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D010190: Pancreatic Neoplasms

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (9)


Name (Synonyms) Correlation
drug927 Cospherunate/Azythromycine Wiki 0.50
drug1570 Hydroxycloroquine and Azythromycine Wiki 0.50
drug83 ADCT-301 Wiki 0.50
Name (Synonyms) Correlation
drug853 Community based combination HIV prevention package Wiki 0.50
drug1189 Endoscopic management according to standard of care Wiki 0.50
drug928 Cospherunate/Phytomedicine/Azythromycien Wiki 0.50
drug1225 Evaluation of changes in the diagnostic-therapeutic pathway for patients affected by pancreatic cancer Wiki 0.50
drug2419 Palliative care assessment Wiki 0.50
drug2458 Pembrolizumab Wiki 0.35

Correlated MeSH Terms (8)


Name (Synonyms) Correlation
D002761 Cholangitis NIH 0.50
D018281 Cholangiocarcinoma NIH 0.50
D008105 Liver Cirrhosis, Biliary NIH 0.50
Name (Synonyms) Correlation
D041781 Jaundice, Obstructive NIH 0.50
D007565 Jaundice, NIH 0.35
D002292 Carcinoma, Renal Cell NIH 0.29
D064726 Triple Negative Breast Neoplasms NIH 0.29
D002277 Carcinoma NIH 0.18

Correlated HPO Terms (7)


Name (Synonyms) Correlation
HP:0002894 Neoplasm of the pancreas HPO 1.00
HP:0030153 Cholangiocarcinoma HPO 0.50
HP:0002613 Biliary cirrhosis HPO 0.50
Name (Synonyms) Correlation
HP:0000952 Jaundice HPO 0.50
HP:0030151 Cholangitis HPO 0.50
HP:0005584 Renal cell carcinoma HPO 0.29
HP:0030731 Carcinoma HPO 0.18

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 A Phase 1b, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of Camidanlumab Tesirine (ADCT-301) as Monotherapy or in Combination in Patients With Selected Advanced Solid Tumors

This study evaluates ADCT-301 in patients with Selected Advanced Solid Tumors. Patients will participate in a Treatment Period with 3-week cycles and a Follow-up Period every 12 weeks for up to 1 year after treatment discontinuation.

NCT03621982
Conditions
  1. Advanced Solid Tumors With Literature Evidence of CD25(+) Treg Content
  2. Head and Neck Cancer Squamous Cell Carcinoma
  3. Non-small Cell Lung Cancer
  4. Gastric Cancer
  5. Esophageal Cancer
  6. Pancreas Cancer
  7. Bladder Cancer
  8. Renal Cell Carcinoma
  9. Melanoma
  10. Triple-negative Breast Cancer
  11. Ovarian Cancer
  12. Colo-rectal Cancer
Interventions
  1. Drug: ADCT-301
  2. Biological: Pembrolizumab
MeSH:Carcinoma Carcinoma, Renal Cell Triple Negative Breast Neoplasms Pancreatic Neoplasms
HPO:Carcinoma Clear cell renal cell carcinoma Neoplasm of the pancreas Papillary renal cell carcinoma Renal cell carcinoma

Primary Outcomes

Description: An AE is defined as any untoward medical occurrence in a participant or clinical investigation subject administered a pharmaceutical product, which does not necessarily have to have a causal relationship with this treatment.

Measure: Assessment of Dose Limiting Toxicities in Determination of the Maximum Tolerated Dose Limiting toxicities as defined per protocol, as related to ADCT-301

Time: Up to 3 years

Description: Adverse events will be graded according to CTAE v4.0 (or more recent). For events not included in the CTCAE criteria, the severity of the AE will be graded on a scale of 1 to 5.

Measure: Number of Adverse Events of Common Terminology Criteria for Adverse Events (CTCAE) Grade 3 or Above

Time: Up to 3 years

Description: A SAE is defined as any AE that results in death, is life threatening, requires inpatient hospitalization of prolongation of existing hospitalization (hospitalization for elective procedures or for protocol compliance is not considered an SAE), results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect or important medical events that do not meet the preceding criteria but based on appropriate medical judgement may jeopardize the patient or may require medical or surgical intervention to prevent any of the outcomes listed above.

Measure: Number of Serious Adverse Events (SAE)

Time: Up to 3 years

Description: AEs will be graded according to CTCAE v.4.0 (or more recent). For events not included in the CTCAE criteria, the severity of the AE will be graded on a scale of 1 to 5.

Measure: Number of SAEs of Common Terminology Criteria for Adverse Events (CTCAE) Grade 3 or Above

Time: Up to 3 years

Measure: Number of Dose Interruptions and/or Dose Reductions

Time: Up to 3 years

Measure: Number of Dose Limiting Toxicities

Time: Up to 3 years

Measure: Number of Participants who Experience a Clinically Significant Change in Baseline in Laboratory Values

Time: Up to 3 years

Measure: Number of Participants who Experience a Clinically Significant Change in Baseline in Vital Signs

Time: Up to 3 years

Measure: Number of Participants who Experience a Clinically Significant Change in Baseline in Electrocardiogram (ECG) Results

Time: Up to 3 years

Measure: Number of Particpants who Experience a Clinically Significant Change in Baseline in Eastern Cooperative Oncology Group (ECOG) Performance Status

Time: Up to 3 years

Secondary Outcomes

Description: Overall response rate (ORR) according to the Response Evaluation Criteria In Solid Tumors (RECIST) v1.1

Measure: Evaluate the preliminary anti-tumor activity of camidanlumab tesirine

Time: Up to 3 years

Description: Duration of response (DOR) defined as the time from the first documentation of tumor response to disease progression as per RECIST v1.1

Measure: Evaluate the preliminary anti-tumor activity of camidanlumab tesirine

Time: Up to 3 years

Description: Progression-free survival (PFS) defined as the time between start of treatment and the first documentation of recurrence or progression as per RECIST v1.1

Measure: Evaluate the preliminary anti-tumor activity of camidanlumab tesirine

Time: Up to 3 years

Description: Overall survival (OS) defined as the time between the start of treatment and death from any cause

Measure: Evaluate the preliminary anti-tumor activity of camidanlumab tesirine

Time: Up to 3 years

Description: Noncompartmental analysis of the maximum concentration (Cmax)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine total antibody, PBD-conjugated antibody, and unconjugated warhead SG3199 in serum

Time: Up to 3 years

Description: Noncompartmental analysis of the time to maximum concentration (Tmax)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: Noncompartmental analysis of the area under the concentration-time curve from time zero to the last quantifiable concentration (AUC0 last)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: Noncompartmental analysis of the area under the concentration-time curve from time zero to infinity (AUC0-∞)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: Noncompartmental analysis of the area under the concentration-time curve from time zero to the end of the dosing interval (AUC0-τ)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: Noncompartmental analysis of the accumulation index (AI)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: Noncompartmental analysis of clearance (CL)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: Noncompartmental analysis of volume of distribution (Vd)

Measure: Pharmacokinetics and Pharmacodynamics assessment- camidanlumab tesirine in serum

Time: Up to 3 years

Description: ADA titers if applicable, neutralizing activity to camidanlumab tesirine after treatment with camidanlumab tesirine.

Measure: Number of confirmed positive anti-drug antibody (ADA) responses

Time: Up to 3 years
2 The Impact of Early Palliative Care on the Quality of Life of Patients With Advanced Pancreas Cancer: A Case-crossover Study

The primary objective is to explore the impact of early palliative care on quality of life in patients with advanced pancreatic cancer. The secondary objectives are to explore the impact of early palliative care on symptom management, depression, anxiety and survival in patients with advanced pancreatic cancer.

NCT03837132
Conditions
  1. Advanced Cancer
Interventions
  1. Behavioral: Palliative care assessment
MeSH:Pancreatic Neoplasms
HPO:Neoplasm of the pancreas

Primary Outcomes

Description: For the primary endpoint, we will use a generalized linear model to test for a statistically significant change score between baseline and 16 weeks. We will assume a normal distribution for the change scores. Model fit will be assessed via a visual assessment of residuals and the ratio of the model deviance to its degrees of freedom.

Measure: Impact of early palliative care on quality of life in patients with advanced pancreatic cancer

Time: registration to 16 weeks

Secondary Outcomes

Description: Secondary endpoints will include: (1) symptom control at 16 weeks as measured by the revised Edmonton Symptom Assessment Scale (ESAS-r) (a widely used and validated tool to assess symptom intensity, which is routinely completed by patients at all CCMB visits); (2) depression and anxiety at 16 weeks using the Hospital Anxiety and Depression Scale (HADS) (a 14 item scale which can be used in the outpatient setting to screen for anxiety and depression within the previous week) and the Patient Health Questionnaire (PHQ-9) (a sensitive (88%) and specific (88%) 9 question tool which incorporates diagnostic criteria for major depression); and overall survival measured from date of registration to death

Measure: To explore the impact of early palliative care on symptom management, depression, anxiety and survival in patients with advanced pancreatic cancer

Time: registration to 16 weeks
3 Effects of Covid-19 Pandemic on Pancreatic Surgery in Italy. A Multicenter Observational Clinical Study

Pancreatic cancer (PC) is recognized as one of the most challenging tumors to deal with and it is still characterized by a poor long-term prognosis. However, treatment of PC in high-volume centers with the support of a multidisciplinary approach has widely demonstrated improvement both in terms of short- and long-term outcomes. The recent worldwide spread of Covid-19 pandemic significantly affected the healthcare systems of most countries in the world, particularly in red areas such as Italy, with more than 100.000 cases in a two-month time lapse. This inevitably reflected in a reorganization of hospital activities, including the diagnostic and therapeutic pathways for PC treatment. With the aim of giving an objective and real representation of the impact of Covid-19 on PC treatment, the investigator here propose a multicenter Italian observational study comparing a 6-month period before and during the Covid-19 pandemic. Only high-volume centers will be involved in the study. A comparison between the general, clinical, endoscopic and surgical outcomes will be performed by means of a global and month-by-month analysis between the two study periods.

NCT04380766
Conditions
  1. Pancreatic Cancer
Interventions
  1. Procedure: Evaluation of changes in the diagnostic-therapeutic pathway for patients affected by pancreatic cancer
MeSH:Pancreatic Neoplasms
HPO:Neoplasm of the pancreas

Primary Outcomes

Measure: Changes in pancreatic cancer management during the COVID-19 pandemic

Time: From admission to discharge/last outpatient visit, whichever comes first, assessed up to the 30th of June 2020
4 The Status of Advanced Endoscopy in the Era of COVID-19: a Multicenter Study

In this study, investigators aim to explore the status of advanced endoscopy in different endoscopy units all over the world.

NCT04385147
Conditions
  1. Cholangitis, Secondary Biliary
  2. Cholangiocarcinoma
  3. Obstructive Jaundice
  4. Pancreas Cancer
  5. COVID-19
  6. SARS-CoV-2
Interventions
  1. Other: Endoscopic management according to standard of care
MeSH:Cholangiocarcinoma Pancreatic Neoplasms Cholangitis Liver Cirrhosis, Biliary Jaundice Jaundice, Obstructive
HPO:Biliary cirrhosis Cholangiocarcinoma Cholangitis Jaundice Neoplasm of the pancreas

Primary Outcomes

Description: Investigators will report the baseline demographic data (age, gender, nationality) of all patients.

Measure: Age, gender, nationality

Time: 3 months

Description: Investigators will report the baseline data clinical data (indication for procedure, status of SARS-CoV-2 infection) of all patients.

Measure: Indication for procedure, status of SARS-CoV-2 infection

Time: 3 months

Description: Investigators will report the baseline laboratory data (complete blood count and liver functions tests) of all patients.

Measure: Complete blood count and liver functions tests

Time: 3 months

Description: Investigators will report the procedure related complications.

Measure: procedure related complications

Time: 3 months

Secondary Outcomes

Description: Investigators will report wether the precautions lead to increase timing of the procedure

Measure: Effect of COVID-19 precautions on procedure time

Time: 3 months

Description: Investigators will report wether the precautions affected staff number (increased or decreased)

Measure: Effect of COVID-19 precautions on staff number

Time: 3 months

HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook