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D006976: Hypertension, Pulmonary

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug2390 PH-combination therapy Wiki 0.50
drug2135 NO gas Wiki 0.50
drug2391 PH-monotherapy Wiki 0.50
Name (Synonyms) Correlation
drug3869 echocardiogram 2D Wiki 0.50
drug380 BAY1237592 Wiki 0.50
drug1150 Echocardiography Wiki 0.29

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D018497 Ventricular Dysfunction, Right NIH 0.50
D006973 Hypertension NIH 0.32
D018754 Ventricular Dysfunction NIH 0.29
Name (Synonyms) Correlation
D018487 Ventricular Dysfunction, Left NIH 0.29

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0002092 Pulmonary arterial hypertension HPO 0.87
HP:0000822 Hypertension HPO 0.38

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 A Non-randomized Two Part Multi-Center, Open-label, Single Dose Trial With an Escalation Part in Untreated Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Patients (Part A), Followed by a Parallel Group Part in Untreated and Pre-treated Patients With PAH and CTEPH (Part B) to Investigate the Safety, Tolerability and Pharmacodynamics of Inhaled BAY1237592

In this trial the effects of the inhaled drug BAY1237592 will be studied in patients with high blood pressure affecting the blood vessels in the lungs due to Pulmonary Arterial Hypertension (PAH) and due to Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Pulmonary hypertension is characterized by the elevation of pressure in the pulmonary arteries (PAP) and of the pulmonary vascular resistance (PVR) leading to increased workload of the right chamber of the heart to eject blood against this elevated resistance. The goal of this study is to measure the safety and tolerability of the drug as well as the reduction of the PVR at different doses In Part A patients without specific treatment for PH (untreated patients) will be tested. In Part B patients stably pretreated with specific PH drugs will be studied in combination with the new inhaled drug

NCT03754660
Conditions
  1. Hypertension, Pulmonary
Interventions
  1. Drug: BAY1237592
  2. Drug: PH-monotherapy
  3. Drug: PH-combination therapy
  4. Procedure: NO gas
MeSH:Hypertension, Pulmonary Hypertension
HPO:Hypertension Pulmonary arterial hypertension

Primary Outcomes

Description: PVR = 80* (PAP - PCWP) / CO (dyn·sec·cm-5) PAP = pulmonary arterial pressure PCWP = pulmonary capillary wedge pressure CO = cardiac output

Measure: Peak percent reduction in PVR (Pulmonary vascular resistance) from "baseline 2" for untreated patients

Time: Up to 5 hours post inhalation of BAY1237592 compared to "baseline 2"

Description: PVR = 80* (PAP - PCWP) / CO (dyn·sec·cm-5)

Measure: Peak percent reduction in PVR from "baseline" for pre-treated patients

Time: Up to 5 hours post inhalation of BAY1237592 compared to "baseline"

Secondary Outcomes

Measure: Incidence of treatment-emergent adverse events (TEAEs)

Time: Up to 30 days after treatment
2 The Prevalence of Pulmonary Hypertension, With or Without Right Ventricular Loading, in Patients With COVID-19 Who Are Being Treated With a Respirator in the Intensive Care Unit.

The virus infection Covid-19 fills our hospitals and intensive care departments in a very unique way and there is a lack of essential insight into the pathophysiology of the disease. As a result, very specific treatment options are missing. The US Medicines Agency (FDA) has in the last days given a general license for treatment with inhaled nitric oxide (iNO). Inhaled NO in Sweden (and Europe) is approved for the indication of pulmonary hypertension in adults. However, no one has yet described the occurrence of pulmonary hypertension, with or without right ventricular loading, in the Covid-19 patients who become so seriously ill that they need to be treated at an IVA ward. Knowledge of this is, of course, a prerequisite for determining the need for pulmonary artery catheterization (PA catheter, Swan-Ganz catheter) and also to better understand whether iNO treatment or other forms of lung selective vasodilation therapy may be of benefit to this patient group.

NCT04459364
Conditions
  1. Hypertension, Pulmonary
  2. Right Ventricular Overload
  3. COVID
MeSH:Hypertension, Pulmonary Hypertension
HPO:Hypertension Pulmonary arterial hypertension

Primary Outcomes

Description: To determine the prevalence of pulmonary hypertension and right ventricular load in patients with COVID-19 treated in intensive care unit evaluated by routine echocardiography.

Measure: Prevalence

Time: Day 1
3 Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system. This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.

NCT04498299
Conditions
  1. Echocardiography, Stress
  2. COVID-19
  3. Hypertension, Pulmonary
Interventions
  1. Diagnostic Test: echocardiogram 2D
MeSH:Hypertension, Pulmonary Hypertension
HPO:Hypertension Pulmonary arterial hypertension

Primary Outcomes

Description: Left atrium volume index

Measure: • LA volume index

Time: 3 minutes

Description: Left ventricle telediastolic diameter

Measure: • LV telediastolic diameter

Time: 3 minutes

Description: Left ventricle telesystolic diameter

Measure: • LV telesystolic diameter

Time: 3 minutes

Description: Left ventricle posterior wall

Measure: • LV posterior wall

Time: 3 minutes

Description: Right atrium area

Measure: • RA area

Time: 3 minutes

Description: Right ventricle basal dimensión

Measure: • RV basal dimensión

Time: 3 minutes

Description: Right ventricle cavity dimensión

Measure: • RV mid cavity dimension;

Time: 3 minutes

Description: Right ventricle longitudinal dimension

Measure: • RV longitudinal dimension

Time: 3 minutes

Description: Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level

Measure: • Distal, RV outflow tract dimension at the distal or pulmonic valve level

Time: 3 minutes

Description: Proximal right ventricle outflow tract dimension at the proximal subvalvular level

Measure: • Proximal RV outflow tract dimension at the proximal subvalvular level

Time: 3 minutes

Description: • Tricuspid annular plane systolic excursion

Measure: • TAPSE

Time: 3 minutes

Description: Right ventricle free Wall strain

Measure: • RV free Wall strain

Time: 3 minutes

Description: Inferior cava vein PW Doppler

Measure: • Inferior cava vein PW Doppler

Time: 3 minutes

Description: E wave mitral

Measure: • E wave mitral

Time: 3 minutes

Description: A wave mitral

Measure: • A wave mitral

Time: 3 minutes

Description: E wave /A wave mitral

Measure: • E wave /A wave mitral

Time: 3 minutes

Description: E-wave at mitral annulus

Measure: • E-wave at mitral annulus

Time: 3 minutes

Description: E-wave at mitral annulus / A-wave at the mitral annulus

Measure: • E-wave at mitral annulus / A-wave at the mitral annulus

Time: 3 minutes

Description: E wave/ E-wave at the mitral annulus

Measure: • E wave/ E-wave at the mitral annulus

Time: 3 minutes

Description: E tricuspid (E)

Measure: • E tricuspid (E)

Time: 3 minutes

Description: A triuspid (A)

Measure: • A tricuspid (A)

Time: 3 minutes

Description: E/A

Measure: • E/A

Time: 3 minutes

Description: Systolic pulmonary artery pressure

Measure: • Systolic pulmonary artery pressure

Time: 3 minutes

Description: E-wave at the tricuspid annulus

Measure: • E-wave at the tricuspid annulus

Time: 3 minutes

Description: Mean pulmonary artery pressure

Measure: • Mean pulmonary artery pressure

Time: 3 minutes

Description: Stroke volume

Measure: • Stroke volume

Time: 3 minutes

Description: Cardiac output

Measure: • Cardiac output

Time: 3 minutes
4 Cardiac Dysfunction in Critically Ill Patients Infected With COVID-19

Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.

NCT04524234
Conditions
  1. Covid19
  2. Left Ventricular Dysfunction
  3. Right Ventricular Dysfunction
  4. Pulmonary Hypertension
Interventions
  1. Diagnostic Test: Echocardiography
MeSH:Hypertension, Pulmonary Ventricular Dysfunction Ventricular Dysfunction, Left Ventricular Dysfunction, Right
HPO:Pulmonary arterial hypertension

Primary Outcomes

Description: All cause death

Measure: Mortality

Time: 30 days

Secondary Outcomes

Description: Prevalence of left ventricular dysfunction

Measure: Left ventricular dysfunction

Time: Within 72 hours from admission

Description: Prevalence of right ventricular dysfunction

Measure: Right ventricular dysfunction

Time: Within 72 hours from admission

HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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