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D006470: Hemorrhage

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug3438 The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: Wiki 0.50
drug3298 Supraflex Cruz 60 Micron Wiki 0.50
drug3570 Ultimaster Tansei 80 Micron Wiki 0.50
Name (Synonyms) Correlation
drug374 Açaí palm berry extract - natural product Wiki 0.50
drug783 Chloroquine or hydroxychloroquine Wiki 0.35
drug2505 Placebo Wiki 0.02

Correlated MeSH Terms (27)


Name (Synonyms) Correlation
D001997 Bronchopulmonary Dysplasia NIH 0.50
D008595 Menorrhagia NIH 0.50
D006929 Hyperaldosteronism NIH 0.50
Name (Synonyms) Correlation
D013226 Status Epilepticus NIH 0.50
D002543 Cerebral Hemorrhage NIH 0.50
D054559 Hyperphosphatemia NIH 0.50
D004314 Down Syndrome NIH 0.50
D013345 Subarachnoid Hemorrhage NIH 0.50
D000309 Adrenal Insufficiency NIH 0.50
D007008 Hypokalemia NIH 0.50
D014552 Urinary Tract Infections NIH 0.35
D009080 Mucocutaneous Lymph Node Syndrome NIH 0.29
D001289 Attention Deficit Disorder with Hyperactivity NIH 0.25
D000070642 Brain Injuries, Traumatic NIH 0.18
D001930 Brain Injuries, NIH 0.15
D006331 Heart Diseases NIH 0.15
D020141 Hemostatic Disorders NIH 0.13
D001778 Blood Coagulation Disorders NIH 0.13
D020521 Stroke NIH 0.13
D006973 Hypertension NIH 0.11
D014947 Wounds and Injuries NIH 0.09
D004194 Disease NIH 0.08
D013577 Syndrome NIH 0.05
D003141 Communicable Diseases NIH 0.04
D007239 Infection NIH 0.02
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (12)


Name (Synonyms) Correlation
HP:0002905 Hyperphosphatemia HPO 0.50
HP:0002900 Hypokalemia HPO 0.50
HP:0002133 Status epilepticus HPO 0.50
Name (Synonyms) Correlation
HP:0000846 Adrenal insufficiency HPO 0.50
HP:0002138 Subarachnoid hemorrhage HPO 0.50
HP:0000132 Menorrhagia HPO 0.50
HP:0001342 Cerebral hemorrhage HPO 0.50
HP:0000859 Hyperaldosteronism HPO 0.50
HP:0007018 Attention deficit hyperactivity disorder HPO 0.25
HP:0001297 Stroke HPO 0.14
HP:0001928 Abnormality of coagulation HPO 0.13
HP:0000822 Hypertension HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.

NCT04278404
Conditions
  1. Coronavirus Infection (COVID-19)
  2. Pulmonary Arterial Hypertension
  3. Urinary Tract Infections in Children
  4. Hypertension
  5. Pain
  6. Hyperphosphatemia
  7. Primary Hyperaldosteronism
  8. Edema
  9. Hypokalemia
  10. Heart Failure
  11. Hemophilia
  12. Menorrhagia
  13. In
  14. Insomnia
  15. Pneumonia
  16. Skin Infection
  17. Arrythmia
  18. Asthma in Children
  19. Bronchopulmonary Dysplasia
  20. Adrenal Insufficiency
  21. Fibrinolysis; Hemorrhage
  22. Attention Deficit Hyperactivity Disorder
  23. Multisystem Inflammatory Syndrome in Children (MIS-C)
  24. Kawasaki Disease
  25. Coagulation Disorder
  26. Down Syndrome
Interventions
  1. Drug: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
MeSH:Infection Communicable Diseases Urinary Tract Infections Coronavirus Infections Severe Acute Respiratory Syndrome Bronchopulmonary Dysplasia Down Syndrome Menorrhagia Hypertension Hemostatic Disorders Mucocutaneous Lymph Node Syndrome Blood Coagulation Disorders Hyperphosphatemia Hypokalemia Adrenal Insufficiency Hyperaldosteronism Disease Syndrome Hemorrhage Attention Deficit Disorder with Hyperactivity
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Adrenal insufficiency Attention deficit hyperactivity disorder Hyperaldosteronism Hyperphosphatemia Hypertension Hypokalemia Menorrhagia Primary hyperaldosteronism

Primary Outcomes

Measure: Clearance (CL) or apparent oral clearance (CL/F) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Volume of distribution (V) or apparent oral volume of distribution (V/F) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Elimination rate constant (ke) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Half-life (t1/2) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Absorption rate constant (ka) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: AUC (area under the curve) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Maximum concentration (Cmax) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Time to achieve maximum concentration (Tmax) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.
2 Prevalence of Severe Bleeding in COVID-19 Patients Treated With Higher Than Recommended Thromboprophylaxis Doses (BLEEDING Study)

The main objectives are: - To establish the prevalence of major bleeding in patients treated with higher than recommended thromboprophylaxis doses. - To identify variables associated to higher risk of bleeding.

NCT04380779
Conditions
  1. COVID-19
MeSH:Hemorrhage

Primary Outcomes

Description: Study endpoints are clinically recognized (and objectively confirmed) major and minor bleeding complications, and death.

Measure: Bleeding events and complications

Time: 30 days
3 Severe Neurologic Injury Outcomes During COVID-19 Crisis

A prospective cohort minimal risk study to determine the impact of the COVID-19 crisis on outcomes of neurologically injured ICU patients.

NCT04496076
Conditions
  1. Sars-CoV2
  2. Severe Neurologic Injury
  3. Ischemic Stroke
  4. Hemorrhagic Stroke
  5. Intracerebral Hemorrhage
  6. Subarachnoid Hemorrhage
  7. Traumatic Brain Injury
  8. Status Epilepticus
MeSH:Stroke Brain Injuries Brain Injuries, Traumatic Subarachnoid Hemorrhage Cerebral Hemorrhage Status Epilepticus Hemorrhage Wounds and Injuries
HPO:Cerebral hemorrhage Status epilepticus Stroke Subarachnoid hemorrhage

Primary Outcomes

Measure: In-hospital Mortality

Time: At hospital discharge, approximately 1 month

Measure: 30-day mortality

Time: 30 days post-hospital discharge

Secondary Outcomes

Description: Care treatment such as ventilator use, intubation, and/or tracheostomy

Measure: Limitations of patient care- Frequency of care not being provided

Time: During In-hospital course, up to 1 month

Measure: Limitations of patient care- Conversion of DNR/DNI/CMO status

Time: During In-hospital course, up to 1 month
4 Comparison of the Supraflex Cruz 60 Micron Stent Strut Versus the Ultimaster Tansei 80 Micron Stent Strut in High Bleeding Risk PCI Population

The study compares the outcome of the ultrathin stent strut Supraflex Cruz stent to the thin stent strut Ultimaster Tansei stent in a PCI population at high risk for bleeding (HBR).

NCT04500912
Conditions
  1. Cardiac Disease
  2. PCI
  3. High Bleeding Risk
Interventions
  1. Device: Supraflex Cruz 60 Micron
  2. Device: Ultimaster Tansei 80 Micron
MeSH:Heart Diseases Hemorrhage

Primary Outcomes

Description: The primary endpoint Net Adverse Clinical Endpoints (NACE) defined as a composite of cardiovascular death, myocardial infarction, target vessel revascularization, stroke and bleeding events defined as BARC 3 or 5 at 12 months follow-up after the index PCI.

Measure: Net Adverse Clinical Endpoints (NACE)

Time: 1 year

Secondary Outcomes

Description: Major adverse cardiac and cerebral events (MACCE) defined as a composite of cardiac death, myocardial infarction, target vessel revascularization and stroke

Measure: Major adverse cardiac and cerebral events (MACCE)

Time: 1 year

Description: Major or clinically relevant non-major bleeding (MCB) defined as a composite of type 2, 3 and 5 BARC bleeding events

Measure: Major or clinically relevant non-major bleeding (MCB)

Time: 1 year

Description: Target Lesion Failure (TLF) is defined as cardiac death, myocardial infarction attributed to the target vessel and clinically indicated target lesion revascularization

Measure: Target Lesion Failure (TLF)

Time: 1 year

Description: Target Vessel Failure (TVF) is defined as cardiac death, myocardial infarction attributed to the target vessel and clinically indicated target vessel revascularization

Measure: Target vessel failure (TVF)

Time: 1 year

Description: The composite endpoint of cardiovascular death, myocardial infarction and stroke

Measure: The composite of cardiovascular death, myocardial infarction and stroke

Time: 1 year

Description: The composite of cardiovascular death, myocardial infarction, stroke and major bleed according to BARC 3 and 5

Measure: The composite of cardiovascular death, myocardial infarction, stroke and major bleed BARC 3 and 5

Time: 1 year

Description: Stent thrombosis according to the ARC definitions

Measure: Stent thrombosis

Time: 1 year

Description: Myocardial infarction.

Measure: Myocardial infarction

Time: 1 year

Description: Urgent target vessel revascularization.

Measure: Urgent target vessel revascularization

Time: 1 year

Description: Non-target vessel revascularization.

Measure: Non-target vessel revascularization

Time: 1 year

Description: Clinically indicated target vessel revascularization.

Measure: Clinically indicated target vessel revascularization

Time: 1 year

Description: Bleeding events according to the BARC, TIMI and GUSTO classification

Measure: Bleeding events

Time: 1 year

Description: Transfusion rates both in patients with and/or without clinically detected over bleeding

Measure: Transfusion rates

Time: 1 year

Description: Event rates according to the PRECISE-DAPT score

Measure: Event rates according to the PRECISE-DAPT

Time: 1 year

Description: Procedural success is defined as angiographic success with no in-hospital MACE, defined as death, MI with new Q-waves on electrocardiogram (ECG) or urgent target vessel revascularization (TVR) (including both repeat PCI and coronary artery bypass graft surgery (CABG)

Measure: Procedural success

Time: At completion of the baseline PCI

Description: Device success (applying a lesion-level analysis)

Measure: Device success

Time: At discharge of baseline hospitalisation, on average 3 days

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook