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D012893: Sleep Wake Disorders

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (4)


Name (Synonyms) Correlation
drug2329 Online bibliotherapy programme Wiki 0.58
drug2330 Online cognitive behavioral therapy (CBT) Wiki 0.58
drug2215 No intervention Wiki 0.13
Name (Synonyms) Correlation
drug2741 Questionnaire Wiki 0.11

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D020447 Parasomnias NIH 0.24

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Efficacy of an Online Cognitive Behavioral Therapy (CBT) Programme Aiming at Reducing the Stress of Health Workers Involved in the Care of Patients During the Covid-19 Epidemic: a Randomized-controlled Trial

Some preliminary epidemiological research conduct in China in health workers involved in the care of Covid-19 patients has shown high rates of depression (>50%), generalized anxiety disorder (>44%), insomnia (>36%) and stress symptoms (>73%), which negatively impact their well-being as well as their ability to work effectively . These rates were observed during the epidemic peak, but they can also have a long-term mental health effect, both individually, but also in a systemic manner , similar to what has been reported relative to the SARS-CoV-1 . Cognitive behavioral therapy (CBT) is recognized as an effective treatment for stress-reduction, as well as for the prevention of multiple mental health problems in at-risk individuals . Moreover, CBT has been found to be effective in brief online formats , which could make it feasible during the current Covid-19 epidemic. To our knowledge, there are no online CBT programmes targeting stress problems in health workers involved in the care of patients during the current epidemic context. The aim of our study is to evaluate the efficacy of the online CBT programme we have developped to specifically address immediate perceived stress in health workers, as well as the prevention of mental health problems at 3- and 6-months follow-up

NCT04362358
Conditions
  1. Stress - Prevention of Sleep Disorders, PTSD and Depression
Interventions
  1. Behavioral: Online cognitive behavioral therapy (CBT)
  2. Behavioral: Online bibliotherapy programme
MeSH:Sleep Wake Disorders

Primary Outcomes

Measure: Significant score reduction at the Perceived Stress Scale

Time: T0 inclusion

Measure: Significant score reduction at the Perceived Stress Scale

Time: T1 (3-month follow-up)

Measure: Significant score reduction at the Perceived Stress Scale

Time: T1 (up to 8 weeks treatment)

Measure: Significant score reduction at the Perceived Stress Scale

Time: T2 (6-month follow-up)
2 COVID-19: Prospective Follow-up of Pulmonary Function, Sleep Disorders, Quality of Life and Post-traumatic Stress

The current project is a prospective, multicentric cohort study aiming at a multidisciplinary assessment (pulmonary, cardiometabolic, sleep and mental health) of the consequences of infection by SARS-CoV-2, 3 months after the diagnosis in order to better characterize these complications. 400 patients with a positive diagnosis of SARS-CoV-2 will be included in the study 3 months after their diagnosis: They will be followed at 6 months, 1 year, 3 years, and 5 years, as function of their after-effects discovered at 3 months and their evolution.

NCT04406324
Conditions
  1. COVID-19
Interventions
  1. Other: No intervention
MeSH:Sleep Wake Disorders

Primary Outcomes

Description: Pulmonary function 3 months after COVID diagnosis, as measured by diffusion capacity of carbon monoxide (DLCO)

Measure: Diffusion Capacity for Carbon Monoxide (CO) 3 months after COVID diagnosis

Time: 3 months after COVID diagnosis

Secondary Outcomes

Description: Prevalence of Sleep Disordered Breathing, as measured by polysomnography

Measure: Prevalence of Sleep Disordered Breathing (SDB) 3 months after COVID diagnosis

Time: 3 months after COVID diagnosis

Description: Prevalence of sleep disorders, as measured by polysomnography

Measure: Prevalence of sleep disorders 3 months after COVID diagnosis

Time: 3 months after COVID diagnosis

Description: Prevalence of ventilatory impairments measured by pulmonary function tests

Measure: Prevalence of ventilatory muscle function impairments, 3 months after COVID diagnosis

Time: 3 months after COVID diagnosis

Description: Prevalence of cardiac impairments measured by cardiac echography

Measure: Prevalence of cardiac impairments 3 months after COVID diagnosis

Time: 3 months after COVID diagnosis

Description: Pulmonary function as measured by diffusion capacity of carbon monoxide (DLCO)

Measure: Follow-up of pulmonary diffusion capacity of carbon monoxide

Time: From Baseline (3 months after COVID diagnosis) to 5 years

Description: Assessment of SDB treatments adherence will be monitored in hours/night

Measure: Follow-up of sleep disorders treatment compliance

Time: From Baseline (3 months after COVID diagnosis) to 5 years

Description: Assessment of SDB treatments efficacy will be based on the residual AHI index (Apnea Hypopnea/hour) under treatment

Measure: Follow-up of sleep disorders treatments efficacy

Time: From Baseline (3 months after COVID diagnosis) to 5 years

Description: HLA alleles will be assessed as a component of genetic immune capacity

Measure: HLA alleles aspect of COVID clinical presentation

Time: 3 months after COVID diagnosis

Description: KIR loci will be assessed as a different component of genetic immune capacity

Measure: KIR loci aspect of COVID clinical presentation

Time: 3 months after COVID diagnosis

Description: metabolome expression in sera

Measure: metabolomic aspect of COVID clinical presentation

Time: 3 months after COVID diagnosis
3 Psychological Impact, Mental Health and Sleep Disorder Among Patients Hospitalized and Health Care Workers During the 2019 Coronavirus Outbreak (COVID-19)

COVID-19 is an infectious disease caused by the last coronavirus discovered, called SARS-CoV-2. Symptoms encountered in COVID-19 are: cough, breathing difficulties (dyspnea, chest pain, etc.), pyrexia, anosmia (loss of smell) and/or dysgeusia (loss of taste), but also ENT symptoms (rhinitis type, odynophagia), headaches, asthenia, muscle pain, confusion and diarrhea. Infection with SARS-CoV-2 can also be asymptomatic. COVID-19 can be passed from person to person by respiratory droplets expelled when a person speaks, coughs or sneezes. The currently estimated incubation period ranges from 1 to 14 days, and most often this is around 5 days. According to a literature review, there is strong evidence that COVID-19 has an impact on mental health (anxiety being the most common symptom) whether in the general population, healthcare workers or vulnerable populations. The objective of this project is to assess mental health and sleep disorders within two populations: elderly patients and nursing staff.

NCT04497246
Conditions
  1. Covid19
Interventions
  1. Other: Questionnaire
MeSH:Sleep Wake Disorders Parasomnias

Primary Outcomes

Description: The IES-R is a 22-item self-report measure that assesses subjective distress caused by traumatic events.Items are rated on a 5-point scale ranging from 0 ("not at all") to 4 ("extremely"). The IES-R yields a total score (ranging from 0 to 88) and subscale scores can also be calculated for the Intrusion, Avoidance, and Hyperarousal subscales.

Measure: Impact Event Scale-Revised (IES-R)

Time: 15 minutes

Description: Self-administered patient questionnaire used as a screening tool and severity measure for generalised anxiety disorder (GAD).The GAD-7 score is calculated by assigning scores of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more than half the days', and 'nearly every day', respectively, and adding together the scores for the seven questions. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe anxiety, respectively. When used as a screening tool, further evaluation is recommended when the score is 10 or greater.

Measure: Generalised Anxiety Disorder-7 (GAD-7)

Time: 15 minutes

Description: The PHQ-9 is the depression module, which scores each of the nine DSM-IV criteria as "0" (not at all) to "3" (nearly every day). It has been validated for use in primary care. It is not a screening tool for depression but it is used to monitor the severity of depression and response to treatment.

Measure: Patient Health Questionnaire-9 (PHQ-9)

Time: 15 minutes

Description: The ISI is a 7-item self-report questionnaire assessing the nature, severity, and impact of insomnia.The dimensions evaluated are: severity of sleep onset, sleep maintenance, and early morning awakening problems, sleep dissatisfaction, interference of sleep difficulties with daytime functioning, noticeability of sleep problems by others, and distress caused by the sleep difficulties. A 5-point Likert scale is used to rate each item (e.g., 0 = no problem; 4 = very severe problem), yielding a total score ranging from 0 to 28. The total score is interpreted as follows: absence of insomnia (0-7); sub-threshold insomnia (8-14); moderate insomnia (15-21); and severe insomnia (22-28).

Measure: Insomnia severity index (ISI)

Time: 15 minutes

Secondary Outcomes

Description: Age, gender, familial status, home status (living alone/family support/healthcare support/ retirement home).

Measure: Demographic data

Time: 1 year

Description: Hospitalization duration

Measure: Hospitalization duration

Time: 1 year

Description: Hospitalization within the intensive care unit (yes/no) with or without intubation

Measure: ICU stay

Time: 1 year

Description: History of chronic diseases

Measure: Medical history

Time: 1 year

Description: Alcohol consumption : none - stable - increased - diminished

Measure: Alcohol consumption

Time: 1 year

Description: Tobacco consumption : none - stable - increased - diminished

Measure: Tobacco consumption

Time: 1 year

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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