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D004715: Endometriosis

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (8)


Name (Synonyms) Correlation
drug383 BAY2328065 tablet Wiki 0.58
drug2561 Placebo tablet Wiki 0.58
drug382 BAY2328065 LSF Wiki 0.58
Name (Synonyms) Correlation
drug2528 Placebo LSF Wiki 0.58
drug2095 Moxifloxacin Wiki 0.41
drug381 BAY1817080 Wiki 0.41
drug2044 Midazolam Wiki 0.26
drug2505 Placebo Wiki 0.03

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D053201 Urinary Bladder, Overactive NIH 0.41

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0030127 Endometriosis HPO 1.00

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Randomized, Placebo-controlled, Double-blind, Parallel Group Study to Investigate Safety, Tolerability and Pharmacokinetics of Increasing Multiple Oral Doses of BAY2328065 Including the CYP3A4 Induction Potential of BAY2328065 and Randomized Cross-over Investigation of the Relative Bioavailability Between Solution and Tablet Formulation in Healthy Male Participants

Study on the safety and tolerability of a new drug BAY2328065 when given increased doses as tablet or solution over 12 days to healthy male participants. Researcher want to study how the body absorbs, breaks down and excrete the new drug, also when given together with a test meal. In addition the study will investigate changes that take place in the body when BAY2328065 is given together with another drug.

NCT04027192
Conditions
  1. Endometriosis
Interventions
  1. Drug: BAY2328065 LSF
  2. Drug: BAY2328065 tablet
  3. Drug: Placebo LSF
  4. Drug: Placebo tablet
  5. Drug: Midazolam
MeSH:Endometriosis
HPO:Endometriosis

Primary Outcomes

Measure: Number of subjects with treatment-emergent adverse events (TEAEs)

Time: From first dosing up to 30 days after end of treatment with study intervention, summing up to approximately 39 to 45 days for a participant

Measure: Severity of TEAEs

Time: From first dosing up to 30 days after end of treatment with study intervention, summing up to approximately 39 to 45 days for a participant

Measure: AUC(0-12)md (twice daily [BID])

Time: From first dose of BAY2328065 until 72 hour after the last dose of BAY2328065

Measure: Cmax,md of BAY2328065

Time: From first dose of BAY2328065 until 72 hour after the last dose of BAY2328065
2 Endometriosis Patients Covid 19 Anxiety

It is aimed to measure the general anxiety and lifestyle information of endometriosis patients about covid 19 pandemic, to evaluate anxiety levels in this period.

NCT04337346
Conditions
  1. Endometriosis
  2. Covid19
MeSH:Endometriosis
HPO:Endometriosis

Primary Outcomes

Description: The Beck Anxiety Inventory (BAI); it measures the frequency of anxiety symptoms experienced by the patient. It consists of 21 questions in total. Each item gets an increasing score between 0-3. The total score ranges from 0 - 63. The following guidelines are recommended for the interpretation of scores: 0 -9, normal or no anxiety; 10 -18, mild to moderate anxiety; 19 -29, moderate to severe anxiety; and 30 - 63, severe anxiety.

Measure: Covid 19 Anxiety levels in Endometriosis Patients

Time: 20 days
3 Randomized, Single-blind, Double-dummy, 4-fold Cross-over, Placebo- and Active-controlled Study to Investigate the Influence of BAY 1817080 on the QTc Interval in Healthy Male and Female Participants (TQT Study)

In this study, researchers want to find whether the study drug BAY1817080 has an effect on the electrocardiogram (ECG). 40 healthy male or female participants with the age of 18 to 65 years will be enrolled into this study. The ECG of the participants will be monitored closely by the researchers to detect any change after intake of the study medication.

NCT04423744
Conditions
  1. Cough
  2. Endometriosis
  3. Overactive Bladder
Interventions
  1. Drug: BAY1817080
  2. Drug: Moxifloxacin
  3. Drug: Placebo
MeSH:Urinary Bladder, Overactive Endometriosis
HPO:Endometriosis

Primary Outcomes

Measure: Time-matched, placebo-corrected change from baseline of the individually corrected QT interval after multiple oral doses of BAY1817080 therapeutic dose

Time: Baseline and Day 3

Measure: Time-matched, placebo-corrected change from baseline of the individually corrected QT interval after multiple oral doses of BAY1817080 supra-therapeutic dose

Time: Baseline and Day 3

Secondary Outcomes

Measure: Time-matched, placebo-corrected change from baseline of the individually corrected QT interval after a single oral dose of moxifloxacin

Time: Baseline and Day 3

Measure: Time-matched, placebo-corrected change from baseline of the QT interval corrected according to Fridericia (QTcF) and Bazett (QTcB) after multiple oral doses of BAY1817080 therapeutic or supra-therapeutic dose

Time: Baseline and Day 3

Measure: Time-matched, placebo-corrected change from baseline of the QT interval corrected according to Fridericia (QTcF) and Bazett (QTcB) after a single oral dose of moxifloxacin

Time: Baseline and Day 3

Description: Area under the concentration vs. time curve from zero to 24 hours after multiple doses

Measure: AUC(0-24)md after multiple oral doses of BAY1817080 therapeutic or supra-therapeutic dose

Time: Predose and up to 24 hours after last dose of BAY1817080 at Day 3

Description: Area under the concentration vs. time curve from zero to infinity after single dose

Measure: AUC after a single oral dose of moxifloxacin

Time: Predose and up to 24 hours after single dose of moxifloxacin at Day 3

Description: Maximum observed drug concentration in measured matrix after multiple doses

Measure: Cmax,md after multiple oral doses of BAY1817080 therapeutic or supra-therapeutic dose

Time: Up to 24 hours after last dose of BAY1817080 at Day 3

Description: Maximum observed drug concentration in measured matrix after single dose

Measure: Cmax after a single oral dose of moxifloxacin

Time: Up to 24 hours after single dose of moxifloxacin at Day 3

Measure: Incidences of treatment-emergent adverse events (TEAEs) after BAY1817080 therapeutic or supra-therapeutic dose

Time: From the start of BAY1817080 administration until 7 days after last dose, assessed up to 10 days

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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