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D003872: Dermatitis

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1448 Hand sanitizer and hand washing Wiki 0.58
drug702 CYP 450 Substrates Wiki 0.58
drug2173 Nemolizumab Wiki 0.58

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D003876 Dermatitis, Atopic NIH 0.82
D004485 Eczema NIH 0.82
D012868 Skin Abnormalities NIH 0.58

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0011123 Inflammatory abnormality of the skin HPO 0.58

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Re-opening of the Country and Dermal Consequences of Mandatory Intensified Handwash and Hand Disinfection Among a Danish Pediatric Population During the COVID19 Pandemic

During the COVID-19 pandemic after reopening of the country, school, kindergarten and daycare, children have been obligated to do frequent handwash. The study group wished to investigate whether this has had implications on symptoms of dry, red, itchy or sore hands and hand eczema. The investigation was performed within the first and second week after reopening by questionnaires distributed to parents electronically via schools, kindergartens and daycare facilities electronic platforms.

NCT04375410
Conditions
  1. Hand Eczema
  2. Hand Dermatitis
  3. Covid19
MeSH:Dermatitis
HPO:Inflammatory abnormality of the skin

Primary Outcomes

Description: Dermal symptoms as a result of frequent hand wash and disinfection among children

Measure: Dermal reaction to frequent hand wash and disinfection in children

Time: 9 days
2 Hand Sanitizer Effects on the Skin Barrier

Hand washing and the use of hand sanitizers are important interventions in disease prevention. Engaging in frequent hand washing is especially effective in preventing the spread of viruses, as this removes microbes and prevents the spread to others. Hand dermatitis, however, is a common occurrence in certain occupations, such as healthcare workers. With the onset of the SARS-CoV2 (COVID-19) pandemic, hand hygiene measures are further enforced as there is no cure or vaccine for this virus. In the study, the effects of hand washing and the use of hand sanitizer on skin proteins and lipids will be assessed.

NCT04525521
Conditions
  1. Dermatitis Hand
  2. Skin Abnormalities
  3. Atopic Dermatitis
  4. Atopic Dermatitis Eczema
Interventions
  1. Other: Hand sanitizer and hand washing
MeSH:Dermatitis, Atopic Skin Abnormalities Dermatitis Eczema
HPO:Abnormality of the skin Atopic dermatitis Eczema Eczematoid dermatitis Inflammatory abnormality of the skin

Primary Outcomes

Description: Skin barrier assessments at baseline, then after hand sanitizer use will be performed. Analysis of skin filaggrin breakdown products, lipid profiles, and transepidermal water loss will be compared.

Measure: Measure the change in transepidermal water loss and skin components after using hand sanitizer.

Time: Through study completion, up to 1 year

Description: Skin barrier assessments after hand washing with soap and water will be performed. Analysis of skin filaggrin breakdown products, lipid profiles, and transepidermal water loss will be compared.

Measure: Measure the change in transepidermal water loss and skin components after hand washing with soap and water.

Time: Through study completion, up to 1 year

Secondary Outcomes

Description: Questionnaires will capture symptoms of hand dryness, frequency of hand washing, and other environmental exposures. This data will be compared to the degree of transepidermal water loss and skin barrier findings.

Measure: Individual reporting of hand dryness and environmental exposures

Time: Through study completion, up to 1 year
3 An Open-label Drug-Drug Interaction Study to Assess the Effects of Nemolizumab on Cytochrome P450 Substrates in Subjects With Moderate-to-Severe Atopic Dermatitis

The purpose of this study is to evaluate the effect of nemolizumab (CD14152) on the pharmacokinetics (PK) of a drug "cocktail" representative of CYP450 (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5 sensitive index substrates) in adult participants with moderateto- severe atopic dermatitis (AD).

NCT04562116
Conditions
  1. Atopic Dermatitis
Interventions
  1. Drug: Nemolizumab
  2. Drug: CYP 450 Substrates
MeSH:Dermatitis, Atopic Dermatitis Eczema
HPO:Atopic dermatitis Eczema Eczematoid dermatitis Inflammatory abnormality of the skin

Primary Outcomes

Description: Change of AUC (0-infinity) of each of the 5 probe drugs before and after 9-week nemolizumab treatment will be assessed. AUC (0-infinity) is defined as AUC from time 0 to infinity, calculated as the sum of AUC (0-last) and C(last)/lambda(z); where C(last) is the last observed measurable (non-BQL) concentration; and lambda(z) is apparent terminal elimination rate constant.

Measure: Change of Area Under the Concentration-time Curve from Time Zero to Infinity (AUC[0-infinity]) of Each of the 5 Probe Drugs Before and After 9-week Nemolizumab Treatment

Time: Baseline (Week 0) and Week 10: Pre-dose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 72 and 120 hours post-dose'

Description: Change of AUC (0-last) of each of the 5 probe drugs before and after 9-week nemolizumab treatment will be assessed. AUC (0-last) is defined as AUC from time 0 to the time of the last measurable (non-below quantification limit [non-BQL]) concentration, calculated by linear-linear trapezoidal summation.

Measure: Change of Area Under the Concentration-time Curve from Time Zero to the Time of the Last Measurable Concentration (AUC [0-last]) of Each of the 5 Probe Drugs Before and After 9-week Nemolizumab Treatment

Time: Baseline (Week 0) and Week 10: Pre-dose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 72 and 120 hours post-dose'

Description: Change of Cmax of each of the 5 probe drugs before and after 9-week nemolizumab treatment will be assessed. Cmax is defined as the maximum observed plasma concentration.

Measure: Maximum Observed Plasma Concentration (Cmax) of Each of the 5 Probe Drugs Before and After 9-week Nemolizumab Treatment

Time: Baseline (Week 0) and Week 10: Pre-dose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 72 and 120 hours post-dose'

Secondary Outcomes

Description: Incidence of AEs including treatment emergent AEs (TEAEs), AEs of special interest (AESIs), and serious AEs (SAEs) will be reported. An AE is defined as any untoward medical occurrence in a study participant administered a medicinal product which does not necessarily have a causal relationship with this treatment. SAE is any untoward medical occurrence that at any dose may results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect, is a suspected transmission of any infectious agent via a medicinal product. A TEAE is defined as an AE that occurs on or after the first date of study drug(s) administration until the date of last study visit. An AESI is a noteworthy treatment-emergent event for the study drug that should be monitored closely and reported promptly.

Measure: Incidence of Adverse Events (AEs)

Time: Up to 24 weeks

Description: The severity of AEs including TEAEs, AESIs, and SAEs will be assessed as mild, moderate or severe.

Measure: Severity of Adverse Events (AEs)

Time: Up to 24 weeks

HPO Nodes


HP:0011123: Inflammatory abnormality of the skin
Genes 475
DOCK8 MPLKIP LBR RAG1 DSG1 IL17F EDAR BLNK ESR1 EPB42 MVK CD79A LYZ IL36RN STAT3 TP63 SUOX RNASEH2C MEFV IRF2BP2 APOA1 IL12A-AS1 CTLA4 SLC6A19 PCCB FOXN1 FLI1 ELANE ZAP70 RAG2 ADA2 STAT3 KRT14 KRT5 HSD3B2 GNA11 BTK CCR1 ITGA6 TTC7A KANSL1 IL6 KLRC4 SRD5A3 SHOC2 PSTPIP1 NCF4 LPIN2 DCLRE1C ERCC3 TMC6 NOD2 CTLA4 NLRP3 SHANK3 GJA1 RNF113A SMARCA2 CYBC1 CACNA1G CHST14 KIT HSPA9 KRT16 GINS1 MYSM1 PCCA FLI1 LACC1 CERS3 CD3G ACADVL TREX1 NSMCE3 AGA IL10RB C4A MNX1 NOD2 ARVCF RAG2 ABCA12 NFKB2 TFRC TRPM1 SPINK5 DSE NCF4 LYST RAG1 LAMB3 FLG KRT10 PLA2G7 TAF1 TEK PIK3CA IL2RG B2M PTPN22 TNFAIP3 SPP1 VEGFC RNASEH2B HLA-DPB1 RFXAP ERCC2 ERCC4 DCLRE1C ANK1 MBTPS2 CARD11 UFD1 C5 FAS SH3PXD2B RFXANK RAC1 TGM1 IL12A LPIN2 NLRC4 CD3D FCGR2B FLT4 WIPF1 IL2RG CTSB SRP54 CTLA4 LMBRD1 NCF2 MEIS2 TRAF3IP2 FOXP1 ALOX12B CARD14 TGFB1 CD3E NCF1 KRT9 CSTA MSMO1 COMT PNPLA1 CIB1 SCNN1G STAT4 WAS RMRP PRKACA JMJD1C IL23R CFI ERCC3 FERMT3 ERAP1 ENPP1 PSTPIP1 AUTS2 HIRA BTD ADAR GJC2 LAMC2 ESR1 IFIH1 NCSTN TGM1 KDF1 TBX1 GJB4 NEK9 NSUN2 JAK3 H6PD RAC1 ERCC2 TGM1 GJB3 SBDS HPGD DNAJC21 ECM1 IGLL1 IRAK1 ABCA12 PRTN3 CYBB TCIRG1 SMARCAD1 HLA-B FECH TARS1 SULT2B1 MEFV SH3PXD2B FOXP3 RNU4ATAC SLC4A1 BTK RFXANK RNASEH2C CLEC7A POLR3A IL17RA TBX1 CCBE1 DCLRE1C PSMB4 CIITA ABCC6 COL5A2 FGA NCF1 IL2RA TGM1 NIPAL4 HDAC4 SEC24C PAH ADA NSUN2 PEPD WIPF1 LMBRD1 WAS MS4A2 PRMT7 COL7A1 FGFR2 XYLT1 TNFRSF1B LIPN STAT1 SCNN1B RAG1 SMARCC2 TNFRSF1B PAH SDR9C7 NLRP12 MYD88 MYSM1 CYBA RNU4ATAC SDHB KIT WNT4 GLUL RTTN SPTB KRT17 IL17RC KRT10 CHST14 PDGFRA NIPAL4 LHCGR SCNN1A TREX1 RIPK1 SLCO2A1 IGHM TTC7A LAMA3 CYP4F22 GTF2H5 SLC29A3 ADAM17 EDA NOD2 HLCS TBCK HYOU1 ITGB4 SDHC NFE2L2 SMARCA2 IL4R RREB1 TRAF6 SAMHD1 NAXD LBR HLA-C GPR101 DOCK8 GTF2H5 BTNL2 HLA-DRB1 KRT1 GTF2E2 NLRP3 ZNF341 RFXAP MSN CD28 LIG4 CARD9 STAT3 IL7R GJB2 CTSC NIPAL4 AIP SP110 POMP TNFRSF1A UBAC2 MBTPS2 PIGA PTPRC NFKB2 ZAP70 MORC2 IKBKG MTHFD1 LIG4 SLC39A4 CARMIL2 UBE2A EGFR TMC8 CTSC AP1S3 ADA POLE BCL11B EXTL3 PNPLA1 GJB6 ABCA12 CCBE1 AK2 CTLA4 ALOXE3 HLA-DPA1 TREX1 LRRC8A EBP GP1BB TLR4 CYP4F22 TRAF3IP2 MVK FAM111B GFI1 SAMHD1 ALOXE3 ERCC5 FOXP3 KDF1 KIT HPGD HLCS KRT1 ELANE PSMB9 LIG4 RBCK1 PSEN1 EDARADD CD247 STAT1 RAG2 HLA-DRB1 WAS GJC2 CASP10 EPG5 KRT1 XIAP DNASE1L3 DHCR7 RBP4 IL10 BRAF CIITA MIF AIRE AIRE STAT4 MBL2 TP63 GJB2 DNAJC21 UROS COX4I2 RFX5 KRT1 HLA-B ADAMTS3 CDH23 COL5A1 BTNL2 FOXC2 PTPN22 CYBA PGM3 IL17RA KRT10 SRP54 ERCC2 GJB2 TBX1 CD79B CHD7 MPDU1 CD28 CASR IL7R KRT5 PSENEN IL2RG POR ALOX12B NFKB1 IL10RA KIF11 STING1 NCF2 CARD14 COL1A1 ZNF750 SIK3 NR3C1 KDSR PEPD SPTA1 RBM8A DNASE1 DDX41 IL6ST IL17F FERMT1 TCF3 TNFRSF1A CYBB PIK3R1 IL1RN CDK10 CTLA4 GATA3 AP1B1 RNASEH2A TGM5 SDHA LYST HLA-DQB1 HLA-DRB1 CASP8 IL7R HPGD BTK SPINK5 TKT MBTPS2 LACC1 CLEC7A BTD IFIH1 RFX5 WNT4 MCCC2 FCGR2A FAT4 GATA1 FECH USP8 PGM3 SLC30A2 EFL1 IL7 PAPSS2
Protein Mutations 4
G2545R H2507Q T454A V66M
SNP 1
rs6265

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0011123: Inflammatory abnormality of the skin
Genes 475
DOCK8 MPLKIP LBR RAG1 DSG1 IL17F EDAR BLNK ESR1 EPB42 MVK CD79A LYZ IL36RN STAT3 TP63 SUOX RNASEH2C MEFV IRF2BP2 APOA1 IL12A-AS1 CTLA4 SLC6A19 PCCB FOXN1 FLI1 ELANE ZAP70 RAG2 ADA2 STAT3 KRT14 KRT5 HSD3B2 GNA11 BTK CCR1 ITGA6 TTC7A KANSL1 IL6 KLRC4 SRD5A3 SHOC2 PSTPIP1 NCF4 LPIN2 DCLRE1C ERCC3 TMC6 NOD2 CTLA4 NLRP3 SHANK3 GJA1 RNF113A SMARCA2 CYBC1 CACNA1G CHST14 KIT HSPA9 KRT16 GINS1 MYSM1 PCCA FLI1 LACC1 CERS3 CD3G ACADVL TREX1 NSMCE3 AGA IL10RB C4A MNX1 NOD2 ARVCF RAG2 ABCA12 NFKB2 TFRC TRPM1 SPINK5 DSE NCF4 LYST RAG1 LAMB3 FLG KRT10 PLA2G7 TAF1 TEK PIK3CA IL2RG B2M PTPN22 TNFAIP3 SPP1 VEGFC RNASEH2B HLA-DPB1 RFXAP ERCC2 ERCC4 DCLRE1C ANK1 MBTPS2 CARD11 UFD1 C5 FAS SH3PXD2B RFXANK RAC1 TGM1 IL12A LPIN2 NLRC4 CD3D FCGR2B FLT4 WIPF1 IL2RG CTSB SRP54 CTLA4 LMBRD1 NCF2 MEIS2 TRAF3IP2 FOXP1 ALOX12B CARD14 TGFB1 CD3E NCF1 KRT9 CSTA MSMO1 COMT PNPLA1 CIB1 SCNN1G STAT4 WAS RMRP PRKACA JMJD1C IL23R CFI ERCC3 FERMT3 ERAP1 ENPP1 PSTPIP1 AUTS2 HIRA BTD ADAR GJC2 LAMC2 ESR1 IFIH1 NCSTN TGM1 KDF1 TBX1 GJB4 NEK9 NSUN2 JAK3 H6PD RAC1 ERCC2 TGM1 GJB3 SBDS HPGD DNAJC21 ECM1 IGLL1 IRAK1 ABCA12 PRTN3 CYBB TCIRG1 SMARCAD1 HLA-B FECH TARS1 SULT2B1 MEFV SH3PXD2B FOXP3 RNU4ATAC SLC4A1 BTK RFXANK RNASEH2C CLEC7A POLR3A IL17RA TBX1 CCBE1 DCLRE1C PSMB4 CIITA ABCC6 COL5A2 FGA NCF1 IL2RA TGM1 NIPAL4 HDAC4 SEC24C PAH ADA NSUN2 PEPD WIPF1 LMBRD1 WAS MS4A2 PRMT7 COL7A1 FGFR2 XYLT1 TNFRSF1B LIPN STAT1 SCNN1B RAG1 SMARCC2 TNFRSF1B PAH SDR9C7 NLRP12 MYD88 MYSM1 CYBA RNU4ATAC SDHB KIT WNT4 GLUL RTTN SPTB KRT17 IL17RC KRT10 CHST14 PDGFRA NIPAL4 LHCGR SCNN1A TREX1 RIPK1 SLCO2A1 IGHM TTC7A LAMA3 CYP4F22 GTF2H5 SLC29A3 ADAM17 EDA NOD2 HLCS TBCK HYOU1 ITGB4 SDHC NFE2L2 SMARCA2 IL4R RREB1 TRAF6 SAMHD1 NAXD LBR HLA-C GPR101 DOCK8 GTF2H5 BTNL2 HLA-DRB1 KRT1 GTF2E2 NLRP3 ZNF341 RFXAP MSN CD28 LIG4 CARD9 STAT3 IL7R GJB2 CTSC NIPAL4 AIP SP110 POMP TNFRSF1A UBAC2 MBTPS2 PIGA PTPRC NFKB2 ZAP70 MORC2 IKBKG MTHFD1 LIG4 SLC39A4 CARMIL2 UBE2A EGFR TMC8 CTSC AP1S3 ADA POLE BCL11B EXTL3 PNPLA1 GJB6 ABCA12 CCBE1 AK2 CTLA4 ALOXE3 HLA-DPA1 TREX1 LRRC8A EBP GP1BB TLR4 CYP4F22 TRAF3IP2 MVK FAM111B GFI1 SAMHD1 ALOXE3 ERCC5 FOXP3 KDF1 KIT HPGD HLCS KRT1 ELANE PSMB9 LIG4 RBCK1 PSEN1 EDARADD CD247 STAT1 RAG2 HLA-DRB1 WAS GJC2 CASP10 EPG5 KRT1 XIAP DNASE1L3 DHCR7 RBP4 IL10 BRAF CIITA MIF AIRE AIRE STAT4 MBL2 TP63 GJB2 DNAJC21 UROS COX4I2 RFX5 KRT1 HLA-B ADAMTS3 CDH23 COL5A1 BTNL2 FOXC2 PTPN22 CYBA PGM3 IL17RA KRT10 SRP54 ERCC2 GJB2 TBX1 CD79B CHD7 MPDU1 CD28 CASR IL7R KRT5 PSENEN IL2RG POR ALOX12B NFKB1 IL10RA KIF11 STING1 NCF2 CARD14 COL1A1 ZNF750 SIK3 NR3C1 KDSR PEPD SPTA1 RBM8A DNASE1 DDX41 IL6ST IL17F FERMT1 TCF3 TNFRSF1A CYBB PIK3R1 IL1RN CDK10 CTLA4 GATA3 AP1B1 RNASEH2A TGM5 SDHA LYST HLA-DQB1 HLA-DRB1 CASP8 IL7R HPGD BTK SPINK5 TKT MBTPS2 LACC1 CLEC7A BTD IFIH1 RFX5 WNT4 MCCC2 FCGR2A FAT4 GATA1 FECH USP8 PGM3 SLC30A2 EFL1 IL7 PAPSS2
Protein Mutations 4
G2545R H2507Q T454A V66M
SNP 1
rs6265

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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