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D018184: Paramyxoviridae Infections

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (11)


Name (Synonyms) Correlation
drug3789 artus Influenza A/B RT-PCR Test Wiki 0.58
drug964 DAS181 COVID-19 Wiki 0.58
drug965 DAS181 OL Wiki 0.58
Name (Synonyms) Correlation
drug1994 Medical/surgical mask Wiki 0.58
drug1162 Eicosapentaenoic acid gastro-resistant capsules Wiki 0.58
drug2118 N95 Respirator Wiki 0.58
drug1403 Glucose tablets Wiki 0.58
drug369 Azithromycin 500Mg Oral Tablet Wiki 0.58
drug1532 Hydroxychloroquine 200 Mg Oral Tablet Wiki 0.41
drug963 DAS181 Wiki 0.24
drug2505 Placebo Wiki 0.03

Correlated MeSH Terms (9)


Name (Synonyms) Correlation
D003384 Coxsackievirus Infections NIH 0.58
D000257 Adenoviridae Infections NIH 0.33
D018357 Respiratory Syncytial Virus Infections NIH 0.20
Name (Synonyms) Correlation
D007251 Influenza, Human NIH 0.14
D012141 Respiratory Tract Infections NIH 0.10
D003141 Communicable Diseases NIH 0.09
D014777 Virus Diseases NIH 0.06
D007239 Infection NIH 0.06
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0011947 Respiratory tract infection HPO 0.11

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Incidence of Respiratory Illness in Outpatient Healthcare Workers Who Wear Respirators or Medical Masks While Caring for Patients

Despite widespread use of respiratory protective equipment in the U.S. healthcare workplace, there is very little clinical evidence that respirators prevent healthcare personnel (HCP) from airborne infectious diseases. Scientific investigation of this issue has been quite complicated, primarily because the use of respirators has become "the standard of care" for protection against airborne diseases in some instances, even without sufficient evidence to support their use. The key question remains: How well do respirators prevent airborne infectious diseases? The answer to this important question has important medical, public health, political and economic implications.

NCT01249625
Conditions
  1. Influenza
  2. Respiratory Syncytial Viruses
  3. Paramyxoviridae Infections
  4. Coronavirus
  5. Rhinovirus
Interventions
  1. Device: N95 Respirator
  2. Device: Medical/surgical mask
MeSH:Paramyxoviridae Infections

Primary Outcomes

Description: Number of influenza A and B events in healthcare practitioners wearing N95 respirators compared to medical masks.

Measure: Protective Effects of N95 Respirators vs Medical Masks (MM) as Assessed by Number of Influenza A and B Events

Time: 60 weeks

Secondary Outcomes

Description: Number of influenza-like illnesses in healthcare practitioners wearing N95 respirators compared to medical masks.

Measure: Protective Effects of N95 Respirators vs Medical Masks as Assessed by Number of Influenza-like Illnesses

Time: 60 weeks

Description: Number of lab confirmed respiratory illnesses in healthcare practitioners wearing N95 respirators compared to medical masks.

Measure: Protective Effects of N95 Respirators vs Medical Masks as Assessed by Number of Lab Confirmed Respiratory Illnesses

Time: 60 weeks

Description: Number of lab detected respiratory infections in healthcare practitioners wearing N95 respirators compared to medical masks.

Measure: Protective Effects of N95 Respirators vs Medical Masks as Assessed by Number of Lab Detected Respiratory Infections

Time: 60 weeks

Description: Number of acute respiratory illnesses in healthcare practitioners wearing N95 respirators compared to medical masks.

Measure: Protective Effects of N95 Respirators vs Medical Masks as Assessed by Number of Acute Respiratory Illnesses

Time: 60 weeks

Description: Number of laboratory confirmed influenza illnesses in healthcare practitioners wearing N95 respirators compared to medical masks.

Measure: Protective Effects of N95 Respirators vs Medical Masks as Assessed by Number of Laboratory Confirmed Illness

Time: 60 weeks
2 Testing of Respiratory Specimens for the Validation of the QIAGEN ResPlex II Advanced Panel Test and the Artus Influenza A/B RT-PCR Test

The study will be conducted using nasopharyngeal swab specimens collected prospectively from individuals suspected of having the signs and symptoms of an acute respiratory tract infection caused by a respiratory virus. A series of standard viral culture tests validated for routine use in the clinical laboratory, and/or a series of PCR-based Laboratory Developed Tests (PCR-LDT) validated by a central reference laboratory will be used to verify the performance of the investigational artus Influenza A/B RT-PCR test and the QIAGEN ResPlex II Advanced Panel test. From each specimen five (5) aliquots will be prepared: (a) one aliquot will be tested in real-time using the assigned viral culture reference methods; (b) one aliquot will be used to extract nucleic acid in real-time for investigational testing; (c) one aliquot of the specimen will be stored at --70C for subsequent shipment to the reference laboratory for PCR-LDT testing, (d) one aliquot will be archived at -70C for subsequent follow-up by the reference laboratory (e.g., bi-directional sequencing of positive specimens), and (e) any remaining specimen will be stored for the Fresh vs. Frozen Study. The extracted nucleic acid generated from the second aliquot (i.e., "b" above) will be split and subjected to testing by both the artus Influenza A/B RT-PCR test and the ResPlex II Advanced Panel test.

NCT01302418
Conditions
  1. QIAGEN ResPlex II Advanced Panel
  2. Influenza A
  3. Respirat
  4. Respiratory Syncytial Virus Infections
  5. Infection Due to Human Parainfluenza Virus 1
  6. Parainfluenza Type 2
  7. Parainfluenza Type 3
  8. Parainfluenza Type 4
  9. Human Metapneumovirus A/B
  10. Rhinovirus
  11. Coxsackie Virus/Echovirus
  12. Adenovirus Types B/C/E
  13. Coronavirus Subtypes 229E
  14. Coronavirus Subtype NL63
  15. Coronavirus Subtype OC43
  16. Coronavirus Subtype HKU1
  17. Human Bocavirus
  18. Artus Influenza A/B RT-PCR Test
  19. Influenza B
Interventions
  1. Device: artus Influenza A/B RT-PCR Test
MeSH:Infection Communicable Diseases Virus Diseases Influenza, Human Coronavirus Infections Adenoviridae Infections Respiratory Syncytial Virus Infections Paramyxoviridae Infections Coxsackievirus Infections

Primary Outcomes

Description: The presence of Influenza A or Influenza B virus.

Measure: Detection of Respiratory Viruses

Time: Specimens will be taken within 5 days of the appearance of symptoms.
3 A Phase III Randomized Placebo-Controlled Study to Examine the Efficacy and Safety of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects

This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.

NCT03808922
Conditions
  1. Lower Respiratory Tract Infection
  2. Parainfluenza
  3. Immunocompromised
  4. COVID-19
Interventions
  1. Drug: DAS181
  2. Drug: Placebo
  3. Drug: DAS181 COVID-19
  4. Drug: DAS181 OL
MeSH:Infection Communicable Diseases Respiratory Tract Infections Paramyxoviridae Infections
HPO:Respiratory tract infection

Primary Outcomes

Description: Removal of all oxygen support (with stable SpO2)

Measure: Percent of subjects who Return to Room Air (RTRA) (main study)

Time: by Day 28

Measure: Percent of subjects with improved COVID-19 Clinical Status Scale (sub-study)

Time: Day 14

Secondary Outcomes

Measure: All-cause mortality rate (main study)

Time: at Day 28

Measure: Percent of subjects who Return to Room Air (RTRA) (main study)

Time: by Day 21

Measure: Time (in days) to RTRA (main study)

Time: Days 10, 14, 21, 28

Measure: Percent of subjects who achieve clinical stability (main study)

Time: by Day 28

Measure: Percent of subjects discharged (without mortality and hospice) (main study)

Time: by Days 14, 21, 28 and 35

Measure: Time (in days) to first hospital discharge (without hospice) (main study)

Time: through Day 35

Measure: Total number of inpatient days (main study)

Time: up to Day 35

Measure: Baseline SAD-RV infection-related mortality rate (main study)

Time: at Day 28

Measure: Baseline SAD-RV infection-related mortality rate (main study)

Time: at Day 35

Measure: All-cause mortality rate (main study)

Time: at Day 35

Measure: Change in pulmonary function (FEV1% predicted) (main study)

Time: Day 1, Day 7, Day 14, Day 28

Measure: Time to improved COVID19 clinical status (Sub-study)

Time: Day 5, Day 10, Day 21, Day 28

Measure: Time to RTRA

Time: Day 10, Day 14, Day 21, Day 28

Measure: Time to Clinical stability

Time: Day 14, Day 21, Day 28

Measure: Time to SARS-CoV-2 RNA in the respiratory specimens being undetectable

Time: Day 5, Day 10, Day 14, Day 21, Day 28

Measure: Time to Clinical deterioration

Time: Day 5, Day 10, Day 14, Day 21, Day 28

Measure: Time to Discharge from hospital (without readmission before Day 28).

Time: Day 14, Day 21, Day 28

Measure: Time to Death (all causes)

Time: Day 14, Day 21, Day 28

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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