SNPMiner Trials by Shray Alag

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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation S253N

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting

Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, it is reported that over 35% of patients treated with ondansetron experience PONV. Though the cause of failure in ondansetron treatment is not clear, the investigators assumed that polymorphism in the 5-HT3 receptor gene would contribute to such inter-individual variation. In this study, the investigators examine whether the polymorphisms of 5-HT3 receptor gene affect the efficacy of ondansetron to prevent PONV in patients undergoing general anesthesia for laparoscopic surgery.

NCT01657786
Conditions
  1. Post Operative Nausea and Vomiting
Interventions
  1. Dietary Supplement: administration of ondanstron and screening of genomic DNA
MeSH:Nausea Vomiting Postoperative Nausea and Vomiting
HPO:Nausea Vomiting

The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG). --- S253N ---

The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).. Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Post Operative Nausea and Vomiting Nausea Vomiting Postoperative Nausea and Vomiting null --- S253N ---

Primary Outcomes

Description: The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).

Measure: The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG)

Time: at first 2 h and 2-24 h after surgery.


HPO Nodes


HP:0002013: Vomiting
Genes 367
ZIC2 IVD TRMU OPLAH AVP MC2R ND4 CFH HSD3B2 GALE TRNL1 CTNNB1 MMUT NDUFS6 NODAL DYRK1A ALG11 ACADM COL5A1 SHANK3 PCCA ACAT1 LIPA PDCD10 CDKN1B NDUFB3 MEN1 SCNN1G SIX3 ACAT1 MRPS7 TYMP ASS1 LAMA3 KMT2E ACP2 HFE HMGCS2 DGAT1 ADNP MCCC2 ALG3 NDUFS1 AVPR2 RET CPS1 HPRT1 MVK STAT4 NDUFV1 SERPING1 SYT1 C11ORF95 EGFR ABCC8 MEN1 NDUFS7 CYP11A1 DBH ALDOB COX3 CYTB F12 MSX2 DISP1 KCNJ11 GAS1 GK FOXH1 LAMC2 NDUFS2 PPOX D2HGDH FLNA RELA TRNL1 SCNN1B CYP11A1 ETFB TRNQ TRNQ SIX3 COX2 DLL1 TXNRD2 SIX3 TDGF1 PMM2 CYP11B1 ASPA BTD MCCC1 TNF ND1 CDKN2C NDUFS3 NDUFA1 NDUFA11 SPP1 TRNF ARG1 MLYCD TP53 ALX4 NDUFAF2 FOXH1 DLD ATP6 KRIT1 ACSF3 CDON NAGS CDON NOTCH2NLC SAR1B AIP GHSR COQ2 ALDH18A1 GAS1 CDK8 MTHFD1 PNPLA8 HIBCH PPM1D KCNJ1 TRNH SLC7A7 FBP1 MPI MRAP HNF1A MMAA CD46 CYP11B2 NDUFS8 ZIC2 COL5A2 NDUFAF4 CDH23 FOXRED1 SCNN1A SLC22A5 ASL TCN2 COX3 NODAL DGUOK BRAF FOXH1 ND1 NLRC4 CLMP NAGS ACTG2 SHH DISP1 NDUFB10 ND1 NDUFS4 ACADM NAXD ND6 ESR1 ACADL FGF8 GLI2 COL1A1 ACY1 MMAB HNF4A SCN2A MTTP SERPING1 APC CPOX ST3GAL5 DISP1 TGIF1 POLG NDUFAF3 SLC6A8 NDUFS4 MPV17 SAA1 FOXP3 FGF8 MEFV TRNW NDUFV1 PSAP ACAD8 TDGF1 NBAS ND5 DHCR7 PTCH1 AQP2 TRNS2 ALAD CDH23 CYTB TDGF1 TRNS2 GLI2 FGF8 TRNS1 HLCS SHH COX2 GLI2 FGFR1 STAR ND3 ND1 TRNK GAS1 NDUFS1 GFM2 ZEB2 GALC MET TRNV NDUFV2 TGIF1 ND4 TMEM126B POLG ND5 SUGCT GLA NDUFAF1 MVK DBT MTRR SLC25A15 LAMB3 CDON ATP6V0A4 SCNN1A ETFDH NFIX STAG2 NDUFAF8 SLC25A15 PTCH1 CCM2 SIX3 COX1 CPOX ETFA ND6 FOXH1 GALC PHGDH TRNV HADH CTNS NDUFA6 TGIF1 ZIC2 ALG11 SLC12A1 TIMMDC1 ATRX EDNRA SERPING1 NDUFAF5 OXCT1 CD55 LPL RANBP2 PMM2 HELLPAR FGF8 ALPL BCKDHA SHH TDGF1 HMBS IRAK1 TRNW SLC5A6 BCKDHB TRNW DLL1 STAG2 TRNC ABCC8 SHH NODAL RRM2B TGIF1 PTCH1 AIMP1 ZIC2 TRNK TNFRSF1A ND6 FGFR1 GAS1 HMGCL SLC25A13 CACNA1A ACSF3 SMPD1 ND2 ALG8 TRNF NEUROG3 PCCB PIGY NDUFB11 CPOX TIMM22 PDSS2 OTC SLC1A3 CPT2 ND2 CYP24A1 CDON TYMP KCNJ11 ND5 NR3C2 CFI SCNN1B ELP1 RARS1 NNT NODAL SCNN1G POLG CDKN1A ACADVL NUBPL NEUROG3 DLL1 PTCH1 STK11 PYCR2 SLC7A7 SAR1B CDKN2B NDUFB9 GLI2 FARSB UCP2 TRNL1 HMGCL ZEB2 COA8 ALDOB COX1 DLL1 ACADVL BOLA3 GALT SSR4 SLC12A3 ZEB2 TRNS1 SLC22A5 DISP1 ND3 SMC1A
Protein Mutations 3
S253N V158M Y129S
SNP 1
rs4680