SNPMiner Trials by Shray Alag

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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation P200T

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders (Diabetic Retinopathy, Dry AMD, Hard Drusen Formation) for Alzheimer's Disease Prevention

The study will explore the impact of photobiomodulation (PBM), pulsating at frequencies of red (660nm) and near-infrared (810nm)(NIR), concurrent with a ketogenic dietary protocol (serum ketones @ .5 - 2.0 mmol/L) to mediate vascular features of diabetic retinopathy (DR), diabetic macular edema (DME), age-related macular degeneration (AMD), mid-peripheral drusens, visual acuity and retinal disorders. Red and near-infrared light via light-emitting diode (LED) treatment promotes retinal healing and improves visual acuity by augmenting cellular energy metabolism, enhancing mitochondrial function, increasing cytochrome C oxidase activity, stimulating antioxidant protective pathways and promoting cell survival. LED therapy directly benefits neurons in the retina, the lateral geniculate nucleus and the visual cortex; likewise, a ketogenic dietary protocol shows metabolic and neuro-modulatory benefits within the CNS, most notably as treatment for refractory epilepsy. Photobiomodulation has been approved as a non-significant risk (NSR) modality for the treatment of eye disorders.

NCT03859245
Conditions
  1. Diabetic Retinopathy (DR)
  2. Age-related Macular Degeneration (AMD)
  3. Mid-peripheral Drusen Formation
  4. Diabetic Macular Edema (DME)
Interventions
  1. Behavioral: Photobiomodulation
  2. Behavioral: Ketogenic diet
MeSH:Alzheimer Disease Macular Degeneration Macular Edema Retinal Diseases Diabetic Retinopathy
HPO:Abnormal retinal morphology Alzheimer disease Cystoid macular edema Macular edema Retinopathy

Improvement in number and severity of hemorrhages and hard and soft exudates as measured by the Daytona Plus (Panoramic Ophthalmoscope P200T). --- P200T ---

Lower incidence of macular edema as measured by Optos Daytona Plus (Panoramic Ophthalmoscope P200T) and Optovue XR Avanti 3 OCT (Ocular Coherence Tomography) Imaging Systems. --- P200T ---

Reduction in size and number of drusen in early and intermediate stages of Dry AMD pathology as measured byOptos Daytona Plus (Panoramic Ophthalmoscope P200T) and Optovue XR Avanti 3 OCT (Ocular Coherence Tomography) Imaging Systems. --- P200T ---

Reduction in size and/or density of drusen as measured by the Optos Daytona Plus (Panoramic Ophthalmoscope P200T). --- P200T ---

Primary Outcomes

Description: Improvement in number and severity of hemorrhages and hard and soft exudates as measured by the Daytona Plus (Panoramic Ophthalmoscope P200T)

Measure: Diabetic Retinopathy (DR) pathology

Time: 36 weeks

Description: Lower incidence of macular edema as measured by Optos Daytona Plus (Panoramic Ophthalmoscope P200T) and Optovue XR Avanti 3 OCT (Ocular Coherence Tomography) Imaging Systems

Measure: Diabetic Macular Edema (DME) pathology

Time: 36 weeks

Description: Reduction in size and number of drusen in early and intermediate stages of Dry AMD pathology as measured byOptos Daytona Plus (Panoramic Ophthalmoscope P200T) and Optovue XR Avanti 3 OCT (Ocular Coherence Tomography) Imaging Systems

Measure: Dry Age-related Macular Degeneration (AMD) pathology

Time: 36 weeks

Description: Reduction in size and/or density of drusen as measured by the Optos Daytona Plus (Panoramic Ophthalmoscope P200T)

Measure: Hard Drusen in the Mid-periphery pathology

Time: 36 weeks

Secondary Outcomes

Description: Assessment of changes in HgA1c (Hemoglobin A1c) over time. Ranges: <5.7%

Measure: HgA1c

Time: 36 weeks

Description: Assessment of changes in fasting insulin over time. Ranges: < 2.6-11.1 mU/L

Measure: Fasting Insulin

Time: 36 weeks

Description: Assessment of changes in fasting glucose over time. Ranges 74-100 mg/dL

Measure: Fasting Glucose

Time: 36 weeks

Description: Assessment of changes in HOMA-IR over time. Ranges <1.0

Measure: HOMA-IR

Time: 36 weeks

Description: Assessment of changes in triglycerides/HDL ratio over time. Ranges <2.0

Measure: Triglycerides/HDL ratio

Time: 36 weeks


HPO Nodes