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D051346: Mobility Limitation

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1846 Live Long Walk Strong rehabilitation program Wiki 0.71
drug607 CME (active control) Wiki 0.71
drug1440 HIIT (intervention) Wiki 0.71

Correlated MeSH Terms (0)


Name (Synonyms) Correlation

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002355 Difficulty walking HPO 0.71

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 The Live Long Walk Strong Rehabilitation Program: What Features Improve Mobility Skills?

This study is being performed to evaluate the efficacy of the Live Long Walk Strong rehabilitation program in Veterans 50 years and older. This study will also examine the features of the program that contribute to improved gait speed.

NCT04026503
Conditions
  1. Mobility Limitation
Interventions
  1. Other: Live Long Walk Strong rehabilitation program
MeSH:Mobility Limitation
HPO:Difficulty walking

Primary Outcomes

Description: Gait speed change will be assessed within 2 weeks post intervention and then in 8 and 16 weeks of subsequent follow-up.

Measure: Gait Speed

Time: within 2 weeks, 8 weeks, 16 weeks
2 High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV

This is a multi-site, randomized, single-blind (researchers), active treatment concurrent control trial with individuals aged 50-80 living with HIV who experience fatigue and live a sedentary lifestyle. The overall goals of this proposal are to determine whether high-intensity interval training (HIIT) can overcome physical function impairments and increased fatigue (Aim 1) and impairments in mitochondrial bioenergetics of older people with HIV (PWH) to a greater extent than continuous moderate-intensity exercise (CME) (Aim 2). We further seek to determine whether a biobehavioral coaching intervention following either HIIT or CME can promote long-term adherence to physical activity (Aim 3), a crucial component of the sustainability of the intervention. This study will enroll 200 participants in Aurora, Colorado and Cleveland, Ohio, and includes 20 visits over a one-year period. Data collection will occur at each visit, with baseline data collected at the initial visit. A 3-month follow-up will be conducted over the phone from the date of the final visit.

NCT04550676
Conditions
  1. Hiv
  2. Fatigue
  3. Mobility Limitation
Interventions
  1. Behavioral: HIIT (intervention)
  2. Behavioral: CME (active control)
MeSH:Mobility Limitation
HPO:Difficulty walking

Primary Outcomes

Description: 400-m walk time is a continuous measure of the total time required to complete a 400-m walking course. Lower values indicate a faster walking speed.

Measure: Change in physical function

Time: 0-16 weeks

Secondary Outcomes

Description: The Lee Fatigue Score measures severity of fatigue. Possible scores range from 0 to 10, with higher scores indicating a worse outcome.

Measure: Change in fatigue

Time: 0-16 weeks

HPO Nodes


HP:0002355: Difficulty walking
Genes 271
CCN6 GMPPB ERLIN1 DNM1 GLE1 CAPN3 SH3TC2 VAMP1 NEB SCN3A NKX6-2 FKRP PSAP ERLIN1 SLC13A5 STRADA SURF1 PLEKHG5 DHTKD1 DMD TIA1 ACTL6B ALG2 KLHL9 TRAPPC11 DNM2 NUBPL CNKSR2 REEP1 SACS SLC1A2 HERC1 COASY ATP6V1A WASHC5 MED25 MYOT LRP4 SCN8A B4GALNT1 CYP2R1 MSTO1 SYNJ1 PIK3CA WWOX MYF6 TPM2 TRAK1 HSPB3 KLHL41 GALC INTS1 AP4M1 SLC5A7 TGM6 GRID2 NTRK2 WARS1 SAMHD1 ALG14 NACC1 DAG1 MORC2 AKT1 RSPRY1 GAN CYP27B1 SGCD GABRA2 ATRX HK1 CIZ1 SGCB ELOVL5 HK1 TCAP COL13A1 MARCHF6 TRNW NEB CACNA1B GYG1 PEX6 TREX1 TTN DES CAPN3 DYSF TPM2 LRP12 MORC2 CRPPA DDHD1 ATP13A2 TTBK2 SPG21 PNPLA2 TRAPPC11 BIN1 FA2H ACTA1 WDR48 ORAI1 PDGFB ARSA SETX SLC18A3 CYFIP2 MICU1 FLNC ABHD5 CAPN1 PUS3 GJB1 BICD2 TRAPPC11 RNASEH2B TRAF7 GOSR2 SUFU MICU1 AP3B2 EEF1A2 KCNB1 TAF1 TIA1 FKRP STXBP1 ALG14 NF2 NUS1 GPAA1 CPT1C TBC1D23 CACNA1A HACE1 MSTO1 PDK3 DARS2 MYO9A RARS1 BAP1 GPT2 CRYAB MATR3 DNM1 AGRN GABRG2 TERT GRIN2D SMO TPP1 ACTA1 SNAP25 CDK8 VCP GABRB2 DPAGT1 CLTC CHCHD10 BAP1 BVES ATP7B KBTBD13 ATP13A2 TPM3 PGAP1 NDUFS8 SLC25A19 TK2 NECAP1 SLC30A10 PRX SZT2 KLC2 VCP MYH7 AP4S1 C19ORF12 AARS1 GJC2 SLC52A2 UBA5 MYPN VDR NOP56 ARV1 ASAH1 KY AP4B1 ERLIN2 TGM6 CDKL5 ADAR IFIH1 YWHAG SMARCB1 MFN2 IBA57 VAMP1 RAB11B SLC25A1 PARS2 ARSI RYR1 HSPB1 HPCA CYP27B1 MECP2 KCNA2 ATP6 MTMR14 PPP3CA FKRP AP4E1 GABRB2 FKTN ARL6IP1 SPART POMT1 CHAT FLRT1 POMT1 KCNC3 RNASEH2C SLC18A3 FA2H NKX2-1 SBF2 SQSTM1 FHL1 GBA2 STUB1 FGF12 RNU12 RNASEH2A DHDDS DNA2 ADCY5 USP9X KCND3 GABRA5 POMT2 SLC5A7 C12ORF65 ARL6IP1 EIF2S3 SMARCE1 C12ORF65 TTN GFPT1 CYP2R1 PYCR2 PMP2 KCNA2 HCN1 SYT2 TPM3 PNPLA2 RTN2 CPT1C KLHL41 FBXO38 POMT1 SYNGAP1 SLC30A9 SLC34A3 FGF14 ANO5 SNAP25 FDX2
Protein Mutations 0
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0002355: Difficulty walking
Genes 271
CCN6 GMPPB ERLIN1 DNM1 GLE1 CAPN3 SH3TC2 VAMP1 NEB SCN3A NKX6-2 FKRP PSAP ERLIN1 SLC13A5 STRADA SURF1 PLEKHG5 DHTKD1 DMD TIA1 ACTL6B ALG2 KLHL9 TRAPPC11 DNM2 NUBPL CNKSR2 REEP1 SACS SLC1A2 HERC1 COASY ATP6V1A WASHC5 MED25 MYOT LRP4 SCN8A B4GALNT1 CYP2R1 MSTO1 SYNJ1 PIK3CA WWOX MYF6 TPM2 TRAK1 HSPB3 KLHL41 GALC INTS1 AP4M1 SLC5A7 TGM6 GRID2 NTRK2 WARS1 SAMHD1 ALG14 NACC1 DAG1 MORC2 AKT1 RSPRY1 GAN CYP27B1 SGCD GABRA2 ATRX HK1 CIZ1 SGCB ELOVL5 HK1 TCAP COL13A1 MARCHF6 TRNW NEB CACNA1B GYG1 PEX6 TREX1 TTN DES CAPN3 DYSF TPM2 LRP12 MORC2 CRPPA DDHD1 ATP13A2 TTBK2 SPG21 PNPLA2 TRAPPC11 BIN1 FA2H ACTA1 WDR48 ORAI1 PDGFB ARSA SETX SLC18A3 CYFIP2 MICU1 FLNC ABHD5 CAPN1 PUS3 GJB1 BICD2 TRAPPC11 RNASEH2B TRAF7 GOSR2 SUFU MICU1 AP3B2 EEF1A2 KCNB1 TAF1 TIA1 FKRP STXBP1 ALG14 NF2 NUS1 GPAA1 CPT1C TBC1D23 CACNA1A HACE1 MSTO1 PDK3 DARS2 MYO9A RARS1 BAP1 GPT2 CRYAB MATR3 DNM1 AGRN GABRG2 TERT GRIN2D SMO TPP1 ACTA1 SNAP25 CDK8 VCP GABRB2 DPAGT1 CLTC CHCHD10 BAP1 BVES ATP7B KBTBD13 ATP13A2 TPM3 PGAP1 NDUFS8 SLC25A19 TK2 NECAP1 SLC30A10 PRX SZT2 KLC2 VCP MYH7 AP4S1 C19ORF12 AARS1 GJC2 SLC52A2 UBA5 MYPN VDR NOP56 ARV1 ASAH1 KY AP4B1 ERLIN2 TGM6 CDKL5 ADAR IFIH1 YWHAG SMARCB1 MFN2 IBA57 VAMP1 RAB11B SLC25A1 PARS2 ARSI RYR1 HSPB1 HPCA CYP27B1 MECP2 KCNA2 ATP6 MTMR14 PPP3CA FKRP AP4E1 GABRB2 FKTN ARL6IP1 SPART POMT1 CHAT FLRT1 POMT1 KCNC3 RNASEH2C SLC18A3 FA2H NKX2-1 SBF2 SQSTM1 FHL1 GBA2 STUB1 FGF12 RNU12 RNASEH2A DHDDS DNA2 ADCY5 USP9X KCND3 GABRA5 POMT2 SLC5A7 C12ORF65 ARL6IP1 EIF2S3 SMARCE1 C12ORF65 TTN GFPT1 CYP2R1 PYCR2 PMP2 KCNA2 HCN1 SYT2 TPM3 PNPLA2 RTN2 CPT1C KLHL41 FBXO38 POMT1 SYNGAP1 SLC30A9 SLC34A3 FGF14 ANO5 SNAP25 FDX2
Protein Mutations 0
SNP 0

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

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MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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