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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation A2142G

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There are 3 clinical trials

Clinical Trials


1 Helicobacter Pylori Eradication Rates of Concomitant Therapy and Tailored Therapy Based on 23S Ribosomal RNA Point Mutations Associated With Clarithromycin Resistance: A Multicenter Prospective Randomized Study

The purpose of this study was to evaluate the efficacy and compliance of tailored therapy which using the polymerase chain reaction for point mutation of clarithromycin, compared to concomitant therapy, in patients without history of H. pylori eradication.

NCT03130452
Conditions
  1. Helicobacter Pylori Infection
Interventions
  1. Drug: Lansoprazole 30mg
  2. Drug: Amoxicillin 1.0g Tab
  3. Drug: Clarithromycin 500mg
  4. Drug: Metronidazole 500 mg

Method> Patients with H. pylori infection who have been screened for a 23S ribosomal RNA point mutation (A2142G, A2143G point mutation) and randomized to a concomitant treatment group and a tailored treatment group. --- A2142G ---

Primary Outcomes

Description: Comparison of percentage of people who succeeded in H. pylori eradication among all participants in each treatment group (tailored therapy vs concomitant therapy)

Measure: Comparison of success rate of H. pylori eradication between tailored therapy and concomitant therapy.

Time: At 4 weeks after the completion of drug administration, the urea breath test is performed to check for eradication, Before the urea breath test, the proton pump inhibitor or H2 blocker should be discontinued for 2 weeks.

Secondary Outcomes

Description: Identify the effect of 23S ribosomal RNA point mutation on the eradication rate regardless of the administration drug.

Measure: Difference in eradication rate according to the frequency of 23S ribosomal RNA point mutation in clarithromycin

Time: Before the treatment, 23S ribosomal RNA point mutation is confirmed and at least 4 weeks after the end of treatment, urea breath test is performed to check whether or not eradication is completed.

Other Outcomes

Description: After taking the treatment drug, take out all remaining medicine in the outpatient clinic room, check the number of remaining medicines, and judge compliance.

Measure: Number of remaining medicines of tailored therapy compared to concomitant therapy

Time: At 4 weeks after the completion of drug administration, when the patient visited for the urea breath test, check the number of remaining medicines.

2 Helicobacter Pylori Eradication According to Sequencing-based 23S Ribosomal RNA Point Mutation Associated With Clarithromycin Resistance

The investigators investigated the point mutations in the 23S rRNA genes of patients infected with clarithromycin-resistant H. pylori and compared the H. pylori eradication rates based on the identified clinically significant point mutations.

NCT03884348
Conditions
  1. Helicobacter Pylori Infection
  2. Antibiotic Resistant Strain
Interventions
  1. Drug: proton pump inhibitor, amoxicillin, clarithromycin
  2. Drug: proton pump inhibitor, amoxicillin, metronidazole
MeSH:Sprains and Strains

Inclusion Criteria: - Clinical diagnosis of Helicobacter pylori infection Exclusion Criteria: - H. pylori eradication therapy within 1 year, - antibiotics within 4 weeks, - surgery for gastric cancer - malignant tumors other than gastric cancer - end-stage renal disease - liver cirrhosis, - pregnancy Inclusion Criteria: - Clinical diagnosis of Helicobacter pylori infection Exclusion Criteria: - H. pylori eradication therapy within 1 year, - antibiotics within 4 weeks, - surgery for gastric cancer - malignant tumors other than gastric cancer - end-stage renal disease - liver cirrhosis, - pregnancy Helicobacter Pylori Infection Antibiotic Resistant Strain Sprains and Strains Sequencing-based detection of point mutations identified four mutations that were considered clinically significant (A2142G, A2142C, A2143G, A2143C), while all the other mutations were considered clinically insignificant. --- A2142G ---

Primary Outcomes

Description: Number of participant with successful Helicobacter pylori eradication

Measure: Helicobacter pylori eradication rate

Time: 2 year

3 Comparison of Empirical and Genotypic Resistance Guided Tailored Therapy for Helicobacter Pylori Infection

We aimed to compare the efficacy of genotypic resistance-guided tailored therapy vs empirical therapy for eradication of Helicobacter pylori (H. pylori) infection in randomized controlled trials.

NCT04006340
Conditions
  1. Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation
  2. Helicobacter Pylori Infection
Interventions
  1. Combination Product: triple therapy
  2. Combination Product: quadruple therapy
  3. Diagnostic Test: dual-priming oligonucleotide-based multiplex (DPO)-PCR test
MeSH:Infection Communicable Diseases Helicobacter Infections

This is a method to confirm the mutation of A2142G and A2143G by PCR, which are known to be highly related to the resistance of clarithromycin 23S rRNA point mutation. --- A2142G ---

Primary Outcomes

Description: Eradication rate of H. pylori infection

Measure: Eradication rate

Time: 13C-UBT at least 4 weeks after completion of treatment


HPO Nodes