|drug3154||Social Communication and Emotional Skill Development (SCESD) module Wiki||0.58|
|drug462||Best Message + Augmented Message or Implementation Strategy Wiki||0.58|
|D008607||Intellectual Disability NIH||0.58|
|D065886||Neurodevelopmental Disorders NIH||0.41|
|D002659||Child Development Disorders, Pervasive NIH||0.26|
There are 3 clinical trials
This study will evaulate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single- and multiple-ascending doses (SAD and MAD) and food effect (FE) of RO6953958 following oral administration in healthy male participants.
In the United Nation's Sustainable Development Goals (SDGs), the conversation has shifted from the complexity of ensuring decrease in infant mortality to that of holistic wellbeing of children from conception onwards by ensuring early learning opportunities along with nutrition, security and safety. About 13 - 23 percent children in Bangladesh present symptoms of diagnosable and preventable mental health conditions in early childhood. The aim of this effectiveness-implementation hybrid type 2 cluster randomized trial is to implement training program to enhance parental understanding of child's social communication and emotional development, ways to support positive behavior management skills, and to enhance parents' cognizance about when professional help may be sought. Shuchona Foundation's module-based training manual on Social Communication and Emotional Skill Development (SCESD) is designed to sensitize and educate parents/ caregivers on child development. This module will be implemented in Sonargaon, Gojaria and Raiganj Upazilas. The administrative wards in the unions will serve as clusters for the study's first phase. The first phase of six months duration will explore qualitatively the adaptability of existing health system, train field level health workers, training of the data collectors on administering Ages and Stages Questionnaire (ASQ), enrol mothers for equipping them with knowledge and skill to stimulate Early Childhood Development (ECD) and identify delayed childhood development, followed by assessment of ability of mothers to note secondary outcomes or delay at the earliest. The sessions for mother will be conducted using the existing health system of Bangladesh. A mixed-methods approach comprising of process mapping, qualitative and quantitative data analyses will be used to assess implementation of the intervention with focus on identifying failures in implementation, why they exist and how to reduce them for future implementation and scale-up.
Description: To assess the effectiveness of the community centered module-based approach in monitoring social communication and emotional development and those factors which may influence social-emotional development, in infants and young children, this instrument will be used.Measure: ASQ score (Ages and stages questionnaire) score Time: 6 months
The primary goal of this project is to identify the best messaging and implementation strategies to maximize SARS-CoV-2 testing for children with intellectual and developmental disabilities (IDD) and their teachers to help ensure a safe school environment. Additionally, we will understand nationally the perceptions of COVID-19 and identify facilitators and barriers to help with the adoption of testing in other parts of the US and the necessary strategies to address other mitigation strategies including vaccination.
Description: Ratio of the total number test per the number of weeks of analysis (eg. Phase 1 20 weeks)Measure: Adoption of weekly testing by each participant Time: 52 weeks
Description: The acceptability of each strategy will be assessed with a validated survey of the families and staff prior to the intervention and at the conclusion of the intervention being utilized.Measure: Acceptability of Messaging/Implementation Strategy Time: 1 year
Description: The feasibility of each strategy will be assessed with a validated survey of the families and staff prior to the intervention and at the conclusion of the intervention being utilized.Measure: Feasibility of Messaging/Implementation Strategy Time: 1 year
Description: The appropriate of each strategy will be assessed with a validated survey of the families and staff prior to the intervention and at the conclusion of the intervention being utilized.Measure: Appropriateness of Messaging/Implementation Strategy Time: 1 year
Description: The total number of days missed by students and staff at the special schools during the 52 weeks of the study will be obtained.Measure: Number of missed school days by students or work days by staff Time: 52 weeks
Description: The percentage of students and staff positive for SARS-CoV-2 virus will be determinedMeasure: Students and staff positive SARS-CoV-2 virus Time: 52 weeks
Description: Number of possible SARS-CoV-2 transmission events occurring between students and staff within the school setting.Measure: School-based SARS-CoV-2 transmission events Time: 52 weeks
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports