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D001289: Attention Deficit Disorder with Hyperactivity

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (9)


Name (Synonyms) Correlation
drug635 COVID-19 FACILITY Wiki 0.50
drug637 COVID-19 IgG/IgM Rapid Test Cassette test (Healgen Scientific, Houston, Texas, USA) Wiki 0.50
drug1426 Guanfacine hydrochloride (SPD503) Wiki 0.50
Name (Synonyms) Correlation
drug3438 The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: Wiki 0.50
drug331 Atomoxetine hydrochloride Wiki 0.50
drug1714 Interview by psychologists Wiki 0.50
drug374 Açaí palm berry extract - natural product Wiki 0.50
drug632 COVID-19 Convalescent Plasma Wiki 0.22
drug2505 Placebo Wiki 0.05

Correlated MeSH Terms (23)


Name (Synonyms) Correlation
D006948 Hyperkinesis NIH 0.71
D001997 Bronchopulmonary Dysplasia NIH 0.50
D008595 Menorrhagia NIH 0.50
Name (Synonyms) Correlation
D006929 Hyperaldosteronism NIH 0.50
D054559 Hyperphosphatemia NIH 0.50
D004314 Down Syndrome NIH 0.50
D000309 Adrenal Insufficiency NIH 0.50
D007008 Hypokalemia NIH 0.50
D014552 Urinary Tract Infections NIH 0.35
D000067877 Autism Spectrum Disorder NIH 0.30
D009080 Mucocutaneous Lymph Node Syndrome NIH 0.29
D006470 Hemorrhage NIH 0.25
D004194 Disease NIH 0.24
D002659 Child Development Disorders, Pervasive NIH 0.22
D001321 Autistic Disorder NIH 0.17
D020141 Hemostatic Disorders NIH 0.13
D001778 Blood Coagulation Disorders NIH 0.13
D006973 Hypertension NIH 0.11
D013577 Syndrome NIH 0.05
D003141 Communicable Diseases NIH 0.04
D007239 Infection NIH 0.02
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (11)


Name (Synonyms) Correlation
HP:0007018 Attention deficit hyperactivity disorder HPO 1.00
HP:0002487 Hyperkinetic movements HPO 0.71
HP:0002905 Hyperphosphatemia HPO 0.50
Name (Synonyms) Correlation
HP:0002900 Hypokalemia HPO 0.50
HP:0000846 Adrenal insufficiency HPO 0.50
HP:0000132 Menorrhagia HPO 0.50
HP:0000859 Hyperaldosteronism HPO 0.50
HP:0000729 Autistic behavior HPO 0.30
HP:0000717 Autism HPO 0.17
HP:0001928 Abnormality of coagulation HPO 0.13
HP:0000822 Hypertension HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 A Phase 4, Multicenter, 2-part Study Composed of a 1-Year Randomized, Double-blind, Parallel-group, Placebo-controlled, Active-comparator, Dose-optimization Evaluation Followed by a 1-Year Open-label Evaluation to Assess the Safety and Efficacy of Guanfacine Hydrochloride Prolonged-release (SPD503) in Children and Adolescents Aged 6 to 17 Years With Attention-deficit/Hyperactivity Disorder

This interventional multicenter dose-optimization Phase IV PASS conducted in Europe and the USA evaluates the comparative long-term safety and efficacy of SPD503 in children and adolescents aged 6 to 17 years diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) for whom stimulants are not suitable, not tolerated, or shown to be ineffective. The study will be conducted in two parts: Study Part A (randomized, double-blinded, parallel-group, placebo- and active comparator-controlled, 3-treatment arm safety and efficacy evaluation of SPD503) and Study Part B (open label SPD503 treatment).

NCT04085172
Conditions
  1. Attention Deficit Hyperactivity Disorder (ADHD)
Interventions
  1. Drug: Guanfacine hydrochloride (SPD503)
  2. Drug: Atomoxetine hydrochloride
  3. Other: Placebo
MeSH:Hyperkinesis Attention Deficit Disorder with Hyperactivity
HPO:Attention deficit hyperactivity disorder Hyperactivity Hyperkinetic movements

Primary Outcomes

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments. The RTI task of CANTAB involves elements of decision-making and attention as measured by choice accuracy as well as motor responses, by measuring motor and mental response speeds, and assesses movement time, reaction time, response accuracy, and impulsivity. This outcome measure will be assessed at Week 10 in both Part A and Part B of the study.

Measure: Change from Baseline in the Reaction Time (RTI) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) at Week 10

Time: Baseline, Week 10

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments. The RTI task of CANTAB involves elements of decision-making and attention as measured by choice accuracy as well as motor responses, by measuring motor and mental response speeds, and assesses movement time, reaction time, response accuracy, and impulsivity. This outcome measure will be assessed at Week 18 in Part A of the study.

Measure: Change from Baseline in the Reaction Time (RTI) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) at Week 18

Time: Baseline, Week 18

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments. The RTI task of CANTAB involves elements of decision-making and attention as measured by choice accuracy as well as motor responses, by measuring motor and mental response speeds, and assesses movement time, reaction time, response accuracy, and impulsivity. This outcome measure will be assessed at Week 49 in both Part A and Part B of the study.

Measure: Change from Baseline in the Reaction Time (RTI) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) at Week 49

Time: Baseline, Week 49

Secondary Outcomes

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments. Cognitive domain, sustained attention will be measured by the CANTAB RVP task. RVP measures the ability to sustain attention over time and is a sensitive measure of frontal-parietal function. In this task, single digits appear in a pseudo--random order at a rate of 100 digits per minute in a box at the center of the screen. Participants are to detect a 3-digit target sequence (e.g. 2-4-6) and respond by pressing a button at the bottom of the screen when the final number of the sequence appears on the screen.

Measure: Change from Baseline in the Rapid Visual Information Processing (RVP) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) in Both Part A and Part B at Specified Time Points

Time: Part A: Baseline, Week 10, Week 18, Week 49 Part B: Baseline, Week 10, Week 49

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments, SWM is a component of cognitive executive function which is measured by SWM task of CANTAB between the errors. The ability to retain spatial information and manipulate remembered items in working memory will be measured with the SWM task of CANTAB which is self-ordered and assesses the individual's ability to strategize heuristically. The test is a sensitive measure of frontal lobe and executive dysfunction.

Measure: Change from Baseline in the Spatial Working Memory (SWM) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) in Both Part A and Part B at Specified Time Points

Time: Part A: Baseline, Week 10, Week 18, Week 49 Part B: Baseline, Week 10, Week 49

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments.Response control or inhibition cognitive domain will be measured by the CANTAB SST. SST measure response inhibition. The participant must respond to an arrow stimulus by touching either of 2 choices depending on the direction the arrow points. If an audio tone is present, the participant is not to respond.

Measure: Change from Baseline in the Stop Signal Task (SST) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) in Both Part A and Part B at Specified Time Points

Time: Part A: Baseline, Week 10, Week 18, Week 49 Part B: Baseline, Week 10, Week 49

Description: The neurocognitive function effects of SPD503 on adolescents and children diagnosed with ADHD will be evaluated using the CANTAB cognitive assessments. Recognition memory of cognition domain will be measured by the CANTAB DMS task. DMS measures both simultaneous matching and short-term visual memory. The participant is shown a complex visual pattern (the sample) and after a brief delay, 4 similar patterns. The participant must identify the pattern that matches the sample.

Measure: Change from Baseline in the Delayed Matching to Sample (DMS) Task of the Cambridge Automated Neuropsychological Test Battery (CANTAB) in Both Part A and Part B at Specified Time Points

Time: Part A: Baseline, Week 10, Week 18, Week 49 Part B: Baseline, Week 10, Week 49

Description: Sexual maturation will be measured by Tanner stage. The stage of puberty or sexual maturation will be evaluated for each participant according to Tanner staging. The Tanner stage for genitals (male, stages I-V), breasts (females, stages I-V), and pubic hair (both sexes, stages I-V) will be documented at the specified times.

Measure: Tanner Stage in Both Part A and Part B at Specified Time Points

Time: Part A: Baseline, Week 10, Week 18, Week 49 Part B: Baseline, Week 10, Week 49

Description: Physical examinations will include height and weight. Growth will be measured by weight, height, and BMI. Body mass index is a measure of body fat based on height and weight. Vital signs will be assessed based on blood pressure, pulse rate, respiratory rate and body temperature in both Part A and Part B. The HR, PR interval, QRS interval, and QT interval will be measured from all ECGs and the QTcB and QTcF assessed at specified time points in both Part A and Part B of the study.

Measure: Number of participants with clinically significant changes in Vital signs, ECG, Physical Examination

Time: From start of study drug administration up to follow up (week 52)

Description: Psychiatric symptoms will be measured by the Brief Psychiatric Rating Scale for Children (BPRS-C) total score. The 21 items of the clinician-rated BPRS-C are grouped into the following 7 scales: depression, anxiety, psychomotor excitation, behavior problems, withdrawal retardation, thinking disturbance, and organicity. Each item of the 21 items is clinician-graded using the following 7-point severity Likert-scale from 0 to 6 (not present=0; very mild=1; mild=2; moderate=3; moderately severe=4; severe=5; extremely severe=6. BPRS-C will be assessed at specified time points in both Part A and Part B.

Measure: Brief Psychiatric Rating Scale for Children (BPRS-C)

Time: Part A: Baseline, Week 10, Week 18, Week 23, Week 36 and Week 49 Part B: Baseline, Week 10, Week 23, Week 36 and Week 49

Description: The C-SSRS is a structured tool to assess suicidal ideation and behavior. A maximum of 19 items will be completed as follows: 7 items are required, a potential 10 additional items will be completed upon a positive response to a required item, and 2 items completed if suicide or suicide-like behavior is observed during the interview. The C-SSRS uses dichotomous scales (i e, yes or no), Likert scales, and text or narrative to further describe thoughts or behaviors. C-SSRS Score will be assessed at specified time points in both Part A and Part B.

Measure: Columbia- Suicide Severity Rating Scale (CSSRS)

Time: Baseline (from start of study drug administration) to Week 52

Description: UKU rating scale was developed for clinicians to assess side effects of psychopharmacological medications based on interviews and other relevant source information. UKU items relevant to the established safety profile of SPD503 such as Increased Duration of Sleep, Asthenia or Lassitude or lncreased Fatigability, Sleepiness or Sedation, and Orthostatic Dizziness. UKU rating scale will be assessed at specified time points in both Part A and Part B.

Measure: Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale

Time: Part A: Baseline, Week 10, Week 18, Week 23, Week 36, Week 49, Week 50, Week 51 and Week 52 Part B: Baseline, Week 10, Week 23, Week 36, Week 49, Week 50, Week 51 and Week 52

Description: Sedative effects will be measured by participant ratings on the Pediatric Daytime Sleepiness Scale (PDSS). The PDSS is a self-reported assessment of daytime sleepiness in children aged 11 to 15 years. PDSS questionnaire was designed to be easy to administer, score, and interpret. Sleepiness-related questions are based on previous research of situations that can be sensitive to sleep loss in this age group. The 8 questions are scored on Likert-scale from 0 to 4 (never=0; seldom=1; sometimes=2; frequently=3; always=4). The total score on the PDSS can range from 0 (never sleepy) to 32 (always sleepy). PDSS will be assessed at specified time points in both Part A and Part B.

Measure: Pediatric Daytime Sleepiness Scale (PDSS)

Time: Part A: Baseline, Week 10, Week 18, Week 23, Week 36 and Week 49 Part B: Baseline, Week 10, Week 23, Week 36 and Week 49

Description: The ADHD-RS-5 (DuPaul et al., 2016) is used widely by mental health, educational, and medical practitioners in screening, diagnosis, and treatment evaluation to determine the frequency and severity of ADHD symptoms and impairments in children and adolescents. Attention-deficit/hyperactivity disorder symptoms is measured by the investigator-administered ADHD Rating Scale-5 (ADHD-RS-5) total score and hyperactivity/impulsivity and inattentiveness symptoms as subscale scores. The ADHD-RS-5 is based on the diagnostic criteria for ADHD as described in the DSM-5 and consists of 2 symptom subscales, inattention and hyperactivity-impulsivity, each with 9 items and a total scale of 18 items. Each item in the subscale is scored with a value ranging from 0 (no symptoms) to 3 (severe symptoms). The total score can range from 0 to 54. ADHD-RS-5 Total Score and Subscales wiil be assessed at specified time points in both Part A and Part B.

Measure: ADHD Rating Scale-5 (ADHD-RS-5) Total Score and Subscales

Time: Part A: Baseline, Week 1, Week 10, Week 18, Week 23, Week 36 and Week 49 Part B: Baseline, Week 10, Week 23, Week 36 and Week 49

Description: Global clinical measurement of ADHD improvement as measured by Clinical Global Impression-Improvement (CGI-I) using the Clinical Global Impression-Severity (CGI-S) to establish baseline. The CGI scale will be used to evaluate the severity of mental illness over time. The CGI-S will be administered to assess the severity of mental illness at baseline. The CGI-S is scored on a 7-point scale ranging from 1 (normal, not at all ill) to 7 (among the most extremely ill participants). The CGI-I is also scored on a 7-point scale ranging from 1 (very much improved) to 7 (very much worse). CGI-I will be measured at specified time points in both Part A and Part B.

Measure: Clinical Global Impression-Improvement (CGI-I)

Time: Part A: Week 1, Week 10, Week 18, Week 23, Week 36 and Week 49 Part B: Week 10, Week 23, Week 36 and Week 49

Description: The Parent Report Form of the Child Health and Illness Profile - Child Edition (CHIP-CE:PRF) will be administered to provide information on self-esteem and school functioning in pediatric participants diagnosed with ADHD. The 5 domains and 12 subdomains covered in the 76 items comprising the CHIP-CE:PRF. Satisfaction: with health (7 items) and self (4 items); Comfort: physical (9 items) and emotional symptoms (9 items) and activity restrictions (4 items) due to illness; Resilience: behaviors and family involvement (8 items) in activities likely to enhance health, Social problem-solving (5 items),Physical activity (6 items); Risk avoidance: behaviors that if not avoided are likely to pose risks to health: Individual risk avoidance (4 items), Threats to achievement (10 items); Achievement: developmentally appropriate role functioning in school and with peers: Academic performance (5 items), Peer relations (5 items). CHIP-CE: PRF will be assessed in both Part A and Part B.

Measure: Child Health and Illness Profile - Child Edition: Parent Report Form (CHIP-CE:PRF)

Time: Part A: Baseline, Week 10, Week 18, Week 23, Week 36 and Week 49 Part B: Baseline, Week 10, Week 23, Week 36 and Week 49

Description: School performance will be measured by teacher ratings of academic skills using the APRS at specified time points in both Part A and Part B. The APRS is a reliable rating scale that has been shown to be valid in assessing teacher perceptions of the quality of a student's academic competency. The scale includes 19 items that are directed toward work performance in various participant areas; academic success, behavioral control in academic situations, and attention to assignments. Teachers mark responses in a Likert-scale format from 1 (never or poor) to 5 (very often or excellent). From the APRS, a total score and the following 3 subscale scores are calculated: academic success, impulse control, and academic productivity.

Measure: Academic Performance Rating Scale (APRS)

Time: Part A: Baseline, Week 10, Week 18, Week 23, Week 36 and Week 49 Part B: Baseline, Week 10, Week 23, Week 36 and Week 49
2 Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.

NCT04278404
Conditions
  1. Coronavirus Infection (COVID-19)
  2. Pulmonary Arterial Hypertension
  3. Urinary Tract Infections in Children
  4. Hypertension
  5. Pain
  6. Hyperphosphatemia
  7. Primary Hyperaldosteronism
  8. Edema
  9. Hypokalemia
  10. Heart Failure
  11. Hemophilia
  12. Menorrhagia
  13. In
  14. Insomnia
  15. Pneumonia
  16. Skin Infection
  17. Arrythmia
  18. Asthma in Children
  19. Bronchopulmonary Dysplasia
  20. Adrenal Insufficiency
  21. Fibrinolysis; Hemorrhage
  22. Attention Deficit Hyperactivity Disorder
  23. Multisystem Inflammatory Syndrome in Children (MIS-C)
  24. Kawasaki Disease
  25. Coagulation Disorder
  26. Down Syndrome
Interventions
  1. Drug: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
MeSH:Infection Communicable Diseases Urinary Tract Infections Coronavirus Infections Severe Acute Respiratory Syndrome Bronchopulmonary Dysplasia Down Syndrome Menorrhagia Hypertension Hemostatic Disorders Mucocutaneous Lymph Node Syndrome Blood Coagulation Disorders Hyperphosphatemia Hypokalemia Adrenal Insufficiency Hyperaldosteronism Disease Syndrome Hemorrhage Attention Deficit Disorder with Hyperactivity
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Adrenal insufficiency Attention deficit hyperactivity disorder Hyperaldosteronism Hyperphosphatemia Hypertension Hypokalemia Menorrhagia Primary hyperaldosteronism

Primary Outcomes

Measure: Clearance (CL) or apparent oral clearance (CL/F) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Volume of distribution (V) or apparent oral volume of distribution (V/F) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Elimination rate constant (ke) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Half-life (t1/2) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Absorption rate constant (ka) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: AUC (area under the curve) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Maximum concentration (Cmax) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.

Measure: Time to achieve maximum concentration (Tmax) as measured by PK sampling

Time: Data will be collected up to 90 days from the time of consent. For participants with Down Syndrome enrolling at sites designated as Down Syndrome sites, participants will be in the study for up to 210 days.
3 Clinical Evolution and Parenting in Children and Adolescents With Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder Quarantined Because of Covid-19 Outbreak

In response to the coronavirus disease 2019 (covid-19) outbreak, the home confinement of the population ordered by governments in many countries raise questions about its impact on individuals' physical and mental health in the short and longer term. In children, reduced physical activity, changes in lifestyle, disturbances in sleep patterns, lack of in-person contact with peers, poor or inadequate understanding of health risks may be risk factors of anxiety, stress, fatigue, sleep disorders (Brooks et al, 2020; Wang et al, 2020; Sprang et al, 2013). These problematic effects could be modulated by social factors (housing in urban or rural areas, availability of personal space at home, parenting stress, etc.) (Cluver et al, 2020; Liu et al, 2020).

NCT04416360
Conditions
  1. Autism Spectrum Disorder
  2. Attention-deficit Hyperactivity Disorder
Interventions
  1. Other: Interview by psychologists
MeSH:Hyperkinesis Disease Autistic Disorder Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder Child Development Disorders, Pervasive
HPO:Attention deficit hyperactivity disorder Autism Autistic behavior Hyperactivity Hyperkinetic movements

Primary Outcomes

Description: composition, home confinement, change in the environment, personal room at home, screens with internet access, parents' current professional status, teleworking, care, family concerns related to Covid-19, parenting stress, schooling, recurrent complaints.

Measure: Interview of the parents : contextual data

Time: Baseline

Description: related to education; related to daily family life; related to leisure, related to care (children/adolescents, parents)

Measure: Interview of the children/adolescents/ parents : Experience of the confinement in general

Time: Baseline

Description: related to education; related to daily family life; related to leisure, related to care (children/adolescents, parents)

Measure: Interview of the children/adolescents/ parents : Experience of the confinement in general

Time: 1 month

Description: related to education; related to daily family life; related to leisure, related to care (children/adolescents, parents)

Measure: Interview of the children/adolescents/ parents : Experience of the confinement in general

Time: 3 months

Description: Data relating to disease and management of care. Experience of the referring caregiver.

Measure: Interview of the referring caregiver : data relating to disease and management of care

Time: 3 months
4 Brain Imaging and Infant Development

The aims of the BIBS Study The Brain Imaging in Babies study (BIBS) aims to improve understanding of how a baby's brain develops from before birth, up until 3-4 years of age. Working with children from a variety of backgrounds and communities, the investigators use a combination of state-of-the-art diagnostic tools such as MRI scans alongside traditional behavioural assessments to capture the earliest information on infant brain development. The focus of the BIBS study MRI scanning is a safe way of producing detailed images using strong magnetic fields and radio waves. It does not use X-ray. Along with learning more about brain development in general, the investigators also try to identify features that may in future help predict whether a child will or will not develop traits of conditions such as Autism Spectrum Disorder (ASD) or Attention Deficit Hyperactivity Disorder (ADHD). Long-term, this may help target useful interventions early on, helping children who are most in need. Since COVID-19 arrived in the United Kingdom (U.K.) in 2020, the investigators have been given ethical approval to include testing for this infection in the mothers and children participating in the study. This may provide an opportunity to better understand how mother and baby respond to infections. The investigators particularly welcome mothers who have had a positive COVID-19 test during their pregnancy to join the study.

NCT04443179
Conditions
  1. Autism Spectrum Disorder
  2. Attention Deficit Hyperactivity Disorder
  3. Neurodevelopmental Conditions
  4. COVID-19
MeSH:Disease Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder
HPO:Attention deficit hyperactivity disorder Autistic behavior

Primary Outcomes

Measure: Neurodevelopmental Outcomes

Time: 3-4 years of age

HPO Nodes


HP:0007018: Attention deficit hyperactivity disorder
Genes 272
PPM1D DRD4 DNM1 DHCR7 SLC6A8 LIMK1 PTCHD1 CLCN4 TSC2 SCN3A STS DHTKD1 STAG2 SLC13A5 PMS2 SIM1 ACTL6B LHCGR FTSJ1 EPCAM HOXA2 KIF11 ELN CNKSR2 UPF3B GABRG2 UPF3B DRD5 SLC1A2 PWAR1 CLTC SETBP1 ATP6V1A NIPBL GNAQ GNE RAI1 RAB39B HCFC1 TSC1 SCN8A FGFR3 SCN8A ARHGEF6 TBX1 DYM HSPG2 SYNJ1 MED12 CACNA1H WWOX CHRNA7 MLH3 GNB5 TRAK1 CXORF56 MSH2 GALC RREB1 SEMA3E CPLX1 ADNP TSC2 NTRK2 NPAP1 CHD7 ARX CRBN ABCD1 BCORL1 SPRED1 TMCO1 IL1RAPL1 DYNC1I2 SMC3 GABRA2 RAI1 SH3KBP1 FGD1 NKAP PIEZO2 YY1 FLI1 RSRC1 GABRG2 MLXIPL CACNA1B TGFBR2 CNKSR2 C12ORF4 SMPD1 YWHAG RAD21 MCTP2 IGF1 CNKSR2 ARVCF RPS6KA3 MID2 RERE NDN IKBKG MAPK1 STS GLUD1 IQSEC2 SEMA4A ASPM HDC BAZ1B MED13 TAF1 WAC CYFIP2 UBE3A TBC1D24 NDP TSPAN7 SIN3A ALKBH8 MECP2 OCRL HERC2 ZDHHC9 TLK2 DPP6 AP3B2 EEF1A2 MAGEL2 GP1BB KCNB1 SMC1A GTF2IRD1 PIK3CA UFD1 RIC1 STXBP1 FAN1 SNORD115-1 NUS1 CACNA1A MKRN3-AS1 PTCHD1 ACSL4 SH2B1 GRIN2A TET3 RFC2 GNE GABRG2 PCNT GRIN2D LIG4 PANK2 CDK8 GTF2I PRKCG IFNG BMPR1A FOXP1 USP27X CLTC KIF14 DEAF1 SRPX2 SPG7 SIN3A SNRPN CLIP2 CRKL COMT NECAP1 GABRA1 GRIN2A SZT2 OPHN1 SH2B1 JMJD1C AARS1 FMR1 UBA5 SOX5 VPS13A NOP56 ARV1 PCGF2 ALG13 AGTR2 AUTS2 HIRA BCR IQSEC2 YWHAG PAK3 GRIA4 TBX1 NSUN2 MSH6 PMS1 MKRN3 JRK TBX1 GABRB3 PARS2 ZNF41 RERE MLH1 DPH1 FLII SETD5 CIC FRMPD4 KRAS KCNA2 TKT ZNF711 TRIO SNORD116-1 ELN PPP3CA MED12 DLG3 FGD1 GABRB2 GATA4 SYP TSC1 TRIO TBL2 CSNK2A1 GDI1 DMD SETD5 SLC9A7 PHIP TBX1 POLA1 PWRN1 MED12 RPS20 USP7 KMT2A TUBB2B MAP11 SATB2 FGF12 DNAJC12 DHDDS HDAC4 TIMM8A SEC24C GABRA5 PAH PRNP THRB IPW TKT ARF1 USP9X RAI1 KCNA2 NBN HCN1 SLC2A1 NR2F1 SYNGAP1 MED12 HDAC8 SLITRK1 ARID2 ZNF81 PAH
Protein Mutations 2
D203E G143E

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0007018: Attention deficit hyperactivity disorder
Genes 272
PPM1D DRD4 DNM1 DHCR7 SLC6A8 LIMK1 PTCHD1 CLCN4 TSC2 SCN3A STS DHTKD1 STAG2 SLC13A5 PMS2 SIM1 ACTL6B LHCGR FTSJ1 EPCAM HOXA2 KIF11 ELN CNKSR2 UPF3B GABRG2 UPF3B DRD5 SLC1A2 PWAR1 CLTC SETBP1 ATP6V1A NIPBL GNAQ GNE RAI1 RAB39B HCFC1 TSC1 SCN8A FGFR3 SCN8A ARHGEF6 TBX1 DYM HSPG2 SYNJ1 MED12 CACNA1H WWOX CHRNA7 MLH3 GNB5 TRAK1 CXORF56 MSH2 GALC RREB1 SEMA3E CPLX1 ADNP TSC2 NTRK2 NPAP1 CHD7 ARX CRBN ABCD1 BCORL1 SPRED1 TMCO1 IL1RAPL1 DYNC1I2 SMC3 GABRA2 RAI1 SH3KBP1 FGD1 NKAP PIEZO2 YY1 FLI1 RSRC1 GABRG2 MLXIPL CACNA1B TGFBR2 CNKSR2 C12ORF4 SMPD1 YWHAG RAD21 MCTP2 IGF1 CNKSR2 ARVCF RPS6KA3 MID2 RERE NDN IKBKG MAPK1 STS GLUD1 IQSEC2 SEMA4A ASPM HDC BAZ1B MED13 TAF1 WAC CYFIP2 UBE3A TBC1D24 NDP TSPAN7 SIN3A ALKBH8 MECP2 OCRL HERC2 ZDHHC9 TLK2 DPP6 AP3B2 EEF1A2 MAGEL2 GP1BB KCNB1 SMC1A GTF2IRD1 PIK3CA UFD1 RIC1 STXBP1 FAN1 SNORD115-1 NUS1 CACNA1A MKRN3-AS1 PTCHD1 ACSL4 SH2B1 GRIN2A TET3 RFC2 GNE GABRG2 PCNT GRIN2D LIG4 PANK2 CDK8 GTF2I PRKCG IFNG BMPR1A FOXP1 USP27X CLTC KIF14 DEAF1 SRPX2 SPG7 SIN3A SNRPN CLIP2 CRKL COMT NECAP1 GABRA1 GRIN2A SZT2 OPHN1 SH2B1 JMJD1C AARS1 FMR1 UBA5 SOX5 VPS13A NOP56 ARV1 PCGF2 ALG13 AGTR2 AUTS2 HIRA BCR IQSEC2 YWHAG PAK3 GRIA4 TBX1 NSUN2 MSH6 PMS1 MKRN3 JRK TBX1 GABRB3 PARS2 ZNF41 RERE MLH1 DPH1 FLII SETD5 CIC FRMPD4 KRAS KCNA2 TKT ZNF711 TRIO SNORD116-1 ELN PPP3CA MED12 DLG3 FGD1 GABRB2 GATA4 SYP TSC1 TRIO TBL2 CSNK2A1 GDI1 DMD SETD5 SLC9A7 PHIP TBX1 POLA1 PWRN1 MED12 RPS20 USP7 KMT2A TUBB2B MAP11 SATB2 FGF12 DNAJC12 DHDDS HDAC4 TIMM8A SEC24C GABRA5 PAH PRNP THRB IPW TKT ARF1 USP9X RAI1 KCNA2 NBN HCN1 SLC2A1 NR2F1 SYNGAP1 MED12 HDAC8 SLITRK1 ARID2 ZNF81 PAH
Protein Mutations 2
D203E G143E

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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