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D018746: Systemic Inflammatory Response Syndrome

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (4)


Name (Synonyms) Correlation
drug1932 MMR vaccine Wiki 0.58
drug960 Cytokines dosage Wiki 0.58
drug860 Complement dosage Wiki 0.58
Name (Synonyms) Correlation
drug46 3D Telemedicine Wiki 0.33

Correlated MeSH Terms (8)


Name (Synonyms) Correlation
D014115 Toxemia NIH 0.41
D009102 Multiple Organ Failure NIH 0.26
D018805 Sepsis NIH 0.24
Name (Synonyms) Correlation
D058186 Acute Kidney Injury NIH 0.13
D013577 Syndrome NIH 0.06
D012127 Respiratory Distress Syndrome, Newborn NIH 0.05
D055371 Acute Lung Injury NIH 0.05
D012128 Respiratory Distress Syndrome, Adult NIH 0.05

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0100806 Sepsis HPO 0.24
HP:0001919 Acute kidney injury HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Uppsala Intensive Care Study of Mechanisms for Organ Dysfunction in Covid-19

The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.

NCT04316884
Conditions
  1. COVID-19
  2. Organ Dysfunction Syndrome Sepsis
  3. Organ Dysfunction Syndrome, Multiple
  4. Septic Shock
  5. Acute Kidney Injury
  6. Acute Respiratory Distress Syndrome
MeSH:Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury Acute Kidney Injury Syndrome Systemic Inflammatory Response Syndrome Multiple Organ Failure
HPO:Acute kidney injury

Primary Outcomes

Description: KDIGO AKI score

Measure: Acute Kidney Injury

Time: During Intensive Care, an estimated average of 10 days.

Secondary Outcomes

Description: Acute Respiratory Distress Syndrome yes/no

Measure: ARDS

Time: During intensive care, an estimated average of 10 days.

Description: Death within 30 days of ICU admission

Measure: 30 day mortality

Time: 30 days

Description: Death within 1 year of ICU admission

Measure: 1 year mortality

Time: 1 year

Description: Development of Chronic Kidney Disease

Measure: Chronic Kidney Disease

Time: 60 days and 1 year after ICU admission

Description: Sequential Organ Failure Score as a continuous variable

Measure: SOFA-score

Time: During Intensive Care, an estimated average of 10 days.
2 Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in SARS-Cov-2 Infected Patients With a Systemic Inflammatory Response Syndrome

In patients infected by the SARS-Cov-2 Coronavirus a severely progressive disease requiring hospitalization in intensive care seems related to deregulation of cytokines with very high levels of IL-6, IL-2, IL-7, IL-10 and TNF-α. In order to elucidate the mechanism of this hyper inflammatory syndrome we will measure a panel of pro and anti inflammatory cytokines, as well as known markers of macrophage activation syndrome. To determine the role of activation of the complement cascade the most important complement factors and their activation markers will be measured. The changes of those parameters will be monitored after administration of an anti-IL6R antibody therapy.

NCT04346017
Conditions
  1. COVID-19
Interventions
  1. Diagnostic Test: Cytokines dosage
  2. Diagnostic Test: Complement dosage
MeSH:Systemic Inflammatory Response Syndrome

Primary Outcomes

Description: Interleukine 6, soluble IL6-R, complex IL6-IL6R concentration

Measure: IL6 concentration

Time: Before anti-IL6R treatment (baseline)

Description: Interleukine 6 soluble IL6-R, complex IL6-IL6R variation compared to baseline value

Measure: IL6 concentration change from baseline value

Time: Twice a week from day 1 to day 14 post anti-IL6R administration

Description: CH50, C3, C4, C3d, C5a, SC5b-9, C4a, MASP-2

Measure: Complement parameters

Time: Before anti-IL6R treatment (baseline)

Description: CH50, C3, C4, C3d, C5a, SC5b-9, C4a, MASP-2 variation compared to baseline values

Measure: Complement parameters change from baseline values

Time: Twice a week from day 1 to day 14 post anti-IL6R administration

Description: Concentration of TNFa, IFNg, IL1, IL7, IL10, IL12, IL17, IL18

Measure: Inflammatory cytokines baseline concentrations

Time: Before anti-IL6R treatment (baseline)

Description: Concentration of TNFa, IFNg, IL1, IL7, IL10, IL12, IL17, IL18 variation compared to baseline values

Measure: Inflammatory cytokines change from baseline values

Time: Twice a week from day 1 to day 14 post anti-IL6R administration

Secondary Outcomes

Description: sCD25, sCD163, sCD14, glycosylated ferritin

Measure: Concentration of markers of macrophage activation

Time: Before anti-IL6R treatment (baseline)

Description: sCD25, sCD163, sCD14, glycosylated ferritin variation compared to baseline values

Measure: Markers of macrophage activation change from baseline values

Time: Twice a week from day 1 to day 14 post anti-IL6R administration
3 Use of a Live Attenuated Vaccine Repurposed as an Innate Immune-based Preventive Against COVID-19-associated Sepsis/Inflammation

The objective of this randomized clinical trial is to test whether administration of live attenuated MMR vaccine (measles mumps rubella; Merck) to eligible adults at highest risk for contracting COVID-19 (healthcare workers, first responders), can induce non-specific trained innate immune leukocytes that can prevent/dampen pathological inflammation and sepsis associated with COVID-19-infection, if exposed.

NCT04475081
Conditions
  1. Sepsis Syndrome
Interventions
  1. Biological: MMR vaccine
MeSH:Sepsis Toxemia Systemic Inflammatory Response Syndrome
HPO:Sepsis

Primary Outcomes

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of myeloid-derived suppressor cells (MDSCs)

Time: 14 days post-vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 30 days post vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 60 days post vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 12 months post vaccination

Secondary Outcomes

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 14 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 30 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 60 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 12 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 14 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 30 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 60 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 3 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 4 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 5 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 6 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 7 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 8 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 9 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 10 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 11 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 12 months post-vaccination

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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