre, prospective, observational study which will include 500 HIV-infected participants
Description: Proportion of patients classified as frail according to Fried at Baseline
Measure: Proportion of frail patients Time: 12 monthsCoronavirus disease 2019 (COVID-19) is an infectious disease. Physical distancing is one of the most effective ways to reduce the spread of COVID-19, but this key prevention intervention may have adverse consequences on older adults living at home. Screening older adults living at home and at risk for adverse consequences of physical and social distancing is, therefore, a priority in order to prevent their occurrence. ESOGER ("Evaluation Social et GERiatrique") is a clinical tool designed to: 1) screen the risk-levels for adverse consequences related to COVID-19 physical distancing and 2) to continue appropriate preventive interventions in older adults living at home including frail older patients and older community dwellers. Experience cumulated during the past two weeks revealed that ESOGER could be improved, in order to be more effective and efficient for the prevention of adverse consequences related to COVID-19 physical distancing. This improvement is based on two key components: 1) Comments of Montreal ESOGER users and 2) Analysis of data. Because at this time no information is saved and stored, there is a need to save and store ESOGER information and create the ESOGER databank.
Description: presence or not of fever, cough and shortness of breath (binary question)
Measure: COVID-19 symptoms Time: 1 dayDescription: presence or not of a rupture of access to food, medication and home care (binary question)
Measure: issues related to medication and food delivery and access to home care Time: 1 dayDescription: Questionnaire Emergency Room Evaluation and Recommandation (ER2), score from 0 = no risk of frailty to 14 = high risk of frailty)
Measure: physical frailty Time: 1 dayDescription: anxiety Verbal analogic scale, score from 0 = no anxiety to 10 = extremely anxious)
Measure: psychological frailty Time: 1 dayDescription: Zarit scale, score from 0 = no caregiver burden to 16 = high caregiver burden)
Measure: Caregiver burden Time: 1 dayThis is a monocentric retro-prospective observational study that wants to evaluate the relation between frailty and clinical outcomes in elderly patients with COVID-19.
Description: The aim of the project is to evaluate whether a tool built to measure frailty in elderly patients admitted to the COVID + hospital wards of San Gerardo hospital is more accurate in predicting clinical states than a clinical evaluation developed on age and comorbidity.
Measure: Development of a tool to measure frailty Time: Until patient discharge from the hospital (approximately 1 year).Description: Assess whether a "proxy" variable of the fragility index can be built on the basis of regional administrative databases only, which is able to predict the clinical outcomes of COVID + patients better than age and comorbidities alone.
Measure: A "proxy" variable of the fragility index can be built on the basis of regional administrative databases only. Time: Until patient discharge from the hospital (approximately 1 year).Description: Relate different levels of chronicity with the susceptibility of the elderly subject to infection to give elements to focus the screening policies for COVID19.
Measure: Give elements to focus the screening policies for COVID19. Time: Until patient discharge from the hospital (approximately 1 year).Description: Relate different levels of chronicity with the susceptibility of the elderly subject to infection to prevent the contagion at the elderly population level.
Measure: Give the prevention of contagion at the elderly population level. Time: Until patient discharge from the hospital (approximately 1 year).Introduction: The World Health Organization has launched the INSPIRE-ICOPE-CARE program towards healthy aging. It includes "intrinsic capacity", defined as "the composite of all the physical and mental capacities of an individual", which has a positive value towards prevention, and is constructed by five domains: cognition, vitality/nutrition, sensory, psychology, and mobility. ICOPE App and ICOPE Monitor are applications for the self-assessment and monitoring of intrinsic capacity. Hypothesis: Intrinsic capacity self-assessed by the ICOPE Apps could be associated with the incidence of frailty and health outcomes. ICOPE Apps might support geriatric and primary care during the COVID-19 pandemic and beyond. Objectives: To assess the association between intrinsic capacity measured by the ICOPE Apps at baseline and the incidence of frailty in community-dwelling older adults during 1-year follow-up. Secondarily, to assess the association of intrinsic capacity and pre-frailty, falls, functional decline, institutionalization, and mortality (COVID-19-related/not related). Methods: Protocol for a cohort study of community-dwelling adults ≥65-year-old, with no other exclusion criteria than the inability to use the Apps or communicate by telephone/video-call for any reason (cognitive or limited access to telephone/video-call). Intrinsic capacity measured by the ICOPE Apps and Rockwood's clinical frailty scale will be assessed at baseline, 4-, 8- and 12-month follow-up by telephone/video-call. Assuming a prevalence of frailty of 10.7%, and incidence of 13% (alpha-risk=0.05), 400 participants at 12-month end-point (relative precision=0.10) and 600 participants at baseline will be required. Associations among the decrease in intrinsic capacity, incidence of frailty, and occurrence of health adverse outcomes during 1-year follow-up are expected. ICOPE Apps might identify individuals at higher risk of frailty and health adverse consequences. The implementation of the ICOPE Apps into clinical practice might help to bring the practitioners closer to their patients, deliver efficient person-centered care-plans, and benefit the healthcare systems during the COVID-19 pandemic and beyond.
Description: Incidence of frailty assessed by Rockwood's clinical frailty scale (CFS) will be assessed at baseline and 12-month follow-up by telephone/video-call. An score <4 will indicate robustness, 4-6 pre-frailty status, and ≥6 frailty
Measure: Incidence of frailty Time: 1 yearThe study team want to see if changes in lifestyle and behaviors and self-monitoring of diet and physical activity in older adults who have type 2 Diabetes (T2D) may help to prevent or reduce frailty. Frailty occurs in older adults and leads people to have falls, become disabled, require nursing home placement, and have increased risk of death. T2D is one of the major risk factors for frailty. T2D is a significant problem in older adults and is known to increase the risk of future frailty.
Description: Change in frailty measured on a scale using a frailty score (0, 1, 2, 3, 4,or 5), with higher scores out of 5 representing greater frailty. Assessments used for scoring include 1) self reported weight loss, 2) self-reported exhaustion 3) low physical activity based on the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) 4) Handgrip strength 5) 10 foot walk pace
Measure: Frailty Scale Time: Baseline to 6 monthsDescription: Change in HbA1c measured over the study period
Measure: Glycated hemoglobin (HbA1c) Time: Baseline to 6 monthsDescription: For PROMIS measures, higher scores equals more of the concept being measured (e.g., more Fatigue, more Physical Function). Thus a score of 60 is one standard deviation above the average referenced population. This could be a desirable or undesirable outcome, depending upon the concept being measured.
Measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Time: Baseline to 6 monthsDescription: The study team will administer the Short Physical Performance Battery (SPPB)69 to assess three lower extremity tasks; 1) standing balance (ability to stand with the feet together in side-by-side, semi-and full-tandem positions for 10 seconds each); 2) a 4-meter walk to assess usual gait speed; 3) time to complete 5 repeated chair stand. Each of the 3 performance measures is assigned a score ranging from 0 (inability to perform the task) to 4 (the highest level of performance) and summed to create a score ranging from 0 to 12 (best). The SPPB is sensitive to change over time
Measure: Short Physical Performance Battery (SPPB) Time: Baseline to 6 monthsThe coronavirus disease 2019 (COVID-19) pandemic is keeping people apart, which can take a toll on physical and mental health. Many healthcare professionals are concerned vulnerable seniors may become deconditioned, which substantially increases risk of health complications and need for hospitalization. To address the immediate impact of COVID-19 policies (i.e., physical distancing, reduced access to care), the GERAS Frailty Rehabilitation model will be adapted to be delivered remotely in the homes of vulnerable seniors. The investigators' aim is to understand how to best build resilience among vulnerable seniors in the community through at-home rehabilitation services (socialization, exercise, nutrition, and medication support).
Description: Assessed by the 5x Sit-to-Stand (time to complete). Faster times to complete indicate better performance.
Measure: Change in Physical Function Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the Depression Anxiety Stress Scale (DASS-21). Higher scores indicate greater risk of depression, anxiety and stress [depression, anxiety, stress subscores range 0-21].
Measure: Change in Mental Health Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the SARC-F - Self-reported strength, assistance with walking, rising from a chair, climbing stairs and falls. Higher scores indicate greater level of sarcopenia [range 0-10].
Measure: Change in Sarcopenia Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the Fit-Frailty Index. Higher scores indicate greater degree of frailty [range 0-1].
Measure: Change in Frailty Time: Baseline and 12 Weeks Post-InterventionDescription: Balance confidence will be assessed using the Activities-specific Balance Confidence Scale (ABCs). Higher scores indicate greater balance confidence [range 0-100].
Measure: Change in Self-Efficacy Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the interRAI Community Rehab Assessment - Self-Report
Measure: Self-Reported Change in Function, Health and Well-Being Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the interRAI Community Rehab Assessment - Clinician-Completed
Measure: Clinician-Reported Change in Function, Health and Well-Being Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the Borg Rate of Perceived Exertion after exercise. Higher scores indicate greater level of exertion [range 6-20].
Measure: Change in Fitness Time: Weekly up to 12 weeksDescription: Assessed using a program questionnaire in accordance with the Kirkpatrick 5-Level Evaluation Model. Scores will be on a 5-point Likert scale ranging from "Strongly Disagree" to "Strongly Agree".
Measure: Program Satisfaction Time: 12 Weeks Post-InterventionDescription: Number of emergency room visits will be recorded. Higher number of emergency room visits indicates higher healthcare utilization.
Measure: Change in Emergency Room Visits Time: Baseline and 12 Weeks Post-InterventionDescription: Number of hospitalizations will be recorded. Higher number of hospitalizations indicates higher healthcare utilization.
Measure: Change in Hospitalizations Time: Baseline and 12 Weeks Post-InterventionDescription: Number of calls to 911 will be recorded. Higher number of calls indicates higher healthcare utilization.
Measure: Change in Number of Calls to 911 Time: Baseline and 12 Weeks Post-InterventionDescription: Assessed by the number of individuals who participated. Target reach is 70 participants.
Measure: Feasibility Outcome #1 - Reach of intervention Time: 12 Weeks Post-InterventionDescription: Assessed by number of referral sites. Target is 5 referral sites.
Measure: Feasibility Outcome #2 - Adoption of the Intervention Time: 12 Weeks Post-InterventionDescription: Assessed by the number of individuals who completed the intervention. Higher number of individuals completing the study indicates greater success in implementation.
Measure: Feasibility Outcome #3 - Implementation of the Intervention Time: 12 Weeks Post-InterventionDescription: Assessed by the number of referral sites continuing with a second cohort. Greater number of referral sites continuing with a second cohort indicates greater maintenance.
Measure: Feasibility Outcome #4 - Maintenance of the Intervention Time: 12 Weeks Post-InterventionAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports