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D059350: Chronic Pain

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (25)


Name (Synonyms) Correlation
drug977 DWJ1248 Wiki 0.30
drug1233 Exercise Group Wiki 0.30
drug3614 VCPM Wiki 0.30
Name (Synonyms) Correlation
drug1847 Liver function tests ,serum ferritin and PCR for COVID-19 . Wiki 0.30
drug962 D-dimer,CBC.ESR,CRP, Wiki 0.30
drug3834 chronic pain team Wiki 0.30
drug3064 Self-Compassion for Chronic Pain Virtual Group Treatment Program Wiki 0.30
drug726 Cannabis, Medical Wiki 0.30
drug1711 Intervention program Wiki 0.30
drug976 DUR-928 Wiki 0.30
drug582 CAP-1002 Allogeneic Cardiosphere-Derived Cells Wiki 0.30
drug1235 Exercise Testing and Training Wiki 0.30
drug956 CytoSorb 300 mL device Wiki 0.30
drug957 CytoSorb-Therapy Wiki 0.30
drug3383 Tele-Yoga Therapy Wiki 0.30
drug3829 chiropractic team Wiki 0.30
drug4071 questionnaire assesment Wiki 0.27
drug963 DAS181 Wiki 0.25
drug978 DWRX2003 Wiki 0.21
drug422 BNT162b2 Wiki 0.21
drug2422 Paracetamol Wiki 0.21
drug421 BNT162b1 Wiki 0.17
drug776 Chloroquine Wiki 0.11
drug2505 Placebo Wiki 0.07
drug2557 Placebo oral tablet Wiki 0.05

Correlated MeSH Terms (31)


Name (Synonyms) Correlation
D000070627 Chronic Traumatic Encephalopathy NIH 0.30
D005879 Tourette Syndrome NIH 0.30
D000070642 Brain Injuries, Traumatic NIH 0.21
Name (Synonyms) Correlation
D013122 Spinal Diseases NIH 0.21
D000690 Amyotrophic Lateral Sclerosis NIH 0.21
D000755 Anemia, Sickle Cell NIH 0.21
D016472 Motor Neuron Disease NIH 0.21
D001714 Bipolar Disorder NIH 0.21
D001930 Brain Injuries, NIH 0.18
D012640 Seizures NIH 0.17
D005356 Fibromyalgia NIH 0.15
D001927 Brain Diseases NIH 0.15
D059352 Musculoskeletal Pain NIH 0.12
D003095 Collagen Diseases NIH 0.12
D010300 Parkinsonian NIH 0.11
D015212 Inflammatory Bowel Diseases NIH 0.11
D012216 Rheumatic Diseases NIH 0.11
D013313 Stress Disorders, Post-Traumatic NIH 0.10
D003424 Crohn Disease NIH 0.10
D001172 Arthritis, Rheumatoid NIH 0.09
D012598 Scoliosi NIH 0.08
D009103 Multiple Sclerosis NIH 0.08
D001168 Arthritis NIH 0.08
D013577 Syndrome NIH 0.06
D040921 Stress Disorders, Traumatic NIH 0.06
D014947 Wounds and Injuries NIH 0.06
D004194 Disease NIH 0.05
D003141 Communicable Diseases NIH 0.02
D007239 Infection NIH 0.02
D045169 Severe Acute Respiratory Syndrome NIH 0.01
D018352 Coronavirus Infections NIH 0.01

Correlated HPO Terms (10)


Name (Synonyms) Correlation
HP:0012532 Chronic pain HPO 0.90
HP:0006802 Abnormal anterior horn cell morphology HPO 0.30
HP:0007354 Amyotrophic lateral sclerosis HPO 0.30
Name (Synonyms) Correlation
HP:0100754 Mania HPO 0.21
HP:0001250 Seizure HPO 0.17
HP:0001298 Encephalopathy HPO 0.15
HP:0002037 Inflammation of the large intestine HPO 0.11
HP:0001370 Rheumatoid arthritis HPO 0.11
HP:0100280 Crohn's disease HPO 0.10
HP:0001369 Arthritis HPO 0.09

Clinical Trials

Navigate: Correlations   HPO

There are 11 clinical trials


1 Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD

The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical injuries and exposure to psychological trauma. Health behavior change has become increasingly important in treating these conditions and proactively preventing long-term negative health sequelae, in order to benefit these Veterans directly and reduce the growing challenges to our healthcare system. The proposed CDA-2 program of research will use an innovative translational research approach to study whether a chronic progressive -based exercise program will reduce chronic pain in patients with PTSD and to elucidate and modify potential PTSD-related deficiencies in neurobiological and psychological responses to exercise to optimize the physical and psychological benefits of exercise for these individuals.

NCT03283163
Conditions
  1. Chronic Musculoskeletal Pain
  2. Posttraumatic Stress Disorder (PTSD)
  3. Mild or Moderate Traumatic Brain Injury
Interventions
  1. Behavioral: Exercise Testing and Training
MeSH:Musculoskeletal Pain Brain Injuries Brain Injuries, Traumatic Chronic Pain Stress Disorders, Post-Traumatic
HPO:Chronic pain

Primary Outcomes

Description: To be administered at: Screening Evaluation & Endpoint 13 week exercise test sessions This 30-item structured interview is designed to assess both the 17 symptoms of PTSD and the 8 hypothesized associated features. The scale yields a dichotomous diagnosis of PTSD, and also provides a continuous score of frequency and severity for each symptom. In addition, a behaviorally anchored probe question is provided for each symptom to increase the reliability of administration. The CAPS-5 is currently in the process of being validated however its previous version demonstrated excellent sensitivity (.81) and specificity (.95).57

Measure: Change from Baseline: Clinician Administered PTSD Scale -5

Time: Baseline and endpoint (at 13 weeks)

Description: The WHY-MPI has been demonstrated to be applicable across a variety of clinical pain conditions. Its brevity, validity/ reliability, self-report nature and ease of scoring make it ideal for both clinical and research purposes. The WHY-MPI is sensitive to change following rehabilitation. Please note only the interference subscale of the WHY-MPI will be administered in this study.

Measure: Change from Baseline: West Haven=Yale Multidimensional Pain Inventory- Interference Subscale (WHY-MPI)

Time: Baseline, Midpoint (at 6 weeks) and Endpoint (at 13 weeks)
2 Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19

This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

NCT03944447
Conditions
  1. Chronic Pain
  2. Chronic Pain Syndrome
  3. Chronic Pain Due to Injury
  4. Chronic Pain Due to Trauma
  5. Fibromyalgia
  6. Seizures
  7. Hepatitis C
  8. Cancer
  9. Crohn Disease
  10. HIV/AIDS
  11. Multiple Sclerosis
  12. Traumatic Brain Injury
  13. Sickle Cell Disease
  14. Post Traumatic Stress Disorder
  15. Tourette Syndrome
  16. Ulcerative Colitis
  17. Glaucoma
  18. Epilepsy
  19. Inflammatory Bowel Diseases
  20. Parkinson Disease
  21. Amyotrophic Lateral Sclerosis
  22. Chronic Traumatic Encephalopathy
  23. Anxiety
  24. Depression
  25. Insomnia
  26. Autism
  27. Opioid-use Disorder
  28. Bipolar Disorder
  29. Covid19
  30. SARS-CoV Infection
  31. COVID-19
  32. Corona Virus Infection
  33. Coronavirus
Interventions
  1. Drug: Cannabis, Medical
MeSH:Infection Communicable Diseases Coronavirus Infections Severe Acute Respiratory Syndrome Fibromyalgia Crohn Disease Inflammatory Bowel Diseases Parkinson Disease Multiple Sclerosis Brain Injuries Brain Injuries, Traumatic Seizures Moto Motor Neuron Disease Amyotrophic Lateral Sclerosis Brain Diseases Tourette Syndrome Chronic Traumatic Encephalopathy Anemia, Sickle Cell Disease Syndrome Sclerosis Chronic Pain Wounds and Injuries Stress Disorders, Traumatic Bipolar Disorder Stress Disorders, Post-Traumatic
HPO:Abnormal anterior horn cell morphology Amyotrophic lateral sclerosis Bilateral tonic-clonic seizure Bipolar affective disorder Chronic pain Crohn's disease Encephalopathy Focal-onset seizure Generalized-onset seizure Inflammation of the large intestine Mania Seizure

Primary Outcomes

Description: Covid-19 infection rates in cannabis users will be compared to rates in the general population. Our online questionnaire responses will compare infection rates of cannabis users in this study against the Johns Hopkins University Coronavirus Research Center data (https://coronavirus.jhu.edu).

Measure: Prevention of COVID-19

Time: Five years

Description: Severity of persistent symptoms in cannabis users testing positive for active infection and/or antibodies will also be compared to the general population. Patients will answer the widely used FLU-PRO questionnaire, which asks about flu symptoms and severity, to capture diagnoses, symptoms, and medical interventions related to COVID-19. The data from cannabis user patients will be compared with national and international data surveys, such as the Covid Symptom Study (https://covid.joinzoe.com/us-2).

Measure: Treatment of COVID-19

Time: Five years

Description: The primary objective is to assess the efficacy and safety of medical cannabis as medicine for treatment of chronic pain and other chronic debilitating diseases. Pain will be measured by Brief Pain Inventory (BPI) numeric scale. Change from baseline in BPI will be assessed at 3-month intervals. For prospective associations between cannabis use and outcomes, use of a lagged mixed-effects models will examine temporal associations between cannabis use and pain severity, opioid sparing, and patient satisfaction. Data will be analyzed from baseline and the annual follow-up waves.

Measure: Treatment of Symptoms

Time: Five years

Secondary Outcomes

Description: Secondary objectives include evaluating increases or decreases in quality of life, and increases or decreases in concomitant opioid use. Satisfaction with treatment will be measured by a Visual Analog Score (VAS). Change From baseline in Satisfaction with treatment measured by (VAS) be assessed at 3-month intervals.

Measure: Cannabis Impact on Quality of Life

Time: Five years

Description: Tertiary objectives will examine preferences for routes of administration, and preferences for THC / CBD ratios. Categorical factors will be summarized using frequencies and percentages, while continuous measure distributions will be described using means, standard deviations, and quartiles of interest.

Measure: Cannabis Route and Dosing

Time: Five years

Description: Incidence of Treatment-Related Adverse Events will be measured by Physician Global Assessment (PGA) numeric scale. Number of participants with Treatment-Related Adverse Events will be assessed by CTCAE v4.0.

Measure: Monitoring Adverse Events

Time: Five years
3 Psychological Impact of Quarantine in Rheumatoid Arthritis Patient During COVID-19 Outbreak

Clinical data about psychological impact of quarantine are well studied in transient event or more prolonged situation like jail incarceration. In recent metaanalysis, psychological impact of quarantine was well documented in a specific population during first SARS epidemy. Even after the end of quarantine several patients were still with symptom of avoiding mainly agoraphobia, frequent hand washing and a carefull return to normal life COVID-19 infection is already associated with psychological symptom like anxiety, depression, sleep disorders and symptoms of acute stress However psychological impact of quarantine is on none in chronic painful inflammatory rheumatism in France. The prevalence of rheumatoid arthritis is 0.5% of the population with frequent comorbidity such as anxiety and depression. During the quarantine secondary to COVID-19 pandemic it's possible to evaluated the psychological impact of adult RA patients. The present study is an "emergency" being realize before the end of the quarantine.

NCT04351399
Conditions
  1. Sars-CoV2
  2. Rheumatic Diseases
  3. Rheumatoid Arthritis
  4. Chronic Pain
Interventions
  1. Other: questionnaire assesment
MeSH:Arthritis Arthritis, Rheumatoid Rheumatic Diseases Collagen Diseases Chronic Pain
HPO:Arthritis Chronic pain Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Measure: Frequency of RA patients with emotional impact (feeling of isolation)

Time: maximum 1 week from baseline on

Secondary Outcomes

Description: Self reported questionnaire with questions to assess the characteristic,intensity of pain on quality of life, and consumption of analgesic.

Measure: self-reported questionnaire for painful

Time: maximum 1 week from baseline on
4 Psychological Impact of Quarantine in Chronic Pain Patient During COVID-19 Outbreak

In the context of quarantine with COVID-19, we will study the experience and psychological impact of pain in adult patients living with chronic pain. We will evaluate the link between the question of physical and psychological confinement in the experience of pain in this particular situation

NCT04353011
Conditions
  1. Sars-CoV2
  2. Chronic Pain
Interventions
  1. Other: questionnaire assesment
MeSH:Chronic Pain
HPO:Chronic pain

Primary Outcomes

Measure: Hospital Anxiety and Depression Scale questionnaire

Time: 1 week from baseline on

Secondary Outcomes

Measure: Quality of life (SF36)

Time: 1 week from baseline on

Measure: self-reported questionnaire for painful

Time: 1 week from baseline on

Measure: qualitive questionnaire

Time: 1 week from baseline on
5 The Impact of Quarantine and the Effectiveness of Telerehabilitation in Patients With Chronic Pain During COVID-19 Pandemic.

The quarantine during COVID-19 pandemic has changed daily routine. Staying at home for prolonged periods of time can pose a significant challenge for patients with chronic pain. The purpose of the current study is to investigate how the quarantine effects of psychosocial factors, quality of life, sleep, nutrition and physical activity in patients with chronic musculoskeletal pain. Another purpose is to examine whether a telerehabilitation exercise program is effective during the lockdown period.

NCT04381000
Conditions
  1. Chronic Pain
Interventions
  1. Other: Exercise Group
MeSH:Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: To measure the levels of anxiety and depression Hospital Anxiety and Depression Scale (HADS), will be used. Patients have to score 14 opinions. Seven of the items relate to anxiety and seven relate to depression. A cut-off point of 8/21 for anxiety or depression has been recommended.

Measure: Anxiety and Depression

Time: Change From Baseline in HADS at 40 days

Description: To measure quality of life, EQ-5D-3L will be used. The EQ-5D-3L essentially consists of 2 pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The EQ-5D-3L descriptive system comprises the following five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 3 levels: no problems, some problems, and extreme problems. The patient is asked to indicate his/her health state by ticking the box next to the most appropriate statement in each of the five dimensions. This decision results into a 1-digit number that expresses the level selected for that dimension. The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.

Measure: Quality of Life and overall health

Time: Change From Baseline in EQ-5D-3L at 40 days

Description: The Numeric Pain Rating Scale (NPRS) is a unidimensional measure of pain intensity in adults and it will be used in the current study. The most commonly used is the 11-item NPRS. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable").The NPRS is a valid and reliable scale to measure pain intensity. In this study, will rate current pain intensity and mean pain intensity during the past 7 days.

Measure: Pain Intensity

Time: Change From Baseline in NPRS Scores at 40 days

Secondary Outcomes

Description: The Pittsburgh Sleep Quality Index (PSQI) is an effective instrument used to measure the quality and patterns of sleep in the older adult. PSQI will be used to assess quality and patterns of sleep in the current study. PSQI differentiates "poor" from "good" sleep by measuring seven domains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction over the last month. The client self-rates each of these seven areas of sleep. Scoring of the answers is based on a 0 to 3 scale, whereby 3 reflects the negative extreme on the Likert Scale. A global sum of "5" or greater indicates a "poor" sleeper. Although there are several questions that request the evaluation of the client's bed mate or roommate, these are not scored, nor reflected in the attached instrument. An update to the scoring: if 5 is not complete or the value is missing, it now counts as a "0".

Measure: Quality and patterns of sleep

Time: Change From Baseline in PSQI Scores at 40 days

Description: Patients' illness perceptions will be measured based on the Brief Illness Perception Questionnaire (BIPQ). The patient has to rate 8 statements on a 10-point scale (1-10). The higher the score, the greater is the extent to which the patient's illness perceptions are threatening him or her.

Measure: Patients' illness perceptions

Time: Change From Baseline in BIPQ Scores at 40 days

Description: Disability will be assessed using Oswestry Disability Index (ODI) that present ten sections cover Pain, Personal Care, Lifting, Walking, Sitting, Standing, Sleeping, Sex Life, Social Life, and Traveling. Each section has six statements reflecting an increasing level of disability. Respondents choose the statement that most applies to them in each section. The first statement is scored 0; the second is scored 1 and so on to 5 for the last statement. The sum of the section scores is divided by 50 if all sections are completed and multiplied by 100 for the final percentage score.

Measure: Disability

Time: Change From Baseline in ODI Scores at 40 days
6 Early Care, Therapeutic Education, and Psychological Intervention for the Management of Post-intensive Care Syndrome and Chronic Pain After Coronavirus Disease 2019 Infection. Simple-blind, Controlled, Randomized Trial.

COVID-19 (coronavirus 2019) disease has led to a large number of hospital admissions, many of which require admission to intensive care (ICU). Post-intensive care syndrome (PICS) is defined as deterioration or worsening of previous deterioration in the mental, physical or cognitive status that appears as a consequence of a critical illness and which persists after acute hospital care. Also, there is evidence that patients who survive a critical illness have a high prevalence of moderate to extreme chronic pain. Patients with COVID-19 disease are an especially susceptible population to develop PICS due to acute respiratory distress syndrome (ARDS) survivors have significant long-term deterioration in mental, cognitive, and functional health. This study hypothesis is that a specific care program based on early therapeutic education and psychological intervention improves the quality of life of patients at risk of developing PICS and chronic pain after COVID-19 disease.

NCT04394169
Conditions
  1. Post ICU Syndrome
  2. Chronic Pain
  3. Covid-19
Interventions
  1. Behavioral: Intervention program
MeSH:Syndrome Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: Health-related quality of life reported by the patient assessed through the visual analogue scale of the EQoL 5D/5L questionnaire at six months after discharge. [European quality of life 5 dimensions/5 levels ; from 0 (the worst imaginable health) to 100 (the best imaginable health) ]

Measure: Impact of intervention program on health-related quality of life (VAS)

Time: Six months after discharge

Secondary Outcomes

Description: Health-related quality of life reported by the patient assessed through the visual analogue scale of the EQoL 5D / 5L questionnaire at three months after discharge. [European quality of life 5 dimensions/5 levels ; from 0 (the worst imaginable health) to 100 (the best imaginable health)]

Measure: Impact of intervention program on health-related quality of life (VAS)

Time: Three months after discharge.

Description: Health-related quality of life reported by the patient assessed through health index of the EQoL 5D/5L questionnaire at three months after discharge. [European quality of life 5 dimensions/5 levels ; the questionnaire assesses quality of life in study participants according to 5 domains (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) each scored according to a scale of 1 (no problems) to 5 (indicating extreme problems) and generating a 5-digit code corresponding to quality of life]

Measure: Impact of intervention program on health-related quality of life (Index)

Time: Three months after discharge

Description: Health-related quality of life reported by the patient assessed through health index of the EQoL 5D/5L questionnaire at six months after discharge. [European quality of life 5 dimensions/5 levels ; the questionnaire assesses quality of life in study participants according to 5 domains (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) each scored according to a scale of 1 (no problems) to 5 (indicating extreme problems) and generating a 5-digit code corresponding to quality of life]

Measure: Impact of intervention program on health-related quality of life (Index)

Time: Six months after discharge

Description: Chronic pain intensity defined by BPI questionnaire (short version), at three and six months after discharge. [Brief pain inventory; A multidimensional questionnaire that evaluates pain intensity in the last 24 hours (worst, lowest, average) and current (right now). The questions are rated on a scale of 0 to 10, with 10 being the worst possible value. Subsequently, the average intensity score (BPI intensity score) is calculated.]

Measure: Impact of intervention program on chronic pain (intensity)

Time: Three and six months after discharge.

Description: Limitation of daily activities due to chronic pain, defined by BPI (short version), at three and six months after discharge. [Brief pain inventory; Multidimensional questionnaire that assesses the impact of pain on daily activities (general activity, encouragement, work, relationships with other people, sleep, enjoying life and the ability to walk). The questions are rated on a scale of 0 to 10, with 10 being the worst possible value. Subsequently, the mean score of the responses related to pain interference in activities (BPI interference score) is calculated.]

Measure: Impact of intervention program on chronic pain (limitation of daily activities)

Time: Three and six months after discharge.

Description: Pain catastrophization assessed by Pain Catastrophizing Scale at three and six months after hospital discharge. [Pain Catastrophizing Scale; Consisting of 13 questions that explore the frequency of thoughts and feelings that the interviewees have in the presence of current or anticipated pain, which are grouped into three scoring subscales (magnification, rumination and defenselessness). Each question is rated on a 5-point scale (0: not at all; 4: all the time). Being the maximum total score of 52 points.]

Measure: Impact of intervention program on chronic pain (Pain catastrophization)

Time: Three and six months after discharge.

Description: Clinically significant anxiety or depression symptoms prevalence at three and six months, assessed by the HAD test. [hospital anxiety and depression test; 14 questions, with two subscales, one for anxiety and the other for depression, with seven items each, the maximum score is 21 for each subscale. The cut-off points from zero to seven imply the absence of clinically relevant anxiety and depression, from eight to ten symptoms that require consideration and from 11 to 21 reports the presence of relevant symptoms, with a very probable diagnosis of anxiety or depression.]

Measure: Impact of intervention program on anxiety or depression incidence

Time: Three and six months after discharge.

Description: Probable post-traumatic stress syndrome prevalence at three and six months after discharge assessed by the DSM ( Diagnostic and Statistical Manual of Mental Disorders) V PTSD Checklist questionnaire (PCL-5) [PTSD Checklist questionnaire; It contains 20 questions that correspond to the DSM V PTSD (Post Traumatic Stress Disorder) criteria. Participants rated their symptoms on a scale of 0 (not at all), 1 (slightly), 2 (moderately), 3 (quite) to 4 (extremely), with a score ranging from 0 to 80. A total of the severity of the symptoms can be made, adding the score of each question (interval 0-80). The severity of each symptom can be evaluated, adding the score of the questions. The cut-off point to use for a provisional diagnosis of PTSD is 31 points.]

Measure: Impact of intervention on probable post-traumatic stress syndrome incidence

Time: Three and six months after discharge.
7 A Self-compassion Group-based Treatment for Chronic Pain Via Video Conferencing During the COVID-19 Pandemic: Feasibility Study for a Potential New Mode of Treatment Delivery

As a result of COVID-19 and measures taken by the Canadian Government to reduce the transmission of the virus, in-person psychology services have been suspended. Psychology services are now being conducted via video conferencing. The purpose of the current project is to pilot-test a 6-week Self Compassion Treatment for Chronic Pain delivered virtually, in order to understand its utility in the current environment. The treatment is to be delivered through a secure professional ZOOM licence. Objective 1 of the project is to assess the feasibility and acceptability of attending the treatment group through virtual participation. Objective 2 is to assess the effectiveness of the group treatment in improving self-compassion, mental health, relationship with pain, and quality of life.

NCT04413006
Conditions
  1. Chronic Pain
Interventions
  1. Behavioral: Self-Compassion for Chronic Pain Virtual Group Treatment Program
MeSH:Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: Change over time in scores on the Self-Compassion Scale (SCS) (score range is 12-60 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Scores on the Self-Compassion Scale (SCS)

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in scores on the Pain Disability Index (score range is 0-70 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Scores on the Pain Disability Index

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Secondary Outcomes

Description: Change over time in scores on the on the Chronic Pain Acceptance Questionnaire - 8 (CPAQ-8) (score range is 0-48 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Scores on the Chronic Pain Acceptance Questionnaire - 8

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in scores on the on the Pain Catastrophizing Scale-6 (PCS-6) (score range is 0-24 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Scores on the Pain Catastrophizing Scale -6

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in Scores on the Pain Self-Efficacy Questionnaire-4 (PSEQ-4) (score range is 0-24 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Scores on the Pain Self-Efficacy Questionnaire-4

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in scores on the Numeric Rating Scale (NRS) for pain (score range is 0-10 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Pain Intensity

Time: at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in scores on the Patient Health Questionnaire-9 (PHQ-9) (score range is 0-27 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Depression Symptoms as measured by the Patient Health Questionnaire-9 (PHQ-9)

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in scores on the Generalized Anxiety Scale (GAD-7) (score range is 0-21 with decreases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Changes over time in Anxiety Symptoms as measured by the Generalized Anxiety Scale-7

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Change over time in scores on the Physical Health and Mental Health Quality of Life scores from the PROMIS GLOBAL-10 (score range is 7-35 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Change over time in Quality of Life as measured by the PROMIS GLOBAL- 10

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Description: Changes over time in score on the Mindfulness Attention and Awareness Scale (MAAS) (score range is 15-90 with increases in scores meaning better outcome). Change over time to be assessed via repeated measures Analysis of Variance (ANOVA)

Measure: Changes over time in Mindfulness

Time: baseline, at treatment end (6-weeks after beginning treatment) and 3 months later

Other Outcomes

Description: Scores on the Client Satisfaction Questionnaire

Measure: Client Satisfaction

Time: post treatment (6 weeks after beginning the treatment)
8 Tele- Yoga Therapy for Patients With Chronic Pain During Covid-19 Lockdown: A Prospective Non-randomized Single Arm Clinical Trial

Chronic pain is highly prevalent and associated with a large symptom burden, that is had been more concerning during Covid-19 outbreak and lockdown. Benefits of yoga in chronic pain management are very well known. With this background we developed Tele-Yoga therapy program and evaluated the success of this single arm study.

NCT04457388
Conditions
  1. Chronic Pain
Interventions
  1. Other: Tele-Yoga Therapy
MeSH:Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: visual-analogic scale (VAS), using pain level from "no pain" (0) to "worst imaginable pain" (10)

Measure: Pain Intensity

Time: From baseline to 6-week post intervention

Secondary Outcomes

Description: Pain Disability Index (PDI) using seven rating scales, structured in Likert form, from "no disability" (0) to "worst disability" (10)

Measure: Pain Disability

Time: From baseline to 6-week post intervention

Description: Hospital Anxiety Depression Scale, consisting of 7 scales for measuring anxiety levels

Measure: Anxiety

Time: From Baseline to 6-week post intervention

Description: Hospital Anxiety Depression Scale, consisting of 7 scales for measuring depression levels

Measure: Depression

Time: From baseline to 6-week post intervention
9 An Observational Study of Integrated Chronic Pain Management in a Community Health Center

This was a prospective observational study with the primary objective of quantifying a change in pain scores after 6-12 months of two separate interventions within the study site (pain team and chiropractic team). Target enrollment was 30 participants for each intervention. The primary outcome was a change from baseline of the Pain Disability Questionnaire (PDQ), the study tool. Secondary outcomes were reduction of opioid dose by morphine equivalent daily dose, and its effect on PDQ scores.

NCT04490291
Conditions
  1. Chronic Pain
  2. Spine Disease
Interventions
  1. Other: chronic pain team
  2. Other: chiropractic team
MeSH:Spinal Diseases Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: 6-12 month follow up pain score - (minus) baseline. scores range from 0 (no pain or disability) to 150 (severe pain and disability)

Measure: change in Pain Disability Questionnaire (PDQ) score

Time: 6-12 month

Secondary Outcomes

Description: ability to successfully wean off opioid prescription

Measure: prescription opioid weaning

Time: 6-12 months
10 Paracetamol Discontinuation in the Elderly After Long-term Consumption

To investigate if long-term treatment of paracetamol can be discontinued without no worsening on pain, health-related quality-of-life and level of function compared to continuing paracetamol treatment in patients aged 65 years or more.

NCT04523740
Conditions
  1. Pain, Chroni
  2. Pain, Chronic
  3. Pain, Medication
  4. Pain, Discontinuation
Interventions
  1. Drug: Placebo
  2. Drug: Paracetamol
MeSH:Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: Comparison of changes in visual analog scale (VAS) pain intensity during the last 24 hours, from baseline value at week 2 between the control and intervention group. VAS is a 0-100 mm scale where 0 is "no pain" and 100 is "worst pain"

Measure: Visual analog scale (VAS) pain during til last 24 hours

Time: Change from baseline value at week 2

Secondary Outcomes

Description: Comparison of changes in EQ5D-5L index from baseline values at week 2 between the control and intervention group. EQ-5D is an abbreviation for "European Quality of life - 5 Dimensions" and measures Quality of Life. The scale has five subcomponents with scores from 1 (best) to 5 (worst). The five subcomponents constitute a health state that is translated into an index value using the Danish Crosswalk Index Value Calculator from Euroqol's website. The index value is anchored at 0 = death and 1 = full health and the range in the Danish population is from -0.624 (worse than death) to 1.0 (full health). Higher values / increases in index value is better than lower values / decreases in index value.

Measure: EQ5D-5L index

Time: Change from baseline value at week 2

Description: Number of participants that initiate other regular analgesics or withdraw from the trial

Measure: Treatment failure.

Time: Week 2

Description: Functional level is measured by grib strength with a Hand Dynamometer

Measure: Grip strength

Time: Change from baseline value at week 2

Description: Functional level is measured by a sitting-rising test

Measure: Sitting-rising test

Time: Change from baseline value at week 2

Description: Collected from a trial diary. Visual analog scale (VAS) is a 0-100 mm scale where 0 is "no pain" and 100 is "worst pain"

Measure: Sum of daily visual analog scale (VAS) pain

Time: Sum from baseline to week 2

Description: Did the intervention change the participants' paracetamol consumption after ending the treatment period.

Measure: Followup: Number of regular users (3 grams of paracetamol or more per day) since ending treatment period.

Time: week 26

Description: Comparison of changes from baseline and week 2 values at week 26 (post treatment period). Visual analog scale (VAS) is a 0-100 mm scale where 0 is "no pain" and 100 is "worst pain"

Measure: Followup: Visual analog scale (VAS) pain during til last 24 hours

Time: Week 26

Description: Comparison of changes in EQ5D-5L index from baseline and week 2 values at week 26 (post treatment period) between the control and intervention group. EQ-5D is an abbreviation for "European Quality of life - 5 Dimensions" and measures Quality of Life. The scale has five subcomponents with scores from 1 (best) to 5 (worst). The five subcomponents constitute a health state that is translated into an index value using the Danish Crosswalk Index Value Calculator from Euroqol's website. The index value is anchored at 0 = death and 1 = full health and the range in the Danish population is from -0.624 (worse than death) to 1.0 (full health). Higher values / increases in index value is better than lower values / decreases in index value.

Measure: Followup: EQ5D-5L index

Time: Week 26

Description: Number of participants who initiated regular use of other analgesics and comparison of changes between the control and intervention group (post treatment period)

Measure: Trial failure

Time: Week 26
11 Virtual Pain Care for High Risk Veterans on Opioids During COVID19 (and Beyond)

The COVID-19 pandemic is exacerbating the challenges faced by Veterans at risk of opioid overdose including Veterans prescribed moderate-to-high dose long-term opioid therapy (LTOT) whose usual treatment resources and coping strategies may be inaccessible. This project combines established VA care components to deploy and evaluate virtual models of care for Veterans on high-risk LTOT to meet the dual challenges of maintaining social distancing and delivery high quality care.

NCT04539821
Conditions
  1. Chronic Pain
Interventions
  1. Other: VCPM
MeSH:Chronic Pain
HPO:Chronic pain

Primary Outcomes

Description: Although the project will use shared decision-making with Veterans, the percent of patients who agree to transfer will provide a realistic indicator of overall feasibility/acceptability.

Measure: the percent of patients who agree to Buprenorphine transfer

Time: 30 days

Secondary Outcomes

Description: overall measure of engagement

Measure: percent of complete tapering or BUP transition

Time: 60 days

HPO Nodes


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