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D009164: Mycobacterium Infections

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug3317 Suspension of heat killed (autoclaved) Mycobacterium w Wiki 0.87
drug3252 Standard therapy of COVID-19 Wiki 0.50
drug1173 Electronic survey Wiki 0.50
Name (Synonyms) Correlation
drug3792 auscultation by using traditional stethoscope and electronic stethoscope under full PPE Wiki 0.50
drug3774 airway management during sedation or general anesthesia Wiki 0.50
drug3970 mobile internet survey on self-test Wiki 0.50
drug2505 Placebo Wiki 0.05

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D004198 Disease Susceptibility NIH 0.22
D016638 Critical Illness NIH 0.13
D003141 Communicable Diseases NIH 0.04
Name (Synonyms) Correlation
D007239 Infection NIH 0.02

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Registry Study on the Efficacy of a Self-test and Self-alert Applet in Detecting Susceptible Infection of COVID-19 --a Population Based Mobile Internet Survey

The "COVID-19 infection self-test and alert system" (hereinafter referred to as "COVID-19 self-test applet") jointly developed by Beijing Tsinghua Changgung Hospital, Institute for precision medicine, artificial intelligence of Tsinghua University was launched on February 1,2020. Residents , according to their actual healthy situation, after answering questions online, the system will conduct intelligent analysis, make disease risk assessment and give healthcare and medical guidance. Based on the Internet population survey, and referring to the diagnosis and screening standards of the National Health Commission of the People's Republic of China, investigators carried out the mobile applet of Internet survey and registry study for the Internet accessible identifiable population, so as to screen the suspected population and guide the medical treatment.

NCT04256395
Conditions
  1. Susceptibility to Viral and Mycobacterial Infection
Interventions
  1. Other: mobile internet survey on self-test
MeSH:Infection Communicable Diseases Mycobacterium Infections Disease Susceptibility

Primary Outcomes

Description: after the end of this study, investigators calculate and sum up the total evaluated population and positively diagnosed population, then check the ROC of this system, finally to calculate the sensitivity and accuracy of this self-test and self-alert system

Measure: positive number diagnosed by national guideline in the evaluated population

Time: 5 months

Secondary Outcomes

Description: after the end of this study, investigators calculate the proportion and distribution of evaluated people with normal and abnormal scores

Measure: distribution map of evaluated people

Time: 5 month

Description: after the end of this study, investigators sent the feedback inform to every evaluated people and collect and analysis the response to find out whether this applet can help them in the following surveillance or medical treatment. And how it works.

Measure: Effect of medical guidance by designated feedback questionnaire

Time: 5 month

Description: after the end of this study, investigators sent the designated mental scale including anxiety, and collect the response and draw the conclusion.

Measure: mental scale of relief the mental anxiety and avoid unnecessary outpatient

Time: 5 month
2 A Clinical Trial to Evaluate the Safety and Efficacy of Mycobacterium W in Critically Ill Patients Suffering From COVID 19 Infection

The trial is randomized, blinded, two arms, active comparator controlled, clinical trial to evaluate the safety and efficacy of Mycobacterium w in combination with standard care as per hospital practice versus standard care alone in critically ill adult patients suffering from COVID-19 infection.

NCT04347174
Conditions
  1. COVID-19
Interventions
  1. Drug: Suspension of heat killed (autoclaved) Mycobacterium w
  2. Drug: Standard therapy of COVID-19
MeSH:Mycobacterium Infections Critical Illness

Primary Outcomes

Description: To study the effect of Mw on recovery of organ function as assessed by Sequential Organ Failure Assessment (SOFA) which is based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction

Measure: Sequential Organ Failure Assessment (SOFA) scores

Time: Change in Sequential Organ Failure Assessment (SOFA) score from baseline to day 3

Description: To study the effect of Mw on recovery of organ function as assessed by Sequential Organ Failure Assessment (SOFA) scores which is based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction

Measure: Sequential Organ Failure Assessment (SOFA) scores

Time: Change in Sequential Organ Failure Assessment (SOFA) score from baseline to day 7

Description: To study the effect of Mw on recovery of organ function as assessed by Sequential Organ Failure Assessment (SOFA) scores which is based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction

Measure: Sequential Organ Failure Assessment (SOFA) scores

Time: Change in Sequential Organ Failure Assessment (SOFA) score from baseline to day 14

Description: To study the effect of Mw on recovery of organ function as assessed by Sequential Organ Failure Assessment (SOFA) scores which is based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction

Measure: Sequential Organ Failure Assessment (SOFA) scores

Time: Change in Sequential Organ Failure Assessment (SOFA) score from baseline to day 21

Description: To study the effect of Mw on recovery of organ function as assessed by Sequential Organ Failure Assessment (SOFA) scores which is based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction

Measure: Sequential Organ Failure Assessment (SOFA) scores

Time: Change in Sequential Organ Failure Assessment (SOFA) score from baseline to day 28

Description: To study the effect of Mw on recovery of organ function as assessed by Sequential Organ Failure Assessment (SOFA) scores which is based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction

Measure: Sequential Organ Failure Assessment (SOFA) scores

Time: Change in Sequential Organ Failure Assessment (SOFA) score from baseline to day of transfer from ICU, if earlier than 28 days.

Description: To study the effect of Mw on recovery of organ function as assessed by Ordinal scale

Measure: 7-category ordinal scale that ranges from 1 (not hospitalized with resumption of normal activities) to 7 (death)

Time: Change in Ordinal scale from baseline to day 3

Description: To study the effect of Mw on recovery of organ function as assessed by Ordinal scale

Measure: 7-category ordinal scale that ranges from 1 (not hospitalized with resumption of normal activities) to 7 (death)

Time: Change in Ordinal scale from baseline to day 7

Description: To study the effect of Mw on recovery of organ function as assessed by Ordinal scale

Measure: 7-category ordinal scale that ranges from 1 (not hospitalized with resumption of normal activities) to 7 (death)

Time: Change in Ordinal scale from baseline to day 14

Description: To study the effect of Mw on recovery of organ function as assessed by Ordinal scale

Measure: 7-category ordinal scale that ranges from 1 (not hospitalized with resumption of normal activities) to 7 (death)

Time: Change in Ordinal scale from baseline to day 21

Description: To study the effect of Mw on recovery of organ function as assessed by Ordinal scale

Measure: 7-category ordinal scale that ranges from 1 (not hospitalized with resumption of normal activities) to 7 (death)

Time: Change in Ordinal scale from baseline to day 28

Description: To study the effect of Mw on recovery of organ function as assessed by Ordinal scale

Measure: 7-category ordinal scale that ranges from 1 (not hospitalized with resumption of normal activities) to 7 (death)

Time: Change in Ordinal scale from baseline to day of transfer from ICU, if earlier than 28 days.

Secondary Outcomes

Description: All-cause mortality

Measure: All-cause mortality

Time: Till day 28

Description: Any AE / SAE or event of clinical significance observed during the study.

Measure: Incidence of AE / SAE or event of clinical significance

Time: Till day 28

Description: Percent of subjects with SARS-CoV-2 detectable in nasal or oropharyngeal (OP) sample.

Measure: SARS-CoV-2 detectable in nasal or oropharyngeal (OP) sample

Time: At days 3, 7, 14, 21, and 28

Description: ICU length of stay

Measure: ICU length of stay

Time: Till day 28

Description: Duration of mechanical ventilation

Measure: Duration of mechanical ventilation

Time: Till day 28

Description: Duration of hospitalization

Measure: Duration of hospitalization

Time: Till day 28

Description: Percentage of subjects having clinical improvement defined as two-point improvement on a seven category ordinal scale.

Measure: Clinical improvement

Time: From base line at day 14 & Day 28

Description: Time (in days) from treatment initiation to death.

Measure: Time (in days) from treatment initiation to death

Time: Till day 28
3 A Randomized, Double-blind, Two Arm, Placebo Controlled Clinical Trial to Evaluate the Efficacy and Safety of Mycobacterium w in Preventing COVID-19 in Subjects at Risk of Getting Infected With COVID-19.

This clinical trial is a randomized, blinded, two arms, placebo controlled, clinical trial to evaluate the safety and efficacy of Mycobacterium w in combination with standard care as per hospital practice to prevent COVID 19 in subjects at risk of getting infected with COVID 19.

NCT04353518
Conditions
  1. COVID-19
Interventions
  1. Drug: Suspension of heat killed (autoclaved) Mycobacterium w
  2. Other: Placebo
MeSH:Mycobacterium Infections

Primary Outcomes

Description: To compare proportion of subjects acquiring COVID-19 infection between two arms over the time till 8 weeks from administration of 1st dose

Measure: Number of subject acquiring COVID-19 infection

Time: From first dosing to week 1, week 2, week 4, week 8 or at any time during the study till 8 week post first dosing..

Secondary Outcomes

Description: Any AE / SAE observed during the study.

Measure: Incidence of Adverse Event and Serious Adverse Event (safety and tolerability)

Time: Till 8 weeks

Description: Whether administration of Mw prevents development of Upper Respiratory Tract Infection (URTI) symptoms in close contacts of COVID-19 patients.

Measure: Number of subject developing Upper Respiratory Tract Infection (URTI) symptoms

Time: From first dosing to week 1, week 2, week 4, week 8 or at any time during the study till 8 week post first dosing.

Description: Whether administration of Mw prevents development of severe COVID-19 infection.

Measure: Number of subject developing severe COVID-19 infection based on ordinal scale

Time: From first dosing to week 1, week 2, week 4, week 8 or at any time during the study till 8 week post first dosing
4 A Randomized, Double-blind, Two Arm, Controlled Clinical Trial to Compare the Efficacy and Safety of Mycobacterium w (Mw) Administered Along With Standard of Care Versus Placebo Administered Along With Standard of Care, in Adult, COVID 19 Positive Patients Hospitalized But Not Critically Ill.

This is a randomized, double blind, two arms, placebo controlled, clinical trial to study to evaluate the the safety and efficacy of Mycobacterium w in combination with standard of care versus placebo with standard of care for preventing the progression of COVID-19 disease and for reduction in transfer to ICU in COVID-19 infected patients admitted to the hospital.

NCT04358809
Conditions
  1. COVID-19
Interventions
  1. Drug: Suspension of heat killed (autoclaved) Mycobacterium w
  2. Other: Placebo
MeSH:Mycobacterium Infections Critical Illness

Primary Outcomes

Description: To compare the difference in proportion of patients with increased disease severity

Measure: Number of patients with increased disease severity

Time: From baseline to Day 3, Day 7, Day 14, Day 21, Day 28 or at any time during the study till 28 days post first dosing.

Secondary Outcomes

Description: To evaluate safety of Mw in COVID-19 patients admitted to hospital

Measure: Incidence of adverse events and serious adverse events (Safety)

Time: Till day 28

Description: To compare the proportion of patients discharged from hospital

Measure: Number of COVID-19 patients discharged from hospital

Time: From baseline to Day 3, Day 7, Day 14, Day 21, Day 28 or at any time during the study till 28 days post first dosing.

Description: To compare the proportion of patients transfer to ICU

Measure: Number of COVID-19 patients transfer to ICU

Time: From baseline to Day 3, Day 7, Day 14, Day 21, Day 28 or at any time during the study till 28 days post first dosing.

Description: To compare the proportion of patients with reduction in disease severity by 1 ordinal scale

Measure: Number of COVID-19 patients with reduction in disease severity by 1 ordinal scale

Time: From baseline to Day 3, Day 7, Day 14, Day 21, Day 28 or at any time during the study till 28 days post first dosing.

Description: To compare the proportion of symptom free patients

Measure: Number of of symptom free patients

Time: From baseline to Day 3, Day 7, Day 14, Day 21, Day 28 or at any time during the study till 28 days post first dosing.

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook