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D015431: Weight Loss

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug1076 Discussion Board for Social Support+Personalized Feedback Wiki 0.50
drug1075 Discussion Board for Social Support +Basic Feedback Wiki 0.50
drug2098 Multi Modal Balance Training Wiki 0.50
Name (Synonyms) Correlation
drug2430 Partner-assisted intervention Wiki 0.50
drug3697 WW Wiki 0.50
drug1988 Med-South Weight Loss Intervention Wiki 0.50
drug2445 Patient-only intervention Wiki 0.50
drug3644 Video Chat +Personalized Feedback Wiki 0.50
drug3643 Video Chat + Basic Feedback Wiki 0.50
drug3716 Weight Loss Wiki 0.50

Correlated MeSH Terms (0)


Name (Synonyms) Correlation

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0001824 Weight loss HPO 0.87

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Multimodel Exercise and Weight Loss in Older Obese Veterans With Dysmobility

Obesity is a major risk factor for mobility problems in older adults and many older adults use a walking aid to help with their mobility. The use of a walking aid changes normal walking patterns and makes walking harder, leading people to have more functional problems. The purpose of this study is to test the effects of 12 months of a multi-modal balance intervention (MMBI) with supervised weight loss compared to MMBI only on fitness, functional performance, balance, and economy of gait. Participants will be one of 120 participants in the VAMHCS. Participation in this study is voluntary. The research will be conducted at the VAMHCS. The entire study will take approximately 4 years to complete. Subjects' participation in the study will last 24 months.

NCT02806336
Conditions
  1. Obesity
  2. Dysmobility
Interventions
  1. Behavioral: Multi Modal Balance Training
  2. Behavioral: Weight Loss
MeSH:Weight Loss
HPO:Decreased body weight Weight loss

Primary Outcomes

Description: Distance walked during the 6 minute walking test

Measure: Change in 6 minute walk distance

Time: baseline, 3 months, 6 months, 12 months, 24 months

Secondary Outcomes

Description: VO2peak measured during graded exercise treadmill test to volitional fatigue

Measure: Change in VO2peak

Time: baseline, 6 months, 12 months, 24 months

Description: 6 minute walk with submaximal assessment of oxygen uptake.

Measure: Change in 6 minute walk with VO2 measurement

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: DXA scan

Measure: Change in Muscle mass/body composition as assessed by DXA scan

Time: baseline, 6 months, 12 months, 24 months

Description: LLDFI Questionnaires

Measure: Change in Quality of Life, LLDFI

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: Gait biomechanics as assessed by walking mechanics on the GAITmat

Measure: Change in gait biomechanics

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: Component scores of the standing balance battery, usual gait speed, and repeated chair stands (which make up the short physical performance battery test); as well as overall short physical performance battery score

Measure: Change in short physical performance battery

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: Dynamic test of balance involving change in stepping direction.

Measure: Change in four square step test

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: Time to get up from a chair and walk around a cone 8 feet away and sit back down, representing agility.

Measure: Change in 8 foot up and go

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: CT scan

Measure: Change in Muscle mass/body composition as assessed by CT scan

Time: baseline, 6 months, 12 months, 24 months

Description: Self-reported ability to complete activities of daily living and independent activities of daily living.

Measure: Change in ADL/IADL questionnaire

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: Self-reported physical activities questionnaire.

Measure: Change in CHAMPS questionnaire

Time: baseline, 3 months, 6 months, 12 months, 24 months

Description: Questionnaire assessing global cognitive function

Measure: Change in MoCA

Time: baseline, 3 months, 6 months, 12 months, 24 months
2 Using Partners to Enhance Long-Term Weight Loss

This study involves an evaluation of the role of domestic partner support in a comprehensive weight loss initiation and maintenance program.

NCT03801174
Conditions
  1. Obesity
Interventions
  1. Behavioral: Partner-assisted intervention
  2. Behavioral: Patient-only intervention
MeSH:Weight Loss
HPO:Decreased body weight Weight loss

Primary Outcomes

Description: Measured on a calibrated, digital scale to the nearest 0.1 kg, assessed every 6 months with 24 months as primary endpoint

Measure: Body weight (kg)

Time: 24 months

Secondary Outcomes

Description: average estimated daily intake from ASA24 Dietary Assessment Tool, assessed every 6 months with 24 months as primary endpoint

Measure: Caloric intake (kcal)

Time: 24 months

Description: average daily minutes of moderate activity over past 7 days from Fitbit, assessed every 6 months with 24 months as primary endpoint

Measure: Physical activity

Time: 24 months

Other Outcomes

Description: Score based on 12-item Unidimensional Relationship Closeness Scale (1-7, strongly disagree to strongly agree) and single-item Inclusion of Other in Self scale (7 Venn diagrams)

Measure: Transformation of motivation for diet

Time: 3 months

Description: 5 items assessed on 11-point scale ranging from 0 (not at all effective) to 10 (very effective)

Measure: Outcome efficacy for diet

Time: 3 months

Description: 5 items assessed on 11-point scale ranging from 0 (not at all confident) to 10 (very confident)

Measure: Couple efficacy for diet

Time: 3 months

Description: 9 items assessed on 5-point scale (never, rarely, sometimes, often, almost always)

Measure: Social support for diet

Time: 3 months

Description: 5 items assessed on 5-point frequency scale (never, sometimes, frequently, often, very often)

Measure: Use of communal coping strategies for diet

Time: 3 months

Description: Score based on 12-item Unidimensional Relationship Closeness Scale (1-7, strongly disagree to strongly agree) and single-item Inclusion of Other in Self scale (7 Venn diagrams)

Measure: Transformation of motivation for physical activity

Time: 3 months

Description: 5 items assessed on 11-point scale ranging from 0 (not at all effective) to 10 (very effective)

Measure: Outcome efficacy for physical activity

Time: 3 months

Description: 5 items assessed on 11-point scale ranging from 0 (not at all confident) to 10 (very confident)

Measure: Couple efficacy for physical activity

Time: 3 months

Description: 9 items assessed on 5-point scale (never, rarely, sometimes, often, almost always)

Measure: Social support for physical activity

Time: 3 months

Description: 5 items assessed on 5-point frequency scale (never, sometimes, frequently, often, very often)

Measure: Use of communal coping strategies for physical activity

Time: 3 months
3 Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices

This study will compare a new weight loss program that focuses on a healthy eating pattern, with WW™ (formally Weight Watchers), an effective and widely available weight loss program. Study researchers have developed an adapted version of the Mediterranean eating pattern to be more acceptable and realistic for southerners; this adapted version is known as "Med-South." Those who take part in the study will be randomly assigned to either the Med-South weight loss program or WW™. Both programs will last for 2 years with measurement visits at the start of the study and at 4-, 12- and 24-month follow-up. While the primary outcome measured by the trial will be weight loss at 24 months, researchers will collect other data which may show additional health benefits of the Med-South diet. The study team will measure blood markers of inflammation, which are known to improve with better diet quality. Researchers will also measure participants' skin carotenoid levels, which increase with greater fruit and vegetable consumption. The study will be conducted within 2 regional catchment areas (n=360 participants) representing a diverse spectrum of patients and settings. Patients with a BMI ≥ 30 kg/m^2 will be enrolled and randomized to intervention or augmented usual care. To assure adequate subgroup representation, ≥ 40% of the sample will have diabetes, ≥ 40% will be male, and ≥ 40% will be African American. The intervention will be delivered in 3 phases over 24 months by research staff: Phase I (4 months) focuses on adopting a Med-style dietary pattern; Phase II (8 months) on weight loss; and Phase III (12 months) on weight loss maintenance. Outcomes will be assessed at 4, 12, and 24 months. The primary outcome is weight loss at 24 months. Secondary outcomes include change in physiologic, behavioral, and psychosocial measures. Researchers will also assess implementation cost and the incremental cost-effectiveness of the intervention relative to the augmented usual care group.

NCT04302727
Conditions
  1. Weight Loss
  2. Diet, Healthy
  3. Cardiovascular Risk Factor
Interventions
  1. Behavioral: Med-South Weight Loss Intervention
  2. Behavioral: WW
MeSH:Weight Loss
HPO:Decreased body weight Weight loss

Primary Outcomes

Description: Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds.

Measure: Mean Weight Change from Baseline to Month 24

Time: Baseline, Month 24

Secondary Outcomes

Description: Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds.

Measure: Mean Weight Change from Baseline to Months 4 and 12

Time: Baseline, Months 4 and 12

Description: Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds. Change in weight will be assessed across 3 pre-specified subgroups: 1) with vs. without diabetes; 2) females vs. males; and 3) whites vs. African Americans.

Measure: Mean Weight Change from Baseline through Follow-Up by Sub-Groups

Time: Baseline, Months 4, 12, and 24

Description: Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds. Assess difference between study groups in percentage losing ≥ 5% body weight for all participants and across 3 pre-specified subgroups: 1) participants with vs. without diabetes; 2) females vs. males; and 3) Whites vs. African Americans.

Measure: Percentage Weight from Baseline through Follow-Up

Time: Baseline, Months 4, 12, and 24

Description: Blood pressure assessed by Omron-907xl, average of 3 readings.

Measure: Mean Change in Systolic Blood Pressure from Baseline through Follow-Up

Time: Baseline, Months 4, 12, and 24

Description: Blood pressure assessed by Omron-907xl, average of 3 readings.

Measure: Mean Change in Diastolic Blood Pressure from Baseline through Follow-Up

Time: Baseline, Months 4, 12, and 24

Description: Total cholesterol assessed by commercial lab (LabCorp).

Measure: Mean Change in Total Cholesterol from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: HDL-Cholesterol assessed by commercial lab (LabCorp).

Measure: Mean Change in HDL-Cholesterol from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Triglycerides as assessed by commercial lab (LabCorp).

Measure: Mean Change in Triglycerides from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Calculated from above lipid assessments by commercial lab (LabCorp).

Measure: Mean Change LDL-cholesterol from Baseline through Follow-up

Time: Baseline, Month 4, 12, and 24

Description: A1c assessed by commercial lab (LabCorp).

Measure: Mean Change in A1c from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: CRP assessed by commercial lab (LabCorp).

Measure: Mean Change in CRP from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Assessed by independent lab blinded to participant arm.

Measure: Mean Change in IL-6 from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Assessed by independent lab blinded to participant arm.

Measure: Mean Change in TNF-alpha from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Evaluated as the sum of 3 measures assessed by veggie-meter by Longevity Link Corporation.

Measure: Mean Change in Skin Carotenoids from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: The Euro Quality of Life five Dimensions Questionnaire EQ-5D-5L scale measures patients' quality of healthy living. It has 5 items (Mobility, Self-care, Usual activities, Pain/discomfort, Depression/anxiety). Each item contains 5 levels: 1= no difficulty, 2= slight difficulty, 3= moderate difficulty, 4= serious difficulty, 5= extremely serious difficulty. The higher the score has the worse the health. Then, the score calculation of the European Five-Dimensional Health Scale is based on the calculation formula published by the EuroQol Group. Based on 5 combinations of different severity levels, a score of 0 to 1 is obtained. 0 is the least healthy and 1 is the most healthy.

Measure: Mean Change in Quality of Life Scale from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: The AHEI-2010 is calculated from items on the Willett Food Frequency Questionnaire. It addresses intake of foods and nutrients consistently associated with lower risk for chronic diseases in the literature. The AHEI-2010 score is comprised of 11 sub-scales, each scored from 0 to 10, yielding a total score with a range of 0-110. A higher score indicates a more healthful dietary pattern.

Measure: Mean Change in Alternate Healthy Eating Index (AHEI)-2010 from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: The GPAQ was developed by the WHO for physical activity surveillance. It collects information on physical activity participation in three settings (or domains) as well as sedentary behavior. The domains are: activity at work, travel to and from places, and recreational activities. The summary measure will be the sum of all activity per day with a higher score indication more physical activity.

Measure: Mean Change in Global Physical Activity Questionnaire (GPAQ) from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: The Weight Efficacy Lifestyle Questionnaire Short-Form (WEL-SF1) is a short version of the original Weight-Efficacy Lifestyle Questionnaire and includes 8 questions and 1 situational component representing "confidence in ability to resist eating." Three of the questions are related to emotional eating situations, two to availability, one to social pressure, one to positive activities, and one to physical discomfort. Scoring: The instrument range scores on a Likert-scale from 0 (not at all confident) to 10 (very confident), with sum scores between 0 and 80. High scores are associated with high eating self-efficacy.

Measure: Mean Change in Weight Loss Self-Efficacy from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Treatment Self-regulation Questionnaire (TSRQ) measures the quality of motivation for a particular health goal. Motivation is psychological energy directed at a particular goal such as weight loss. This measure assesses three types of motivation: autonomous self-regulation, controlled self-regulation, and a-motivation or lack of motivation. This 15-item scale will focus on the reasons why people would either start eating a healthier diet or continue to do so. Scoring: Participants rate each statement on a 7-point Likert scale ranging from 1 (not at all true) to 7 (very true). It assesses the degree to which a person's motivation for eating a healthy diet is autonomous or self-determined. The three sub-scale scores can be used separately or a Relative Autonomous Motivation score can be calculated. A higher score indicates greater motivation.

Measure: Mean Change in Dietary Self-Regulation from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: The Three Factor Eating Questionnaire (18 item revised version) measures eating attitudes with scales representing three dimensions of eating behavior: cognitive restraint (control over food intake in order to influence body weight / body shape), uncontrolled eating (loss of control over eating), and emotional eating (eating in response to positive and negative emotions). Scoring: Each scale (dimension) is scored separately. Six of the eighteen items measure cognitive restraint, nine measure uncontrolled eating, and three measure emotional eating. Higher scores indicate greater cognitive restraint.

Measure: Mean Change in Eating Attitudes from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Perceived self-efficacy is regarded as a suitable predictor of behavioral intentions and reported health behaviors. This 5-item scale of perceived self-efficacy measuring action self-efficacy and coping self-efficacy related to healthful eating behaviors. Responses are on a 4-point scale of 'very uncertain' to 'very certain.' Scoring: Higher scores indicate higher perceived self-efficacy. Validation: Evidence for the validity of the scales has been published in several articles. Cronbach's alpha for the nutrition self-efficacy measure ranges from 0.79 to 0.85.

Measure: Mean Change in Diet Self-Efficacy from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: EARLY Self-Weighing Questionnaire: This is a 2-item screener measures frequency of self-weighing and access to a bathroom scale. It was adapted from the Pound of Prevention Health Habits Questionnaire, Year 2. Validity of construct confirmed in Linde et al, 2005, as reports of higher weighing frequency was associated with greater 24-month weight loss or less weight gain. Scoring: Higher scores indicate higher frequency of self-weighing and access to a bathroom scale.

Measure: Mean Change in Self-Weighing Behaviors from Baseline through Follow-Up

Time: Baseline, Month 4, 12, and 24

Description: Computed as the incremental cost per kilogram of weight loss relative to control. The budgetary assessment will quantify the total and per participant costs of intervention delivery from the health system perspective using an Activity Based Costing (ABC) approach and cost tracking forms that the health economist (Finkelstein) has developed and refined in past behavioral trials. Using this approach, all relevant labor, materials and supplies, contracted services, and other relevant costs required to deliver the interventions will be captured by key activities

Measure: Economic Outcome--Incremental Cost-Effectiveness

Time: Month 24

Description: The numerator for this analysis will be the incremental program delivery costs of the intervention relative to control, minus any cost offsets based on differences in health services and medication use across arms. The denominator will be the incremental QALYs based on average differences in Euro Quality of Life five Dimensions Questionnaire (EQ-5D-5L) scores across arms collected at each assessment point. These scores can be used to quantify net QALY differences during the intervention period. EQ-5D-5L scale measures patients' quality of healthy living. It has 5 items (Mobility, Self-care, Usual activities, Pain/discomfort, Depression/anxiety). The score calculation of the European Five-Dimensional Health Scale is based on the calculation formula published by the EuroQol Group. Based on 5 combinations of different severity levels, a score of 0 to 1 is obtained. 0 is the least healthy and 1 is the most healthy.

Measure: Economic Outcome--Incremental Cost per Quality Adjusted Life Year (QALY) gained

Time: Month 24
4 Exploring the Optimal Treatment Components for a Contactless Online Group-based Behavioral Weight Loss Program for the COVID 19 Pandemic

The current pilot study will explore the optimal cost-effective treatment configuration for online group-based weight control by focusing on two aspects of our existing treatment program which have significant associated cost and determine which contribute meaningfully to weight loss outcomes. Specifically, we will explore whether adding synchronous group social support (weekly group video chat sessions facilitated by a trained weight loss counselor) to on demand (asynchronous) social support provided through the program discussion board significantly increases weight losses achieved. We will also examine whether detailed feedback on dietary and physical activity self-monitoring records from a counselor enhances weight loss outcomes in comparison with basic feedback. Finally, we will examine the cost efficiency of the treatment constellations. Further, this pilot study will also explore the feasibility of recruiting participants nationally (rather than just locally) and the capture of data electronically (including body weight measurements) without any in-person contact.

NCT04514900
Conditions
  1. Obesity
Interventions
  1. Behavioral: Video Chat +Personalized Feedback
  2. Behavioral: Video Chat + Basic Feedback
  3. Behavioral: Discussion Board for Social Support +Basic Feedback
  4. Behavioral: Discussion Board for Social Support+Personalized Feedback
MeSH:Weight Loss
HPO:Decreased body weight Weight loss

Primary Outcomes

Description: Change in body weight from baseline calculated as kg lost

Measure: Weight loss

Time: Baseline, 2 and 4 months

Description: 1 - [follow-up body weight/ baseline body weight] = % body weight change

Measure: Change in body weight from baseline calculated as % of body weight lost

Time: 2 and 4 months

Secondary Outcomes

Description: Self-monitoring rates for daily weighing and will be calculated as the total number of days of weight submitted over the 4 month period divided by the total number of days of potential self-weighing.

Measure: Treatment Engagement: daily weighing

Time: Weeks 1 to 16

Description: Self-monitoring rates for daily dietary self monitoring will be calculated as the total number of weeks of digital food diaries submitted over the 4 month period divided by the total number of weeks of potential digital diary submissions.

Measure: Treatment Engagement: weekly food journal submissions

Time: Weeks 1 to 16

Description: Percent of weekly module completion will be calculated as the total number of weeks of completed modules submitted over the 4 month period divided by 16 (the total number of modules available).

Measure: Treatment Engagement: completion of the 16 weekly interactive online modules

Time: Weeks 1 to 16

Description: Percent of weekly video chat attendance will be calculated as the total number of weeks each participant attended video chat over the 4 month period divided by 16 (the total number of video chats available).- Collected only for those randomized to a condition with video chat

Measure: Treatment Engagement: Attendance at Video Chat condition

Time: Weeks 1 to 16

Other Outcomes

Description: All participants will be administered the Supportive Accountability Questionnaire to determine whether there is a difference in accountability experienced by participants depending on which intervention they receive.

Measure: Supportive Accountability

Time: 2 months and 4 months

Description: All participants will be administered the Perceived Social Support Scale to determine whether perceptions of social support differ depending on which intervention participants receive.

Measure: Social Support

Time: baseline, 2 months and 4 months

Description: Actual counselor time spent in delivering group video chats and giving feedback will be tracked in order to quantify the relative costs of delivering behavioral weight control programs.

Measure: Cost-Effectiveness Analyses

Time: Weeks 1 to 16

Description: All participants will be queried as to their expectations and preferences in treatment prior to intervention.using a measure designed for the current study

Measure: Treatment Expectations

Time: Baseline

Description: Each month participants will be asked to complete a survey inquiring about the helpfulness of the treatment modules, skills building assignments, and satisfaction with their treatment experiences in the previous month. Response options will be a 5-point Likert scale with 1=not at all helpful/useful and 5=extremely helpful/useful on a measure that is developed for this study and tailored to the treatment elements provided.

Measure: Treatment Satisfaction

Time: through study completion, up to 24 weeks

Description: Participants self report on their self management behaviors

Measure: Self Regulation Questionnaire

Time: baseline

HPO Nodes


HP:0001824: Weight loss
Genes 324
FANCE NALCN CBL DNAJC13 HTT TTR PDX1 COL6A2 BIRC3 ABCC8 NAB2 JAK2 SDHB CEP152 SDHAF2 GBA FANCL VHL PTEN STAT5B RFWD3 PMS2 POLG EPCAM POLG NF1 TP53 SDHB SCNN1A MEFV TP53 IL12A-AS1 SLC11A1 CTLA4 KCNJ11 ATRX MLX BRIP1 GPR35 PTEN THPO STAT3 PML TYMP IGH RRM2B HLCS HSPG2 CCR1 MALT1 SDHD GPC3 MLH3 RRM2B MSH2 CCND1 KLRC4 KCNJ18 SDHC SDHC FH JPH3 FANCF TSHR GIGYF2 POLG PALLD HLA-B TCF4 CDKN2A RUNX1 EDN3 BCOR SDHB BRCA2 ERCC3 NOD2 HLA-DRB1 KRT1 PRNP GJA1 BCL10 IRF2BP2 MRAP BCL6 SUCLA2 RHBDF2 FANCG B2M BCL2 ZBTB16 SNCA SLX4 PALB2 KIF1B HLA-DQA1 SCNN1A TGFBR2 KCNJ11 KRAS SDHD SDHA SMAD4 HLA-B INS FANCI POU6F2 UNC80 DAXX C4A IKZF1 CNTNAP1 ATM LIPA UBAC2 FANCD2 NUMA1 COL6A1 LRP12 FANCA RARA RB1 MST1 SLC39A4 EPAS1 PTPN22 SEMA4A KRT10 TRPV4 PCNT F5 SLC25A11 EWSR1 XRCC2 TRIM28 GALC NDP VPS35 MPL AK2 FIP1L1 ASXL1 CDC73 WT1 WT1 TXNRD2 SEMA3D HLA-DPB1 UBE2T TP53 HLA-DPA1 ERCC4 MPL TRIM28 TLR4 NPM1 SCNN1B ACAT1 PIK3CA GDNF SDHD FAN1 FANCB PLA2G6 FAS HLA-DQB1 CENPE RAD51 STAR ERCC5 CHEK2 SDHD IL12A IGH RET LPIN2 FANCM SLC6A8 ERCC4 SNCA SDHAF1 CRLF1 DLST REST PANK2 SLC9A6 SDHA PRKAR1A LRRK2 EDNRB BMPR1A FLI1 CACNA1S TET2 TET2 ABCC8 PTEN MC2R ATP7B ERCC4 UNC80 GNPTAB NABP1 ATRIP IL10 IFNGR1 IL12B GCK SCNN1G HLA-DRB1 STAT4 RNF168 ZFP57 COL6A3 IL23R BMPR1A COL12A1 DIS3L2 ERAP1 FOXP1 CACNA1S STAT3 STAT6 CALR VPS13A MPL MAFB CENPJ TSHR WT1 BRCA1 TRIP13 NNT TP53 RAD51C BRCA2 AKT1 COL5A1 BTNL2 TBL1XR1 GJB4 CCND1 PTPN22 MSH6 PMS1 ERCC2 PRNP GJB3 TYMP NOS1 JPH3 TMEM127 ACADM GATA2 SDHB BRCA1 CYP24A1 LMNA PRTN3 MLH1 MDH2 SRSF2 DNMT3A HLA-B IGH KRAS DCTN1 BRCA2 JAK2 HMGCL MAD2L2 RET FANCC COL1A1 PLK4 PRNP GATA4 ECE1 AVP FOXP3 TRIM37 PLAGL1 HMBS RBBP8 NOD2 DCTN1 KDSR SEMA3C PIK3R1 MAX SCNN1G KIF1B RPS20 JAK2 GALT COL5A2 RET NRTN H19 CFTR ATR TRAIP KCNJ18 HLA-DQB1 HLA-DRB1 PSAP CDH23 EIF2AK3 MECP2 BTK HLA-DRB1 HYMAI IL6 EIF4G1 CUL4B NBN TGFB1 PALB2 VHL SCNN1B HAVCR2 TET2 JAK2 GABRA3
Protein Mutations 2
I148M P12A
HP:0004325: Decreased body weight
Genes 1639
CTBP1 ELMO2 KCNJ1 TCIRG1 MICOS13 RAG1 INSR NEUROG3 KCNAB2 ARHGAP31 RAB3GAP1 EPCAM POLG NF1 TP53 UBE3B KCNJ11 ASAH1 NDUFS7 NDUFAF1 NDUFV2 GPR35 DYNC2LI1 RAG2 PKP1 SPRY4 TACR3 CYP11B2 FGF17 PUS7 SCN8A ARHGEF6 KMT2A HCCS TERT LAT CCR1 WWOX NDUFS3 PTF1A AUH BPTF LAMC2 EMG1 NUP62 FGFR1 ARX HESX1 ERCC3 CEP57 MRPS16 RAB33B BSCL2 PIEZO2 SUGCT BCL2 SLX4 OCLN GNRHR CSF2RB CHRNG KMT2D WDR11 ACADVL NSMCE3 SFTPB SERAC1 NFIX PDE8B LIPA KRT5 AQP2 FCGR2A DYNC2I1 PLP1 TBR1 FANCI IGHMBP2 PEX7 BRF1 NDUFV1 RAI1 KRT10 ORAI1 SLC25A11 EVC2 ABCC8 MPL WT1 IGHM SOX9 SDHA EBP NEXMIF EEF1A2 MAGEL2 TUBB4A UFD1 LETM1 NDUFAF3 SNORD115-1 TMEM126B RFXANK NDUFS2 SDHD ICOS MECP2 LPIN2 CD3D GPC1 FANCE DLST COX6B1 MTR LMBRD1 SLC9A6 LRRK2 COX14 GPR161 EP300 CLTC DEAF1 SIN3A CUL7 HLA-DRB1 PIGP ZFP57 IL23R DIS3L2 UBA5 FOXP1 CACNA1S CALR NDUFV1 PEX5 ATP6V0A2 DNMT3B BRCA1 IQSEC2 CRIPT STT3A MRPL3 MSH6 CREBBP ERCC2 OTUD6B DNAJC21 PREPL PARS2 DUSP6 ACADM IGLL1 ABCA12 TPM3 NALCN ND6 AKT1 DNMT3A NSD2 PEX2 HMGCL MAD2L2 ATXN7 MED12 ERCC4 FOXP3 SLC25A3 VPS13B TRNL1 KCNA1 PRDX1 PEX13 ALPL MTFMT NDUFB3 PRKACA KCNJ10 RYR1 USP7 HUWE1 PTEN COL5A2 NDUFAF3 H19 ABL1 CFTR PYGL NIPAL4 TRAIP ACAD9 CDC45 TCF4 ADA CYB5R3 HLA-DRB1 NUS1 TAPT1 ERCC4 MTRR GATM PRKCD CDC6 RECQL4 DNMT3A MED12 BRCA2 PALB2 KISS1R NDUFS7 PDE6D ASAH1 SDHD CAMKMT DNM1 ASNS NSDHL RTTN ABCC8 SC5D SDHB STXBP1 NAGS STRADA PMS2 POLG TACO1 LTC4S LYRM4 SDHB TGFB3 NUP188 UBTF TRNF EPHX1 NAT8L OTC ND3 ZNF335 AVPR2 AMER1 GCDH SPATA5 PRDM16 HLCS GMNN SLC9A6 COG4 RREB1 SDHC SELENON TSHR STT3B LBR CFTR SLC5A1 PHOX2B SCN2A RFT1 PEX3 MMUT HLA-DRB1 FAM111A ALG12 RET TCN2 ACTB PEX19 NDUFS1 TRMT10A IGF1 ZBTB16 ANTXR2 COA8 RASGRP1 KCNJ11 KRAS FLT1 RECQL4 SP110 PPP2R3C HLA-B VPS37A BCOR CNTNAP1 DGAT1 SLC25A24 CNKSR2 MMACHC TMEM165 MBTPS2 MOGS GNPAT COX10 ADAT3 PTPN22 SEMA4A ATP6V0A2 CYFIP2 VPS35 ASXL1 CDC73 WT1 EARS2 TBX4 UBR1 SMAD4 EBP TRIM28 GP1BB CYP7B1 PIK3CA EPRS1 SBDS MIPEP SLC12A3 MVK ERCC1 RAD51 GLYCTK PTCHD1 ACSL4 CYP11B2 GALT TACO1 IGH SLC6A8 PEX11B PSMB9 SLC17A5 ADAT3 TRNS1 NFKB1 ALG3 BMPR1A CENPJ ERCC3 TET2 RAG2 EPG5 HRAS RTEL1 HADHB MAP2K2 NDUFV2 POLG CLCNKB MS4A1 BRAF FAM111A RTTN STAT4 MMADHC UQCRFS1 TCOF1 DKC1 CENPJ RAD51C ACSF3 CDH23 NDUFS4 PAK3 TUBB4A PRNP TBX1 TBL1XR1 SLC25A15 CD96 MLH1 CYP27B1 SETD5 OTUD6B HIKESHI IL7R MYL2 TRAIP KCNA4 IGH MECP2 IL2RG DCTN1 PRPS1 DDOST PDE11A ND4 MGAT2 PRNP CNTNAP2 PEX10 NR3C2 KDSR DHCR24 DMD CDK10 HSD11B2 GALT NDUFB9 NRTN AHDC1 NDUFA13 ETHE1 CBS HLA-DRB1 TRNV PSAP GNRH1 NDUFB11 SCNN1G KIF7 ABCA3 CUL4B NDUFB11 ANKLE2 BUB1B RAI1 C12ORF65 SCN3A GALE PDX1 EXOSC8 MCCC2 MRPS2 GTF2E2 SLC34A3 MCM9 RPS6KA3 EFL1 OSGEP NUBPL NDUFS1 LIMK1 LIPT1 HTT B4GALT7 SUCLA2 JAK2 HYMAI CD79A SURF1 SLC22A5 FGFR1 ELN NDUFS8 NADK2 MED12 DPM2 MYH3 TWIST2 GBE1 RRM2B FGFRL1 FUT8 DPYD ORC6 SYNJ1 HADH DNM2 TRAK1 XPC KANSL1 NDUFV2 SMARCD2 PHGDH HMGA2 POLG HPD TNFRSF13B TRNQ CDKN2A POLR1D IGF2 CYP27B1 IL1RAPL1 RARS2 GABRA2 KMT2A GJA1 WDR4 MYMK B2M DOCK6 TOP3A UFC1 NDUFB10 PIK3CA SCNN1A IL21R SDHD COL6A3 SKI NADK2 CORIN CYP11B2 NUMA1 DLL4 COL6A1 PRKAR1A H19-ICR NDN GCK SPINK5 LAMA2 LRPPRC TGFB1 HNRNPH2 SELENON UBR1 TRIM28 FOS CPLANE1 PUS3 TSPAN7 SEMA3D ARMC5 STAMBP LEMD3 HLA-DPB1 BMP1 RFXAP DHDDS CDON DPP6 TRNS1 ROBO1 TRNH XYLT2 NAGS PEX11B CACNA1A PEX14 CD79A GPT2 IL12A PRF1 ERCC4 DMXL2 GTPBP2 ACTA1 REST MMAA PEX12 SRP54 DHCR24 ABCC8 ALOX12B NSDHL NDUFAF5 NDUFA12 DSP NSD2 ALAD SDHA LMNA NABP1 NLRP1 PNPLA1 NECAP1 GMNN SLC25A15 SKIV2L COA3 COL12A1 SUCLG1 STAT6 VDR ERCC6 UMPS CNTN1 BRCA2 LAMC2 NELFA COX1 TBL1XR1 GJB4 CCND1 DNM1L GJB3 TYMP LMNA ITCH JPH3 PIK3R1 BRCA1 PCSK1 LMNA PRTN3 PYCR1 DPM1 PROKR2 PTS KCNA2 ZNF711 COX15 ELN SON RYR1 RAG2 TERT SLC25A24 AHCY KDM6A GATA6 ATP6V1E1 GDI1 PIK3C2A CAV1 STRA6 CDKL5 ERCC2 GPT2 PSMB4 CIITA COX2 RET STOX1 COX20 TGM1 LCK INTU PPM1B DOLK IARS1 CTNS TPM2 IPW FGF8 PYCR2 ARFGEF2 SAR1B PEX2 HSD11B2 SON STT3B RAG1 AARS2 DNAJC3 ACO2 GBA NALCN CBL SCO1 NDUFAF6 SLC46A1 G6PC3 NUP62 KAT6B MPI COL1A1 SPRTN ACTL6B FTSJ1 SCNN1A ALG11 SLC39A4 HADHA RIPK1 COX7B IGHM CLMP PET100 SAMD9 PTEN PML INSR COG8 CYP2R1 HSPG2 RFT1 CD19 CXORF56 KLHL41 AUTS2 PROK2 AUH HIBCH SDHC FANCF NTRK2 NECTIN1 AKR1D1 NR0B1 PLEC BCL6 SUCLA2 FANCG TRAC PPP3CA YY1 ASXL1 IL7R PTRH2 COQ7 KIF1B TAZ ALDOB NDUFAF5 LETM1 GRIN2A INS FANCI ZAP70 MCM5 PMPCB CARMIL2 ACTA1 EPAS1 GTPBP3 ASXL3 EWSR1 HACD1 TRIM8 ASXL1 TXNRD2 MECP2 PNPO TRNN HERC2 SLC46A1 LARP7 MRPS7 NDUFB3 FAN1 PLA2G6 NDUFAF4 LMNA CENPE NOTCH2 ERCC5 DACT1 AIMP1 TWNK NNT ACVR1 KLLN ATP6V0A2 YARS2 CD247 XPA PRKAR1A EDNRB CACNA1S OCRL TAC3 USP27X PPP1R15B MC2R MMAB PNPO CA2 ATP7B DHCR7 TK2 FBN2 COL12A1 CIITA RNF168 PTF1A MBL2 COL6A3 BMPR1A KIF7 COX4I2 KIAA0753 GNB1 MYPN NNT TP53 TKFC GRIA4 SLC3A1 ITGB4 VIPAS39 RARB ORC4 SRP54 IFIH1 ORC4 TMEM127 CD79B MPDU1 WDR4 PDX1 KRT5 PACS1 SRSF2 KRAS TIMMDC1 GOT2 NDUFAF1 RET PPP3CA NDUFS3 FBXL4 PEX13 WHCR COL1A1 TRIO HMBS ERMARD DCTN1 TGDS NOTCH2 MAX VAC14 KIF1B PIK3R1 PEX16 USF3 DNAJC21 PUS1 TNFSF12 ACTA1 HLA-DQB1 PEX3 CDT1 EIF2AK3 UBA5 USP9X BSND AGPS USP8 WDR73 TET2 JAK2 HBA2 FUCA1 GABRA3 GNB1 POLR1A SLC6A8 CLCN4 NEB KRAS BLNK GBA SLC13A5 PTEN TCF4 PNPLA6 KISS1 MEFV NEB CTLA4 BRIP1 TRAK1 TYMP TTC37 GJA1 IGH MTRR BANF1 MCCC2 PEX1 DNA2 ND4 GPC3 MLH3 MSH2 EXT1 POLG2 CCND1 NCAPG2 MCEE MEGF10 GIGYF2 TCF4 RUNX1 BCOR SDHB ORC6 DCLRE1C TAF13 SLC7A7 HRAS SETBP1 IRF2BP2 RAI1 SLC35A2 PIGQ CKAP2L PCCA CLDN16 PALB2 PEX10 COL7A1 CACNA1B WRN CERS3 CD3G TIMM50 COX8A BRAF POU6F2 RAD21 DAXX C4A CASK MARS1 FLCN TPM2 RPS6KA3 EXOSC9 MMACHC LRP12 BCS1L PSMB8 FANCA KLHL7 MST1 PEX12 NDUFS6 SLC2A2 RAG1 COPB2 TRPV4 F5 XRCC2 ASCL1 CCDC8 SSR4 BCAP31 OCRL ZSWIM6 TP53 ERCC2 ERCC4 AGPAT2 HSD17B4 DCLRE1C RPS6KA3 KCNB1 HSD3B7 SCNN1B ACAT1 PMM2 GTF2IRD1 ND5 COG8 NDUFS8 SDHD FANCB FAS MYH3 GPIHBP1 FANCM ETHE1 SNX10 ERCC6 RNF13 TET2 JAGN1 TGFB1 DGUOK CD3E SNRPN GALC CLIP2 GCK COG6 COMT POR SFTPC SLC4A1 PEX5 SIL1 RMRP PLAA TP63 ERAP1 TRMT5 NDUFS2 PCGF2 TFAM TSHR NOTCH1 HIRA PEX19 AKT1 PTDSS1 CPLX1 PMS1 GNAO1 COL6A1 SEC23B TJP2 ZNF41 CHRM3 CYP24A1 MDH2 HLA-B CYTB BRCA2 IL2RB CHD7 DDB2 FGD1 PLK4 GATA4 SYP NDUFA10 BCS1L PLAGL1 NDUFS1 TALDO1 RIN2 RFXANK ND3 SEMA3C MYH3 TGFB1 SLC9A7 PIK3R1 SLC12A1 ND6 POLA1 PWRN1 RPS20 KMT2A CYP17A1 FGF12 SLC26A3 CR2 ATR DNA2 SLC7A7 NDUFA4 CAVIN1 NFKB2 TPM3 EIF2S3 IGF1R EIF4G1 PDHA1 NSMF KCNA2 NBN LMBRD1 ALG8 SGO1 ATP6V0A2 PMM2 TRNL1 POLR3A HDAC8 MTO1 SCNN1B HAVCR2 TRIT1 PIK3CA MSX1 SNAP29 COL6A2 SCN3A NAB2 CEP152 NDUFB8 VHL TCTN3 NGLY1 PPP1CB PEX16 SARS1 TP53 ALB SETBP1 ERCC5 ATRX BRCA1 NDUFA13 INSR CLCNKA ATP6V0A4 CPLANE1 RNU4ATAC B3GALT6 LAMA3 B3GLCT RAI1 HCFC1 SYNE1 KRT14 MALT1 ND1 SDHD ATPAF2 SCNN1A KCNJ18 CD40LG ND1 UBE3B JPH3 SLC39A8 COX10 MC2R NACC1 MKKS EDN3 CYP17A1 POMC IL21 BCL10 TNFRSF13C ALG9 FANCC LIG4 GBA COG1 ADAR NFASC MAP3K7 TGFBR2 MED17 POMP NHLRC2 ANOS1 HADHA MYH7 FANCD2 PTPRC ZIC3 HCFC1 CYP11A1 SLC39A4 POLG ADA POLE WDR11 POLG2 BAZ1B CYP7B1 TRNS2 NDUFS4 UBA1 GK DCLRE1C THRB CLCNKB SMOC1 ASS1 MPL BCAP31 ACTB ARX TSHR NONO COA8 ACTG1 GRIN2D MYH7 NDUFB8 EFL1 CAVIN1 CASK PYGL FLNA ACSF3 ALOXE3 JAG1 MMUT RIT1 FAH NONO SAR1B MAP2K1 SLC10A2 MUSK TPM3 KIF15 GNPTAB ATRIP IL12B NPHS1 COL6A2 ATM NDUFA6 INS SURF1 TIMM50 COL1A2 SMC1A ALG13 RFX5 FH NFIX RELB GBA PUF60 BTNL2 BRAF PGM3 NOS1 MBTPS1 NDUFA1 PDHA1 CHD7 NDUFA11 POC1A FLII FRMPD4 PNKP SNORD116-1 NDUFS2 ECE1 EOGT TRIM37 CDT1 ATP6V1A CTCF RBBP8 DLD AHCY TRNK GATA6 GABRD RET ADK NACC1 COG4 ATP6V1E1 CSPP1 FANCA OFD1 GABRA5 PARN CASP8 TNFSF12 C12ORF65 CYP2R1 IL6 B3GALT6 AARS1 RPS19 TGFB1 SCN1B TBL1XR1 PLAA ZNF81 LIPA PARN NKX2-1 CCDC47 DNAJC13 FMR1 TTR PDX1 BIRC3 FGFR1 FANCL FBN1 GNAS IKBKB STAT5B ND2 KCNJ11 COG7 IL12A-AS1 CNKSR2 ARID1B MLX SLC1A2 PWAR1 PCCB ECHS1 CD81 MRPS14 THPO ZAP70 STAT3 RAB39B KRT14 WNT2B PNPT1 DYRK1A LRBA BAAT PET100 KLRC4 ATP5F1A NDUFAF2 EVC PEX6 AGXT WDR26 PALLD HLA-B MPV17 NOD2 SCO2 NDUFS2 NDUFB11 SLC25A22 SMARCA2 MRAP HSD3B7 SNCA GYS2 TIMMDC1 OTULIN NDUFAF8 HLA-DQA1 COX3 ASL STRADA SDHA SMAD4 UNC80 MCTP2 PEX1 ATM LARS1 ARVCF MID2 RAG2 KIAA0586 NFKB2 COG1 TFRC SELENON HBA1 FOXRED1 IQSEC2 SKI LAMB3 SDHC RBPJ VPS33B FOXRED1 GALC CREB3L1 NDUFAF4 IL2RG AQP2 NR1H4 CYB5A GNPTAB UBE2T VPS45 ATP8B1 NPM1 SMC1A PEX1 AVPR2 HS6ST1 PEX16 PPARG GDNF STAG1 LRP5 HLA-DQB1 SLC19A3 TBC1D23 RBM10 STAR PEX5 RBM10 PREPL RET RFC2 PSMD12 NLRC4 SDHAF1 GABRG2 MCCC1 IL2RG CCNQ SLC39A13 MCCC1 FOXP1 PROKR2 ANOS1 ERCC4 ACOX1 NEB GRIA3 MSMO1 SCNN1G SZT2 LYRM7 CASR JMJD1C ST3GAL5 GRIA3 RPL5 TMEM70 AARS1 ARPC1B MAFB FLNA AUTS2 TRIP13 SLC25A13 YWHAG JAK3 TMEM126B POLR1C SBDS ND5 SDHB ACD EHMT1 PTPN11 JAK2 CARS2 SIX2 ACTA1 SMPD1 YY1AP1 AVP NDUFAF2 ATP6 RMRP CSNK2A1 SELENON TCTN3 POLR3A PYCR2 CDC45 TRNW SCNN1G CDC6 TBX1 KCNJ6 DCLRE1C JAK2 PPP1R15B NDUFA2 AMPD2 GHSR DHDDS KCNJ18 DDX3X AHDC1 CD3D FZD4 NGLY1 SEC24C NEUROD2 NSUN2 MAGEL2 BMP4 MECP2 FTO HCN1 NDUFA9 HADHB MAP2K1 TRMT10C SLC25A4 SLC25A21 SYNGAP1 HPD SMARCC2 FANCE NDUFAF5 TRMT1 SDHAF2 STAG2 PEX19 SLC25A13 RFWD3 ELAC2 CPS1 SHROOM4 SLC11A1 CTNS UPF3B HERC1 SURF1 ATP6V1A NIPBL SCNN1B RRM2B PEX26 PEX5 NFE2L2 RRM2B ABCB11 FH SLC34A1 PEX26 NPAP1 TTN RAG1 BRCA2 JAK3 FIG4 SMC3 KRT1 PRNP AGTPBP1 ALDH18A1 CASK MDH2 RFXAP CYP19A1 RHBDF2 TTC37 FARSB RERE NRXN1 CYP11A1 LAMA3 KRAS MLXIPL ZFP57 RBBP8 SALL1 ATP6 PCLO PEX12 IGF1 CYB5A IKZF1 PEX13 UBAC2 ORC1 EXT2 RARA RB1 TPM2 LIG4 SSR4 EGFR MAP2K1 NDP PCNT ND1 CSF2RA NDP AK2 KCNJ6 FIP1L1 PNP ITGA7 PEX2 HLA-DPA1 LRRC8A AP3B2 TLR4 SLC25A13 PSAT1 ADA STXBP1 NUS1 MKRN3-AS1 CHEK2 TMEM216 ATP6V1A FANCD2 SNCA CRLF1 GRIN2D FAM149B1 ACADS BMPR1A PANK2 TMPRSS15 SDHA RBCK1 GTF2I FLI1 DEGS1 PAM16 PTEN NUP214 EPCAM KBTBD13 LAMB3 UNC80 IL10 IFNGR1 PEX6 SPR DDOST DNAJC21 SKIV2L STAT3 VPS13A MPL ARV1 STT3A COX15 AGTR2 WT1 VPS13B GLI1 COL5A1 PTPN22 TRNW MKRN3 ARCN1 GATA2 CLTCL1 ORC1 OBSL1 SLC12A3 SLC3A1 STING1 FIG4 DLG3 FANCC NDUFS4 GABRB2 ERCC2 SIK1 TBL2 IRF6 SDHB TMEM216 PEX14 NOD2 CA12 IGF2 TCF3 ND2 HADHA AP1B1 FBN1 ESR2 CDH23 LHX4 IL7R BTK SARS2 HYMAI SMAD4 FLNA ZMPSTE24 MAP3K20 KDM6A RFX5 AMACR NFU1 VHL ACTB POLA1 TINF2 ALG13 CD96 CIT
Protein Mutations 0
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0001824: Weight loss
Genes 324
FANCE NALCN CBL DNAJC13 HTT TTR PDX1 COL6A2 BIRC3 ABCC8 NAB2 JAK2 SDHB CEP152 SDHAF2 GBA FANCL VHL PTEN STAT5B RFWD3 PMS2 POLG EPCAM POLG NF1 TP53 SDHB SCNN1A MEFV TP53 IL12A-AS1 SLC11A1 CTLA4 KCNJ11 ATRX MLX BRIP1 GPR35 PTEN THPO STAT3 PML TYMP IGH RRM2B HLCS HSPG2 CCR1 MALT1 SDHD GPC3 MLH3 RRM2B MSH2 CCND1 KLRC4 KCNJ18 SDHC SDHC FH JPH3 FANCF TSHR GIGYF2 POLG PALLD HLA-B TCF4 CDKN2A RUNX1 EDN3 BCOR SDHB BRCA2 ERCC3 NOD2 HLA-DRB1 KRT1 PRNP GJA1 BCL10 IRF2BP2 MRAP BCL6 SUCLA2 RHBDF2 FANCG B2M BCL2 ZBTB16 SNCA SLX4 PALB2 KIF1B HLA-DQA1 SCNN1A TGFBR2 KCNJ11 KRAS SDHD SDHA SMAD4 HLA-B INS FANCI POU6F2 UNC80 DAXX C4A IKZF1 CNTNAP1 ATM LIPA UBAC2 FANCD2 NUMA1 COL6A1 LRP12 FANCA RARA RB1 MST1 SLC39A4 EPAS1 PTPN22 SEMA4A KRT10 TRPV4 PCNT F5 SLC25A11 EWSR1 XRCC2 TRIM28 GALC NDP VPS35 MPL AK2 FIP1L1 ASXL1 CDC73 WT1 WT1 TXNRD2 SEMA3D HLA-DPB1 UBE2T TP53 HLA-DPA1 ERCC4 MPL TRIM28 TLR4 NPM1 SCNN1B ACAT1 PIK3CA GDNF SDHD FAN1 FANCB PLA2G6 FAS HLA-DQB1 CENPE RAD51 STAR ERCC5 CHEK2 SDHD IL12A IGH RET LPIN2 FANCM SLC6A8 ERCC4 SNCA SDHAF1 CRLF1 DLST REST PANK2 SLC9A6 SDHA PRKAR1A LRRK2 EDNRB BMPR1A FLI1 CACNA1S TET2 TET2 ABCC8 PTEN MC2R ATP7B ERCC4 UNC80 GNPTAB NABP1 ATRIP IL10 IFNGR1 IL12B GCK SCNN1G HLA-DRB1 STAT4 RNF168 ZFP57 COL6A3 IL23R BMPR1A COL12A1 DIS3L2 ERAP1 FOXP1 CACNA1S STAT3 STAT6 CALR VPS13A MPL MAFB CENPJ TSHR WT1 BRCA1 TRIP13 NNT TP53 RAD51C BRCA2 AKT1 COL5A1 BTNL2 TBL1XR1 GJB4 CCND1 PTPN22 MSH6 PMS1 ERCC2 PRNP GJB3 TYMP NOS1 JPH3 TMEM127 ACADM GATA2 SDHB BRCA1 CYP24A1 LMNA PRTN3 MLH1 MDH2 SRSF2 DNMT3A HLA-B IGH KRAS DCTN1 BRCA2 JAK2 HMGCL MAD2L2 RET FANCC COL1A1 PLK4 PRNP GATA4 ECE1 AVP FOXP3 TRIM37 PLAGL1 HMBS RBBP8 NOD2 DCTN1 KDSR SEMA3C PIK3R1 MAX SCNN1G KIF1B RPS20 JAK2 GALT COL5A2 RET NRTN H19 CFTR ATR TRAIP KCNJ18 HLA-DQB1 HLA-DRB1 PSAP CDH23 EIF2AK3 MECP2 BTK HLA-DRB1 HYMAI IL6 EIF4G1 CUL4B NBN TGFB1 PALB2 VHL SCNN1B HAVCR2 TET2 JAK2 GABRA3
Protein Mutations 2
I148M P12A
HP:0004325: Decreased body weight
Genes 1639
CTBP1 ELMO2 KCNJ1 TCIRG1 MICOS13 RAG1 INSR NEUROG3 KCNAB2 ARHGAP31 RAB3GAP1 EPCAM POLG NF1 TP53 UBE3B KCNJ11 ASAH1 NDUFS7 NDUFAF1 NDUFV2 GPR35 DYNC2LI1 RAG2 PKP1 SPRY4 TACR3 CYP11B2 FGF17 PUS7 SCN8A ARHGEF6 KMT2A HCCS TERT LAT CCR1 WWOX NDUFS3 PTF1A AUH BPTF LAMC2 EMG1 NUP62 FGFR1 ARX HESX1 ERCC3 CEP57 MRPS16 RAB33B BSCL2 PIEZO2 SUGCT BCL2 SLX4 OCLN GNRHR CSF2RB CHRNG KMT2D WDR11 ACADVL NSMCE3 SFTPB SERAC1 NFIX PDE8B LIPA KRT5 AQP2 FCGR2A DYNC2I1 PLP1 TBR1 FANCI IGHMBP2 PEX7 BRF1 NDUFV1 RAI1 KRT10 ORAI1 SLC25A11 EVC2 ABCC8 MPL WT1 IGHM SOX9 SDHA EBP NEXMIF EEF1A2 MAGEL2 TUBB4A UFD1 LETM1 NDUFAF3 SNORD115-1 TMEM126B RFXANK NDUFS2 SDHD ICOS MECP2 LPIN2 CD3D GPC1 FANCE DLST COX6B1 MTR LMBRD1 SLC9A6 LRRK2 COX14 GPR161 EP300 CLTC DEAF1 SIN3A CUL7 HLA-DRB1 PIGP ZFP57 IL23R DIS3L2 UBA5 FOXP1 CACNA1S CALR NDUFV1 PEX5 ATP6V0A2 DNMT3B BRCA1 IQSEC2 CRIPT STT3A MRPL3 MSH6 CREBBP ERCC2 OTUD6B DNAJC21 PREPL PARS2 DUSP6 ACADM IGLL1 ABCA12 TPM3 NALCN ND6 AKT1 DNMT3A NSD2 PEX2 HMGCL MAD2L2 ATXN7 MED12 ERCC4 FOXP3 SLC25A3 VPS13B TRNL1 KCNA1 PRDX1 PEX13 ALPL MTFMT NDUFB3 PRKACA KCNJ10 RYR1 USP7 HUWE1 PTEN COL5A2 NDUFAF3 H19 ABL1 CFTR PYGL NIPAL4 TRAIP ACAD9 CDC45 TCF4 ADA CYB5R3 HLA-DRB1 NUS1 TAPT1 ERCC4 MTRR GATM PRKCD CDC6 RECQL4 DNMT3A MED12 BRCA2 PALB2 KISS1R NDUFS7 PDE6D ASAH1 SDHD CAMKMT DNM1 ASNS NSDHL RTTN ABCC8 SC5D SDHB STXBP1 NAGS STRADA PMS2 POLG TACO1 LTC4S LYRM4 SDHB TGFB3 NUP188 UBTF TRNF EPHX1 NAT8L OTC ND3 ZNF335 AVPR2 AMER1 GCDH SPATA5 PRDM16 HLCS GMNN SLC9A6 COG4 RREB1 SDHC SELENON TSHR STT3B LBR CFTR SLC5A1 PHOX2B SCN2A RFT1 PEX3 MMUT HLA-DRB1 FAM111A ALG12 RET TCN2 ACTB PEX19 NDUFS1 TRMT10A IGF1 ZBTB16 ANTXR2 COA8 RASGRP1 KCNJ11 KRAS FLT1 RECQL4 SP110 PPP2R3C HLA-B VPS37A BCOR CNTNAP1 DGAT1 SLC25A24 CNKSR2 MMACHC TMEM165 MBTPS2 MOGS GNPAT COX10 ADAT3 PTPN22 SEMA4A ATP6V0A2 CYFIP2 VPS35 ASXL1 CDC73 WT1 EARS2 TBX4 UBR1 SMAD4 EBP TRIM28 GP1BB CYP7B1 PIK3CA EPRS1 SBDS MIPEP SLC12A3 MVK ERCC1 RAD51 GLYCTK PTCHD1 ACSL4 CYP11B2 GALT TACO1 IGH SLC6A8 PEX11B PSMB9 SLC17A5 ADAT3 TRNS1 NFKB1 ALG3 BMPR1A CENPJ ERCC3 TET2 RAG2 EPG5 HRAS RTEL1 HADHB MAP2K2 NDUFV2 POLG CLCNKB MS4A1 BRAF FAM111A RTTN STAT4 MMADHC UQCRFS1 TCOF1 DKC1 CENPJ RAD51C ACSF3 CDH23 NDUFS4 PAK3 TUBB4A PRNP TBX1 TBL1XR1 SLC25A15 CD96 MLH1 CYP27B1 SETD5 OTUD6B HIKESHI IL7R MYL2 TRAIP KCNA4 IGH MECP2 IL2RG DCTN1 PRPS1 DDOST PDE11A ND4 MGAT2 PRNP CNTNAP2 PEX10 NR3C2 KDSR DHCR24 DMD CDK10 HSD11B2 GALT NDUFB9 NRTN AHDC1 NDUFA13 ETHE1 CBS HLA-DRB1 TRNV PSAP GNRH1 NDUFB11 SCNN1G KIF7 ABCA3 CUL4B NDUFB11 ANKLE2 BUB1B RAI1 C12ORF65 SCN3A GALE PDX1 EXOSC8 MCCC2 MRPS2 GTF2E2 SLC34A3 MCM9 RPS6KA3 EFL1 OSGEP NUBPL NDUFS1 LIMK1 LIPT1 HTT B4GALT7 SUCLA2 JAK2 HYMAI CD79A SURF1 SLC22A5 FGFR1 ELN NDUFS8 NADK2 MED12 DPM2 MYH3 TWIST2 GBE1 RRM2B FGFRL1 FUT8 DPYD ORC6 SYNJ1 HADH DNM2 TRAK1 XPC KANSL1 NDUFV2 SMARCD2 PHGDH HMGA2 POLG HPD TNFRSF13B TRNQ CDKN2A POLR1D IGF2 CYP27B1 IL1RAPL1 RARS2 GABRA2 KMT2A GJA1 WDR4 MYMK B2M DOCK6 TOP3A UFC1 NDUFB10 PIK3CA SCNN1A IL21R SDHD COL6A3 SKI NADK2 CORIN CYP11B2 NUMA1 DLL4 COL6A1 PRKAR1A H19-ICR NDN GCK SPINK5 LAMA2 LRPPRC TGFB1 HNRNPH2 SELENON UBR1 TRIM28 FOS CPLANE1 PUS3 TSPAN7 SEMA3D ARMC5 STAMBP LEMD3 HLA-DPB1 BMP1 RFXAP DHDDS CDON DPP6 TRNS1 ROBO1 TRNH XYLT2 NAGS PEX11B CACNA1A PEX14 CD79A GPT2 IL12A PRF1 ERCC4 DMXL2 GTPBP2 ACTA1 REST MMAA PEX12 SRP54 DHCR24 ABCC8 ALOX12B NSDHL NDUFAF5 NDUFA12 DSP NSD2 ALAD SDHA LMNA NABP1 NLRP1 PNPLA1 NECAP1 GMNN SLC25A15 SKIV2L COA3 COL12A1 SUCLG1 STAT6 VDR ERCC6 UMPS CNTN1 BRCA2 LAMC2 NELFA COX1 TBL1XR1 GJB4 CCND1 DNM1L GJB3 TYMP LMNA ITCH JPH3 PIK3R1 BRCA1 PCSK1 LMNA PRTN3 PYCR1 DPM1 PROKR2 PTS KCNA2 ZNF711 COX15 ELN SON RYR1 RAG2 TERT SLC25A24 AHCY KDM6A GATA6 ATP6V1E1 GDI1 PIK3C2A CAV1 STRA6 CDKL5 ERCC2 GPT2 PSMB4 CIITA COX2 RET STOX1 COX20 TGM1 LCK INTU PPM1B DOLK IARS1 CTNS TPM2 IPW FGF8 PYCR2 ARFGEF2 SAR1B PEX2 HSD11B2 SON STT3B RAG1 AARS2 DNAJC3 ACO2 GBA NALCN CBL SCO1 NDUFAF6 SLC46A1 G6PC3 NUP62 KAT6B MPI COL1A1 SPRTN ACTL6B FTSJ1 SCNN1A ALG11 SLC39A4 HADHA RIPK1 COX7B IGHM CLMP PET100 SAMD9 PTEN PML INSR COG8 CYP2R1 HSPG2 RFT1 CD19 CXORF56 KLHL41 AUTS2 PROK2 AUH HIBCH SDHC FANCF NTRK2 NECTIN1 AKR1D1 NR0B1 PLEC BCL6 SUCLA2 FANCG TRAC PPP3CA YY1 ASXL1 IL7R PTRH2 COQ7 KIF1B TAZ ALDOB NDUFAF5 LETM1 GRIN2A INS FANCI ZAP70 MCM5 PMPCB CARMIL2 ACTA1 EPAS1 GTPBP3 ASXL3 EWSR1 HACD1 TRIM8 ASXL1 TXNRD2 MECP2 PNPO TRNN HERC2 SLC46A1 LARP7 MRPS7 NDUFB3 FAN1 PLA2G6 NDUFAF4 LMNA CENPE NOTCH2 ERCC5 DACT1 AIMP1 TWNK NNT ACVR1 KLLN ATP6V0A2 YARS2 CD247 XPA PRKAR1A EDNRB CACNA1S OCRL TAC3 USP27X PPP1R15B MC2R MMAB PNPO CA2 ATP7B DHCR7 TK2 FBN2 COL12A1 CIITA RNF168 PTF1A MBL2 COL6A3 BMPR1A KIF7 COX4I2 KIAA0753 GNB1 MYPN NNT TP53 TKFC GRIA4 SLC3A1 ITGB4 VIPAS39 RARB ORC4 SRP54 IFIH1 ORC4 TMEM127 CD79B MPDU1 WDR4 PDX1 KRT5 PACS1 SRSF2 KRAS TIMMDC1 GOT2 NDUFAF1 RET PPP3CA NDUFS3 FBXL4 PEX13 WHCR COL1A1 TRIO HMBS ERMARD DCTN1 TGDS NOTCH2 MAX VAC14 KIF1B PIK3R1 PEX16 USF3 DNAJC21 PUS1 TNFSF12 ACTA1 HLA-DQB1 PEX3 CDT1 EIF2AK3 UBA5 USP9X BSND AGPS USP8 WDR73 TET2 JAK2 HBA2 FUCA1 GABRA3 GNB1 POLR1A SLC6A8 CLCN4 NEB KRAS BLNK GBA SLC13A5 PTEN TCF4 PNPLA6 KISS1 MEFV NEB CTLA4 BRIP1 TRAK1 TYMP TTC37 GJA1 IGH MTRR BANF1 MCCC2 PEX1 DNA2 ND4 GPC3 MLH3 MSH2 EXT1 POLG2 CCND1 NCAPG2 MCEE MEGF10 GIGYF2 TCF4 RUNX1 BCOR SDHB ORC6 DCLRE1C TAF13 SLC7A7 HRAS SETBP1 IRF2BP2 RAI1 SLC35A2 PIGQ CKAP2L PCCA CLDN16 PALB2 PEX10 COL7A1 CACNA1B WRN CERS3 CD3G TIMM50 COX8A BRAF POU6F2 RAD21 DAXX C4A CASK MARS1 FLCN TPM2 RPS6KA3 EXOSC9 MMACHC LRP12 BCS1L PSMB8 FANCA KLHL7 MST1 PEX12 NDUFS6 SLC2A2 RAG1 COPB2 TRPV4 F5 XRCC2 ASCL1 CCDC8 SSR4 BCAP31 OCRL ZSWIM6 TP53 ERCC2 ERCC4 AGPAT2 HSD17B4 DCLRE1C RPS6KA3 KCNB1 HSD3B7 SCNN1B ACAT1 PMM2 GTF2IRD1 ND5 COG8 NDUFS8 SDHD FANCB FAS MYH3 GPIHBP1 FANCM ETHE1 SNX10 ERCC6 RNF13 TET2 JAGN1 TGFB1 DGUOK CD3E SNRPN GALC CLIP2 GCK COG6 COMT POR SFTPC SLC4A1 PEX5 SIL1 RMRP PLAA TP63 ERAP1 TRMT5 NDUFS2 PCGF2 TFAM TSHR NOTCH1 HIRA PEX19 AKT1 PTDSS1 CPLX1 PMS1 GNAO1 COL6A1 SEC23B TJP2 ZNF41 CHRM3 CYP24A1 MDH2 HLA-B CYTB BRCA2 IL2RB CHD7 DDB2 FGD1 PLK4 GATA4 SYP NDUFA10 BCS1L PLAGL1 NDUFS1 TALDO1 RIN2 RFXANK ND3 SEMA3C MYH3 TGFB1 SLC9A7 PIK3R1 SLC12A1 ND6 POLA1 PWRN1 RPS20 KMT2A CYP17A1 FGF12 SLC26A3 CR2 ATR DNA2 SLC7A7 NDUFA4 CAVIN1 NFKB2 TPM3 EIF2S3 IGF1R EIF4G1 PDHA1 NSMF KCNA2 NBN LMBRD1 ALG8 SGO1 ATP6V0A2 PMM2 TRNL1 POLR3A HDAC8 MTO1 SCNN1B HAVCR2 TRIT1 PIK3CA MSX1 SNAP29 COL6A2 SCN3A NAB2 CEP152 NDUFB8 VHL TCTN3 NGLY1 PPP1CB PEX16 SARS1 TP53 ALB SETBP1 ERCC5 ATRX BRCA1 NDUFA13 INSR CLCNKA ATP6V0A4 CPLANE1 RNU4ATAC B3GALT6 LAMA3 B3GLCT RAI1 HCFC1 SYNE1 KRT14 MALT1 ND1 SDHD ATPAF2 SCNN1A KCNJ18 CD40LG ND1 UBE3B JPH3 SLC39A8 COX10 MC2R NACC1 MKKS EDN3 CYP17A1 POMC IL21 BCL10 TNFRSF13C ALG9 FANCC LIG4 GBA COG1 ADAR NFASC MAP3K7 TGFBR2 MED17 POMP NHLRC2 ANOS1 HADHA MYH7 FANCD2 PTPRC ZIC3 HCFC1 CYP11A1 SLC39A4 POLG ADA POLE WDR11 POLG2 BAZ1B CYP7B1 TRNS2 NDUFS4 UBA1 GK DCLRE1C THRB CLCNKB SMOC1 ASS1 MPL BCAP31 ACTB ARX TSHR NONO COA8 ACTG1 GRIN2D MYH7 NDUFB8 EFL1 CAVIN1 CASK PYGL FLNA ACSF3 ALOXE3 JAG1 MMUT RIT1 FAH NONO SAR1B MAP2K1 SLC10A2 MUSK TPM3 KIF15 GNPTAB ATRIP IL12B NPHS1 COL6A2 ATM NDUFA6 INS SURF1 TIMM50 COL1A2 SMC1A ALG13 RFX5 FH NFIX RELB GBA PUF60 BTNL2 BRAF PGM3 NOS1 MBTPS1 NDUFA1 PDHA1 CHD7 NDUFA11 POC1A FLII FRMPD4 PNKP SNORD116-1 NDUFS2 ECE1 EOGT TRIM37 CDT1 ATP6V1A CTCF RBBP8 DLD AHCY TRNK GATA6 GABRD RET ADK NACC1 COG4 ATP6V1E1 CSPP1 FANCA OFD1 GABRA5 PARN CASP8 TNFSF12 C12ORF65 CYP2R1 IL6 B3GALT6 AARS1 RPS19 TGFB1 SCN1B TBL1XR1 PLAA ZNF81 LIPA PARN NKX2-1 CCDC47 DNAJC13 FMR1 TTR PDX1 BIRC3 FGFR1 FANCL FBN1 GNAS IKBKB STAT5B ND2 KCNJ11 COG7 IL12A-AS1 CNKSR2 ARID1B MLX SLC1A2 PWAR1 PCCB ECHS1 CD81 MRPS14 THPO ZAP70 STAT3 RAB39B KRT14 WNT2B PNPT1 DYRK1A LRBA BAAT PET100 KLRC4 ATP5F1A NDUFAF2 EVC PEX6 AGXT WDR26 PALLD HLA-B MPV17 NOD2 SCO2 NDUFS2 NDUFB11 SLC25A22 SMARCA2 MRAP HSD3B7 SNCA GYS2 TIMMDC1 OTULIN NDUFAF8 HLA-DQA1 COX3 ASL STRADA SDHA SMAD4 UNC80 MCTP2 PEX1 ATM LARS1 ARVCF MID2 RAG2 KIAA0586 NFKB2 COG1 TFRC SELENON HBA1 FOXRED1 IQSEC2 SKI LAMB3 SDHC RBPJ VPS33B FOXRED1 GALC CREB3L1 NDUFAF4 IL2RG AQP2 NR1H4 CYB5A GNPTAB UBE2T VPS45 ATP8B1 NPM1 SMC1A PEX1 AVPR2 HS6ST1 PEX16 PPARG GDNF STAG1 LRP5 HLA-DQB1 SLC19A3 TBC1D23 RBM10 STAR PEX5 RBM10 PREPL RET RFC2 PSMD12 NLRC4 SDHAF1 GABRG2 MCCC1 IL2RG CCNQ SLC39A13 MCCC1 FOXP1 PROKR2 ANOS1 ERCC4 ACOX1 NEB GRIA3 MSMO1 SCNN1G SZT2 LYRM7 CASR JMJD1C ST3GAL5 GRIA3 RPL5 TMEM70 AARS1 ARPC1B MAFB FLNA AUTS2 TRIP13 SLC25A13 YWHAG JAK3 TMEM126B POLR1C SBDS ND5 SDHB ACD EHMT1 PTPN11 JAK2 CARS2 SIX2 ACTA1 SMPD1 YY1AP1 AVP NDUFAF2 ATP6 RMRP CSNK2A1 SELENON TCTN3 POLR3A PYCR2 CDC45 TRNW SCNN1G CDC6 TBX1 KCNJ6 DCLRE1C JAK2 PPP1R15B NDUFA2 AMPD2 GHSR DHDDS KCNJ18 DDX3X AHDC1 CD3D FZD4 NGLY1 SEC24C NEUROD2 NSUN2 MAGEL2 BMP4 MECP2 FTO HCN1 NDUFA9 HADHB MAP2K1 TRMT10C SLC25A4 SLC25A21 SYNGAP1 HPD SMARCC2 FANCE NDUFAF5 TRMT1 SDHAF2 STAG2 PEX19 SLC25A13 RFWD3 ELAC2 CPS1 SHROOM4 SLC11A1 CTNS UPF3B HERC1 SURF1 ATP6V1A NIPBL SCNN1B RRM2B PEX26 PEX5 NFE2L2 RRM2B ABCB11 FH SLC34A1 PEX26 NPAP1 TTN RAG1 BRCA2 JAK3 FIG4 SMC3 KRT1 PRNP AGTPBP1 ALDH18A1 CASK MDH2 RFXAP CYP19A1 RHBDF2 TTC37 FARSB RERE NRXN1 CYP11A1 LAMA3 KRAS MLXIPL ZFP57 RBBP8 SALL1 ATP6 PCLO PEX12 IGF1 CYB5A IKZF1 PEX13 UBAC2 ORC1 EXT2 RARA RB1 TPM2 LIG4 SSR4 EGFR MAP2K1 NDP PCNT ND1 CSF2RA NDP AK2 KCNJ6 FIP1L1 PNP ITGA7 PEX2 HLA-DPA1 LRRC8A AP3B2 TLR4 SLC25A13 PSAT1 ADA STXBP1 NUS1 MKRN3-AS1 CHEK2 TMEM216 ATP6V1A FANCD2 SNCA CRLF1 GRIN2D FAM149B1 ACADS BMPR1A PANK2 TMPRSS15 SDHA RBCK1 GTF2I FLI1 DEGS1 PAM16 PTEN NUP214 EPCAM KBTBD13 LAMB3 UNC80 IL10 IFNGR1 PEX6 SPR DDOST DNAJC21 SKIV2L STAT3 VPS13A MPL ARV1 STT3A COX15 AGTR2 WT1 VPS13B GLI1 COL5A1 PTPN22 TRNW MKRN3 ARCN1 GATA2 CLTCL1 ORC1 OBSL1 SLC12A3 SLC3A1 STING1 FIG4 DLG3 FANCC NDUFS4 GABRB2 ERCC2 SIK1 TBL2 IRF6 SDHB TMEM216 PEX14 NOD2 CA12 IGF2 TCF3 ND2 HADHA AP1B1 FBN1 ESR2 CDH23 LHX4 IL7R BTK SARS2 HYMAI SMAD4 FLNA ZMPSTE24 MAP3K20 KDM6A RFX5 AMACR NFU1 VHL ACTB POLA1 TINF2 ALG13 CD96 CIT
Protein Mutations 0
SNP 0

Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook