Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
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Navigate: Correlations HPO
There is one clinical trial.
Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort. The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
Description: Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry
Measure: SMI Time: Change from Baseline to 26 weeksDescription: Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry
Measure: BMD-LS Time: Change from Baseline to 26 weeksDescription: Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry
Measure: BMD-hip Time: Change from Baseline to 26 weeksDescription: Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity)
Measure: Sarcopenia-Z-Score Time: Change from Baseline to 26 weeksDescription: Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Measure: Fat infiltration thigh muscles Time: Change from Baseline to 26 weeksDescription: Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Measure: Fat infiltration para-vertebral muscles Time: Change from Baseline to 26 weeksDescription: Maximum hip-/leg extensor strength as determined by an isokinetic leg press
Measure: Maximum hip-/leg extensor strength Time: Change from Baseline to 26 weeksDescription: Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure)
Measure: Metabolic Syndrome Z-Score Time: Change from Baseline to 26 weeksDescription: Late-Life Function and Disability Index of McAuley et al.
Measure: Self rated physical performance Time: Change from Baseline to 26 weeksAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports