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D000257: Adenoviridae Infections

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug3789 artus Influenza A/B RT-PCR Test Wiki 0.58
drug178 Ad5-nCoV Wiki 0.58
drug370 Azithromycin Capsule Wiki 0.58
Name (Synonyms) Correlation
drug2834 Recombinant novel coronavirus vaccine (Adenovirus type 5 vector) Wiki 0.58
drug1403 Glucose tablets Wiki 0.58
drug369 Azithromycin 500Mg Oral Tablet Wiki 0.58
drug371 Azithromycin Tablets Wiki 0.41
drug1532 Hydroxychloroquine 200 Mg Oral Tablet Wiki 0.41
drug1538 Hydroxychloroquine Sulfate Wiki 0.17
drug2505 Placebo Wiki 0.03

Correlated MeSH Terms (8)


Name (Synonyms) Correlation
D003384 Coxsackievirus Infections NIH 0.58
D018184 Paramyxoviridae Infections NIH 0.33
D018357 Respiratory Syncytial Virus Infections NIH 0.20
Name (Synonyms) Correlation
D007251 Influenza, Human NIH 0.14
D014777 Virus Diseases NIH 0.06
D003141 Communicable Diseases NIH 0.04
D007239 Infection NIH 0.03
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Testing of Respiratory Specimens for the Validation of the QIAGEN ResPlex II Advanced Panel Test and the Artus Influenza A/B RT-PCR Test

The study will be conducted using nasopharyngeal swab specimens collected prospectively from individuals suspected of having the signs and symptoms of an acute respiratory tract infection caused by a respiratory virus. A series of standard viral culture tests validated for routine use in the clinical laboratory, and/or a series of PCR-based Laboratory Developed Tests (PCR-LDT) validated by a central reference laboratory will be used to verify the performance of the investigational artus Influenza A/B RT-PCR test and the QIAGEN ResPlex II Advanced Panel test. From each specimen five (5) aliquots will be prepared: (a) one aliquot will be tested in real-time using the assigned viral culture reference methods; (b) one aliquot will be used to extract nucleic acid in real-time for investigational testing; (c) one aliquot of the specimen will be stored at --70C for subsequent shipment to the reference laboratory for PCR-LDT testing, (d) one aliquot will be archived at -70C for subsequent follow-up by the reference laboratory (e.g., bi-directional sequencing of positive specimens), and (e) any remaining specimen will be stored for the Fresh vs. Frozen Study. The extracted nucleic acid generated from the second aliquot (i.e., "b" above) will be split and subjected to testing by both the artus Influenza A/B RT-PCR test and the ResPlex II Advanced Panel test.

NCT01302418
Conditions
  1. QIAGEN ResPlex II Advanced Panel
  2. Influenza A
  3. Respirat
  4. Respiratory Syncytial Virus Infections
  5. Infection Due to Human Parainfluenza Virus 1
  6. Parainfluenza Type 2
  7. Parainfluenza Type 3
  8. Parainfluenza Type 4
  9. Human Metapneumovirus A/B
  10. Rhinovirus
  11. Coxsackie Virus/Echovirus
  12. Adenovirus Types B/C/E
  13. Coronavirus Subtypes 229E
  14. Coronavirus Subtype NL63
  15. Coronavirus Subtype OC43
  16. Coronavirus Subtype HKU1
  17. Human Bocavirus
  18. Artus Influenza A/B RT-PCR Test
  19. Influenza B
Interventions
  1. Device: artus Influenza A/B RT-PCR Test
MeSH:Infection Communicable Diseases Virus Diseases Influenza, Human Coronavirus Infections Adenoviridae Infections Respiratory Syncytial Virus Infections Paramyxoviridae Infections Coxsackievirus Infections

Primary Outcomes

Description: The presence of Influenza A or Influenza B virus.

Measure: Detection of Respiratory Viruses

Time: Specimens will be taken within 5 days of the appearance of symptoms.
2 A Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of the Recombinant Novel Coronavirus Vaccine (Adenovirus Vector) in Healthy Adults Aged Above 18 Years

This is a phase II, randomised, double-blinded and placebo-controlled clinical trial in healthy adults above 18 years of age. This clinical trial is designed to evaluate the immunogenicity and safety of Ad5-nCoV which encodes for a full-length spike (S) protein of SARS-CoV-2.

NCT04341389
Conditions
  1. COVID-19
Interventions
  1. Biological: Recombinant novel coronavirus vaccine (Adenovirus type 5 vector)
  2. Other: Placebo
MeSH:Adenoviridae Infections

Primary Outcomes

Measure: Occurrence of adverse reactions

Time: 0-14 days post vaccination

Measure: Anti SARS-CoV-2 S IgG antibody response(ELISA)

Time: 28 days post vaccination

Measure: Neutralizing antibody response to SARS-CoV-2

Time: 28 days post vaccination

Secondary Outcomes

Measure: Occurrence of adverse events

Time: 0-28 days post vaccination

Measure: Occurrence of serious adverse reaction

Time: 0-6 months post vaccination

Measure: Anti SARS-CoV-2 S IgG antibody response(ELISA)

Time: 0, 14 days and 6 months post vaccination

Measure: Neutralizing antibody response to SARS-CoV-2

Time: 0 and 6 months post vaccination

Measure: Neutralizing antibody response to Ad5-vector

Time: 0, 28 days and 6 months post vaccination

Measure: IFN-γ ELISpot responses to SARS-CoV-2 spike protein

Time: 0 and 28 days post vaccination
3 A Clinical Trial to Evaluate the Safety and Immunogenicity of a Recombinant Adenovirus 5 Vectored COVID-19 Vaccine (Ad5-nCoV) With Two Doses in Healthy Adults Aged 18 Years and Older

This is a clinical trial to evaluate the safety and immunogenicity of a recombinant adenovirus 5 vectored COVID-19 vaccine (Ad5-nCoV) with two doses and with different adminstration routes in healthy adults aged 18 years and older.

NCT04552366
Conditions
  1. COVID-19
Interventions
  1. Biological: Ad5-nCoV
MeSH:Adenoviridae Infections

Primary Outcomes

Description: The occurrence of AE in all groups within 0-7 days after each vaccination;

Measure: Incidence of the AE in all groups

Time: 0-7 days after each vaccination

Description: Seroconversion rate the IgG antibody against SARS-CoV-2 measured on Day 28 after last vaccination

Measure: Seroconversion rate of the IgG antibody against SARS-CoV-2

Time: Day 28 after last vaccination

Description: Geomean titers of the IgG antibody against SARS-CoV-2 measured on Day 28 after last vaccination

Measure: Geomean titers of the IgG antibody against SARS-CoV-2

Time: Day 28 after last vaccination

Description: Seroconversion rate of the neutralizing antibody against SARS-CoV-2 measured on Day 28 after last vaccination

Measure: Seroconversion rate of the neutralizing antibody against SARS-CoV-2

Time: Day 28 after last vaccination

Description: Geomean titers of the neutralizing antibody against SARS-CoV-2 measured on Day 28 after last vaccination

Measure: Geomean titers of the neutralizing antibody against SARS-CoV-2

Time: Day 28 after last vaccination

Secondary Outcomes

Description: The occurrence of AE in all groups within 0-30 minutes and 0-28 days after each vaccination.

Measure: Incidence of the AE in all groups

Time: 0-30 minutes, 0-28 days after each vaccination

Description: The occurrence of Serious adverse events (SAE) in all groups within 6 months after the final vaccination.

Measure: Incidence of Serious adverse events (SAE) in all groups

Time: 6 months after the final vaccination

Description: Geomean titers of the IgG antibody against SARS-CoV-2 measured on Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

Measure: Geomean titers of the IgG antibody against SARS-CoV-2

Time: Day 0, 14, 28 and 56 after first vaccination and Day 14 and Day168 after last vaccination.

Description: Seroconversion rate of the IgG antibody against SARS-CoV-2 measured on Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

Measure: Seroconversion rate of the IgG antibody against SARS-CoV-2

Time: Day 0, 14, 28 and 56 after first vaccination and Day 14 and Day168 after last vaccination.

Description: Geomean titers of the neutralizing antibody against SARS-CoV-2 measured on Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

Measure: Geomean titers of the neutralizing antibody against SARS-CoV-2

Time: Day 0, 14, 28 and 56 after first vaccination and Day 14 and Day168 after last vaccination.

Description: Seroconversion rate of the neutralizing antibody against SARS-CoV-2 measured on Day 0, Day14, Day 28 or Day 56 after first vaccination and on day 14, day 28 and day168 after last vaccination.

Measure: Seroconversion rate of the neutralizing antibody against SARS-CoV-2

Time: Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

Description: The positive rate of IFN-γ stimulated by S protein overlapping peptide library detected by ELISpot on Day 0 and Day 14 after each vaccination

Measure: Cellular immune response by ELISpot

Time: Day 0 and Day 14 after each vaccination

Description: Geomean titers of neutralizing antibody response to Ad5-vector on Day 0, 14 and 28 after each vaccination.

Measure: Geomean titers of neutralizing antibody response to Ad5-vector

Time: Day 0, 14 and 28 after each vaccination.

Description: The positive rate of the specific cytokines expressed by CD4+ and CD8+ T lymphocytes stimulated by S protein overlapping peptide library detected by intracellular cytokine staining on Day 0 and Day 14 after each vaccination

Measure: Cellular immune response by ICS

Time: Day 0 and Day 14 after each vaccination

Description: Geomean titers of the IgA antibody against SARS-CoV-2 on Day 0, 14 and 28 after each vaccination.

Measure: Geomean titers of the IgA antibody against SARS-CoV-2

Time: Day 0, 14 and 28 after each vaccination

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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