There is one clinical trial.
Mitochondrial disease is a rare disorder. It can cause poor growth, developmental delays,
muscle weakness, and other symptoms. The disease is usually inherited. It can be present at
birth or develop later in life. Infection is a major cause of disease and death in people
with this disease. Researchers want to learn more about how infection and the declining
health of people who have this disease may be related to the COVID-19 pandemic. To do this,
researchers will study the DNA of people who become ill with suspected or confirmed
coronavirus. Their DNA will be compared to the DNA of their family members.
To learn more about how genes may play a role in how COVID-19 affects people with
People age 2 months and older with mitochondrial disease and a suspected or confirmed
diagnosis of COVID-19.
Description: To identify immune signatures that associate with host responses todisease that would allow improved patient stratification and identification of potential therapeutic targets to mitigate the severesymptoms and sequelae of infection in mitochondrial disease.Measure: We will perform whole blood transcriptomic analysis, humoral response profiling and soluble mediator profiling. Time: Undefined for natural history study
Description: to stratify severity of illness based on clinical factors (e.g. intensive care status, ventilatory support, clinical laboratory data, radiologyrecords)Measure: Patient Medical Records for Data Abstraction Time: Undefined for natural history study
Description: to understand functional status, healthcare resource access and other sociodynamic factors as they affect the mitochondrial disease community.Measure: Patient centered outcomes data via questionnaires Time: Undefined for natural history study
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports