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D003072: Cognition Disorders

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug669 COVID-19 swap test PCR Wiki 0.71
drug1406 Goal Management Training (GMT) Wiki 0.71
drug998 Data collection and clinical testing of subjects Wiki 0.71
Name (Synonyms) Correlation
drug2109 Muse headband with Myndlift app Wiki 0.71
drug3163 Sofosbuvir Wiki 0.71
drug981 Daclatasvir Wiki 0.50

Correlated MeSH Terms (7)


Name (Synonyms) Correlation
D004827 Epilepsy NIH 0.71
D012640 Seizures NIH 0.41
D009422 Nervous System Diseases NIH 0.41
Name (Synonyms) Correlation
D060825 Cognitive Dysfunction NIH 0.41
D020521 Stroke NIH 0.18
D040921 Stress Disorders, Traumatic NIH 0.13
D013313 Stress Disorders, Post-Traumatic NIH 0.12

Correlated HPO Terms (3)


Name (Synonyms) Correlation
HP:0001268 Mental deterioration HPO 0.43
HP:0001250 Seizure HPO 0.41
HP:0001297 Stroke HPO 0.20

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 COVID-19 Prevalence, Morbidity and Long Term Cognitive Deficits in Consecutive Patients Presenting With Acute Neurological Symptoms

The purpose is to investigate the COVID-19 prevalence, associated morbidity and long-term cognitive deficits in consecutive patients presenting with acute neurological symptoms

NCT04377425
Conditions
  1. Neurological Diseases or Conditions
  2. Stroke, Acute
  3. Seizure Disorder
Interventions
  1. Diagnostic Test: COVID-19 swap test PCR
MeSH:Stroke Seizures Nervous System Diseases Epilepsy Cognition Disorders Cognitive Dysfunction
HPO:Bilateral tonic-clonic seizure Cognitive impairment Focal sensory seizure Focal-onset seizure Generalized-onset seizure Mental deterioration Seizure Stroke

Primary Outcomes

Description: To investigate the prevalence of COVID-19 infections in consecutive patients with acute onset of neurological symptoms (with or without prior neurological disease)

Measure: Prevalence of COVID-19 infection in consecutive patients with neurological symptoms

Time: 6 months

Secondary Outcomes

Description: Three months cognitive function (Montreal Cognitive Assessment) of COVID-19 positive patients compared to COVID-19 negative patients

Measure: Three months cognitive function of COVID-19 positive patients

Time: 3 months

Description: Characterization of the neurological symptoms in neurological COVID-19 positive patients (exploratory endpoint)

Measure: Clinical presentation of neurological symptoms in COVID-19 positive patients

Time: 6 months

Description: Prevalence of pre-symptomatic and asymptomatic COVID-19pos in acutely admitted patients with a primary complaint of neurological symptoms.

Measure: Prevalence of pre- and asymptomatic COVID-19 positive patients in acutely admitted neurological patients

Time: 6 months

Description: Prevalence of anosmia in COVID-19pos patients compared to COVID-19neg patients

Measure: Anosmia in COVID-19 positive patients

Time: 6 months

Description: Neuro-specific and inflammatory blood- and cerebrospinal fluid markers in COVID-19 positive patients compared to COVID-19 negative matched controls

Measure: Exploratory analysis on neuro-specific and inflammatory blood and cerebrospinal fluid markers of COVID-19 infection

Time: 24 months

Description: Functional and immunologic plasma assays will be employed to analyze proteins and pathways in coagulation and fibrinolysis

Measure: Exploratory analysis of the coagulation profile of COVID-19 positive patients compared to COVID-19neg patients

Time: 24 months
2 A Randomized Control Trial Examining the Treatment Efficacy of a Novel Approach to Cognitive Remediation in Individuals With Post-Traumatic Stress Disorder and Co-Morbid Conditions

This study will evaluate the effect of a manualized treatment (Goal Management Training, or GMT) on the cognitive impairments associated with PTSD (Post-Traumatic Stress Disorder) in certain populations. Participants will be randomized to either GMT group treatment (with or without use of a mindfulness meditation aid), or a wait-list condition.

NCT04457271
Conditions
  1. PTSD
  2. Post-traumatic Stress Disorder
  3. Cognitive Impairment
  4. Cognitive Dysfunction
  5. Cognitive Deficit
Interventions
  1. Behavioral: Goal Management Training (GMT)
  2. Device: Muse headband with Myndlift app
MeSH:Cognitive Dysfunction Stress Disorders, Traumatic Stress Disorders, Post-Traumatic Cognition Disorders
HPO:Cognitive impairment Mental deterioration

Primary Outcomes

Description: A computer-based go/no-go task that requires participants to withhold behavioral response to a single, infrequent target presented amidst a background of frequent non-targets. This task assesses inattentiveness, impulsivity, sustained attention, and vigilance.

Measure: Change in Sustained Attention to Response Task (SART) scores from baseline to post-treatment assessment

Time: 9 weeks

Description: A computer-based go/no-go task that requires participants to withhold behavioral response to a single, infrequent target presented amidst a background of frequent non-targets. This task assesses inattentiveness, impulsivity, sustained attention, and vigilance.

Measure: Change in Sustained Attention to Response Task (SART) scores from post-treatment to 3-month follow-up assessment

Time: 12 weeks

Description: Assesses the participant's ability to act with forethought, and sequence behaviour in an orderly fashion to reach specific goals (i.e., executive functioning). Similar to the Tower of London test.

Measure: Change in score on Spatial Planning task (part of Cambridge Brain Science's online battery) from baseline to post-treatment assessment.

Time: 9 weeks

Description: Assesses the participant's ability to act with forethought, and sequence behaviour in an orderly fashion to reach specific goals (i.e., executive functioning). Similar to the Tower of London test.

Measure: Change in score on Spatial Planning task (part of Cambridge Brain Science's online battery) from post-treatment to 3-month follow-up assessment.

Time: 12 weeks

Description: A 36-item self-report measure that assesses difficulties with emotion regulation across six domains. A total score is derived by summing all the items - ranging from 36 to 180. Higher scores indicate greater dysfunction in emotion regulation.

Measure: Change in Difficulties in Emotion Regulation Scale (DERS) score from baseline to post-treatment assessment

Time: 9 weeks

Description: A 36-item self-report measure that assesses difficulties with emotion regulation across six domains. A total score is derived by summing all the items - ranging from 36 to 180. Higher scores indicate greater dysfunction in emotion regulation.

Measure: Change in Difficulties in Emotion Regulation Scale (DERS) score from post-treatment to 3-month follow-up assessment

Time: 12 weeks

Description: Gold standard, clinician administered PTSD assessment tool; min. score=0, max=80, with higher scores representing greater PTSD symptoms

Measure: Change in Clinician Administered PTSD Scale (CAPS) score from baseline to post-treatment assessment

Time: 9 weeks

Description: Gold standard, clinician administered PTSD assessment tool; min. score=0, max=80, with higher scores representing greater PTSD symptoms

Measure: Change in Clinician Administered PTSD Scale (CAPS) score from post-treatment to 3-month follow-up assessment

Time: 12 weeks

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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4,180 reports on interventions/drugs

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691 reports on MeSH terms

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Python example via Google Colab Notebook