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D007008: Hypokalemia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug3438 The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: Wiki 1.00
drug374 Açaí palm berry extract - natural product Wiki 1.00
drug2505 Placebo Wiki 0.05

Correlated MeSH Terms (19)


Name (Synonyms) Correlation
D001997 Bronchopulmonary Dysplasia NIH 1.00
D008595 Menorrhagia NIH 1.00
D006929 Hyperaldosteronism NIH 1.00
Name (Synonyms) Correlation
D054559 Hyperphosphatemia NIH 1.00
D004314 Down Syndrome NIH 1.00
D000309 Adrenal Insufficiency NIH 1.00
D014552 Urinary Tract Infections NIH 0.71
D009080 Mucocutaneous Lymph Node Syndrome NIH 0.58
D001289 Attention Deficit Disorder with Hyperactivity NIH 0.50
D006470 Hemorrhage NIH 0.50
D020141 Hemostatic Disorders NIH 0.27
D001778 Blood Coagulation Disorders NIH 0.27
D006973 Hypertension NIH 0.21
D004194 Disease NIH 0.16
D013577 Syndrome NIH 0.10
D003141 Communicable Diseases NIH 0.08
D007239 Infection NIH 0.05
D045169 Severe Acute Respiratory Syndrome NIH 0.04
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (8)


Name (Synonyms) Correlation
HP:0002905 Hyperphosphatemia HPO 1.00
HP:0002900 Hypokalemia HPO 1.00
HP:0000846 Adrenal insufficiency HPO 1.00
Name (Synonyms) Correlation
HP:0000132 Menorrhagia HPO 1.00
HP:0000859 Hyperaldosteronism HPO 1.00
HP:0007018 Attention deficit hyperactivity disorder HPO 0.50
HP:0001928 Abnormality of coagulation HPO 0.27
HP:0000822 Hypertension HPO 0.25

Clinical Trials

Navigate: Correlations   HPO

There is one clinical trial.


1 Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.

NCT04278404
Conditions
  1. Coronavirus Infection (COVID-19)
  2. Pulmonary Arterial Hypertension
  3. Urinary Tract Infections in Children
  4. Hypertension
  5. Pain
  6. Hyperphosphatemia
  7. Primary Hyperaldosteronism
  8. Edema
  9. Hypokalemia
  10. Heart Failure
  11. Hemophilia
  12. Menorrhagia
  13. In
  14. Insomnia
  15. Pneumonia
  16. Skin Infection
  17. Arrythmia
  18. Asthma in Children
  19. Bronchopulmonary Dysplasia
  20. Adrenal Insufficiency
  21. Fibrinolysis; Hemorrhage
  22. Attention Deficit Hyperactivity Disorder
  23. Multisystem Inflammatory Syndrome in Children (MIS-C)
  24. Kawasaki Disease
  25. Coagulation Disorder
  26. Down Syndrome
Interventions
  1. Drug: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
MeSH:Infection Communicable Diseases Urinary Tract Infections Coronavirus Infections Severe Acute Respiratory Syndrome Bronchopulmonary Dysplasia Down Syndrome Menorrhagia Hypertension Hemostatic Disorders Mucocutaneous Lymph Node Syndrome Blood Coagulation Disorders Hyperphosphatemia Hypokalemia Adrenal Insufficiency Hyperaldosteronism Disease Syndrome Hemorrhage Attention Deficit Disorder with Hyperactivity
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Adrenal insufficiency Attention deficit hyperactivity disorder Hyperaldosteronism Hyperphosphatemia Hypertension Hypokalemia Menorrhagia Primary hyperaldosteronism

Primary Outcomes

Measure: Clearance (CL) or apparent oral clearance (CL/F) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Volume of distribution (V) or apparent oral volume of distribution (V/F) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Elimination rate constant (ke) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Half-life (t1/2) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Absorption rate constant (ka) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: AUC (area under the curve) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Maximum concentration (Cmax) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Time to achieve maximum concentration (Tmax) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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