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D012216: Rheumatic Diseases

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (17)


Name (Synonyms) Correlation
drug2762 RAPID-3 Wiki 0.35
drug1588 IER-R (posttraumatic stress) Wiki 0.35
drug4100 self-administered structured questionnaire Wiki 0.35
Name (Synonyms) Correlation
drug1055 Dietary counselling on Food Groups according to IYC Feeding practices, WHO Wiki 0.35
drug3694 WHOQOL-BREF Wiki 0.35
drug661 COVID-19 infection Wiki 0.35
drug651 COVID-19 antibody point of care test kit Wiki 0.35
drug560 Bromhexine 8 MG Wiki 0.35
drug1061 Digital Health Online Platform Wiki 0.35
drug668 COVID-19 survey Wiki 0.35
drug652 COVID-19 barrier box Wiki 0.35
drug966 DASS-21 instrument (depression and anxiety) Wiki 0.35
drug582 CAP-1002 Allogeneic Cardiosphere-Derived Cells Wiki 0.35
drug1050 Diet tracking and survey Wiki 0.35
drug4071 questionnaire assesment Wiki 0.32
drug1538 Hydroxychloroquine Sulfate Wiki 0.10
drug2741 Questionnaire Wiki 0.06

Correlated MeSH Terms (11)


Name (Synonyms) Correlation
D003095 Collagen Diseases NIH 0.87
D012213 Rheumatic Fever NIH 0.61
D001327 Autoimmune Diseases NIH 0.32
Name (Synonyms) Correlation
D001167 Arteritis NIH 0.25
D015535 Arthritis, Psoriatic NIH 0.20
D011111 Polymyalgia Rheumatica NIH 0.20
D013700 Giant Cell Arteritis NIH 0.20
D001168 Arthritis NIH 0.18
D008180 Lupus Erythematosus, Systemic NIH 0.14
D059350 Chronic Pain NIH 0.11
D001172 Arthritis, Rheumatoid NIH 0.11

Correlated HPO Terms (6)


Name (Synonyms) Correlation
HP:0002960 Autoimmunity HPO 0.35
HP:0012089 Arteritis HPO 0.25
HP:0001369 Arthritis HPO 0.20
Name (Synonyms) Correlation
HP:0002725 Systemic lupus erythematosus HPO 0.16
HP:0001370 Rheumatoid arthritis HPO 0.12
HP:0012532 Chronic pain HPO 0.12

Clinical Trials

Navigate: Correlations   HPO

There are 8 clinical trials


1 COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic Diseases

The trial is a prospective, observational study aiming to identify risk factors for serious COVID-19 infection by evaluating clinical measures and biomarkers of inflammation in patients with inflammatory rheumatic disease hospitalized with COVID-19 compared with control groups.

NCT04335747
Conditions
  1. Rheumatoid Arthritis
  2. Psoriatic Arthritis
  3. Axial Spondyloarthritis
  4. Systemic Lupus Erythematosus
  5. Giant Cell Arteritis
Interventions
  1. Other: COVID-19 infection
MeSH:Arthritis Arthritis, Psoriatic Rheumatic Diseases Polymyalgia Rheumatica Giant Cell Arteritis Arteritis Lupus Erythematosus, Systemic Collagen Diseases
HPO:Arteritis Arthritis Polyarticular arthritis Systemic lupus erythematosus

Primary Outcomes

Description: The objective is to examine whether increased disease activity leads to increased risk of hospitalization due to COVID-19 in patients with inflammatory rheumatic disease

Measure: Disease activity

Time: Last registration of disease activity in the medical journal before admission/inclusion

Secondary Outcomes

Description: Examine whether immune modulating treatments protect or leads to increased risk of hospitalization due to COVID-19 in patients with inflammatory rheumatic disease.

