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D013921: Thrombocytopenia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (2)


Name (Synonyms) Correlation
drug4089 rhTPO Wiki 1.00
drug1175 Eltrombopag Wiki 0.82

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D016553 Purpura, Thrombocytopenic, Idiopathic NIH 1.00

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 The Combination of Eltrombopag and Recombinant Human Thrombopoietin (rhTPO) Versus Eltrombopag Monotherapy as Subsequent Treatment for Immune Thrombocytopenia During the COVID-19 Pandemic

This is a prospective, multicenter, randomized, open-label study to investigate the efficacy and safety of eltrombopag plus recombinant human thrombopoietin (rhTPO) versus eltrombopag as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) during the COVID-19 pandemic.

NCT04516837
Conditions
  1. Immune Thrombocytopenia
Interventions
  1. Drug: Eltrombopag
  2. Drug: rhTPO
MeSH:Thrombocytopenia Purpura, Thrombocytopenic, Idiopathic
HPO:Autoimmune thrombocytopenia Thrombocytopenia

Primary Outcomes

Description: A complete response (CR) was defined as a sustained (≥ 3 months) platelet count ≥ 100×10^9/L.

Measure: Complete response

Time: 6 months

Description: A response (R) was defined as a sustained (≥ 3 months) platelet count ≥ 30×10^9/L without recurrence of thrombocytopenia.

Measure: Response

Time: 6 months

Description: No response (NR) was defined as platelet count < 30 × 10^9/L or a less than two fold increase in platelet count from baseline or the presence of bleeding. Platelet count must be measured on two occasions more than a day apart.

Measure: No response

Time: 6 months

Description: A relapses was defined as platelet count falls below 30×10^9/L or bleeding accrues after achieving R or CR.

Measure: Relapses

Time: 6 months

Secondary Outcomes

Description: Early response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 week.

Measure: Early response

Time: 7 days

Description: Initial treatment was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 month.

Measure: Initial response

Time: 1 month

Description: Durable response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 6 months.

Measure: Durable response

Time: 6 months

Description: The time to achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

Measure: TOR (time to response)

Time: 6 months

Description: The duration of achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

Measure: DOR (duration of response)

Time: 6 months

Description: All patients were assessed for safety every week during the first 8 weeks of treatment, and at 2-week intervals thereafter. Adverse events were scaled according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

Measure: Treatments associated adverse events

Time: 6 months

Description: Changes of bleeding after treatment. Bleeding was defined in accordance with the WHO bleeding scale (0, no bleeding; 1, petechiae; 2, mild blood loss; 3, gross blood loss; and 4, debilitating blood loss).

Measure: Reduction in bleeding symptoms

Time: 6 months
2 Combination of Fixed Low-dose Eltrombopag and rhTPO for Treatment of Immune Thrombocytopenia

This is a prospective, single-arm study to investigate the efficacy and safety of the combination of fixed low-dose eltrombopag plus recombinant human thrombopoietin (rhTPO) as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) patients during the COVID-19 pandemic.

NCT04518878
Conditions
  1. Immune Thrombocytopenia
Interventions
  1. Drug: Eltrombopag
  2. Drug: rhTPO
MeSH:Thrombocytopenia Purpura, Thrombocytopenic, Idiopathic
HPO:Autoimmune thrombocytopenia Thrombocytopenia

Primary Outcomes

Description: A complete response (CR) was defined as a sustained (≥ 3 months) platelet count ≥ 100×10^9/L.

Measure: Complete response

Time: 6 weeks

Description: A response (R) was defined as a sustained (≥ 3 months) platelet count ≥ 30×10^9/L without recurrence of thrombocytopenia.

Measure: Response

Time: 6 weeks

Description: No response (NR) was defined as platelet count < 30 × 10^9/L or a less than two fold increase in platelet count from baseline or the presence of bleeding. Platelet count must be measured on two occasions more than a day apart.

Measure: No response

Time: 6 weeks

Description: A relapses was defined as platelet count falls below 30×10^9/L or bleeding accrues after achieving R or CR.

Measure: Relapses

Time: 6 weeks

Secondary Outcomes

Description: Early response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 week.

Measure: Early response

Time: 7 days

Description: Initial treatment was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 month.

Measure: Initial response

Time: 1 month

Description: The time to achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

Measure: TOR (time to response)

Time: 6 weeks

Description: The duration of achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

Measure: DOR (duration of response)

Time: 6 weeks

Description: All patients were assessed for safety every week during the first 8 weeks of treatment, and at 2-week intervals thereafter. Adverse events were scaled according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

Measure: Treatments associated adverse events

Time: 6 weeks

Description: Changes of bleeding after treatment. Bleeding was defined in accordance with the WHO bleeding scale (0, no bleeding; 1, petechiae; 2, mild blood loss; 3, gross blood loss; and 4, debilitating blood loss).

Measure: Reduction in bleeding symptoms

Time: 6 weeks

HPO Nodes


HP:0001873: Thrombocytopenia
Genes 413
KMT2D NHP2 SMARCAL1 ARHGEF1 ATRX NHEJ1 RAG1 ARHGAP31 FANCL TERT STAT5B STAT3 RNASEH2C ITGA2B OSTM1 CASP10 TERT BRIP1 ERBB3 RUNX1 PCCB FLI1 ELANE CD81 PNP WRAP53 MPL RNASEH2A TERT LAT LRBA MAD2L2 GATA1 SMARCD2 CFH TNFSF11 TNFRSF13B HLA-B BCOR CFI MPIG6B CTLA4 SLC7A7 AGK GBA CFI IRF2BP2 VPS33A GBA DOCK6 MYSM1 SLX4 PCCA FLI1 ESCO2 DHFR CD46 OCLN FASLG TREX1 GATA1 STX11 SLC19A2 NBEAL2 GP1BB CORIN ARVCF NUMA1 DLL4 GP1BA RAG2 SCARB2 PSMB8 FANCA NFKB2 MYH9 TFRC CLCN7 JAK2 WFS1 FANCB LYST RAG1 TPP2 XIAP RBPJ XPR1 XRCC2 PLAU PTPN22 TNFAIP3 PDGFRB FAS SPP1 RNASEH2B OCRL UBE2T FYB1 TINF2 VPS45 NPM1 APOE UFD1 FANCB CTC1 MYH9 ICOS PRF1 FANCM ERCC4 FCGR2B FANCE SNX10 WIPF1 MMAA CTLA4 LMBRD1 SRP54 DGUOK ANKRD11 STIM1 NABP1 GALC COG6 COMT VWF IFNG MTOR STAT4 WAS GP1BA JMJD1C ARPC1B IVD CALR CFH NOTCH1 HIRA DKC1 ADAR GP1BA BRCA2 IFIH1 TBL1XR1 NSUN2 CFHR1 DIAPH1 SBDS BCR ACD BRCA1 IRAK1 VWF PTPN11 SLC35A1 TERT FANCG JAK2 MAD2L2 TERT FOXP3 LARS2 PRKCD TALDO1 ADAMTS13 PRDX1 ABCA1 RFXANK RNASEH2C SF3B1 TERC TBX1 CD36 DCLRE1C PSMB4 CIITA TET2 STOX1 CR2 ACAD9 SLC7A7 GBA SEC24C NFKB2 ANKRD26 PEPD FAS WIPF1 ABL1 MMUT NBN WAS GATA1 ALG8 PRKCD CTC1 STT3B PALB2 ASAH1 MYSM1 FANCE GBA SLC46A1 G6PC3 SC5D CD81 NOP10 UBE2T RBM8A RFWD3 SALL4 TREX1 TBXAS1 ETV6 SAMD9 SPATA5 PML GFI1B GP1BA GNA14 HLCS PRF1 SCARB2 HYOU1 NHP2 PHGDH HPS5 TNFRSF11A UROS CD19 RREB1 CD40LG RUNX1 FANCF SAMHD1 STT3B LBR HOXA11 GP9 SALL4 THBD MMUT ACTN1 GATA1 USP18 NRAS PSAP TNFRSF13C ITGA2 PDGFB FANCC MYORG RFXAP FANCG NIPBL GBA COG1 ZBTB16 ITGA2B FCGR2C TINF2 FLT1 SP110 CFB TUBB1 FARS2 POMP SMPD1 FANCI IKZF1 FAS FANCD2 MMACHC APOE TMEM165 ACP5 ZAP70 SLFN14 RARA LIG4 TCN2 DGKE RTEL1 FIP1L1 PNP SLC46A1 TREX1 GBA ACAD9 COL4A5 GP1BB MECOM EFL1 SBDS ADA MVK SRC SAMHD1 RAD51 VPS33A FOXP3 MMUT FANCD2 HLCS SBDS PSMB9 C3 LIG4 NFKB1 PRKAR1A STAT1 PRKACG RAG2 MAP2K1 WAS FLNA CASP10 MECOM RTEL1 MMAB CA2 ATP7B KIF15 SLC35A1 MS4A1 RASGRP1 TET2 ITGB3 NPM1 GFI1B UQCRFS1 DNAJC21 NBEAL2 CDC42 UROS DKC1 STAT3 MPL GBA RAD51C BTNL2 SH2D1A BRAF GATA1 CDC42 SRP54 TBX1 GATA2 TERC ABCD4 SAMD9L IL7R SMARCAL1 ERCC6L2 NFKB1 TINF2 FANCC ITGB3 PARN EOGT GP1BB RBM8A DNASE1 HELLPAR FASLG TERC SLC20A2 HOXA11 CYCS NOP10 DNAJC21 COG4 TNFSF12 GP1BB FANCA ITK GP9 RNASEH2A LYST NHP2 HLA-DRB1 NBN PARN CD46 TNFSF12 CD109 BTK SARS2 USB1 IFIH1 MPL RFX5 PRKCD STIM1 SLC19A2 RPS19 TALDO1 SPATA5 FCGR2A DKC1 GUCY1A1 KDM6A JAM2 GATA1 TINF2 CFHR3 EFL1 NOS3 AP3B1 TET2 BLOC1S6 TET2 KRAS
Protein Mutations 2
G20210A V617F
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0001873: Thrombocytopenia
Genes 413
KMT2D NHP2 SMARCAL1 ARHGEF1 ATRX NHEJ1 RAG1 ARHGAP31 FANCL TERT STAT5B STAT3 RNASEH2C ITGA2B OSTM1 CASP10 TERT BRIP1 ERBB3 RUNX1 PCCB FLI1 ELANE CD81 PNP WRAP53 MPL RNASEH2A TERT LAT LRBA MAD2L2 GATA1 SMARCD2 CFH TNFSF11 TNFRSF13B HLA-B BCOR CFI MPIG6B CTLA4 SLC7A7 AGK GBA CFI IRF2BP2 VPS33A GBA DOCK6 MYSM1 SLX4 PCCA FLI1 ESCO2 DHFR CD46 OCLN FASLG TREX1 GATA1 STX11 SLC19A2 NBEAL2 GP1BB CORIN ARVCF NUMA1 DLL4 GP1BA RAG2 SCARB2 PSMB8 FANCA NFKB2 MYH9 TFRC CLCN7 JAK2 WFS1 FANCB LYST RAG1 TPP2 XIAP RBPJ XPR1 XRCC2 PLAU PTPN22 TNFAIP3 PDGFRB FAS SPP1 RNASEH2B OCRL UBE2T FYB1 TINF2 VPS45 NPM1 APOE UFD1 FANCB CTC1 MYH9 ICOS PRF1 FANCM ERCC4 FCGR2B FANCE SNX10 WIPF1 MMAA CTLA4 LMBRD1 SRP54 DGUOK ANKRD11 STIM1 NABP1 GALC COG6 COMT VWF IFNG MTOR STAT4 WAS GP1BA JMJD1C ARPC1B IVD CALR CFH NOTCH1 HIRA DKC1 ADAR GP1BA BRCA2 IFIH1 TBL1XR1 NSUN2 CFHR1 DIAPH1 SBDS BCR ACD BRCA1 IRAK1 VWF PTPN11 SLC35A1 TERT FANCG JAK2 MAD2L2 TERT FOXP3 LARS2 PRKCD TALDO1 ADAMTS13 PRDX1 ABCA1 RFXANK RNASEH2C SF3B1 TERC TBX1 CD36 DCLRE1C PSMB4 CIITA TET2 STOX1 CR2 ACAD9 SLC7A7 GBA SEC24C NFKB2 ANKRD26 PEPD FAS WIPF1 ABL1 MMUT NBN WAS GATA1 ALG8 PRKCD CTC1 STT3B PALB2 ASAH1 MYSM1 FANCE GBA SLC46A1 G6PC3 SC5D CD81 NOP10 UBE2T RBM8A RFWD3 SALL4 TREX1 TBXAS1 ETV6 SAMD9 SPATA5 PML GFI1B GP1BA GNA14 HLCS PRF1 SCARB2 HYOU1 NHP2 PHGDH HPS5 TNFRSF11A UROS CD19 RREB1 CD40LG RUNX1 FANCF SAMHD1 STT3B LBR HOXA11 GP9 SALL4 THBD MMUT ACTN1 GATA1 USP18 NRAS PSAP TNFRSF13C ITGA2 PDGFB FANCC MYORG RFXAP FANCG NIPBL GBA COG1 ZBTB16 ITGA2B FCGR2C TINF2 FLT1 SP110 CFB TUBB1 FARS2 POMP SMPD1 FANCI IKZF1 FAS FANCD2 MMACHC APOE TMEM165 ACP5 ZAP70 SLFN14 RARA LIG4 TCN2 DGKE RTEL1 FIP1L1 PNP SLC46A1 TREX1 GBA ACAD9 COL4A5 GP1BB MECOM EFL1 SBDS ADA MVK SRC SAMHD1 RAD51 VPS33A FOXP3 MMUT FANCD2 HLCS SBDS PSMB9 C3 LIG4 NFKB1 PRKAR1A STAT1 PRKACG RAG2 MAP2K1 WAS FLNA CASP10 MECOM RTEL1 MMAB CA2 ATP7B KIF15 SLC35A1 MS4A1 RASGRP1 TET2 ITGB3 NPM1 GFI1B UQCRFS1 DNAJC21 NBEAL2 CDC42 UROS DKC1 STAT3 MPL GBA RAD51C BTNL2 SH2D1A BRAF GATA1 CDC42 SRP54 TBX1 GATA2 TERC ABCD4 SAMD9L IL7R SMARCAL1 ERCC6L2 NFKB1 TINF2 FANCC ITGB3 PARN EOGT GP1BB RBM8A DNASE1 HELLPAR FASLG TERC SLC20A2 HOXA11 CYCS NOP10 DNAJC21 COG4 TNFSF12 GP1BB FANCA ITK GP9 RNASEH2A LYST NHP2 HLA-DRB1 NBN PARN CD46 TNFSF12 CD109 BTK SARS2 USB1 IFIH1 MPL RFX5 PRKCD STIM1 SLC19A2 RPS19 TALDO1 SPATA5 FCGR2A DKC1 GUCY1A1 KDM6A JAM2 GATA1 TINF2 CFHR3 EFL1 NOS3 AP3B1 TET2 BLOC1S6 TET2 KRAS
Protein Mutations 2
G20210A V617F
SNP 0

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook