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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation E27Q

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Genetic Influences of Albuterol Response In Children With Bronchiolitis

Bronchiolitis is a significant cause of morbidity and hospitalization in children, accounting for approximately 125,000 hospitalizations per year in the U.S. Recently, genetic variations of the β2-adrenergic receptor (β2-AR) have been shown to influence response to β2-AR agonist therapy in children with asthma. We suspect that genetic variations of the β2-AR also affect response to β2-AR agonist therapy in children with bronchiolitis.

NCT00570297
Conditions
  1. Bronchiolitis
MeSH:Bronchiolitis
HPO:Bronchiolitis

The next most common polymorphism of the β2-AR gene, glutamine to glutamic acid at position 27 (Glu27Gln), may be associated with the development of asthma and airway hyperresponsiveness, but these relationships are less clear. --- Glu27Gln ---

Primary Outcomes

Description: The primary end point is change in lung resistance following a single dose of inhaled b2-AR agonist therapy (albuterol).

Measure: Change in lung resistance

Time: Immediate

Secondary Outcomes

Description: To assess the change in lung compliance following a single dose of inhaled b2-AR agonist therapy (albuterol)

Measure: Change in lung compliance

Time: Duration of hospitalization

Description: To compare duration of mechanical ventilation and ICU hospital length of stay by genotype

Measure: Comparison by genotype

Time: Duration of Hospitalization


HPO Nodes