Measure: Immune modulating treatments

Time: Current immune modulating treatments at admission/inclusion

Description: Identify prognostic biomarkers by comparing serology of patients with inflammatory rheumatic disease hospitalized with COVID-19 and comparing them with the two control groups

Measure: Biomarkers

Time: Blood sample 1 is taken 0-3 days after inclusion and blood sample 2 is taken 2-6 weeks after blood sample 1
2 Psychological Impact of Quarantine in Rheumatoid Arthritis Patient During COVID-19 Outbreak

Clinical data about psychological impact of quarantine are well studied in transient event or more prolonged situation like jail incarceration. In recent metaanalysis, psychological impact of quarantine was well documented in a specific population during first SARS epidemy. Even after the end of quarantine several patients were still with symptom of avoiding mainly agoraphobia, frequent hand washing and a carefull return to normal life COVID-19 infection is already associated with psychological symptom like anxiety, depression, sleep disorders and symptoms of acute stress However psychological impact of quarantine is on none in chronic painful inflammatory rheumatism in France. The prevalence of rheumatoid arthritis is 0.5% of the population with frequent comorbidity such as anxiety and depression. During the quarantine secondary to COVID-19 pandemic it's possible to evaluated the psychological impact of adult RA patients. The present study is an "emergency" being realize before the end of the quarantine.

NCT04351399
Conditions
  1. Sars-CoV2
  2. Rheumatic Diseases
  3. Rheumatoid Arthritis
  4. Chronic Pain
Interventions
  1. Other: questionnaire assesment
MeSH:Arthritis Arthritis, Rheumatoid Rheumatic Diseases Collagen Diseases Chronic Pain
HPO:Arthritis Chronic pain Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Measure: Frequency of RA patients with emotional impact (feeling of isolation)

Time: maximum 1 week from baseline on

Secondary Outcomes

Description: Self reported questionnaire with questions to assess the characteristic,intensity of pain on quality of life, and consumption of analgesic.

Measure: self-reported questionnaire for painful

Time: maximum 1 week from baseline on
3 Covid-19 in Patients With Chronic Inflammatory Rheumatism, Auto-immune or Auto-inflammatory Rare and Non-rare Diseases : a Retrospective Multicenter Observational Study

Since December 2019, an international outbreak of respiratory illnesses caused by SARS-CoV-2 called covid-19 has become a global challenge. In France, while the first cases were reported in January, more than 20 000 cases were confirmed at end of March. Early estimations from epidemiological data seem to show that 18-20% of patients with confirmed covid-19 are admitted in an intensive care unit (ICU). Patients with chronic inflammatory rheumatism, auto-immune or auto-inflammatory rare and non-rare diseases are susceptible to severe covid-19 (i.e ICU) due to the specific therapeutic management of their illness (corticosteroid, immunosuppressive and immunomodulatory drugs,..). No data are available for this particular population in France. This retrospective multicentre observational study aims to evaluate the frequency of severe forms of covid-19 and risk factors associated with specific outcomes in covid-19 in patients with chronic inflammatory rheumatism, auto-immune or auto-inflammatory rare and non-rare diseases.

NCT04353609
Conditions
  1. Sars-CoV2
  2. Chronic Inflammatory Rheumatism
  3. Autoimmune Diseases
MeSH:Rheumatic Fever Rheumatic Diseases Collagen Diseases Autoimmune Diseases
HPO:Autoimmunity

Primary Outcomes

Measure: Proportion of patients presenting a severe form of covid-19 requiring an intensive care unit admission or leading to death

Time: From Baseline up to Day 21 after first symptoms of covid-19

Secondary Outcomes

Measure: Proportion of patients who die from a severe form of covid-19

Time: From Baseline up to Day 21 after first symptoms of covid-19

Measure: Proportion of patients who present an history of diabetes according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present obesity (validated by Body Mass Index value > 30 kg/cm2)

Time: At the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of Chronic Pulmonary Obstructive Disease according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of Asthma according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of Hypertension according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of cardiac disease according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of Pulmonary Interstitial Disease according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of stroke according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of angiotensin-converting-enzyme inhibitor according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)

Measure: Proportion of patients who present an history of cancer according to medical records

Time: Before the set-up of first symptoms of covid-19 (Baseline visit)
4 Impact of COVID-19 Pandemic on Attitude, Behaviour and Mental Health of Patients With Rheumatic Diseases

A study to assess the impact of coronavirus disease 2019 (COVID-19) pandemic on the attitude, behaviour and mental health of rheumatic patients and to compare them with healthy individuals.

NCT04407299
Conditions
  1. COVID
Interventions
  1. Behavioral: self-administered structured questionnaire
MeSH:Rheumatic Diseases

Primary Outcomes

Description: 7. Six questions for mental health assessment for patients and controls: Mental health was measured by the five-item Brief Symptom Rating Scale (BSRS-5) which was derived from the 50-item BSRS

Measure: Score of five-item Brief Symptom Rating Scale (BSRS-5)

Time: 3 weeks
5 Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants

A retrospective monocentric study with large active files of patients monitored for rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus with as main endpoint the morbimortality of Covid-19 in these patients (number of patients hospitalized in conventional units and/or in intensive care and/or deceased). The results will be compared with those of the general population based on the epidemiological data of Covid-19.

NCT04426279
Conditions
  1. Sars-CoV2
  2. Rheumatoid Arthritis
  3. Rheumatic Diseases
Interventions
  1. Other: questionnaire assesment
MeSH:Rheumatic Fever Rheumatic Diseases Collagen Diseases

Primary Outcomes

Description: the number of patients with severe Covid-19 who were admitted to a conventional unit and/or an ICU and/or deceased, during the Covid-19 epidemic wave (from March to August 2020) among patients with IRC under IS. The diagnosis of Covid-19 is either confirmed by diagnostic test (RT-PCR), or by a physician, or by serology. The results will be compared with those of the general population based on Covid-19 epidemiological data.

Measure: analysis of Covid-19-related morbidity and mortality in patients with IRC under IS.

Time: At 6 months

Secondary Outcomes

Description: Diagnosis of Covid-19 either confirmed by diagnostic test (RT-PCR), or by a physician, or by serology.

Measure: To evaluate the frequency of Covid-19 in patients with IRC under IS.

Time: At 6 months

Description: The number of patients admitted to conventional unit and/or ICU and/or deceased among patients with IRC under IS between the Covid-19 epidemic wave (March to August 2020) and the six-month period preceding it (September to February 2020).

Measure: To compare the morbidity and mortality of patients with IRC under IS during the Covid-19 epidemic wave (March to August 2020) with the six months prior to this wave (September 2019 to February 2020).

Time: At 6 months

Description: The number of patients who maintained, modified, or discontinued their treatment. Treatment modification will be assessed by the number of weeks of treatment not taken, the number of injections not given, the number of delayed or missed infusions. Among those who have modified or stopped their treatment, the impact on their diseases will be evaluated by the loss of remission, the patient's opinion on the notion of relapse, the increase or initiation of corticosteroid therapy and the substantive change in treatment.

Measure: Patients' conduct in relation to their treatment during the epidemic wave (maintenance, modification or discontinuation) and the impact on their disease (loss of remission, flare, corticosteroids requirement and need for switch of DMARD therapy)

Time: At 6 months
6 Mental Health Consequences of COVID19 Infection in the French Rheumatic Musculoskeletal Diseases (RMD) Cohort

this observational, cross-sectional, national, comparative study, including RMD patients followed in hospital centres of the FAI²R Rare Diseases Healthcare Pathway network and specialist private practitioners caring for patients suffering from inflammatory rheumatism, systemic autoimmune diseases and auto-inflammatory diseases. The objective of the study is to compare RMD patients with COVID 19 infection (cases) to RMD patients who have not had COVID 19 infection (controls) on their mental health.

NCT04510467
Conditions
  1. Covid19
  2. Systemic Autoimmune Disease
  3. Inflammatory Rheumatism
  4. Auto Inflammatory Diseases
MeSH:Rheumatic Fever Rheumatic Diseases Autoimmune Diseases
HPO:Autoimmunity

Primary Outcomes

Measure: Frequency of PTSD depending on whether or not autoimmune patients have experienced COVID

Time: at one month following exposure to the traumatic factor (i.e. one month from COVID-19 infection

Secondary Outcomes

Measure: Severity of PTSD depending on whether or not autoimmune patients have experienced COVID

Time: at one month following exposure to the traumatic factor (i.e. one month from COVID-19 infection
7 COVID-19 Prevalence in a Single Large UK Rheumatology Centre and the Impact on Quality of Life From Stringent Social Distancing

The COVID-19 pandemic represents a threat to rheumatology patients. National advice for patients to 'shield' is based on risk stratification of therapies and other risk factors. While the epidemiology of COVID-19 in the rheumatological population is largely unknown large case registries are beginning to show potential drug treatment interactions. Strict self-isolation (shielding) has been recommended for those deemed 'high risk' although its impact on the likelihood of COVID-19 infection and health related quality of life (HRQoL) is unclear. The study aims to explore how this unprecedented situation has impacted the Trust patients primarily evaluating prevalence of the infection, effect of stringent social distancing (shielding) and Quality of Life (QOL). This will be done via a voluntary questionnaire, sent via text messaging at 6 and 12 months.

NCT04542031
Conditions
  1. Covid19
  2. Rheumatic Diseases
Interventions
  1. Other: Questionnaire
MeSH:Rheumatic Diseases Collagen Diseases

Primary Outcomes

Description: percentage of cases

Measure: Prevalence of COVID 19

Time: 1 year

Description: number of deaths per 1000 individuals

Measure: Mortality rates from COVID 19

Time: 1 year

Description: mental and physical component scores through patient reported outcomes. Normative score set at 50 with minimum score being 0 and maximum score being 100. Scores >50 indicate better mental or physical health than the mean. Scores <50 indicate worse mental or physical health than the mean

Measure: Health related quality of life - Short Form 12

Time: 1 year
8 Impact in the Medical Care Among the Rheumatic Diseases Patients in a Tertiary Hospital in México During the COVID-19 Pandemic

The National Institute of Medical Sciences and Nutrition is a national reference center for rheumatic diseases that belongs to The National Institutes of Health, and has Federal founding. More than 8,000 patients with a wide variety of rheumatologic diagnosis receive medical care. On March 2020, the WHO announced COVID-19 outbreak a pandemic. The first case was registered in Mexico on February 2020. In March 2020, the Mexican Government requested that our Institution should restrict health care to exclusively COVID-19 patients; accordingly, outpatient consultations were, and up to August 2020 still, hold on. Meanwhile, when possible, the Department of Immunology and Rheumatology has implemented an "on-demand", non-organized patient´s health care, through email and phone contact; nonetheless, and due to the middle-low socioeconomic status of most of our patients and limited technical resources available at our Institution, the attempt has been challenging.

NCT04557358
Conditions
  1. Rheumatoid Arthritis
  2. Quality of Life
Interventions
  1. Other: COVID-19 survey
  2. Other: RAPID-3
  3. Other: WHOQOL-BREF
  4. Other: DASS-21 instrument (depression and anxiety)
  5. Other: IER-R (posttraumatic stress)
MeSH:Rheumatic Diseases Collagen Diseases

Primary Outcomes

Description: To determinate the proportion of the rheumatic disease patients affected in their usual medical care during the COVID-19 pandemic in our Institution with the COVID-19 survey (locally development)

Measure: Change in the pattern of the usual medical care among the rheumatic disease patients

Time: At study inclusion (The first medical consultation posterior to open the external outpatient's service, post COVID-19 pandemic)

Secondary Outcomes

Description: Change in the activity disease measured as RAPID-3 of the Rheumatic disease patients in a 6 months follow-up. The results will express with a scale 0 to 30 a > number > disease activity

Measure: Change in the patient's activity disease

Time: In the first medical consultation posterior to open the external outpatient's service (post COVID-19 pandemic) to 6 months follow-up

Description: Change in the activity disease measured by their rheumatologist (4 questions) of the rheumatic disease patients in a 6 months follow-up. The results will express with 3 categories (without activity, low activity, moderate activity, high activity)

Measure: Change in the patient's activity disease measures by their rheumatologist

Time: In the first medical consultation posterior to open the external outpatient's service (post COVID-19 pandemic) to 6 months follow-up

Description: Change in the quality of life measured as WHOQOL-BREF of the Rheumatic disease patients in a 6 months follow-up. The results will express with a scale 0 to 100 a > number > quality of life

Measure: Change in patient´s quality of life

Time: In the first medical consultation posterior to open the external outpatient's service (post COVID-19 pandemic) to 6 months follow-up

Description: Change in the psychopathology measured as DASS-21 instrument (depression and anxiety) of the Rheumatic disease patients in a 6 months follow-up. The results will express with a scale 0 to 8 a cut of point > 8 suggests depression and stress presence, and > 5 suggests anxiety presence

Measure: Change in patient´s depression and anxiety

Time: In the first medical consultation posterior to open the external outpatient's service (post COVID-19 pandemic) to 6 months follow-up

Description: Change in the psychopathology measured as IER-R (posttraumatic stress) of the Rheumatic disease patients in a 6 months follow-up. The results will express with a scale 0 to 88 a cut of point > 24 would be significant

Measure: Change in patient´s posttraumatic stress

Time: In the first medical consultation posterior to open the external outpatient's service (post COVID-19 pandemic) to 6 months follow-up

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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