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D018149: Glucose Intolerance

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1899 Low-Carbohydrate Diet Wiki 0.58
drug3942 lifestyle modification Wiki 0.58
drug974 DPPFit Wiki 0.58

Correlated MeSH Terms (9)


Name (Synonyms) Correlation
D011236 Prediabetic State NIH 0.58
D003929 Diabetic Neuropathies NIH 0.58
D010523 Peripheral Nervous System Diseases NIH 0.58
Name (Synonyms) Correlation
D006943 Hyperglycemia NIH 0.41
D004700 Endocrine System Diseases NIH 0.41
D008659 Metabolic Diseases NIH 0.33
D044882 Glucose Metabolism Disorders NIH 0.33
D024821 Metabolic Syndrome NIH 0.29
D003920 Diabetes Mellitus, NIH 0.12

Correlated HPO Terms (4)


Name (Synonyms) Correlation
HP:0011998 Postprandial hyperglycemia HPO 0.58
HP:0001271 Polyneuropathy HPO 0.58
HP:0000818 Abnormality of the endocrine system HPO 0.41
Name (Synonyms) Correlation
HP:0000819 Diabetes mellitus HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Improving Autonomic Function and Balance in Diabetic Neuropathy

Type 2 diabetes (DM2) affects nearly 20 million people in the United States while impaired glucose regulation (IGR), which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and early diabetes affects a considerably larger but unknown population group. At the current time there is no effective therapy to completely prevent, or reverse neuropathy associated with IGR and this represents a considerable challenge in rehabilitation. There is a particularly strong incentive to prevent IGT and related complications from advancing to DM2. IGR is a growing problem among all older adults and its strong association with many functional limitations, particularly mobility limitations, is not always recognized, even though diabetes-related disability occurs in up to 2/3 of older adults with diabetes and is associated with dependency, poor quality of life, and increased acute and long-term care utilization. Autonomic dysfunction is a significant problem in subjects with IGT. The Preliminary Data shows that over 90% of subjects with IGT have an abnormal score on questionnaires about autonomic symptoms such as lightheadedness, dry mouth or dry eyes, pale or blue feet, feet that are colder than the rest of the body, decreased sweating in the feet or increased sweating in the hands, nausea or bloating after eating, persistent diarrhea or constipation, or leaking of urine. In addition, patients with IGR have impaired balance control. These factors can increase the risk of falls in affected subjects. A non-randomized and non-controlled study showed that a diet and exercise intervention in patients with diabetes led to an overall improvement in autonomic function. Furthermore, it was shown that standing balance can be improved with a balance intervention program. However, there are no published studies that assess the effect of an intense physical activity intervention on autonomic function in IGR related neuropathy. This study will test an aerobic exercise and balance intervention in participants with IGR. The investigators will examine if an individually tailored, carefully monitored, Diet, Physical Activity, and Balance Enhancement Program (DPAEP) can improve autonomic function and balance control when compared to patients who receive standard care. Improving balance control and autonomic function can decrease the risk of falls and have a significant effect on the health of participants. The research is also significant because it will test subjects either before they become diabetic, or at an early stage in their diabetes, thus enhancing the chance of reversing the autonomic neuropathy or balance impairment. Furthermore, the study is designed to test whether improvement in autonomic function and balance is associated with improvement in clinical outcomes, quality of life, and the metabolic state of participants. Thus, the proposed interventions are likely to have a real life impact on participants and their health.

NCT01864460
Conditions
  1. Diabetes
  2. Neuropathy
  3. Impaired Glucose Tolerance
Interventions
  1. Behavioral: lifestyle modification
MeSH:Peripheral Nervous System Diseases Diabetic Neuropathies Glucose Intolerance
HPO:Abnormal peripheral nervous system morphology Peripheral neuropathy Polyneuropathy

Primary Outcomes

Description: This is a cardiac autonomic measure that will be carried out using clinical equipment in the autonomic laboratory at the site. The measurement requires placing electrodes near the heart similar to an EKG.

Measure: Autonomic Function: heart rate variability

Time: 12 months

Secondary Outcomes

Description: This outcome measure assesses changes in trunk positioning using a standardized, validated test.

Measure: balance

Time: 6 and 12 months

Other Outcomes

Description: This outcome assesses sweat gland nerve fiber density, which is proposed as a sensitive neuropathy pathology biomarker.

Measure: Sweat gland nerve fiber density

Time: 12 months
2 Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial

The proposed randomized controlled trial will test the effect of a low-carbohydrate diet on hemoglobin A1c among individuals with elevated hemoglobin A1c that are within the range of prediabetes or diabetes. Results may provide evidence about the role of carbohydrate restriction in individuals with or at high risk of type 2 diabetes.

NCT03675360
Conditions
  1. Diabetes
  2. PreDiabetes
  3. Metabolic Disease
  4. Hyperglycemia
  5. Diet Modification
  6. Glucose Intolerance
  7. Glucose Metabolism Disorders (Including Diabetes Mellitus)
  8. Endocrine System Diseases
Interventions
  1. Behavioral: Low-Carbohydrate Diet
MeSH:Diabetes Mellitus Hyperglycemia Prediabetic State Glucose Intolerance Metabolic Diseases Glucose Metabolism Disorders Endocrine System Diseases
HPO:Abnormality of the endocrine system Diabetes mellitus Hyperglycemia Postprandial hyperglycemia

Primary Outcomes

Measure: Change in Hemoglobin A1c

Time: Baseline and six months

Secondary Outcomes

Measure: Change in fasting plasma glucose

Time: Baseline and six months

Measure: Change in systolic blood pressure

Time: Baseline and six months

Measure: Change in total-to-HDL-cholesterol ratio

Time: Baseline and six months

Measure: Change in body weight

Time: Baseline and six months

Other Outcomes

Measure: Change in insulin

Time: Baseline and six months

Measure: Change in homeostasis model assessment of insulin resistance (HOMA-IR)

Time: Baseline and six months

Measure: Change in diastolic blood pressure

Time: Baseline and six months

Measure: Change in waist circumference

Time: Baseline and six months

Description: Based on 10-year cardiovascular disease risk assessed by 2013 American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease Risk Score

Measure: Change in estimated cardiovascular disease risk

Time: Baseline and six months
3 Developing and Testing a Technology-Based Translation of the Diabetes Prevention Program for Adult Primary Care Patients At-Risk of Developing Type 2 Diabetes Mellitus

DPPFit is a Healthy Lifestyle Intervention designed to reformat the effective strategies of the Diabetes Prevention Program (NDPP) into a tool for use in a primary care setting. DPPFit is a 16-week technology-based intervention for diabetes prevention. In keeping with the National DPP educational sessions, the intervention weeks follow the order and presentation of the N-DPP 16 session topics. The goal is to develop a pragmatic translation of the DPP that is effective in the real-world setting of primary care clinic. The hope is that in doing so, those at risk of developing type II diabetes mellitus will have evidenced-based prevention methods at their disposal.

NCT04564586
Conditions
  1. PreDiabetes
  2. Metabolic Syndrome, Protection Against
Interventions
  1. Behavioral: DPPFit
MeSH:Metabolic Syndrome Prediabetic State Glucose Intolerance

Primary Outcomes

Description: Weight Loss by % of Body Weight Loss, by # of Participants losing 5% and 7% of Body Weight

Measure: Weight Loss

Time: 12 Months

Description: Increase in PA days/week, Increase > 10% of PA, Kcal/week

Measure: Physical Activity

Time: 6 months

Description: Decrease in Sedentary Time, Mins/day

Measure: Inactivity

Time: 6 months

Secondary Outcomes

Description: MOS SF-20 / MOS Social Support Scale

Measure: Health Related Quality of Life

Time: 6 months /

Description: Reduction in % of HbA1c at 1 year follow-up

Measure: Hemoglobin A1c

Time: 12 months

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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HPO

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